JPS5553262A - Phenylethanolamine derivative - Google Patents
Phenylethanolamine derivativeInfo
- Publication number
- JPS5553262A JPS5553262A JP12809978A JP12809978A JPS5553262A JP S5553262 A JPS5553262 A JP S5553262A JP 12809978 A JP12809978 A JP 12809978A JP 12809978 A JP12809978 A JP 12809978A JP S5553262 A JPS5553262 A JP S5553262A
- Authority
- JP
- Japan
- Prior art keywords
- lower alkyl
- phenylethanolamine derivative
- phenylethanolamine
- derivative
- acosmia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:A phenylethanolamine derivative I [X is H, lower alkyl, lower alkoxy, halogen, OH, sulfamoyl, carbamoyl, cyano, etc.; R1 is H or lower alkyl; n is 0.1 or 3; Y is methylene, O or S; R2 is (substituted) aryl, benzodioxane ring, etc.].
EXAMPLE: 5-[ 1-Hydroxy-2-{ 1-( 1,4-benzodioxan-2-yl )ethylamino }propyl ]-2- methoxybenzenesulfonamide.
USE: An agent having both β-and α-adrenalin-blocking activities, useful as a hypotensor having reduced side effects, and as a remedy for peripheral acosmia, e.g. Raynaud's disease, etc., or angina pectoris.
PROCESS: A compound I is prepared by aminolysis of a halohydrin II1 or an epoxide II2 with an amine III1.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12809978A JPS5553262A (en) | 1978-10-17 | 1978-10-17 | Phenylethanolamine derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12809978A JPS5553262A (en) | 1978-10-17 | 1978-10-17 | Phenylethanolamine derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5553262A true JPS5553262A (en) | 1980-04-18 |
JPS6213344B2 JPS6213344B2 (en) | 1987-03-25 |
Family
ID=14976361
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12809978A Granted JPS5553262A (en) | 1978-10-17 | 1978-10-17 | Phenylethanolamine derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5553262A (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0034432A2 (en) * | 1980-02-08 | 1981-08-26 | Yamanouchi Pharmaceutical Co., Ltd. | Sulfamoyl-substituted phenethylamine derivatives, their preparation, and pharmaceutical compositions, containing them |
US6037362A (en) * | 1996-01-10 | 2000-03-14 | Asahi Kasei Kogyo Kabushiki Kaisha | Tricyclic compounds and drug compositions containing the same |
US6172099B1 (en) | 1997-07-03 | 2001-01-09 | Asahi Kasei Kogyo Kabushiki Kaisha | Tricyclic compounds having saturated rings and medicinal compositions containing the same |
US6861444B2 (en) | 2000-04-28 | 2005-03-01 | Asahi Kasei Pharma Corporation | Bicyclic compounds |
US7271190B2 (en) | 2001-10-25 | 2007-09-18 | Asahi Kasei Pharma Corporation | Indazole compounds as β3 adrenoceptor agonist |
US8008506B2 (en) | 2008-10-09 | 2011-08-30 | Asahi Kasei Pharma Corporation | Indazole compounds |
US8304443B2 (en) | 2008-10-09 | 2012-11-06 | Asahi Kasei Pharma Corporation | Indazole derivatives |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS53111029A (en) * | 1977-02-03 | 1978-09-28 | Allen & Hanburys Ltd | New derivative of benzensulfonamido and benzencarboxyamido * method of its production and drug composition containing these |
JPS5950671A (en) * | 1982-09-16 | 1984-03-23 | Olympus Optical Co Ltd | Method for displaying focus information of television camera or the like |
-
1978
- 1978-10-17 JP JP12809978A patent/JPS5553262A/en active Granted
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS53111029A (en) * | 1977-02-03 | 1978-09-28 | Allen & Hanburys Ltd | New derivative of benzensulfonamido and benzencarboxyamido * method of its production and drug composition containing these |
JPS5950671A (en) * | 1982-09-16 | 1984-03-23 | Olympus Optical Co Ltd | Method for displaying focus information of television camera or the like |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0034432A2 (en) * | 1980-02-08 | 1981-08-26 | Yamanouchi Pharmaceutical Co., Ltd. | Sulfamoyl-substituted phenethylamine derivatives, their preparation, and pharmaceutical compositions, containing them |
US6037362A (en) * | 1996-01-10 | 2000-03-14 | Asahi Kasei Kogyo Kabushiki Kaisha | Tricyclic compounds and drug compositions containing the same |
US6187809B1 (en) * | 1996-01-10 | 2001-02-13 | Asahi Kasei Kogyo Kabushiki Kaisha | Tricyclic compounds and drug compositions containing the same |
US6545053B1 (en) | 1996-01-10 | 2003-04-08 | Asahi Kasei Kogyo Kabushiki Kaisha | Tricyclic compounds and drug compositions containing same |
US6172099B1 (en) | 1997-07-03 | 2001-01-09 | Asahi Kasei Kogyo Kabushiki Kaisha | Tricyclic compounds having saturated rings and medicinal compositions containing the same |
US6861444B2 (en) | 2000-04-28 | 2005-03-01 | Asahi Kasei Pharma Corporation | Bicyclic compounds |
US7271190B2 (en) | 2001-10-25 | 2007-09-18 | Asahi Kasei Pharma Corporation | Indazole compounds as β3 adrenoceptor agonist |
US7511069B2 (en) | 2001-10-25 | 2009-03-31 | Asahi Pharma Corporation | Indazole compounds as β3 andrenoceptor agonist |
US7598284B2 (en) | 2001-10-25 | 2009-10-06 | Asahi Kasei Pharma Corporation | Indazole compounds as B3 adrenoceptor agonist |
US8008506B2 (en) | 2008-10-09 | 2011-08-30 | Asahi Kasei Pharma Corporation | Indazole compounds |
US8304443B2 (en) | 2008-10-09 | 2012-11-06 | Asahi Kasei Pharma Corporation | Indazole derivatives |
Also Published As
Publication number | Publication date |
---|---|
JPS6213344B2 (en) | 1987-03-25 |
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