AR030273A1 - Compuestos de hidroxifenil urea sustituidos con sulfonamidas, composiciones farmaceuticas que los comprenden, y uso de los mismos en la fabricacion de medicamentos para tratar una enfermedad mediada por una quimioquina - Google Patents

Compuestos de hidroxifenil urea sustituidos con sulfonamidas, composiciones farmaceuticas que los comprenden, y uso de los mismos en la fabricacion de medicamentos para tratar una enfermedad mediada por una quimioquina

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AR030273A1
AR030273A1 ARP010101098A ARP010101098A AR030273A1 AR 030273 A1 AR030273 A1 AR 030273A1 AR P010101098 A ARP010101098 A AR P010101098A AR P010101098 A ARP010101098 A AR P010101098A AR 030273 A1 AR030273 A1 AR 030273A1
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Argentina
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alkyl
optionally substituted
heteroaryl
heterocyclyl
aryl
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ARP010101098A
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Smithkline Beecham Corp
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Abstract

Compuestos de hidroxifenil urea sustituidos con sulfonamidas, de formula (1) o sal farmacéuticamente aceptables de los mismos, en donde Rb se selecciona independientemente del grupo que consta de hidrogeno, NR6R7, OH, Ora, alquilo C1-5 arilo, aril-alquilo C1-4 aril-alquenilo C2-4, cicloalquilo, cicloalquilo-alquilo C1-5, heteroarilo, heteroaril-alquilo C1-4, heteroaril-alquenilo C2-4, heterociclilo, heterociclil-alquilo C1-4 y un resto heterociclil-alquenilo C2-4, restos que pueden estar opcionalmente sustituidos de una a tres veces independientemente con un sustituyente seleccionado del grupo que consta de halogeno, nitro, alquilo C1-4 sustituido con halo, alquilo C1-4 amino, amina mono û o dialquilo C1-4sustituida, ORa, C(O)Ra, NRaC(O)ORa, OC(O)NR6R7, hidroxi, NR9C(O)Ra, S(O)m'Ra, C(O)NR6R7 C(O)OH, C(O)Ora, S(O)2NR6R7 y NHS(O)2Ra o los sustituyentes Rb se unen para formar un anillo de 3-10 miembros, opcionalmente sustituido y que contiene, además de carbono, independientemente, de 1 a 3 restos opcionalmente sustituidos seleccionados del grupo que consta de NRa, O, S, SO y SO2; Ra se selecciona del grupo que consta de alquilo, arilo, arilalquilo C1-4, heteroarilo, heteroaril-alquilo C1-4, heterociclilo, COORa, y un resto heterociclil-alquilo C2-4, restos todos que pueden estar opcionalmente sustituidos; m es un numero entero que tiene un valor de 1 a 3; m' es 0 o un numero entero que tiene un valor de 1 o 2; n es un numero entero que tiene un valor de 1 a 3; q es 0 o un numero entero que tiene un valor de 1 a 10; t es 0, o un numero entero que tiene un valor de 1 o 2; s es un numero entero que tiene un valor de 1 a 3; R1 se selecciona independientemente del grupo que consta de hidrogeno, halogeno, nitro, ciano, alquilo C1-10, alquilo C1-10 sustituido con halo, alquenilo C2-10, alcoxi C1-10, alcoxi C1-10 sustituido con halo, azida, S(O)tR4, (CR8R8)qS(O)tR4, hidroxi, alquilo C1-4 hidroxi sustituido, arilo, aril-alquilo C1-4 aril alquenilo C2-10 ariloxi, aril-alcoxi C1-4, heteroarilo, hetroarilalquilo, heteroaril-alquenilo C2-10, heteroaril-alquiloxi C1-4, heterociclilo, heterociclilalquilo C1-4, heterociclil-alquiloxi C1-4, heterociclil-alquenilo C2-10, (CR8R8)qNR4R5, (CR8R8)qC(O)-NR4R5, alquenilo C2-10C(O)NR4R5, (CR8R8)qC(O)NR4R10, S(O)3R8, (CR8R8)qC(O)R11, alquenilo C2-10C(O)R11, alquenilo C2-10C(O)-OR11, (CR8R8)qC(O)R11, (CR8R8)qOC(O)R11, (CR8R8)qNR4C(O)R11, (CR8R8)qC(NR4)NR4R5, (CR8R8)qNR4C(NR5)R11, (CR8R8)qNHS(O)2R13, y (VR8R8)qS(O)2NR4R5, o dos restos R1, conjuntamente pueden formar O-(CH2)sO o un anillo saturado o insaturado de 5 a 6 miembros, tal que los restos de alquilo, arilo, arilalquilo o heterociclilo pueden estar opcionalmente sustituidos; R4 y R5 se seleccionan independientemente del grupo que consta de hidrogeno, alquilo C1-4 opcionalmente sustituido, arilo opcionalmente sustituido, aril-alquilo C1-4 opcionalmente sustituido, heteroarilo opcionalmente sustituido, heteroaril-alquilo C1-4 opcionalmente sustituido, heterociclilo, y heterociclil-alquilo C1-4 o R4 y R5 junto con el nitrogeno al que están unidos forman un anillo de 5 a 7 miembros que opcionalmente puede comprender un heteroátomo adicional seleccionado de O, N y S; R6 y R7 se seleccionan independientemente del grupo que consta de hidrogeno, alquilo C1-4, heteroarilo, arilo, alquilarilo y alquil C1-4-heteroalquilo; o R6 y R7 junto con el nitrogeno al que están unidos forman un anillo de 5 a 7 miembros, anillo que opcionalmente puede contener un heteroátomo adicional que se selecciona del grupo que consta de oxígeno, nitrogeno o azufre y anillo que puede estar opcionalmente sustituido; Y se selecciona del grupo que consta de furano, tiofeno, pirrol, oxazol, imidazol, tiazol, tieno (2-3-b) piridina, pirazol, isooxazol, isotiazol, 1,2,3- o 1,2,4-oxadiazol, 1,2,3û o 1,2,4-triazol, 1,2,3- o 1,2,4-tiadiazol, piridina, piridina-N-oxido, pirimidina, piridazina, pirazina 1,3,5- o 1,2,3- o 1,2,4-triazina, 1,2,4,5-tetrazina, indol, benzofurano, indazol, bencimidazol, benzotiazol, quinolina, isoquinolina, cinolina, ftalazina, quinazolina y quinoxalina, restos todos que pueden estar 1-3 veces sustituidos con R1; R8 es hidrogeno o alquilo C1-4; R9 es hidrogeno o alquilo C1-4, R10 es alquilo C1-10-C(O)2R8; R11 se selecciona del grupo que consta de hidrogeno, alquilo C1-4 opcionalmente sustituido, arilo opcionalmente sustituido, aril-alquilo C1-4 opcionalmente sustituido, heteroarilo opcionalmente sustituido, heteroaril-alquilo C1-4 opcionalmente sustituido, heterociclilo opcionalmente sustituido; y heterociclil-alquilo C1-4 opcionalmente sustituido; y R13 se selecciona del grupo que consta de alquilo C1-4, arilo, aril-alquilo C1-4, heteroarilo, heteroaril-alquilo C1-4, heterociclilo y heterociclil-alquilo C1-4. También se dan a conocer composiciones farmacéuticas que los comprenden y el uso de los mismos en la fabricacion de medicamentos para tratar enfermedades mediadas por quimioquinas.
ARP010101098A 2000-03-10 2001-03-08 Compuestos de hidroxifenil urea sustituidos con sulfonamidas, composiciones farmaceuticas que los comprenden, y uso de los mismos en la fabricacion de medicamentos para tratar una enfermedad mediada por una quimioquina AR030273A1 (es)

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