BR9916159A - Sulfonamidas de hidróxi-difenil-uréia comoantagonistas dos receptores de il-8 - Google Patents

Sulfonamidas de hidróxi-difenil-uréia comoantagonistas dos receptores de il-8

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Publication number
BR9916159A
BR9916159A BR9916159-1A BR9916159A BR9916159A BR 9916159 A BR9916159 A BR 9916159A BR 9916159 A BR9916159 A BR 9916159A BR 9916159 A BR9916159 A BR 9916159A
Authority
BR
Brazil
Prior art keywords
hydroxy
sulphonamides
antagonists
receptors
diphenylurea
Prior art date
Application number
BR9916159-1A
Other languages
English (en)
Inventor
Qi Jin
Brent W Mccleland
Michael R Palovich
Katherine L Widdowson
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of BR9916159A publication Critical patent/BR9916159A/pt

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/76—Nitrogen atoms to which a second hetero atom is attached
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Abstract

"SULFONAMIDAS DE HIDRóXI-DIFENIL-URéIA COMOANTAGONISTAS DOS RECEPTORES DE IL-8". A invençãorefere-se a sulfonamidas de hidróxi-difenil-uréia, inovadoras, suascomposições e intermediários. As sulfonamidas dehidróxi-difenil-uréia são úteis no tratamento de estados doentiosmediados pela quimiocina, Interleucina-8.
BR9916159-1A 1998-12-16 1999-12-15 Sulfonamidas de hidróxi-difenil-uréia comoantagonistas dos receptores de il-8 BR9916159A (pt)

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US11248198P 1998-12-16 1998-12-16
US13700399P 1999-06-01 1999-06-01
PCT/US1999/029940 WO2000035442A1 (en) 1998-12-16 1999-12-15 Hydroxy diphenyl urea sulfonamides as il-8 receptor antagonists

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Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7517880B2 (en) * 1997-12-22 2009-04-14 Bayer Pharmaceuticals Corporation Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas
EP1140840B1 (en) * 1999-01-13 2006-03-22 Bayer Pharmaceuticals Corp. -g(v)-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
EP1158985B1 (en) 1999-01-13 2011-12-28 Bayer HealthCare LLC OMEGA-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS
AR029637A1 (es) * 1999-05-28 2003-07-10 Smithkline Beecham Corp Compuestos de guanidina, antagonistas de los receptores de la il-8, una composicion farmaceutica que los contiene y el uso de los mismos para la manufactura de un medicamento
EP1265905A4 (en) * 2000-03-01 2003-03-12 Smithkline Beecham Corp IL-2 RECEPTOR ANTAGONISTS
MY133845A (en) * 2000-03-10 2007-11-30 Smithkline Beecham Corp Il-8 receptor antagonists
WO2001068033A2 (en) * 2000-03-10 2001-09-20 Smithkline Beecham Corporation Il-8 receptor antagonists
AR030689A1 (es) * 2000-03-14 2003-09-03 Smithkline Beecham Corp Compuestos de 3-aminosulfonil-2-hidroxifenil urea, composiciones farmaceuticas que los comprenden, y uso de dichos compuestos en la manufactura de medicamentos para tratar enfermedades mediadas por quimioquinas
WO2001068569A2 (en) * 2000-03-14 2001-09-20 Smithkline Beecham Corporation Il-8 receptor antagonists
US6664259B2 (en) * 2000-03-16 2003-12-16 Smithkline Beecham Corporation Il-8 receptor antagonists
CO5280089A1 (es) * 2000-03-16 2003-05-30 Smithkline Beecham Corp Antagonistas del receptor il-8
UY26627A1 (es) * 2000-03-24 2001-09-28 Smithkline Beecham Corp Antagonistas de receptores de il-8
US6653310B2 (en) 2000-04-07 2003-11-25 Smithkline Beecham Corporation IL-8 receptor antagonists
WO2002012243A2 (en) * 2000-08-09 2002-02-14 Boehringer Ingelheim Pharmaceuticals, Inc. SYNTHESIS OF (R)-3-(4-BROMOBENZYL)-1-(3,5-DICHLOROPHENYL)-5-IODO-3-METHYL-1-H-IMIDAZO[1,2-a]IMIDAZOL-2-ONE
EA011719B1 (ru) * 2000-12-18 2009-04-28 Институт Оф Медисинал Молекьюлар Дизайн, Инк. Ингибитор высвобождения воспалительного цитокина
EP1351933B1 (en) * 2001-01-16 2006-11-22 SmithKline Beecham Corporation Il-8 receptor antagonists
US20040110954A1 (en) * 2001-03-30 2004-06-10 Palovich Michael R. Methods of synthesizing phenol-contining compounds
TW200303742A (en) * 2001-11-21 2003-09-16 Novartis Ag Organic compounds
US20030207872A1 (en) * 2002-01-11 2003-11-06 Bayer Corporation Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
JP4636486B2 (ja) 2002-02-11 2011-02-23 バイエル、ファーマシューテイカルズ、コーポレイション 脈管形成阻害活性を有するアリール尿素
US20060100257A1 (en) * 2002-06-05 2006-05-11 Susumu Muto Inhibitors against the activation of ap-1 and nfat
MY143477A (en) * 2002-10-29 2011-05-31 Smithkline Beecham Corp Il-8 receptor antagonists
US7557129B2 (en) 2003-02-28 2009-07-07 Bayer Healthcare Llc Cyanopyridine derivatives useful in the treatment of cancer and other disorders
DK1636585T3 (da) 2003-05-20 2008-05-26 Bayer Pharmaceuticals Corp Diarylurinstoffer med kinasehæmmende aktivitet
BRPI0412219B8 (pt) 2003-07-23 2021-07-27 Bayer Healthcare Llc compostos ômega-carboxi aril difenil uréia fluoro substituídos e composições farmacêuticas compreendendo os referidos compostos
WO2006043950A1 (en) * 2004-10-20 2006-04-27 Smithkline Beecham Corporation Il-8 receptor antagonists
CN101495113A (zh) * 2006-04-21 2009-07-29 史密丝克莱恩比彻姆公司 Il-8受体拮抗剂
CL2007001142A1 (es) * 2006-04-21 2008-01-25 Smithkline Beecham Corp Compuestos derivados de sulfona, antagonistas del receptor il-8; procedimiento de preparacion;compuestos intermediarios;composicion farmaceutica; combinacion farmaceutica; y uso en el tratamiento de asma, enfermedad pulmonar obstructiva cronica, dermatitis, psoriasis, alzheimer, aterosclerosis, osteoporosis.
US7671058B2 (en) 2006-06-21 2010-03-02 Institute Of Medicinal Molecular Design, Inc. N-(3,4-disubstituted phenyl) salicylamide derivatives
AR061571A1 (es) * 2006-06-23 2008-09-03 Smithkline Beecham Corp Compuesto sal del acido toluenosulfonico de 4-{[6-cloro-3-({[(2- cloro-3-fluorofenil) amino]carbonil} amino)- 2- hidroxifenil]sulfonil] -1- piperazinacarbxilato de 1.1-dimetiletilo, composicion farmaceutica que lo comprende su uso para la fabricacion de un medicamento combinacion farmaceutica con un
EP2203432A4 (en) * 2007-09-21 2011-04-27 Glaxosmithkline Llc PROCESSING METHOD
EP2110019A1 (de) 2008-04-19 2009-10-21 Bayer CropScience AG Herbizide Verbindungen auf Basis von N-Azinyl-N'-phenylsulfonylharnstoffen
US20120121515A1 (en) 2009-03-13 2012-05-17 Lenny Dang Methods and compositions for cell-proliferation-related disorders
KR101712035B1 (ko) 2009-06-29 2017-03-03 아지오스 파마슈티컬스 아이엔씨. 치료용 화합물 및 조성물
EP2491015A1 (en) * 2009-10-21 2012-08-29 Bayer Pharma Aktiengesellschaft Substituted benzosulphonamides
EP2525790B1 (en) 2009-10-21 2020-05-27 Agios Pharmaceuticals, Inc. Methods and compositions for cell-proliferation-related disorders
EP3561077B1 (en) 2009-10-21 2022-12-21 Les Laboratoires Servier Methods for cell-proliferation-related disorders
CA2783696A1 (en) 2009-12-17 2011-06-23 Galderma Research & Development Use of compounds in the treatment or prevention of skin disorders
SG194697A1 (en) 2011-05-03 2013-12-30 Agios Pharmaceuticals Inc Pyruvate kinase activators for use in therapy
CN102827073A (zh) 2011-06-17 2012-12-19 安吉奥斯医药品有限公司 治疗活性组合物和它们的使用方法
CN102827170A (zh) 2011-06-17 2012-12-19 安吉奥斯医药品有限公司 治疗活性组合物和它们的使用方法
CN104114543B (zh) 2012-01-06 2019-03-15 安吉奥斯医药品有限公司 治疗活性化合物及其使用方法
US9474779B2 (en) 2012-01-19 2016-10-25 Agios Pharmaceuticals, Inc. Therapeutically active compositions and their methods of use
JP6385352B2 (ja) * 2012-10-15 2018-09-05 アジオス ファーマシューティカルズ， インコーポレイテッド 治療化合物および組成物
US10376510B2 (en) 2013-07-11 2019-08-13 Agios Pharmaceuticals, Inc. 2,4- or 4,6-diaminopyrimidine compounds as IDH2 mutants inhibitors for the treatment of cancer
WO2015003360A2 (en) 2013-07-11 2015-01-15 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
WO2015003355A2 (en) 2013-07-11 2015-01-15 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
US9579324B2 (en) 2013-07-11 2017-02-28 Agios Pharmaceuticals, Inc Therapeutically active compounds and their methods of use
BR112016000489A8 (pt) 2013-07-11 2020-01-07 Agios Pharmaceuticals Inc composto, composição farmacêutica que o compreende, uso da composição e métodos para fabricar compostos
US20150031627A1 (en) 2013-07-25 2015-01-29 Agios Pharmaceuticals, Inc Therapeutically active compounds and their methods of use
JP6564796B2 (ja) 2014-03-14 2019-08-21 アジオス ファーマシューティカルズ， インコーポレイテッド 治療活性化合物の医薬組成物
FR3030515B1 (fr) * 2014-12-23 2017-01-20 Galderma Res & Dev Nouveaux composes antagonistes des recepteurs cxcr1 et cxcr2 aux chimiokines, et leur utilisation dans le traitement de pathologies mediees par des chimiokines
EP4344703A1 (en) 2015-06-11 2024-04-03 Agios Pharmaceuticals, Inc. Methods of using pyruvate kinase activators
EP3362065B1 (en) 2015-10-15 2024-04-03 Les Laboratoires Servier Combination therapy comprising ivosidenib, cytarabine and daunorubicin or idarubicin for treating acute myelogenous leukemia
LT3362066T (lt) 2015-10-15 2022-02-10 Les Laboratoires Servier Sas Kombinuota terapija, skirta piktybinių susirgimų gydymui
US10980788B2 (en) 2018-06-08 2021-04-20 Agios Pharmaceuticals, Inc. Therapy for treating malignancies
CN112778167A (zh) * 2019-11-01 2021-05-11 邵阳学院 一种快速制备n-苯磺酰基氨基酸酯类化合物的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3972886A (en) * 1972-07-13 1976-08-03 Leo Pharmaceutical Products Ltd. Certain 4-phenoxy-3-heteroarylmethyl or ethyl sulfamyl benzoic acid derivatives
US4155930A (en) * 1978-07-11 1979-05-22 American Cyanamid Company Ureylene phenylene anionic naphthalenesulfonic acids
US4786316A (en) * 1984-07-13 1988-11-22 E. I. Du Pont De Nemours And Company Herbicidal ortho-sulfamoyl sulfonamides
US6218539B1 (en) * 1996-06-27 2001-04-17 Smithkline Beecham Corporation IL-8 receptor antagonists
TR199802695T2 (xx) * 1996-06-27 1999-04-21 Smithkline Beecham Corporation IL-8 Resept�r kar��tlar�
DE69826695T2 (de) * 1997-05-23 2006-02-02 Bayer Pharmaceuticals Corp., West Haven Arylharnstoffderivate zur behandlung von inflammatorischen oder immunomodulatorischen erkrankungen

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