NZ515232A - IL-8 receptor antagonists - Google Patents
IL-8 receptor antagonistsInfo
- Publication number
- NZ515232A NZ515232A NZ515232A NZ51523200A NZ515232A NZ 515232 A NZ515232 A NZ 515232A NZ 515232 A NZ515232 A NZ 515232A NZ 51523200 A NZ51523200 A NZ 51523200A NZ 515232 A NZ515232 A NZ 515232A
- Authority
- NZ
- New Zealand
- Prior art keywords
- receptor antagonists
- chemokine
- interleukin
- formula
- treatment
- Prior art date
Links
- 102000010681 interleukin-8 receptors Human genes 0.000 title 1
- 108010038415 interleukin-8 receptors Proteins 0.000 title 1
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
- 102000004890 Interleukin-8 Human genes 0.000 abstract 2
- 108090001007 Interleukin-8 Proteins 0.000 abstract 2
- XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 abstract 2
- 229940096397 interleukin-8 Drugs 0.000 abstract 2
- 102000019034 Chemokines Human genes 0.000 abstract 1
- 108010012236 Chemokines Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/66—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/28—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to cyano groups, e.g. cyanoguanidines, dicyandiamides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
This invention relates to novel compounds of Formula (I), pharmaceutical compositions and their use in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13967499P | 1999-06-16 | 1999-06-16 | |
PCT/US2000/016813 WO2000076516A1 (en) | 1999-06-16 | 2000-06-16 | Il-8 receptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
NZ515232A true NZ515232A (en) | 2004-02-27 |
Family
ID=22487784
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NZ515232A NZ515232A (en) | 1999-06-16 | 2000-06-16 | IL-8 receptor antagonists |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP1191934A4 (en) |
JP (1) | JP2003501471A (en) |
KR (1) | KR20020009635A (en) |
CN (1) | CN1494424A (en) |
AR (1) | AR029368A1 (en) |
AU (1) | AU766086B2 (en) |
BR (1) | BR0010985A (en) |
CA (1) | CA2377397A1 (en) |
CZ (1) | CZ20014490A3 (en) |
EC (2) | ECSP003525A (en) |
HK (1) | HK1044716A1 (en) |
HU (1) | HUP0202019A3 (en) |
IL (1) | IL146214A0 (en) |
MX (1) | MXPA01013287A (en) |
NO (1) | NO20016065L (en) |
NZ (1) | NZ515232A (en) |
PE (1) | PE20010319A1 (en) |
PL (1) | PL352218A1 (en) |
TR (1) | TR200103690T2 (en) |
UY (1) | UY26209A1 (en) |
WO (1) | WO2000076516A1 (en) |
ZA (1) | ZA200110203B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6642215B2 (en) * | 2001-05-24 | 2003-11-04 | Leo Pharma A/S | Method of modulating NF-kB activity |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0344425B1 (en) * | 1988-03-30 | 1993-12-08 | Warner-Lambert Company | N-[[(2,6-disubstituted)phenyl]-N'- arylalkyl] ureas as antihypercholesterolemic and antiatherosclerotic agents |
US5780483A (en) * | 1995-02-17 | 1998-07-14 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
AR008290A1 (en) * | 1996-08-15 | 1999-12-29 | Smithkline Beecham Corp | NEW COMPOUNDS CONTAINING GUANIDINE USEFUL AS ANTAGONISTS OF IL-8 RECEPTORS, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM PROCEDURE FOR THE PREPARATION OF SUCH COMPOUNDS AND PROCEDURE FOR THE PREPARATION OF INTERMEDIARIES. |
-
2000
- 2000-06-12 EC EC2000003525A patent/ECSP003525A/en unknown
- 2000-06-14 AR ARP000102925A patent/AR029368A1/en not_active Application Discontinuation
- 2000-06-14 PE PE2000000589A patent/PE20010319A1/en not_active Application Discontinuation
- 2000-06-14 UY UY26209A patent/UY26209A1/en not_active Application Discontinuation
- 2000-06-16 HU HU0202019A patent/HUP0202019A3/en unknown
- 2000-06-16 CZ CZ20014490A patent/CZ20014490A3/en unknown
- 2000-06-16 TR TR2001/03690T patent/TR200103690T2/en unknown
- 2000-06-16 KR KR1020017016140A patent/KR20020009635A/en not_active Application Discontinuation
- 2000-06-16 IL IL14621400A patent/IL146214A0/en unknown
- 2000-06-16 WO PCT/US2000/016813 patent/WO2000076516A1/en not_active Application Discontinuation
- 2000-06-16 EP EP00942933A patent/EP1191934A4/en not_active Withdrawn
- 2000-06-16 NZ NZ515232A patent/NZ515232A/en unknown
- 2000-06-16 JP JP2001502849A patent/JP2003501471A/en not_active Withdrawn
- 2000-06-16 CN CNA008089205A patent/CN1494424A/en active Pending
- 2000-06-16 AU AU57482/00A patent/AU766086B2/en not_active Ceased
- 2000-06-16 CA CA002377397A patent/CA2377397A1/en not_active Abandoned
- 2000-06-16 BR BR0010985-1A patent/BR0010985A/en not_active IP Right Cessation
- 2000-06-16 MX MXPA01013287A patent/MXPA01013287A/en unknown
- 2000-06-16 PL PL00352218A patent/PL352218A1/en not_active Application Discontinuation
- 2000-08-14 EC EC2000003528A patent/ECSP003528A/en unknown
- 2000-12-12 ZA ZA200110203A patent/ZA200110203B/en unknown
-
2001
- 2001-12-12 NO NO20016065A patent/NO20016065L/en not_active Application Discontinuation
-
2002
- 2002-08-27 HK HK02106332.2A patent/HK1044716A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
AR029368A1 (en) | 2003-06-25 |
ECSP003525A (en) | 2002-01-25 |
UY26209A1 (en) | 2000-12-29 |
HK1044716A1 (en) | 2002-11-01 |
HUP0202019A2 (en) | 2002-10-28 |
CZ20014490A3 (en) | 2002-07-17 |
WO2000076516A1 (en) | 2000-12-21 |
AU766086B2 (en) | 2003-10-09 |
CA2377397A1 (en) | 2000-12-21 |
CN1494424A (en) | 2004-05-05 |
HUP0202019A3 (en) | 2003-03-28 |
BR0010985A (en) | 2002-03-26 |
PE20010319A1 (en) | 2001-05-24 |
NO20016065D0 (en) | 2001-12-12 |
EP1191934A1 (en) | 2002-04-03 |
MXPA01013287A (en) | 2002-06-04 |
ZA200110203B (en) | 2002-09-11 |
NO20016065L (en) | 2001-12-12 |
IL146214A0 (en) | 2002-07-25 |
EP1191934A4 (en) | 2004-02-04 |
PL352218A1 (en) | 2003-08-11 |
AU5748200A (en) | 2001-01-02 |
ECSP003528A (en) | 2002-01-25 |
JP2003501471A (en) | 2003-01-14 |
TR200103690T2 (en) | 2002-05-21 |
KR20020009635A (en) | 2002-02-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RENW | Renewal (renewal fees accepted) | ||
PSEA | Patent sealed |