AR061571A1 - Compuesto sal del acido toluenosulfonico de 4-{[6-cloro-3-({[(2- cloro-3-fluorofenil) amino]carbonil} amino)- 2- hidroxifenil]sulfonil] -1- piperazinacarbxilato de 1.1-dimetiletilo, composicion farmaceutica que lo comprende su uso para la fabricacion de un medicamento combinacion farmaceutica con un - Google Patents
Compuesto sal del acido toluenosulfonico de 4-{[6-cloro-3-({[(2- cloro-3-fluorofenil) amino]carbonil} amino)- 2- hidroxifenil]sulfonil] -1- piperazinacarbxilato de 1.1-dimetiletilo, composicion farmaceutica que lo comprende su uso para la fabricacion de un medicamento combinacion farmaceutica con unInfo
- Publication number
- AR061571A1 AR061571A1 ARP070102742A ARP070102742A AR061571A1 AR 061571 A1 AR061571 A1 AR 061571A1 AR P070102742 A ARP070102742 A AR P070102742A AR P070102742 A ARP070102742 A AR P070102742A AR 061571 A1 AR061571 A1 AR 061571A1
- Authority
- AR
- Argentina
- Prior art keywords
- amino
- chloro
- fluorophenyl
- hydroxyphenyl
- sulfonyl
- Prior art date
Links
- -1 2- CHLORO-3-FLUOROPHENYL Chemical class 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical compound O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- 229940000425 combination drug Drugs 0.000 title 1
- 239000002131 composite material Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- LBLYYCQCTBFVLH-UHFFFAOYSA-N 2-Methylbenzenesulfonic acid Chemical compound CC1=CC=CC=C1S(O)(=O)=O LBLYYCQCTBFVLH-UHFFFAOYSA-N 0.000 abstract 1
- 108010061300 CXCR3 Receptors Proteins 0.000 abstract 1
- 102000011963 CXCR3 Receptors Human genes 0.000 abstract 1
- 108010012236 Chemokines Proteins 0.000 abstract 1
- 102000019034 Chemokines Human genes 0.000 abstract 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
- 206010009126 Chronic respiratory failure Diseases 0.000 abstract 1
- 108090001007 Interleukin-8 Proteins 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 102000012740 beta Adrenergic Receptors Human genes 0.000 abstract 1
- 108010079452 beta Adrenergic Receptors Proteins 0.000 abstract 1
- 239000003067 chemokine receptor CCR5 antagonist Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
- 201000004193 respiratory failure Diseases 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
Un compuesto que es la sal del ácido toluenosulfonico de 4-{[6-cloro-3-({[(2-cloro-3-fluorofenil)amino]carbonil}amino)-2-hidroxifenil]sulfonil}-1-piperazina carboxilato de 1,1-dimetiletilo. Composicion farmacéutica que lo comprende. Uso de dicho compuesto para la fabricacion de un medicamento util para el tratamiento de una enfermedad mediada por quimioquinas que se unen a un receptor IL-8 alfa o beta, como ser asma, enfermedad pulmonar obstructiva cronica o síndrome de insuficiencia respiratoria en adultos. Combinacion farmacéutica que dicho compuesto y uno o más ingredientes terapéuticos adicionales, como ser un antagonista del receptor CXCR3 o un antagonista del receptor CCR5. Método para sintetizar dicho compuesto.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80562606P | 2006-06-23 | 2006-06-23 |
Publications (1)
Publication Number | Publication Date |
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AR061571A1 true AR061571A1 (es) | 2008-09-03 |
Family
ID=38834411
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070102742A AR061571A1 (es) | 2006-06-23 | 2007-06-21 | Compuesto sal del acido toluenosulfonico de 4-{[6-cloro-3-({[(2- cloro-3-fluorofenil) amino]carbonil} amino)- 2- hidroxifenil]sulfonil] -1- piperazinacarbxilato de 1.1-dimetiletilo, composicion farmaceutica que lo comprende su uso para la fabricacion de un medicamento combinacion farmaceutica con un |
Country Status (21)
Country | Link |
---|---|
US (2) | US20090281110A1 (es) |
EP (2) | EP2034832B1 (es) |
JP (3) | JP5711461B2 (es) |
KR (1) | KR20090032097A (es) |
CN (1) | CN101505595A (es) |
AR (1) | AR061571A1 (es) |
AU (1) | AU2007260842B2 (es) |
BR (1) | BRPI0713304A2 (es) |
CA (1) | CA2655468A1 (es) |
CL (1) | CL2007001829A1 (es) |
CR (1) | CR10535A (es) |
EA (1) | EA015520B1 (es) |
ES (1) | ES2437115T3 (es) |
IL (1) | IL196056A0 (es) |
MA (1) | MA30528B1 (es) |
MX (1) | MX2009000162A (es) |
NO (1) | NO20090203L (es) |
NZ (1) | NZ573733A (es) |
PE (1) | PE20080943A1 (es) |
TW (1) | TW200817006A (es) |
WO (2) | WO2007150016A2 (es) |
Families Citing this family (23)
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MY143477A (en) | 2002-10-29 | 2011-05-31 | Smithkline Beecham Corp | Il-8 receptor antagonists |
JP5624276B2 (ja) | 2006-03-31 | 2014-11-12 | 中外製薬株式会社 | 抗体の血中動態を制御する方法 |
CL2007001142A1 (es) * | 2006-04-21 | 2008-01-25 | Smithkline Beecham Corp | Compuestos derivados de sulfona, antagonistas del receptor il-8; procedimiento de preparacion;compuestos intermediarios;composicion farmaceutica; combinacion farmaceutica; y uso en el tratamiento de asma, enfermedad pulmonar obstructiva cronica, dermatitis, psoriasis, alzheimer, aterosclerosis, osteoporosis. |
WO2007124423A2 (en) * | 2006-04-21 | 2007-11-01 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
AR061571A1 (es) * | 2006-06-23 | 2008-09-03 | Smithkline Beecham Corp | Compuesto sal del acido toluenosulfonico de 4-{[6-cloro-3-({[(2- cloro-3-fluorofenil) amino]carbonil} amino)- 2- hidroxifenil]sulfonil] -1- piperazinacarbxilato de 1.1-dimetiletilo, composicion farmaceutica que lo comprende su uso para la fabricacion de un medicamento combinacion farmaceutica con un |
PE20080209A1 (es) | 2006-06-23 | 2008-05-15 | Smithkline Beecham Corp | Derivados de glicina como inhibidores de prolil hidroxilasa |
EP4368721A2 (en) | 2007-09-26 | 2024-05-15 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substitution in cdr |
MY195714A (en) | 2008-04-11 | 2023-02-07 | Chugai Pharmaceutical Co Ltd | Antigen-Binding Molecule Capable of Binding to Two or More Antigen Molecules Repeatedly |
KR101449785B1 (ko) | 2008-04-21 | 2014-10-14 | 오토노미, 인코포레이티드 | 귀 질환 및 병태를 치료하기 위한 귀 조제물 |
US11969501B2 (en) | 2008-04-21 | 2024-04-30 | Dompé Farmaceutici S.P.A. | Auris formulations for treating otic diseases and conditions |
WO2010011605A2 (en) | 2008-07-21 | 2010-01-28 | Otonomy, Inc. | Controlled-release otic structure modulating and innate immune system modulating compositions and methods for the treatment of otic disorders |
KR102385507B1 (ko) | 2010-11-30 | 2022-04-12 | 추가이 세이야쿠 가부시키가이샤 | 복수 분자의 항원에 반복해서 결합하는 항원 결합 분자 |
WO2014030750A1 (ja) | 2012-08-24 | 2014-02-27 | 中外製薬株式会社 | マウスFcγRII特異的Fc抗体 |
KR102273985B1 (ko) | 2012-08-24 | 2021-07-06 | 추가이 세이야쿠 가부시키가이샤 | FcγRIIb 특이적 Fc영역 개변체 |
CN113621057A (zh) | 2013-04-02 | 2021-11-09 | 中外制药株式会社 | Fc区变体 |
MA41294A (fr) | 2014-12-19 | 2017-11-08 | Chugai Pharmaceutical Co Ltd | Anticorps anti-myostatine, polypeptides contenant des variants de régions fc, et procédés d'utilisation |
EP3253778A1 (en) | 2015-02-05 | 2017-12-13 | Chugai Seiyaku Kabushiki Kaisha | Antibodies comprising an ion concentration dependent antigen-binding domain, fc region variants, il-8-binding antibodies, and uses therof |
WO2017110981A1 (en) | 2015-12-25 | 2017-06-29 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin antibodies and methods of use |
AU2017305073B2 (en) | 2016-08-05 | 2024-02-01 | Chugai Seiyaku Kabushiki Kaisha | Composition for prevention or treatment of IL-8 related diseases |
SG10201607778XA (en) | 2016-09-16 | 2018-04-27 | Chugai Pharmaceutical Co Ltd | Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use |
AU2017330741A1 (en) * | 2016-09-26 | 2019-05-02 | Mpo, Inc. | Egg, fertilized egg, or embryo quality improving agent |
KR20200132938A (ko) | 2018-03-15 | 2020-11-25 | 추가이 세이야쿠 가부시키가이샤 | 지카 바이러스에 대해 교차-반응성을 갖는 항-뎅기 바이러스 항체 및 사용 방법 |
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2007
- 2007-06-21 AR ARP070102742A patent/AR061571A1/es not_active Application Discontinuation
- 2007-06-21 CL CL2007001829A patent/CL2007001829A1/es unknown
- 2007-06-21 TW TW096122377A patent/TW200817006A/zh unknown
- 2007-06-21 PE PE2007000793A patent/PE20080943A1/es not_active Application Discontinuation
- 2007-06-22 EP EP07812248.8A patent/EP2034832B1/en active Active
- 2007-06-22 NZ NZ573733A patent/NZ573733A/en not_active IP Right Cessation
- 2007-06-22 WO PCT/US2007/071866 patent/WO2007150016A2/en active Application Filing
- 2007-06-22 EP EP07798924A patent/EP2032131A4/en not_active Withdrawn
- 2007-06-22 ES ES07812248.8T patent/ES2437115T3/es active Active
- 2007-06-22 JP JP2009516744A patent/JP5711461B2/ja active Active
- 2007-06-22 US US12/306,024 patent/US20090281110A1/en not_active Abandoned
- 2007-06-22 EA EA200970051A patent/EA015520B1/ru not_active IP Right Cessation
- 2007-06-22 BR BRPI0713304-9A patent/BRPI0713304A2/pt not_active IP Right Cessation
- 2007-06-22 JP JP2009516743A patent/JP2009541352A/ja not_active Withdrawn
- 2007-06-22 CA CA002655468A patent/CA2655468A1/en not_active Abandoned
- 2007-06-22 MX MX2009000162A patent/MX2009000162A/es not_active Application Discontinuation
- 2007-06-22 AU AU2007260842A patent/AU2007260842B2/en not_active Expired - Fee Related
- 2007-06-22 WO PCT/US2007/071864 patent/WO2007150015A2/en active Application Filing
- 2007-06-22 CN CNA200780031405XA patent/CN101505595A/zh active Pending
- 2007-06-22 KR KR1020097001495A patent/KR20090032097A/ko not_active Application Discontinuation
- 2007-06-22 US US12/305,756 patent/US20090170871A1/en not_active Abandoned
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2008
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- 2008-12-18 CR CR10535A patent/CR10535A/es not_active Application Discontinuation
- 2008-12-24 MA MA31504A patent/MA30528B1/fr unknown
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2009
- 2009-01-13 NO NO20090203A patent/NO20090203L/no not_active Application Discontinuation
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2013
- 2013-10-18 JP JP2013217294A patent/JP2014055145A/ja active Pending
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WO2007150016A3 (en) | 2008-12-04 |
CR10535A (es) | 2009-03-20 |
CL2007001829A1 (es) | 2008-01-25 |
US20090170871A1 (en) | 2009-07-02 |
CA2655468A1 (en) | 2007-12-27 |
TW200817006A (en) | 2008-04-16 |
NO20090203L (no) | 2009-03-20 |
WO2007150015A2 (en) | 2007-12-27 |
JP2009541352A (ja) | 2009-11-26 |
JP2009541353A (ja) | 2009-11-26 |
EP2034832A2 (en) | 2009-03-18 |
EP2032131A4 (en) | 2009-09-02 |
JP2014055145A (ja) | 2014-03-27 |
EP2032131A2 (en) | 2009-03-11 |
BRPI0713304A2 (pt) | 2012-04-17 |
MX2009000162A (es) | 2009-01-23 |
KR20090032097A (ko) | 2009-03-31 |
EP2034832A4 (en) | 2010-12-08 |
CN101505595A (zh) | 2009-08-12 |
JP5711461B2 (ja) | 2015-04-30 |
MA30528B1 (fr) | 2009-06-01 |
WO2007150015A3 (en) | 2008-02-28 |
EA015520B1 (ru) | 2011-08-30 |
US20090281110A1 (en) | 2009-11-12 |
EP2034832B1 (en) | 2013-10-02 |
PE20080943A1 (es) | 2008-09-27 |
NZ573733A (en) | 2011-03-31 |
AU2007260842A1 (en) | 2007-12-27 |
WO2007150016A2 (en) | 2007-12-27 |
EA200970051A1 (ru) | 2009-06-30 |
AU2007260842B2 (en) | 2012-03-15 |
ES2437115T3 (es) | 2014-01-09 |
IL196056A0 (en) | 2009-09-01 |
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