PT882707E - Novos compostos trciclicos e composicoes medicamentosas contendo os mesmos - Google Patents

Novos compostos trciclicos e composicoes medicamentosas contendo os mesmos

Info

Publication number
PT882707E
PT882707E PT96942564T PT96942564T PT882707E PT 882707 E PT882707 E PT 882707E PT 96942564 T PT96942564 T PT 96942564T PT 96942564 T PT96942564 T PT 96942564T PT 882707 E PT882707 E PT 882707E
Authority
PT
Portugal
Prior art keywords
represents hydrogen
same
new
amino
compositions containing
Prior art date
Application number
PT96942564T
Other languages
English (en)
Inventor
Shiro Miyoshi
Kohei Ogawa
Original Assignee
Asahi Chemical Ind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Chemical Ind filed Critical Asahi Chemical Ind
Publication of PT882707E publication Critical patent/PT882707E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/91—Dibenzofurans; Hydrogenated dibenzofurans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C307/04—Diamides of sulfuric acids
    • C07C307/10—Diamides of sulfuric acids having nitrogen atoms of the sulfamide groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/76—Dibenzothiophenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Furan Compounds (AREA)
PT96942564T 1996-01-10 1996-12-18 Novos compostos trciclicos e composicoes medicamentosas contendo os mesmos PT882707E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP257696 1996-01-10

Publications (1)

Publication Number Publication Date
PT882707E true PT882707E (pt) 2004-02-27

Family

ID=11533209

Family Applications (1)

Application Number Title Priority Date Filing Date
PT96942564T PT882707E (pt) 1996-01-10 1996-12-18 Novos compostos trciclicos e composicoes medicamentosas contendo os mesmos

Country Status (14)

Country Link
US (4) US6037362A (pt)
EP (1) EP0882707B1 (pt)
JP (1) JP2000239255A (pt)
KR (1) KR100395280B1 (pt)
CN (2) CN1083831C (pt)
AT (1) ATE251608T1 (pt)
AU (1) AU715233B2 (pt)
CA (1) CA2242351C (pt)
DE (1) DE69630319T2 (pt)
ES (1) ES2208772T3 (pt)
HK (1) HK1017669A1 (pt)
NO (2) NO312159B1 (pt)
PT (1) PT882707E (pt)
WO (1) WO1997025311A1 (pt)

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AU735249B2 (en) * 1997-07-03 2001-07-05 Asahi Kasei Kabushiki Kaisha Novel tricyclic compounds having saturated rings and medicinal compositions containing the same
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US20030073644A1 (en) * 1998-11-11 2003-04-17 Smithkline Beecham P.L.C. Combinations comprising a beta-agonist and a further antidiabetic agent
TR200101336T2 (tr) * 1998-11-11 2001-11-21 Smithkline Beecham P.L.C. Bir-beta-agonisti ile başka bir antidiyabetik madde içeren kombinasyonlar
WO2000035890A1 (fr) * 1998-12-15 2000-06-22 Asahi Kasei Kabushiki Kaisha Nouveaux composes heterocycliques et compositions de medicaments les renfermant
TW519537B (en) 1999-03-26 2003-02-01 Asahi Chemical Ind Process for the preparation of tricylic amino-alcohol derivatives
KR20020005648A (ko) * 1999-04-01 2002-01-17 야마모토 카즈모토 삼환성 아미노알콜 유도체의 아지드를 경유하는 제조법
WO2001004092A1 (fr) * 1999-07-09 2001-01-18 Asahi Kasei Kabushiki Kaisha Procede de preparation de derives d'alcools amines tricycliques
AU6596800A (en) * 1999-09-03 2001-04-10 Asahi Kasei Kabushiki Kaisha Processes for the preparation of tricyclic amino alcohol derivatives
US20030220329A1 (en) * 1999-09-17 2003-11-27 Duke University Method of improving beta-adrenergic receptor function
KR20020068513A (ko) * 1999-10-04 2002-08-27 아사히 가세이 가부시키가이샤 삼환성 아미노 알코올 유도체의 용해성 개선 방법
CA2394778A1 (en) * 1999-12-16 2002-06-14 Shiro Miyoshi Novel substituted tricyclic compounds
CA2398199A1 (en) * 2000-01-28 2001-08-02 Asahi Kasei Kabushiki Kaisha Novel therapeutic agents that use a .beta.3 agonist
WO2001083453A1 (fr) * 2000-04-28 2001-11-08 Asahi Kasei Kabushiki Kaisha Nouveaux composes tricycliques substitues
AU5257401A (en) * 2000-04-28 2001-11-12 Asahi Chemical Ind Novel bicyclic compounds
AU2001252575A1 (en) * 2000-04-28 2001-11-12 Asahi Kasei Kabushiki Kaisha Novel tricyclic compounds
GB0010757D0 (en) * 2000-05-05 2000-06-28 Astrazeneca Ab Chemical compounds
MXPA03005648A (es) * 2000-12-22 2003-10-06 Astrazeneca Ab Derivados de carbazol y su uso, como ligandos de receptor del neuropeptido y5.
WO2002074306A1 (fr) * 2001-03-19 2002-09-26 Asahi Kasei Kabushiki Kaisha Remedes pour la steatose hepatique
GB0121941D0 (en) * 2001-09-11 2001-10-31 Astrazeneca Ab Chemical compounds
KR100816527B1 (ko) * 2001-09-12 2008-04-10 한국화학연구원 페닐테트라졸 유도체로 치환된 β-아미노알코올 화합물
DE60228990D1 (de) * 2001-10-25 2008-10-30 Asahi Kasei Pharma Corp Bicyclische verbindung
EP1478625A1 (en) 2002-02-27 2004-11-24 Pfizer Products Inc. Processes and intermediates useful in preparing beta-3-adrenergic receptor agonists
AU2003209527A1 (en) 2002-02-27 2003-09-09 Pfizer Products Inc. Crystal forms of (r)-2-(2-(4-oxazol-4-yl-phenoxy)-ethylamino)-1-pyridin-3-yl-ethanol
US6864268B2 (en) 2002-02-27 2005-03-08 Pfizer Inc. β3 adrenergic receptor agonists
EP1424079A1 (en) * 2002-11-27 2004-06-02 Boehringer Ingelheim International GmbH Combination of a beta-3-receptor agonist and of a reuptake inhibitor of serotonin and/or norepinephrine
MXPA05008587A (es) 2003-02-14 2005-11-04 Kissei Pharmaceutical Derivados de alcohol amino, composiciones farmaceuticas que contienen los mismos, y usos de los mismos.
WO2005040093A1 (ja) * 2003-10-24 2005-05-06 Kissei Pharmaceutical Co., Ltd. アミノアルコール誘導体、それを含有する医薬組成物およびそれらの用途
US7718822B2 (en) 2007-08-28 2010-05-18 Sepracor Inc. Carbamate Stereoisomer
US8501994B2 (en) 2007-08-28 2013-08-06 Sunovion Pharmaceuticals Inc. Acetamide stereoisomer
WO2010041568A1 (ja) 2008-10-09 2010-04-15 旭化成ファーマ株式会社 インダゾール誘導体
EP2345644A4 (en) 2008-10-09 2012-03-21 Asahi Kasei Pharma Corp INDAZOLE COMPOUND
US20100222404A1 (en) * 2008-11-04 2010-09-02 Asahi Kasei Pharma Corporation Indazole derivative dihydrochloride
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WO2012032546A2 (en) * 2010-09-08 2012-03-15 Cadila Healthcare Limited Process for the preparation of salmeterol and its intermediates
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US11053255B2 (en) 2015-06-22 2021-07-06 Georgetown University Synthesis of mahanine and related compounds
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Also Published As

Publication number Publication date
JP2000239255A (ja) 2000-09-05
AU1170897A (en) 1997-08-01
EP0882707A4 (en) 2001-04-11
DE69630319T2 (de) 2004-07-29
ES2208772T3 (es) 2004-06-16
CN1083831C (zh) 2002-05-01
EP0882707B1 (en) 2003-10-08
NO20012876L (no) 1998-09-10
CA2242351C (en) 2003-03-11
NO312159B1 (no) 2002-04-02
CN1295064A (zh) 2001-05-16
CA2242351A1 (en) 1997-07-17
ATE251608T1 (de) 2003-10-15
WO1997025311A1 (fr) 1997-07-17
NO983197L (no) 1998-09-10
EP0882707A1 (en) 1998-12-09
CN1209119A (zh) 1999-02-24
HK1017669A1 (en) 1999-11-26
NO20012876D0 (no) 2001-06-11
US6187809B1 (en) 2001-02-13
US6037362A (en) 2000-03-14
KR19990077162A (ko) 1999-10-25
US20030139475A1 (en) 2003-07-24
KR100395280B1 (ko) 2004-06-04
DE69630319D1 (de) 2003-11-13
AU715233B2 (en) 2000-01-20
US6545053B1 (en) 2003-04-08

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