AR061571A1 - Compuesto sal del acido toluenosulfonico de 4-{[6-cloro-3-({[(2- cloro-3-fluorofenil) amino]carbonil} amino)- 2- hidroxifenil]sulfonil] -1- piperazinacarbxilato de 1.1-dimetiletilo, composicion farmaceutica que lo comprende su uso para la fabricacion de un medicamento combinacion farmaceutica con un - Google Patents

Compuesto sal del acido toluenosulfonico de 4-{[6-cloro-3-({[(2- cloro-3-fluorofenil) amino]carbonil} amino)- 2- hidroxifenil]sulfonil] -1- piperazinacarbxilato de 1.1-dimetiletilo, composicion farmaceutica que lo comprende su uso para la fabricacion de un medicamento combinacion farmaceutica con un

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Publication number
AR061571A1
AR061571A1 ARP070102742A ARP070102742A AR061571A1 AR 061571 A1 AR061571 A1 AR 061571A1 AR P070102742 A ARP070102742 A AR P070102742A AR P070102742 A ARP070102742 A AR P070102742A AR 061571 A1 AR061571 A1 AR 061571A1
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AR
Argentina
Prior art keywords
amino
chloro
fluorophenyl
hydroxyphenyl
sulfonyl
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ARP070102742A
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English (en)
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Smithkline Beecham Corp
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Publication of AR061571A1 publication Critical patent/AR061571A1/es

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    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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Abstract

Un compuesto que es la sal del ácido toluenosulfonico de 4-{[6-cloro-3-({[(2-cloro-3-fluorofenil)amino]carbonil}amino)-2-hidroxifenil]sulfonil}-1-piperazina carboxilato de 1,1-dimetiletilo. Composicion farmacéutica que lo comprende. Uso de dicho compuesto para la fabricacion de un medicamento util para el tratamiento de una enfermedad mediada por quimioquinas que se unen a un receptor IL-8 alfa o beta, como ser asma, enfermedad pulmonar obstructiva cronica o síndrome de insuficiencia respiratoria en adultos. Combinacion farmacéutica que dicho compuesto y uno o más ingredientes terapéuticos adicionales, como ser un antagonista del receptor CXCR3 o un antagonista del receptor CCR5. Método para sintetizar dicho compuesto.
ARP070102742A 2006-06-23 2007-06-21 Compuesto sal del acido toluenosulfonico de 4-{[6-cloro-3-({[(2- cloro-3-fluorofenil) amino]carbonil} amino)- 2- hidroxifenil]sulfonil] -1- piperazinacarbxilato de 1.1-dimetiletilo, composicion farmaceutica que lo comprende su uso para la fabricacion de un medicamento combinacion farmaceutica con un AR061571A1 (es)

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Application Number Priority Date Filing Date Title
US80562606P 2006-06-23 2006-06-23

Publications (1)

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AR061571A1 true AR061571A1 (es) 2008-09-03

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ARP070102742A AR061571A1 (es) 2006-06-23 2007-06-21 Compuesto sal del acido toluenosulfonico de 4-{[6-cloro-3-({[(2- cloro-3-fluorofenil) amino]carbonil} amino)- 2- hidroxifenil]sulfonil] -1- piperazinacarbxilato de 1.1-dimetiletilo, composicion farmaceutica que lo comprende su uso para la fabricacion de un medicamento combinacion farmaceutica con un

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US (2) US20090170871A1 (es)
EP (2) EP2034832B1 (es)
JP (3) JP2009541352A (es)
KR (1) KR20090032097A (es)
CN (1) CN101505595A (es)
AR (1) AR061571A1 (es)
AU (1) AU2007260842B2 (es)
BR (1) BRPI0713304A2 (es)
CA (1) CA2655468A1 (es)
CL (1) CL2007001829A1 (es)
CR (1) CR10535A (es)
EA (1) EA015520B1 (es)
ES (1) ES2437115T3 (es)
IL (1) IL196056A0 (es)
MA (1) MA30528B1 (es)
MX (1) MX2009000162A (es)
NO (1) NO20090203L (es)
NZ (1) NZ573733A (es)
PE (1) PE20080943A1 (es)
TW (1) TW200817006A (es)
WO (2) WO2007150016A2 (es)

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AU2007260842A1 (en) 2007-12-27
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CN101505595A (zh) 2009-08-12
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EP2034832B1 (en) 2013-10-02
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