IL160771A0 - Carbazole derivatives and their use as nyp5 receptor anatagonists - Google Patents
Carbazole derivatives and their use as nyp5 receptor anatagonistsInfo
- Publication number
- IL160771A0 IL160771A0 IL16077102A IL16077102A IL160771A0 IL 160771 A0 IL160771 A0 IL 160771A0 IL 16077102 A IL16077102 A IL 16077102A IL 16077102 A IL16077102 A IL 16077102A IL 160771 A0 IL160771 A0 IL 160771A0
- Authority
- IL
- Israel
- Prior art keywords
- nyp5
- carbazole derivatives
- receptor anatagonists
- anatagonists
- receptor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0121941.9A GB0121941D0 (en) | 2001-09-11 | 2001-09-11 | Chemical compounds |
PCT/GB2002/004109 WO2003022849A1 (en) | 2001-09-11 | 2002-09-09 | Carbazole derivatives and their use as npy5 receptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
IL160771A0 true IL160771A0 (en) | 2004-08-31 |
Family
ID=9921890
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL16077102A IL160771A0 (en) | 2001-09-11 | 2002-09-09 | Carbazole derivatives and their use as nyp5 receptor anatagonists |
Country Status (14)
Country | Link |
---|---|
US (1) | US7408064B2 (es) |
EP (1) | EP1427729A1 (es) |
JP (1) | JP2005516892A (es) |
KR (1) | KR20040036939A (es) |
CN (1) | CN1653067A (es) |
BR (1) | BR0212484A (es) |
CA (1) | CA2459973A1 (es) |
GB (1) | GB0121941D0 (es) |
IL (1) | IL160771A0 (es) |
MX (1) | MXPA04002338A (es) |
NO (1) | NO20041008L (es) |
NZ (1) | NZ531678A (es) |
WO (1) | WO2003022849A1 (es) |
ZA (1) | ZA200401956B (es) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0010757D0 (en) | 2000-05-05 | 2000-06-28 | Astrazeneca Ab | Chemical compounds |
GB0121941D0 (en) | 2001-09-11 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
CN100503607C (zh) | 2003-06-02 | 2009-06-24 | 新疆华世丹药物研究有限责任公司 | 去氢骆驼蓬碱衍生物类化合物及其应用 |
EP2305352A1 (en) | 2004-04-02 | 2011-04-06 | Merck Sharp & Dohme Corp. | 5-alpha-reductase inhibitors for use in the treatment of men with metabolic and anthropometric disorders |
US7732447B2 (en) | 2006-06-22 | 2010-06-08 | Cephalon, Inc. | Fused [d]pyridazin-7-ones |
US7879802B2 (en) | 2007-06-04 | 2011-02-01 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
EP2003129B1 (en) | 2007-06-11 | 2017-08-09 | Nerviano Medical Sciences S.r.l. | 1H-Pyrido[3,4-B]indol-1-one and 2,3,4,9-Tetrahydro-1H-Beta-Carbolin-1-one Derivatives |
EP3239170B1 (en) | 2008-06-04 | 2019-03-20 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
EP2706059A1 (en) | 2008-06-11 | 2014-03-12 | Genentech, Inc. | Diazacarbazoles and methods of use |
EP3241839B1 (en) | 2008-07-16 | 2019-09-04 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
CA2741125A1 (en) | 2008-10-22 | 2010-04-29 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
WO2010051206A1 (en) | 2008-10-31 | 2010-05-06 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
US20110183938A1 (en) | 2009-12-16 | 2011-07-28 | Genentech, Inc. | 1,7-diazacarbazoles and methods of use |
US8895596B2 (en) | 2010-02-25 | 2014-11-25 | Merck Sharp & Dohme Corp | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
EP2677869B1 (en) | 2011-02-25 | 2017-11-08 | Merck Sharp & Dohme Corp. | Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents |
AU2013296470B2 (en) | 2012-08-02 | 2016-03-17 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
AU2014219020A1 (en) | 2013-02-22 | 2015-07-23 | Merck Sharp & Dohme Corp. | Antidiabetic bicyclic compounds |
WO2014139388A1 (en) | 2013-03-14 | 2014-09-18 | Merck Sharp & Dohme Corp. | Novel indole derivatives useful as anti-diabetic agents |
US9708367B2 (en) | 2013-03-15 | 2017-07-18 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase and their uses |
CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
JP6606491B2 (ja) | 2013-06-05 | 2019-11-13 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼcの超高純度アゴニスト、その作成および使用方法 |
WO2015051496A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
EP3551176A4 (en) | 2016-12-06 | 2020-06-24 | Merck Sharp & Dohme Corp. | ANTIDIABETIC HETEROCYCLIC COMPOUNDS |
EP3558298A4 (en) | 2016-12-20 | 2020-08-05 | Merck Sharp & Dohme Corp. | ANTIDIABETIC SPIROCHROMAN COMPOUNDS |
Family Cites Families (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4111850A (en) * | 1977-02-16 | 1978-09-05 | Amp Incorporated | Organic photoconductors and methods |
FR2546163B1 (fr) * | 1983-05-16 | 1987-10-09 | Centre Nat Rech Scient | Nouveaux derives acyles hydrosolubles de peptides ou d'amino-acides, leur preparation et leur application |
JPS6079348A (ja) | 1983-10-06 | 1985-05-07 | Fuji Photo Film Co Ltd | ハロゲン化銀写真感光材料 |
US5234942A (en) * | 1984-10-19 | 1993-08-10 | Ici Americas Inc. | Heterocyclic amides and leucotriene antagonistic use thereof |
GB8524157D0 (en) | 1984-10-19 | 1985-11-06 | Ici America Inc | Heterocyclic amides |
US5223509A (en) * | 1987-08-17 | 1993-06-29 | Merck & Co., Inc. | β-carbolines as cholecystokinin and gastrin antagonists |
EP0304223A3 (en) * | 1987-08-17 | 1990-10-24 | Merck & Co. Inc. | Beta-carbolines as cholecy-stokinin and gastrin antagonist |
EP0342433A3 (en) | 1988-05-19 | 1991-06-19 | American Cyanamid Company | Substituted dibenzothiaphenes |
CA1285827C (en) * | 1988-06-03 | 1991-07-09 | Richard Barr | Life step stabilizer |
DE69028934T2 (de) | 1989-02-02 | 1997-03-20 | Yamanouchi Pharma Co Ltd | Tetrahydrobenzimidazol-Derivate |
US5254135A (en) * | 1989-10-20 | 1993-10-19 | L'oreal | Methods for dyeing keratinous fibres with aminoindoles, compositions and devices for use |
CA2032427A1 (en) * | 1989-12-18 | 1991-06-19 | Mark G. Bock | Benzodiazepines analogs |
PT98927A (pt) | 1990-09-13 | 1992-07-31 | Beecham Group Plc | Processo para a preparacao de piridil-indolil-ureias |
EG20380A (en) | 1991-10-16 | 1999-02-28 | Richardson Vicks Inc | Enhanced skin penetration system for improved topical delivery of drugs |
EP0608320B1 (en) | 1991-10-16 | 1998-01-28 | Richardson-Vicks, Inc. | Enhanced skin penetration system for improved topical delivery of drugs |
GB9203637D0 (en) | 1992-02-19 | 1992-04-08 | Smithkline Beecham Plc | Novel treatment |
WO1993018026A1 (en) | 1992-03-04 | 1993-09-16 | Beecham Group Plc | Indole ureas as 5-ht1c receptor antogonists |
GB9317764D0 (en) | 1993-08-26 | 1993-10-13 | Pfizer Ltd | Therapeutic compound |
SI9520096A (sl) | 1994-09-30 | 1998-04-30 | Pfizer Inc. | Derivati 2,7-substituiranega oktahidro-1H-pirido /1,2-a/ pirazina |
US5602024A (en) | 1994-12-02 | 1997-02-11 | Synaptic Pharmaceutical Corporation | DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5) and uses thereof |
WO1997020821A1 (en) | 1995-12-01 | 1997-06-12 | Novartis Ag | Heteroaryl derivatives |
WO1997019682A1 (en) | 1995-12-01 | 1997-06-05 | Synaptic Pharmaceutical Corporation | Aryl sulfonamide and sulfamide derivatives and uses thereof |
PT882707E (pt) * | 1996-01-10 | 2004-02-27 | Asahi Chemical Ind | Novos compostos trciclicos e composicoes medicamentosas contendo os mesmos |
WO1998001417A1 (fr) | 1996-07-08 | 1998-01-15 | Kirin Beer Kabushiki Kaisha | Composes actifs comme recepteurs du calcium |
JP3679207B2 (ja) | 1996-09-12 | 2005-08-03 | 富士写真フイルム株式会社 | ハロゲン化銀写真感光材料 |
WO1998025907A1 (fr) | 1996-12-12 | 1998-06-18 | Banyu Pharmaceutical Co., Ltd. | Derives de pyrazole |
WO1998035944A1 (en) | 1997-02-14 | 1998-08-20 | Bayer Corporation | Amides as npy5 receptor antagonists |
AU6144098A (en) | 1997-02-14 | 1998-09-08 | Bayer Corporation | Amide derivatives as selective neuropeptide y receptor antagonists |
CA2282390A1 (en) | 1997-04-17 | 1998-10-22 | Yukio Fujisawa | Thermogenic composition and benzazepine thermogenics |
FR2763942B1 (fr) | 1997-06-02 | 2002-09-13 | Asepta Sa Lab | Nouveau procede de preparation de n-acylaminoacides |
AU735249B2 (en) | 1997-07-03 | 2001-07-05 | Asahi Kasei Kabushiki Kaisha | Novel tricyclic compounds having saturated rings and medicinal compositions containing the same |
DE19730847A1 (de) | 1997-07-18 | 1999-01-28 | Bayer Ag | Tricyclisch substituierte Oxazolidinone |
JPH11130817A (ja) | 1997-08-28 | 1999-05-18 | Junji Kido | ビニル系重合体及びそれを用いたエレクトロルミネッセンス素子 |
DE19753522A1 (de) | 1997-12-03 | 1999-06-10 | Boehringer Ingelheim Pharma | Substituierte Indole, ihre Herstellung und ihre Verwendung als Arzneimittel |
SE9704545D0 (sv) | 1997-12-05 | 1997-12-05 | Astra Pharma Prod | Novel compounds |
JPH11174077A (ja) | 1997-12-09 | 1999-07-02 | Hokuriku Electric Ind Co Ltd | 加速度検出装置 |
WO1999032111A1 (en) | 1997-12-22 | 1999-07-01 | Bayer Corporation | INHIBITION OF p38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS |
ATE297383T1 (de) | 1997-12-22 | 2005-06-15 | Bayer Pharmaceuticals Corp | Hemmung der p38 kinase unter verwendung von symmetrischen und asymmetrischen diphenylharnstoffen |
US6063934A (en) | 1998-03-25 | 2000-05-16 | Bristol-Myers Squibb Company | Imidazolone anorectic agents: 1. 2-substituted-3,5-dihydro-5,5-diphenyl-4H-imidazol-4-ones |
AU3363599A (en) | 1998-03-26 | 1999-10-18 | Max-Planck Institut Fur Biochemie | Heterocyclic families of compounds for the modulation of tyrosine protein kinase |
WO1999051598A1 (en) | 1998-04-02 | 1999-10-14 | Neurogen Corporation | SUBSTITUTED 9H-PYRIDINO[2,3-b]INDOLE AND 9H-PYRIMIDINO[4,5-b]INDOLE DERIVATIVES: SELECTIVE NEUROPEPTIDE y RECEPTOR LIGANDS |
AU3464599A (en) | 1998-04-02 | 1999-10-25 | Neurogen Corporation | Aminoalkyl substituted 9h-pyridino(2,3-b)indole and 9h-pyrimidino(4,5-b)indole derivatives |
AUPP285898A0 (en) | 1998-04-07 | 1998-04-30 | Fujisawa Pharmaceutical Co., Ltd. | Amido derivatives |
PT1076644E (pt) | 1998-04-29 | 2004-10-29 | Ortho Mcneil Pharm Inc | Aminotetralinas substituidas emn como ligandos para o receptor de neuropeptideoy y5 util no tratamento da obesidade e de outras perturbacoes |
ES2188264T3 (es) | 1998-06-08 | 2003-06-16 | Schering Corp | Antagonistas del receptor del neuropeptido y5. |
JP4511042B2 (ja) | 1998-08-07 | 2010-07-28 | メルク セローノ ソシエテ アノニム | 不妊症の治療のためのfsh模倣物 |
CN1329589A (zh) | 1998-10-07 | 2002-01-02 | 奥索-麦克尼尔药品公司 | 用作神经肽yy5受体的配体的n-芳烷基氨基1,2,3,4-四氢萘 |
WO2000023425A1 (en) | 1998-10-21 | 2000-04-27 | Novo Nordisk A/S | New compounds, their preparation and use |
AU3840000A (en) * | 1999-04-20 | 2000-11-02 | Meiji Seika Kaisha Ltd. | Tricyclic compounds |
CA2373510A1 (en) | 1999-05-12 | 2000-11-23 | Ortho-Mcneil Pharmaceutical, Inc. | Pyrazole carboxamides useful for the treatment of obesity and other disorders |
WO2001007409A1 (en) | 1999-07-23 | 2001-02-01 | Astrazeneca Uk Limited | Carbazole derivatives and their use as neuropeptide y5 receptor ligands |
GB0011013D0 (en) | 2000-05-09 | 2000-06-28 | Astrazeneca Ab | Chemical compounds |
AU2001263367A1 (en) | 2000-05-19 | 2001-12-03 | Genaissance Pharmaceuticals, Inc. | Haplotypes of the evx1 gene |
IL156487A0 (en) * | 2000-12-22 | 2004-01-04 | Astrazeneca Ab | Carbazole derivatives and their use as neuropeptide y5 receptor ligands |
GB0121941D0 (en) | 2001-09-11 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
-
2001
- 2001-09-11 GB GBGB0121941.9A patent/GB0121941D0/en not_active Ceased
-
2002
- 2002-09-09 JP JP2003526924A patent/JP2005516892A/ja active Pending
- 2002-09-09 WO PCT/GB2002/004109 patent/WO2003022849A1/en active IP Right Grant
- 2002-09-09 MX MXPA04002338A patent/MXPA04002338A/es not_active Application Discontinuation
- 2002-09-09 NZ NZ531678A patent/NZ531678A/en unknown
- 2002-09-09 KR KR10-2004-7003611A patent/KR20040036939A/ko not_active Application Discontinuation
- 2002-09-09 IL IL16077102A patent/IL160771A0/xx unknown
- 2002-09-09 EP EP02767626A patent/EP1427729A1/en not_active Withdrawn
- 2002-09-09 CA CA002459973A patent/CA2459973A1/en not_active Abandoned
- 2002-09-09 CN CNA02821465XA patent/CN1653067A/zh active Pending
- 2002-09-09 BR BR0212484-0A patent/BR0212484A/pt not_active Application Discontinuation
- 2002-09-09 US US10/488,982 patent/US7408064B2/en not_active Expired - Lifetime
-
2004
- 2004-03-10 ZA ZA200401956A patent/ZA200401956B/en unknown
- 2004-03-10 NO NO20041008A patent/NO20041008L/no unknown
Also Published As
Publication number | Publication date |
---|---|
US20050065157A1 (en) | 2005-03-24 |
ZA200401956B (en) | 2005-04-15 |
CN1653067A (zh) | 2005-08-10 |
NO20041008L (no) | 2004-03-10 |
BR0212484A (pt) | 2004-08-24 |
NZ531678A (en) | 2005-09-30 |
EP1427729A1 (en) | 2004-06-16 |
MXPA04002338A (es) | 2004-06-29 |
WO2003022849A1 (en) | 2003-03-20 |
KR20040036939A (ko) | 2004-05-03 |
CA2459973A1 (en) | 2003-03-20 |
JP2005516892A (ja) | 2005-06-09 |
GB0121941D0 (en) | 2001-10-31 |
US7408064B2 (en) | 2008-08-05 |
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