DE69919212D1 - Aromatische amiden - Google Patents

Aromatische amiden

Info

Publication number
DE69919212D1
DE69919212D1 DE69919212T DE69919212T DE69919212D1 DE 69919212 D1 DE69919212 D1 DE 69919212D1 DE 69919212 T DE69919212 T DE 69919212T DE 69919212 T DE69919212 T DE 69919212T DE 69919212 D1 DE69919212 D1 DE 69919212D1
Authority
DE
Germany
Prior art keywords
aromatic amides
inhibitor
factor
compound
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69919212T
Other languages
English (en)
Other versions
DE69919212T2 (de
Inventor
Wade Beight
Joyce Craft
Penman Denny
Bernard Franciskovich
Junior Goodson
Edward Hall
Kent Herron
Sajan Pariyadan Joseph
Joseph Klimkowski
Joseph Masters
David Mendel
Guy Milot
Maria Pineiro-Nunez
Scott Sawyer
Theodore Shuman
Floyd Smith
Louise Tebbe
Marie Tinsley
Crayton Weir
Robert Wiley
Kwong Yee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of DE69919212D1 publication Critical patent/DE69919212D1/de
Application granted granted Critical
Publication of DE69919212T2 publication Critical patent/DE69919212T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
DE69919212T 1998-12-23 1999-12-15 Aromatische amiden Expired - Fee Related DE69919212T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11355698P 1998-12-23 1998-12-23
US113556P 1998-12-23
PCT/US1999/029946 WO2000039118A1 (en) 1998-12-23 1999-12-15 Aromatic amides

Publications (2)

Publication Number Publication Date
DE69919212D1 true DE69919212D1 (de) 2004-09-09
DE69919212T2 DE69919212T2 (de) 2005-07-28

Family

ID=22350118

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69919212T Expired - Fee Related DE69919212T2 (de) 1998-12-23 1999-12-15 Aromatische amiden

Country Status (9)

Country Link
US (3) US6635657B1 (de)
EP (1) EP1140903B1 (de)
JP (1) JP2002533454A (de)
AT (1) ATE272633T1 (de)
AU (1) AU2055500A (de)
CA (1) CA2361149A1 (de)
DE (1) DE69919212T2 (de)
ES (1) ES2226485T3 (de)
WO (1) WO2000039118A1 (de)

Families Citing this family (77)

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AU8270298A (en) 1997-06-26 1999-01-19 Eli Lilly And Company Antithrombotic agents
WO1999000126A1 (en) 1997-06-26 1999-01-07 Eli Lilly And Company Antithrombotic agents
IL133625A0 (en) 1997-06-26 2001-04-30 Lilly Co Eli Antithrombotic agents
US6313122B1 (en) 1997-06-26 2001-11-06 Eli Lilly And Company Antithrombotic agents
US6689780B1 (en) 1998-12-23 2004-02-10 Eli Lilly And Company Heteroroaromatic amides as inhibitor of factor Xa
CA2358091A1 (en) 1998-12-23 2000-07-06 Eli Lilly And Company Antithrombotic amides
JP2002533454A (ja) * 1998-12-23 2002-10-08 イーライ・リリー・アンド・カンパニー 芳香族アミド類
DE69915687T2 (de) 1998-12-24 2005-02-10 Eli Lilly And Co., Indianapolis Heterocyclische amide als inhibitoren von faktor xa
ATE309237T1 (de) * 1999-03-12 2005-11-15 Boehringer Ingelheim Pharma Aromatische heterozyklische verbindungen als antientzündungwirkstoffe
JP2003502314A (ja) 1999-06-14 2003-01-21 イーライ・リリー・アンド・カンパニー 化合物
US6844367B1 (en) 1999-09-17 2005-01-18 Millennium Pharmaceuticals, Inc. Benzamides and related inhibitors of factor Xa
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AU2001250783A1 (en) 2000-02-29 2001-09-12 Cor Therapeutics, Inc. Benzamides and related inhibitors of factor xa
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GB0030304D0 (en) 2000-12-13 2001-01-24 Lilly Co Eli Compounds
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EP1379506A2 (de) * 2000-11-28 2004-01-14 Eli Lilly And Company Substituierte carbonsäureamide
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US7102009B2 (en) 2001-01-12 2006-09-05 Amgen Inc. Substituted amine derivatives and methods of use
US7105682B2 (en) * 2001-01-12 2006-09-12 Amgen Inc. Substituted amine derivatives and methods of use
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EP1456175A1 (de) 2001-12-07 2004-09-15 Eli Lilly And Company Substituierte heterozyklische karboxamide mit antithrombotischer aktivität
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ES2297489T3 (es) * 2003-05-30 2008-05-01 Eli Lilly And Company Eteres antitromboticos.
TWI287010B (en) * 2003-06-12 2007-09-21 Euro Celtique Sa Therapeutic agents useful for treating pain
TW200512181A (en) * 2003-09-26 2005-04-01 Tanabe Seiyaku Co Amide-type carboxamide derivatives
TW200524915A (en) * 2003-09-26 2005-08-01 Tanabe Seiyaku Co Carbamoyl-type benzofuran derivatives
EP1670783A2 (de) * 2003-09-30 2006-06-21 Eli Lilly And Company Aromatische ether mit antithrombotischer wirkung
US7906533B2 (en) 2004-11-03 2011-03-15 Bayer Schering Pharma Ag Nicotinamide pyridinureas as vascular endothelial growth factor (VEGF) receptor kinase inhibitors
EP1657241A1 (de) 2004-11-03 2006-05-17 Schering Aktiengesellschaft Neue Antranilamidpyrdinharnstoffe mit hemmender Wirkung auf VEGF-Rezeptor Kinase
EP1655295A1 (de) 2004-11-03 2006-05-10 Schering Aktiengesellschaft Anthranilamid-Pyridinharnstoffe als VEGF Rezeptor Kinase Inhibitoren
US7700628B2 (en) 2004-11-24 2010-04-20 Eli Lilly And Company Aromatic ether derivatives useful as thrombin inhibitors
WO2006057868A1 (en) * 2004-11-29 2006-06-01 Eli Lilly And Company Antithrombotic diamides
JPWO2006070878A1 (ja) * 2004-12-28 2008-06-12 アステラス製薬株式会社 カルボン酸誘導体またはその塩
US7264402B2 (en) * 2005-03-10 2007-09-04 Corning Cable Systems Llc Multi-fiber optic receptacle and plug assembly
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US8247556B2 (en) * 2005-10-21 2012-08-21 Amgen Inc. Method for preparing 6-substituted-7-aza-indoles
CA2667488C (en) 2006-11-02 2015-07-07 Millennium Pharmaceuticals, Inc. Methods of synthesizing pharmaceutical salts of a factor xa inhibitor
RU2452484C2 (ru) * 2006-12-08 2012-06-10 Милленниум Фармасьютикалз, Инк. Стандартные лекарственные препараты и способы лечения тромбоза пероральным введением ингибитора фактора ха
PA8775701A1 (es) * 2007-04-06 2009-04-23 Neurocrine Biosciences Inc Antagonista de los receptores de la hormona liberadora de gonadotropina y procedimientos relacionados con ellos
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US20130261130A1 (en) * 2010-11-01 2013-10-03 Shaheen Ahmed Neurotrypsin inhibitors
DK2748157T3 (en) * 2011-08-26 2016-01-18 Bayer Ip Gmbh PROCEDURE FOR THE PREPARATION OF TETRAZOLE SUBSTITUTED ANTHRANILY ACID DIAMIDE DERIVATIVES BY USING BENZOXAZINONES WITH AMINES
CN104245666B (zh) 2012-02-07 2019-01-11 拜耳知识产权有限责任公司 取代的邻氨基苯甲酸衍生物的制备方法
CN103304489B (zh) * 2012-03-16 2015-03-11 中国农业科学院兰州畜牧与兽药研究所 嘧啶苯甲酰胺类化合物及其制备和应用
EP2924108A1 (de) * 2014-03-28 2015-09-30 The Procter and Gamble Company Dosierungsartikel für wasserlösliche Einheit
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TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
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Also Published As

Publication number Publication date
EP1140903B1 (de) 2004-08-04
ATE272633T1 (de) 2004-08-15
US7129245B2 (en) 2006-10-31
US6759414B2 (en) 2004-07-06
JP2002533454A (ja) 2002-10-08
CA2361149A1 (en) 2000-07-06
US20040029874A1 (en) 2004-02-12
US20050282862A1 (en) 2005-12-22
AU2055500A (en) 2000-07-31
ES2226485T3 (es) 2005-03-16
DE69919212T2 (de) 2005-07-28
WO2000039118A1 (en) 2000-07-06
EP1140903A1 (de) 2001-10-10
US6635657B1 (en) 2003-10-21

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Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336

8339 Ceased/non-payment of the annual fee