ATE326453T1 - Antithrombotische amide - Google Patents
Antithrombotische amideInfo
- Publication number
- ATE326453T1 ATE326453T1 AT99964269T AT99964269T ATE326453T1 AT E326453 T1 ATE326453 T1 AT E326453T1 AT 99964269 T AT99964269 T AT 99964269T AT 99964269 T AT99964269 T AT 99964269T AT E326453 T1 ATE326453 T1 AT E326453T1
- Authority
- AT
- Austria
- Prior art keywords
- antithrbotic
- amides
- inhibitor
- factor
- compound
- Prior art date
Links
- 150000001408 amides Chemical class 0.000 title 1
- 108010074860 Factor Xa Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11377898P | 1998-12-23 | 1998-12-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE326453T1 true ATE326453T1 (de) | 2006-06-15 |
Family
ID=22351471
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99964269T ATE326453T1 (de) | 1998-12-23 | 1999-12-15 | Antithrombotische amide |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US6610704B1 (de) |
| EP (1) | EP1140881B1 (de) |
| JP (1) | JP2004522689A (de) |
| AT (1) | ATE326453T1 (de) |
| AU (1) | AU2054700A (de) |
| CA (1) | CA2358091A1 (de) |
| DE (1) | DE69931393T2 (de) |
| ES (1) | ES2263294T3 (de) |
| WO (1) | WO2000039111A1 (de) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1007037A4 (de) | 1997-06-26 | 2004-10-06 | Lilly Co Eli | Antithrombose mittel |
| AU8270898A (en) | 1997-06-26 | 1999-01-19 | Eli Lilly And Company | Antithrombotic agents |
| US6313151B1 (en) | 1997-06-26 | 2001-11-06 | Eli Lilly And Company | Antithrombotic agents |
| IL133623A0 (en) | 1997-06-26 | 2001-04-30 | Lilly Co Eli | Antithrombotic agents |
| US6689780B1 (en) | 1998-12-23 | 2004-02-10 | Eli Lilly And Company | Heteroroaromatic amides as inhibitor of factor Xa |
| ATE272633T1 (de) | 1998-12-23 | 2004-08-15 | Lilly Co Eli | Aromatische amiden |
| ATE261941T1 (de) | 1998-12-24 | 2004-04-15 | Lilly Co Eli | Heterocyclische amide als inhibitoren von faktor xa |
| US6855715B1 (en) | 1999-06-14 | 2005-02-15 | Eli Lilly And Company | Serine protease inhibitors |
| GB0001930D0 (en) | 2000-01-27 | 2000-03-22 | Novartis Ag | Organic compounds |
| AU776053B2 (en) | 2000-03-31 | 2004-08-26 | Astellas Pharma Inc. | Diazepan derivatives or salts thereof |
| TWI290136B (en) | 2000-04-05 | 2007-11-21 | Daiichi Seiyaku Co | Ethylenediamine derivatives |
| DE10023492A1 (de) * | 2000-05-09 | 2001-11-22 | Schering Ag | Aza- und Polyazanthranylamide und deren Verwendung als Arzneimittel |
| GB0030305D0 (en) | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| GB0030306D0 (en) | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| GB0030304D0 (en) | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| GB0030303D0 (en) | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| EP1307444B1 (de) | 2000-07-27 | 2007-10-03 | Eli Lilly And Company | Substituierte heterocyclische amide |
| AU2001282871A1 (en) | 2000-08-17 | 2002-02-25 | Eli Lilly And Company | Antithrombotic agents |
| RU2276137C2 (ru) * | 2000-11-22 | 2006-05-10 | Астеллас Фарма Инк. | Замещенные производные бензола или их соли, фармацевтическая композиция на их основе |
| US7163938B2 (en) | 2000-11-28 | 2007-01-16 | Eli Lilly And Company | Substituted carboxamides |
| US6995162B2 (en) | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| US20030134836A1 (en) * | 2001-01-12 | 2003-07-17 | Amgen Inc. | Substituted arylamine derivatives and methods of use |
| US7105682B2 (en) | 2001-01-12 | 2006-09-12 | Amgen Inc. | Substituted amine derivatives and methods of use |
| US6878714B2 (en) | 2001-01-12 | 2005-04-12 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| US7102009B2 (en) | 2001-01-12 | 2006-09-05 | Amgen Inc. | Substituted amine derivatives and methods of use |
| US6864255B2 (en) | 2001-04-11 | 2005-03-08 | Amgen Inc. | Substituted triazinyl amide derivatives and methods of use |
| WO2003000657A1 (en) | 2001-06-20 | 2003-01-03 | Daiichi Pharmaceutical Co., Ltd. | Diamine derivatives |
| HUP0401595A3 (en) * | 2001-11-02 | 2005-11-28 | Basf Ag | Method for producing 2-halogen-pyridine-carboxylic acid amides |
| US7449457B2 (en) | 2001-12-07 | 2008-11-11 | Eli Lilly And Company | Substituted heterocyclic carboxamides with antithrombotic activity |
| EP1569912B1 (de) | 2002-12-03 | 2015-04-29 | Pharmacyclics, Inc. | 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidinderivate als faktor vii-a hemmer |
| US7307088B2 (en) * | 2002-07-09 | 2007-12-11 | Amgen Inc. | Substituted anthranilic amide derivatives and methods of use |
| US7427632B2 (en) | 2002-12-30 | 2008-09-23 | Eli Lilly And Company | Factor Xa inhibitors |
| ATE382607T1 (de) * | 2003-05-30 | 2008-01-15 | Lilly Co Eli | Antitrombotische aether |
| WO2005049604A2 (en) * | 2003-09-30 | 2005-06-02 | Eli Lilly And Company | Antithrombotic aromatic ethers |
| DE602005019316D1 (en) | 2004-11-24 | 2010-03-25 | Lilly Co Eli | Aromatische etherderivate als thrombin-hemmer |
| ATE440833T1 (de) * | 2004-11-29 | 2009-09-15 | Lilly Co Eli | Antithrombotische diamide |
| WO2006070878A1 (ja) * | 2004-12-28 | 2006-07-06 | Astellas Pharma Inc. | カルボン酸誘導体またはその塩 |
| US7264402B2 (en) * | 2005-03-10 | 2007-09-04 | Corning Cable Systems Llc | Multi-fiber optic receptacle and plug assembly |
| US8247556B2 (en) | 2005-10-21 | 2012-08-21 | Amgen Inc. | Method for preparing 6-substituted-7-aza-indoles |
| FR2926297B1 (fr) | 2008-01-10 | 2013-03-08 | Centre Nat Rech Scient | Molecules chimiques inhibitrices du mecanisme d'epissage pour traiter des maladies resultant d'anomalies d'epissage. |
| AU2010303567B2 (en) * | 2009-10-06 | 2016-06-09 | Millennium Pharmaceuticals, Inc | Heterocyclic compounds useful as PDK1 inhibitors |
| EP2505198A1 (de) | 2011-04-01 | 2012-10-03 | Société Splicos | Verbindungen zur Verwendung als Therapiemittel mit Beeinträchtigung der p53-Expression und/oder -Aktivität |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1156362A1 (ru) | 1983-02-17 | 1991-07-30 | Пермский государственный фармацевтический институт | Ариламиды П-(2 @ ,4 @ )- или (3 @ ,4 @ )-диметоксибензилантраниловых кислот как промежуточные вещества дл синтеза биологически активных перхлоратов 1-[(2 @ ,4 @ ) или (3 @ ,4 @ )-диметоксибензил]-2-метил-3-арил-4-(3Н)-хиназолинони |
| US5658885A (en) | 1993-04-27 | 1997-08-19 | The Dupont Merck Pharmaceutical Company | Amidino and guanidino substituted boronic acid inhibitors of trypsin-like enzymes |
| CA2241904C (en) | 1996-01-02 | 2004-12-21 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Substituted n-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides |
| DE19637777C1 (de) | 1996-09-17 | 1997-11-20 | Leica Mikroskopie & Syst | Verfahren und Vorrichtung zur Fehlerkorrektur eines Heterodyn-Interferometers |
| AU8270898A (en) | 1997-06-26 | 1999-01-19 | Eli Lilly And Company | Antithrombotic agents |
| EP1007037A4 (de) * | 1997-06-26 | 2004-10-06 | Lilly Co Eli | Antithrombose mittel |
| IL133623A0 (en) * | 1997-06-26 | 2001-04-30 | Lilly Co Eli | Antithrombotic agents |
| US6313151B1 (en) * | 1997-06-26 | 2001-11-06 | Eli Lilly And Company | Antithrombotic agents |
| US6140351A (en) | 1997-12-19 | 2000-10-31 | Berlex Laboratories, Inc. | Ortho-anthranilamide derivatives as anti-coagulants |
| NZ503809A (en) | 1997-12-19 | 2002-04-26 | Schering Ag | Ortho-anthranilamide derivatives as anti-coagulants |
| ES2196917T3 (es) | 1998-12-23 | 2003-12-16 | Lilly Co Eli | Amidas heteroaromaticas como inhibidores del factor xa`. |
| ATE272633T1 (de) | 1998-12-23 | 2004-08-15 | Lilly Co Eli | Aromatische amiden |
| ATE261941T1 (de) | 1998-12-24 | 2004-04-15 | Lilly Co Eli | Heterocyclische amide als inhibitoren von faktor xa |
| US6567857B1 (en) * | 1999-07-29 | 2003-05-20 | Sun Microsystems, Inc. | Method and apparatus for dynamic proxy insertion in network traffic flow |
| US6871235B1 (en) * | 1999-12-10 | 2005-03-22 | Nortel Networks Limited | Fast path forwarding of link state advertisements using reverse path forwarding |
| US7698463B2 (en) * | 2000-09-12 | 2010-04-13 | Sri International | System and method for disseminating topology and link-state information to routing nodes in a mobile ad hoc network |
| US7289505B2 (en) * | 2002-06-04 | 2007-10-30 | Lucent Technologies Inc. | Efficient reverse path forwarding check mechanism |
| US7280557B1 (en) * | 2002-06-28 | 2007-10-09 | Cisco Technology, Inc. | Mechanisms for providing stateful NAT support in redundant and asymetric routing environments |
| CN1277375C (zh) * | 2003-07-31 | 2006-09-27 | 华为技术有限公司 | 一种光网络中永久连接和交换连接之间的转换方法 |
| US20050076099A1 (en) * | 2003-10-03 | 2005-04-07 | Nortel Networks Limited | Method and apparatus for live streaming media replication in a communication network |
-
1999
- 1999-12-15 CA CA002358091A patent/CA2358091A1/en not_active Abandoned
- 1999-12-15 DE DE69931393T patent/DE69931393T2/de not_active Expired - Fee Related
- 1999-12-15 JP JP2000591022A patent/JP2004522689A/ja not_active Withdrawn
- 1999-12-15 WO PCT/US1999/029832 patent/WO2000039111A1/en not_active Ceased
- 1999-12-15 AT AT99964269T patent/ATE326453T1/de not_active IP Right Cessation
- 1999-12-15 US US09/857,747 patent/US6610704B1/en not_active Expired - Fee Related
- 1999-12-15 EP EP99964269A patent/EP1140881B1/de not_active Expired - Lifetime
- 1999-12-15 ES ES99964269T patent/ES2263294T3/es not_active Expired - Lifetime
- 1999-12-15 AU AU20547/00A patent/AU2054700A/en not_active Abandoned
-
2003
- 2003-02-25 US US10/374,124 patent/US6716855B2/en not_active Expired - Fee Related
- 2003-02-26 US US10/378,108 patent/US6716839B2/en not_active Expired - Fee Related
- 2003-02-28 US US10/377,906 patent/US6710057B2/en not_active Expired - Fee Related
- 2003-03-05 US US10/382,614 patent/US6780878B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US6710057B2 (en) | 2004-03-23 |
| US20030199505A1 (en) | 2003-10-23 |
| US6716855B2 (en) | 2004-04-06 |
| US20030199504A1 (en) | 2003-10-23 |
| CA2358091A1 (en) | 2000-07-06 |
| US20030191153A1 (en) | 2003-10-09 |
| US6780878B2 (en) | 2004-08-24 |
| DE69931393T2 (de) | 2007-03-29 |
| US6716839B2 (en) | 2004-04-06 |
| US20030212069A1 (en) | 2003-11-13 |
| EP1140881B1 (de) | 2006-05-17 |
| US6610704B1 (en) | 2003-08-26 |
| EP1140881A1 (de) | 2001-10-10 |
| DE69931393D1 (de) | 2006-06-22 |
| JP2004522689A (ja) | 2004-07-29 |
| AU2054700A (en) | 2000-07-31 |
| WO2000039111A1 (en) | 2000-07-06 |
| ES2263294T3 (es) | 2006-12-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |