JPS55115877A - Novel amidine compound and its preparation - Google Patents

Novel amidine compound and its preparation

Info

Publication number
JPS55115877A
JPS55115877A JP2396879A JP2396879A JPS55115877A JP S55115877 A JPS55115877 A JP S55115877A JP 2396879 A JP2396879 A JP 2396879A JP 2396879 A JP2396879 A JP 2396879A JP S55115877 A JPS55115877 A JP S55115877A
Authority
JP
Japan
Prior art keywords
formula
alkyl
compound shown
preparation
amidine compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2396879A
Other languages
Japanese (ja)
Inventor
Yasufumi Hirata
Isao Yanagisawa
Yoshio Ishii
Masaaki Takeda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Priority to JP2396879A priority Critical patent/JPS55115877A/en
Publication of JPS55115877A publication Critical patent/JPS55115877A/en
Pending legal-status Critical Current

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Landscapes

  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:An amidine compound shown by the formula I (X is N or methine; Y os O or S; R1 is H, alkyl, aminoalkyl or cycloalkylaminoalkyl which may be bonded through O in its chain; R2 is H or alkyl; m and n are 1W3; R3 is cyano, acyl, carbamoyl, trihalogenomethylcarbonyl; R4 is H, alkyl, alkenyl, etc.; R3 and R4 together with N form 5 or 6 membered heterocyclic ring) and its acid addition salt.
EXAMPLE: N-cyano-3-[ ( 5-dimethylaminomethylfuran-2-yl )methylthio ] propionamidine.
USE: An inhibitor of the secretion of acid in the stomach. Not depending upon an anticholinergic action.
PROCESS: For example, a compound shown by the formula III is reacted with an amine shown by the formula H2N-R4 to give a compound shown by the formula I.
COPYRIGHT: (C)1980,JPO&Japio
JP2396879A 1979-02-28 1979-02-28 Novel amidine compound and its preparation Pending JPS55115877A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2396879A JPS55115877A (en) 1979-02-28 1979-02-28 Novel amidine compound and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2396879A JPS55115877A (en) 1979-02-28 1979-02-28 Novel amidine compound and its preparation

Publications (1)

Publication Number Publication Date
JPS55115877A true JPS55115877A (en) 1980-09-06

Family

ID=12125342

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2396879A Pending JPS55115877A (en) 1979-02-28 1979-02-28 Novel amidine compound and its preparation

Country Status (1)

Country Link
JP (1) JPS55115877A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0087274A2 (en) * 1982-02-20 1983-08-31 Smith Kline & French Laboratories Limited Pyrimidone derivatives
US4694008A (en) * 1984-08-23 1987-09-15 Smith Kline & French Laboratories Limited Chemical compounds
US4748165A (en) * 1981-05-18 1988-05-31 Imperial Chemical Industries Plc Amidine derivatives
JP2008162063A (en) * 2006-12-27 2008-07-17 King Jim Co Ltd Binder and filing implement
WO2022034121A1 (en) 2020-08-11 2022-02-17 Université De Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4748165A (en) * 1981-05-18 1988-05-31 Imperial Chemical Industries Plc Amidine derivatives
EP0087274A2 (en) * 1982-02-20 1983-08-31 Smith Kline & French Laboratories Limited Pyrimidone derivatives
US4808589A (en) * 1982-02-20 1989-02-28 Smith Kline & French Laboratories Limited Pyrimidone derivatives
US4694008A (en) * 1984-08-23 1987-09-15 Smith Kline & French Laboratories Limited Chemical compounds
JP2008162063A (en) * 2006-12-27 2008-07-17 King Jim Co Ltd Binder and filing implement
WO2022034121A1 (en) 2020-08-11 2022-02-17 Université De Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

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