MXPA04002338A - Derivados de carbazol y su uso como antagonistas receptores del npy5. - Google Patents
Derivados de carbazol y su uso como antagonistas receptores del npy5.Info
- Publication number
- MXPA04002338A MXPA04002338A MXPA04002338A MXPA04002338A MXPA04002338A MX PA04002338 A MXPA04002338 A MX PA04002338A MX PA04002338 A MXPA04002338 A MX PA04002338A MX PA04002338 A MXPA04002338 A MX PA04002338A MX PA04002338 A MXPA04002338 A MX PA04002338A
- Authority
- MX
- Mexico
- Prior art keywords
- receptor antagonists
- carbazole derivatives
- npy5 receptor
- formula
- npy5
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
Se describe el uso de un compuesto de la formula (I) en la obtencion de un medicamento para el tratamiento de un animal de sangre caliente de los desordenes regulados por el receptor del neuropeptido Y5 (I), en donde R1, R2, R3 y X1- X6 son como se definen en la presente o una sal aceptable farmaceuticamente, pro-farmaco o solvato del mismo. Las composiciones farmaceuticas, los metodos y los procedimientos para la preparacion de los compuestos de la formula (I) son tambien descritos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0121941.9A GB0121941D0 (en) | 2001-09-11 | 2001-09-11 | Chemical compounds |
PCT/GB2002/004109 WO2003022849A1 (en) | 2001-09-11 | 2002-09-09 | Carbazole derivatives and their use as npy5 receptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA04002338A true MXPA04002338A (es) | 2004-06-29 |
Family
ID=9921890
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA04002338A MXPA04002338A (es) | 2001-09-11 | 2002-09-09 | Derivados de carbazol y su uso como antagonistas receptores del npy5. |
Country Status (14)
Country | Link |
---|---|
US (1) | US7408064B2 (es) |
EP (1) | EP1427729A1 (es) |
JP (1) | JP2005516892A (es) |
KR (1) | KR20040036939A (es) |
CN (1) | CN1653067A (es) |
BR (1) | BR0212484A (es) |
CA (1) | CA2459973A1 (es) |
GB (1) | GB0121941D0 (es) |
IL (1) | IL160771A0 (es) |
MX (1) | MXPA04002338A (es) |
NO (1) | NO20041008L (es) |
NZ (1) | NZ531678A (es) |
WO (1) | WO2003022849A1 (es) |
ZA (1) | ZA200401956B (es) |
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GB0010757D0 (en) | 2000-05-05 | 2000-06-28 | Astrazeneca Ab | Chemical compounds |
GB0121941D0 (en) | 2001-09-11 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
CN100503607C (zh) * | 2003-06-02 | 2009-06-24 | 新疆华世丹药物研究有限责任公司 | 去氢骆驼蓬碱衍生物类化合物及其应用 |
WO2005097127A2 (en) | 2004-04-02 | 2005-10-20 | Merck & Co., Inc. | Method of treating men with metabolic and anthropometric disorders |
US7732447B2 (en) | 2006-06-22 | 2010-06-08 | Cephalon, Inc. | Fused [d]pyridazin-7-ones |
CA2688161C (en) | 2007-06-04 | 2020-10-20 | Kunwar Shailubhai | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
EP2003129B1 (en) | 2007-06-11 | 2017-08-09 | Nerviano Medical Sciences S.r.l. | 1H-Pyrido[3,4-B]indol-1-one and 2,3,4,9-Tetrahydro-1H-Beta-Carbolin-1-one Derivatives |
ES2522968T3 (es) | 2008-06-04 | 2014-11-19 | Synergy Pharmaceuticals Inc. | Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
CA2725754C (en) * | 2008-06-11 | 2017-05-23 | Hazel Joan Dyke | Diazacarbazoles and methods of use |
ES2624828T3 (es) | 2008-07-16 | 2017-07-17 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros |
WO2010047982A1 (en) | 2008-10-22 | 2010-04-29 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
CA2741672A1 (en) | 2008-10-31 | 2010-05-06 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
US20110183938A1 (en) | 2009-12-16 | 2011-07-28 | Genentech, Inc. | 1,7-diazacarbazoles and methods of use |
WO2011106273A1 (en) | 2010-02-25 | 2011-09-01 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
EA025380B1 (ru) | 2011-02-25 | 2016-12-30 | Мерк Шарп Энд Домэ Корп. | Новые циклические производные азабензимидазола, используемые в качестве антидиабетических агентов |
KR20150036245A (ko) | 2012-08-02 | 2015-04-07 | 머크 샤프 앤드 돔 코포레이션 | 항당뇨병 트리시클릭 화합물 |
RU2015140066A (ru) | 2013-02-22 | 2017-03-30 | Мерк Шарп И Доум Корп. | Противодиабетические бициклические соединения |
WO2014139388A1 (en) | 2013-03-14 | 2014-09-18 | Merck Sharp & Dohme Corp. | Novel indole derivatives useful as anti-diabetic agents |
EP2970384A1 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
US9486494B2 (en) | 2013-03-15 | 2016-11-08 | Synergy Pharmaceuticals, Inc. | Compositions useful for the treatment of gastrointestinal disorders |
JP6606491B2 (ja) | 2013-06-05 | 2019-11-13 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼcの超高純度アゴニスト、その作成および使用方法 |
WO2015051496A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
US11072602B2 (en) | 2016-12-06 | 2021-07-27 | Merck Sharp & Dohme Corp. | Antidiabetic heterocyclic compounds |
US10968232B2 (en) | 2016-12-20 | 2021-04-06 | Merck Sharp & Dohme Corp. | Antidiabetic spirochroman compounds |
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WO2001007409A1 (en) | 1999-07-23 | 2001-02-01 | Astrazeneca Uk Limited | Carbazole derivatives and their use as neuropeptide y5 receptor ligands |
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MXPA03005648A (es) * | 2000-12-22 | 2003-10-06 | Astrazeneca Ab | Derivados de carbazol y su uso, como ligandos de receptor del neuropeptido y5. |
GB0121941D0 (en) | 2001-09-11 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
-
2001
- 2001-09-11 GB GBGB0121941.9A patent/GB0121941D0/en not_active Ceased
-
2002
- 2002-09-09 MX MXPA04002338A patent/MXPA04002338A/es not_active Application Discontinuation
- 2002-09-09 CN CNA02821465XA patent/CN1653067A/zh active Pending
- 2002-09-09 CA CA002459973A patent/CA2459973A1/en not_active Abandoned
- 2002-09-09 US US10/488,982 patent/US7408064B2/en not_active Expired - Lifetime
- 2002-09-09 KR KR10-2004-7003611A patent/KR20040036939A/ko not_active Application Discontinuation
- 2002-09-09 JP JP2003526924A patent/JP2005516892A/ja active Pending
- 2002-09-09 BR BR0212484-0A patent/BR0212484A/pt not_active Application Discontinuation
- 2002-09-09 WO PCT/GB2002/004109 patent/WO2003022849A1/en active IP Right Grant
- 2002-09-09 EP EP02767626A patent/EP1427729A1/en not_active Withdrawn
- 2002-09-09 IL IL16077102A patent/IL160771A0/xx unknown
- 2002-09-09 NZ NZ531678A patent/NZ531678A/en unknown
-
2004
- 2004-03-10 NO NO20041008A patent/NO20041008L/no unknown
- 2004-03-10 ZA ZA200401956A patent/ZA200401956B/en unknown
Also Published As
Publication number | Publication date |
---|---|
CA2459973A1 (en) | 2003-03-20 |
IL160771A0 (en) | 2004-08-31 |
NO20041008L (no) | 2004-03-10 |
CN1653067A (zh) | 2005-08-10 |
US7408064B2 (en) | 2008-08-05 |
BR0212484A (pt) | 2004-08-24 |
ZA200401956B (en) | 2005-04-15 |
US20050065157A1 (en) | 2005-03-24 |
GB0121941D0 (en) | 2001-10-31 |
JP2005516892A (ja) | 2005-06-09 |
NZ531678A (en) | 2005-09-30 |
EP1427729A1 (en) | 2004-06-16 |
KR20040036939A (ko) | 2004-05-03 |
WO2003022849A1 (en) | 2003-03-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |