ATE297383T1 - Hemmung der p38 kinase unter verwendung von symmetrischen und asymmetrischen diphenylharnstoffen - Google Patents
Hemmung der p38 kinase unter verwendung von symmetrischen und asymmetrischen diphenylharnstoffenInfo
- Publication number
- ATE297383T1 ATE297383T1 AT98964221T AT98964221T ATE297383T1 AT E297383 T1 ATE297383 T1 AT E297383T1 AT 98964221 T AT98964221 T AT 98964221T AT 98964221 T AT98964221 T AT 98964221T AT E297383 T1 ATE297383 T1 AT E297383T1
- Authority
- AT
- Austria
- Prior art keywords
- ureases
- kinase
- symmetric
- inhibition
- asymmetric diphenyl
- Prior art date
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- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US99574997A | 1997-12-22 | 1997-12-22 | |
PCT/US1998/027265 WO1999032463A1 (en) | 1997-12-22 | 1998-12-22 | INHIBITION OF p38 KINASE USING SYMMETRICAL AND UNSYMMETRICAL DIPHENYL UREAS |
Publications (1)
Publication Number | Publication Date |
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ATE297383T1 true ATE297383T1 (de) | 2005-06-15 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98964221T ATE297383T1 (de) | 1997-12-22 | 1998-12-22 | Hemmung der p38 kinase unter verwendung von symmetrischen und asymmetrischen diphenylharnstoffen |
Country Status (12)
Country | Link |
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EP (2) | EP1042305B1 (de) |
JP (1) | JP3887769B2 (de) |
AT (1) | ATE297383T1 (de) |
AU (1) | AU1939999A (de) |
CA (1) | CA2315715C (de) |
DE (2) | DE1042305T1 (de) |
DK (1) | DK1042305T3 (de) |
ES (1) | ES2154252T3 (de) |
HK (1) | HK1032050A1 (de) |
IL (3) | IL136737A0 (de) |
PT (1) | PT1042305E (de) |
WO (1) | WO1999032463A1 (de) |
Families Citing this family (153)
Publication number | Priority date | Publication date | Assignee | Title |
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US6696475B2 (en) | 1997-04-22 | 2004-02-24 | Neurosearch A/S | Substituted phenyl derivatives, their preparation and use |
WO1999032436A1 (en) * | 1997-12-22 | 1999-07-01 | Bayer Corporation | Inhibition of raf kinase using symmetrical and unsymmetrical substituted diphenyl ureas |
NZ510098A (en) | 1998-10-22 | 2003-09-26 | Neurosearch As | Substituted phenyl derivatives, pharmaceuticals thereof and their use as blockers of the chloride channel |
US20020065296A1 (en) * | 1999-01-13 | 2002-05-30 | Bayer Corporation | Heteroaryl ureas containing nitrogen hetero-atoms as p38 kinase inhibitors |
EP1690853B1 (de) * | 1999-01-13 | 2010-03-10 | Bayer HealthCare LLC | Verwendung von Omega-Carboxyaryl-substituierten Diphenylharnstoffen als raf-Kinase-Inhibitoren |
ATE538794T1 (de) | 1999-01-13 | 2012-01-15 | Bayer Healthcare Llc | Gamma carboxyarylsubstituierte diphenylharnstoffverbindungen als p38 kinasehemmer |
AU2004200566B2 (en) * | 1999-01-13 | 2006-08-17 | Bayer Pharmaceuticals Corporation | Omega-carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors |
US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
WO2000042012A1 (en) * | 1999-01-13 | 2000-07-20 | Bayer Corporation | φ-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS |
UA73492C2 (en) | 1999-01-19 | 2005-08-15 | Aromatic heterocyclic compounds as antiinflammatory agents | |
MXPA01008440A (es) | 1999-02-22 | 2002-04-24 | Boehringer Ingelheim Pharma | Derivados heterociclicos policiclos como agentes anti-inflamatorios.. |
US6358945B1 (en) | 1999-03-12 | 2002-03-19 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compounds useful as anti-inflammatory agents |
JP2002539206A (ja) * | 1999-03-12 | 2002-11-19 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | 抗炎症剤としての芳香族複素環化合物 |
US6337418B1 (en) * | 1999-04-09 | 2002-01-08 | Eastman Chemical Co. | Preparation of C1-C5 alkyl esters of nitro or thioether substituted aromatic carboxylic acids |
CA2374737C (en) | 1999-07-09 | 2008-02-12 | Boehringer Ingelheim Pharmaceuticals, Inc. | Novel process for synthesis of heteroaryl-substituted urea compounds |
US7030109B2 (en) | 1999-07-19 | 2006-04-18 | Pharmacia & Upjohn Company | 1,2,3,4,5,6-Hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position |
MY122278A (en) | 1999-07-19 | 2006-04-29 | Upjohn Co | 1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position |
MXPA02004594A (es) | 1999-11-16 | 2002-10-23 | Boehringer Ingelheim Pharma | Derivados de urea como agentes anti-inflamatorios. |
EP1229925A2 (de) * | 1999-11-19 | 2002-08-14 | Axxima Pharmaceuticals Aktiengesellschaft | Hemmstoffe gegen helicobacter pylori verursachte gastrointestinale krankheiten |
US6525046B1 (en) | 2000-01-18 | 2003-02-25 | Boehringer Ingelheim Pharmaceuticals, Inc. | Aromatic heterocyclic compounds as antiinflammatory agents |
US6608052B2 (en) | 2000-02-16 | 2003-08-19 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compounds useful as anti-inflammatory agents |
GB0010757D0 (en) | 2000-05-05 | 2000-06-28 | Astrazeneca Ab | Chemical compounds |
US6645990B2 (en) | 2000-08-15 | 2003-11-11 | Amgen Inc. | Thiazolyl urea compounds and methods of uses |
PE20020506A1 (es) | 2000-08-22 | 2002-07-09 | Glaxo Group Ltd | Derivados de pirazol fusionados como inhibidores de la proteina cinasa |
US6849409B2 (en) | 2000-10-16 | 2005-02-01 | Axxima Pharmaceuticals Ag | Cellular kinases involved in Cytomegalovirus infection and their inhibition |
EP1341771A2 (de) | 2000-11-29 | 2003-09-10 | Glaxo Group Limited | Benzimidazolderivate und ihre verwendung als tie-2 und/oder vegfr-2 hemmer |
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CA2315715C (en) | 2010-06-22 |
DK1042305T3 (da) | 2005-09-19 |
EP1616865A1 (de) | 2006-01-18 |
IL136737A0 (en) | 2001-06-14 |
DE1042305T1 (de) | 2001-04-19 |
DE69830513T2 (de) | 2006-03-16 |
JP2001526276A (ja) | 2001-12-18 |
HK1032050A1 (en) | 2001-07-06 |
IL170235A (en) | 2010-04-15 |
JP3887769B2 (ja) | 2007-02-28 |
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