ATE397605T1 - Nebivolol und dessen pharmazeutisch unbedenkliche salze, herstellungsverfahren und pharmazeutische zusammensetzungen von nebivolol - Google Patents
Nebivolol und dessen pharmazeutisch unbedenkliche salze, herstellungsverfahren und pharmazeutische zusammensetzungen von nebivololInfo
- Publication number
- ATE397605T1 ATE397605T1 AT05815690T AT05815690T ATE397605T1 AT E397605 T1 ATE397605 T1 AT E397605T1 AT 05815690 T AT05815690 T AT 05815690T AT 05815690 T AT05815690 T AT 05815690T AT E397605 T1 ATE397605 T1 AT E397605T1
- Authority
- AT
- Austria
- Prior art keywords
- nebivolol
- pharmaceutically acceptable
- acceptable salts
- pharmaceutical compositions
- production process
- Prior art date
Links
- KOHIRBRYDXPAMZ-YHBROIRLSA-N (S,R,R,R)-nebivolol Chemical compound C1CC2=CC(F)=CC=C2O[C@H]1[C@H](O)CNC[C@@H](O)[C@H]1OC2=CC=C(F)C=C2CC1 KOHIRBRYDXPAMZ-YHBROIRLSA-N 0.000 title abstract 4
- 229960000619 nebivolol Drugs 0.000 title abstract 4
- 150000003839 salts Chemical class 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- JWEXHQAEWHKGCW-VCVZPGOSSA-N (S,R,R,R)-nebivolol hydrochloride Chemical compound [Cl-].C1CC2=CC(F)=CC=C2O[C@H]1[C@H](O)C[NH2+]C[C@@H](O)[C@H]1OC2=CC=C(F)C=C2CC1 JWEXHQAEWHKGCW-VCVZPGOSSA-N 0.000 abstract 1
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000007884 disintegrant Substances 0.000 abstract 1
- 229940068174 nebivolol hydrochloride Drugs 0.000 abstract 1
- 239000006186 oral dosage form Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 239000000080 wetting agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
- Saccharide Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN811MU2004 | 2004-07-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE397605T1 true ATE397605T1 (de) | 2008-06-15 |
Family
ID=35653988
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06021645T ATE512961T1 (de) | 2004-07-30 | 2005-08-01 | Amorphes nebivolol hydrochlorid und seine herstellung |
| AT05815690T ATE397605T1 (de) | 2004-07-30 | 2005-08-01 | Nebivolol und dessen pharmazeutisch unbedenkliche salze, herstellungsverfahren und pharmazeutische zusammensetzungen von nebivolol |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06021645T ATE512961T1 (de) | 2004-07-30 | 2005-08-01 | Amorphes nebivolol hydrochlorid und seine herstellung |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US8604222B2 (de) |
| EP (2) | EP1741712B1 (de) |
| JP (3) | JP5757005B2 (de) |
| KR (1) | KR100896266B1 (de) |
| CN (2) | CN101862322A (de) |
| AT (2) | ATE512961T1 (de) |
| AU (1) | AU2005278782B2 (de) |
| BR (1) | BRPI0513672A (de) |
| DE (1) | DE602005007339D1 (de) |
| ES (1) | ES2307219T3 (de) |
| HR (1) | HRP20080297T3 (de) |
| MX (1) | MX2007000911A (de) |
| PL (1) | PL1737847T3 (de) |
| RU (1) | RU2378272C2 (de) |
| WO (1) | WO2006025070A2 (de) |
| ZA (1) | ZA200700765B (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2307219T3 (es) * | 2004-07-30 | 2008-11-16 | Torrent Pharmaceuticals Ltd | Nebivolol y sus sales farmaceuticamente aceptables, procedimiento de preparacion y composiciones farmaceuticas de nebivolol. |
| EP1839658A1 (de) * | 2006-03-30 | 2007-10-03 | Hexal A/S | Pharmazeutische Zusammensetzungen enthaltend mikronisiertes Nebivolol |
| DE502007003278D1 (de) * | 2006-08-04 | 2010-05-12 | Alfred E Tiefenbacher Gmbh & C | Pharmazeutische Zusammensetzung enthaltend Nebivolol |
| ITMI20061889A1 (it) * | 2006-10-03 | 2008-04-04 | Zambon Spa | Processo di preparazione di nebivololo |
| CA2835833C (en) | 2006-11-27 | 2014-11-04 | Zach System S.P.A. | Process for preparing nebivolol |
| WO2008089549A1 (en) | 2007-01-22 | 2008-07-31 | Genpharm Ulc | Pharmaceutical compositions comprising nebivolol or a nebivolol analogue |
| US8212026B2 (en) * | 2007-05-30 | 2012-07-03 | Ind-Swift Laboratories Limited | Process for the preparation of ivabradine hydrochloride and polymorph thereof |
| EP2163551B1 (de) * | 2008-09-08 | 2011-11-16 | Cadila Pharmaceuticals Ltd. | Verbesserter Herstellungsprozess für Nebivolol-Hydrocholorid |
| IT1392067B1 (it) * | 2008-10-31 | 2012-02-09 | Zach System Spa | Processo di preparazione di nebivololo |
| WO2010089764A2 (en) * | 2009-01-05 | 2010-08-12 | Msn Laboratories Limited | Improved process for the preparation of nebivolol hydrochloride |
| IT1395354B1 (it) | 2009-07-23 | 2012-09-14 | Zach System Spa | Processo di preparazione di nebivololo |
| DE102010005953A1 (de) | 2010-01-27 | 2011-07-28 | Corden PharmaChem GmbH, 68305 | Verfahren zur Herstellung von Nebivolol |
| US8785664B2 (en) | 2010-02-11 | 2014-07-22 | Menarini International Operations Luxembourg S.A. | Process for the preparation of nebivolol |
| IT1397962B1 (it) * | 2010-02-11 | 2013-02-04 | Menarini Int Operations Lu Sa | Processo per la preparazione del nebivololo. |
| KR20110130872A (ko) * | 2010-05-28 | 2011-12-06 | 현대약품 주식회사 | 결정형 염산 네비볼롤을 포함하는 약학 조성물 및 제조방법 |
| US9456997B2 (en) | 2010-08-26 | 2016-10-04 | The Regents Of The University Of Colorado, A Body Corporate | Selective inhibition of β1-adrenergic receptors for the treatment of pediatric heart failure |
| IT1402974B1 (it) * | 2010-11-30 | 2013-09-27 | Menarini Int Operations Lu Sa | Processo per la preparazione del nebivololo. |
| US20140057954A1 (en) * | 2012-08-22 | 2014-02-27 | Forest Laboratories Holdings Ltd. | Chemical composition |
| PT2907809T (pt) | 2014-02-14 | 2019-01-16 | Corden Pharma Int Gmbh | Processo sem base para a preparação de intermediários de cetona utilizáveis para fabrico de nebivolol |
| EP2907810A1 (de) | 2014-02-14 | 2015-08-19 | Corden Pharma International GmbH | Neues Verfahren zur Herstellung von hochreinem Nebivolol-Hydrochlorid |
| DE102014107132A1 (de) | 2014-05-20 | 2015-11-26 | Corden Pharma International Gmbh | Verfahren zur Herstellung von Epoxiden die in der Herstellung von Nebivolol und dessen Derivaten einsetzbar sind |
| JP6154417B2 (ja) * | 2015-03-20 | 2017-06-28 | 株式会社三共 | 遊技機 |
| WO2016185492A1 (en) * | 2015-05-19 | 2016-11-24 | Ipca Laboratories Limited | Process for preparation of nebivolol and it's salts |
| KR102203229B1 (ko) * | 2016-01-08 | 2021-01-14 | 에리슨제약(주) | 용출률이 개선된 네비보롤을 포함하는 약학적 조성물 |
| WO2017119629A1 (ko) * | 2016-01-08 | 2017-07-13 | 에리슨제약(주) | 용출률이 개선된 네비보롤을 포함하는 약학적 조성물 |
| ES3040411T3 (en) | 2018-03-22 | 2025-10-30 | Incarda Therapeutics Inc | A novel method to slow ventricular rate |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7908031A (nl) | 1979-11-01 | 1981-06-01 | Acf Chemiefarma Nv | Nieuwe chinolinederivaten en farmaceutische preparaten die een dergelijke verbinding bevatten, alsmede werk- wijze voor het bereiden van deze verbindingen. |
| DE3033919A1 (de) | 1980-09-09 | 1982-04-22 | Bayer Ag, 5090 Leverkusen | Feste arzneizubereitungen enthaltend nifedipin und verfahren zu ihrer herstellung |
| DE3133156A1 (de) * | 1981-08-21 | 1983-03-10 | Herberts Gmbh, 5600 Wuppertal | Verfahren zum markieren von verkehrsflaechen und vorrichtung hierfuer |
| CA1337429C (en) * | 1983-12-05 | 1995-10-24 | Guy Rosalia Eugene Van Lommen | Derivatives of 2,2'-iminobisethanol |
| US4654362A (en) | 1983-12-05 | 1987-03-31 | Janssen Pharmaceutica, N.V. | Derivatives of 2,2'-iminobisethanol |
| DE3419131A1 (de) | 1984-05-23 | 1985-11-28 | Bayer Ag, 5090 Leverkusen | Dihydropyridinkombinationspraeparate und verfahren zu ihrer herstellung |
| US4681765A (en) | 1984-09-13 | 1987-07-21 | American Home Products Corporation | Rapid releasing triamterene containing gelatin capsule dosage forms for once daily antihypertensive use |
| US4904477A (en) | 1987-07-08 | 1990-02-27 | American Home Products Corporation | Spray dried ibuprofen compositions |
| US6545040B1 (en) | 1988-03-23 | 2003-04-08 | Janssen Pharmaceutica N.V. | Method of lowering the blood pressure |
| CA1337432C (en) * | 1988-03-23 | 1995-10-24 | Raymond M. Xhonneux | Method of lowering the blood pressure |
| US4911921A (en) | 1989-02-02 | 1990-03-27 | Mallinckrodt, Inc. | High ibuprofen content granulations |
| ZA93436B (en) | 1992-01-24 | 1993-08-25 | Chugai Pharmaceutical Co Ltd | Benzopyran derivatives |
| TW355683B (en) * | 1994-02-17 | 1999-04-11 | Janssen Pharmaceutica Nv | Composition containing micronized nebivolol |
| JPH10507156A (ja) | 1994-05-16 | 1998-07-14 | セル・セラピューティックス・インコーポレーテッド | キラル第二級アルコールの不斉合成 |
| JP3993651B2 (ja) | 1994-10-21 | 2007-10-17 | アスビオファーマ株式会社 | シクロプロパクロメンカルボン酸誘導体 |
| CA2207333C (en) | 1994-12-28 | 2006-10-17 | Janssen Pharmaceutica, Naamloze Vennootschap | Use of nebivolol as an anti-atherogenic |
| JP2000507997A (ja) | 1996-02-09 | 2000-06-27 | サーフェス ソルーションズ ラボラトリーズ インコーポレイテッド | 水性の親水性被覆組成物及びそれから製造した物品 |
| JP3454832B2 (ja) * | 1996-06-07 | 2003-10-06 | バンダービルト ユニバーシティ | 抗炎症剤として有用なジヒドロベンゾピランおよび関連化合物 |
| US5948440A (en) | 1997-12-17 | 1999-09-07 | Ranbaxy Laboratories Limited | Modified release matrix formulation of cefaclor and cephalexin |
| US6200990B1 (en) * | 1998-12-21 | 2001-03-13 | Alcon Laboratories, Inc. | Neuroprotective agents having antioxidant and NMDA antagonist activity |
| US6482799B1 (en) | 1999-05-25 | 2002-11-19 | The Regents Of The University Of California | Self-preserving multipurpose ophthalmic solutions incorporating a polypeptide antimicrobial |
| JP2003520210A (ja) | 2000-01-05 | 2003-07-02 | イマレックス セラピューティクス， インコーポレイテッド | 低い水溶性を有する薬物の送達のための薬学的処方物 |
| BR0116994A (pt) | 2001-04-27 | 2004-03-02 | Lupin Ltd | Um processo aperfeiçoado para a preparação de uma composição que abrange uma combinação de dose fixa (fdc) de quatro drogas antituberculose |
| CA2446064A1 (en) | 2001-05-02 | 2002-11-07 | Nitromed, Inc. | Nitrosated and nitrosylated nebivolol and its metabolites, compositions and methods of use |
| IL152573A (en) | 2002-10-31 | 2009-11-18 | Transpharma Medical Ltd | A system for the transmission through the skin of a medical preparation against vomiting and nausea |
| HU227236B1 (en) | 2002-11-06 | 2010-12-28 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | New process for the production of racemic and the pure [2s[2r*[r[r*]]]]-and [2r[2s*[s[s*]]]]-enantiomers of nebivolol |
| WO2005065639A2 (en) | 2003-11-21 | 2005-07-21 | Torrent Pharmaceuticals Limited | Novel pharmaceutical compositions |
| ES2307219T3 (es) * | 2004-07-30 | 2008-11-16 | Torrent Pharmaceuticals Ltd | Nebivolol y sus sales farmaceuticamente aceptables, procedimiento de preparacion y composiciones farmaceuticas de nebivolol. |
| US20070021623A1 (en) | 2004-08-11 | 2007-01-25 | Hetero Drugs Limited | Novel process for preparation of nebivolol intermediates |
| WO2006084684A1 (de) | 2005-02-11 | 2006-08-17 | Stada Arzneimittel Ag | Pharmazeutische zusammensetzungen nebivolo und ein hydrophiles polymer |
-
2005
- 2005-08-01 ES ES05815690T patent/ES2307219T3/es not_active Expired - Lifetime
- 2005-08-01 CN CN201010002590A patent/CN101862322A/zh active Pending
- 2005-08-01 AT AT06021645T patent/ATE512961T1/de not_active IP Right Cessation
- 2005-08-01 KR KR1020077004512A patent/KR100896266B1/ko not_active Expired - Fee Related
- 2005-08-01 EP EP06021645A patent/EP1741712B1/de not_active Expired - Lifetime
- 2005-08-01 RU RU2007106103/04A patent/RU2378272C2/ru not_active IP Right Cessation
- 2005-08-01 PL PL05815690T patent/PL1737847T3/pl unknown
- 2005-08-01 JP JP2007523241A patent/JP5757005B2/ja not_active Expired - Fee Related
- 2005-08-01 WO PCT/IN2005/000252 patent/WO2006025070A2/en not_active Ceased
- 2005-08-01 US US11/658,979 patent/US8604222B2/en active Active
- 2005-08-01 MX MX2007000911A patent/MX2007000911A/es active IP Right Grant
- 2005-08-01 DE DE602005007339T patent/DE602005007339D1/de not_active Expired - Lifetime
- 2005-08-01 HR HR20080297T patent/HRP20080297T3/xx unknown
- 2005-08-01 BR BRPI0513672-5A patent/BRPI0513672A/pt not_active IP Right Cessation
- 2005-08-01 AT AT05815690T patent/ATE397605T1/de not_active IP Right Cessation
- 2005-08-01 EP EP05815690A patent/EP1737847B1/de not_active Revoked
- 2005-08-01 CN CN2005800258506A patent/CN101006081B/zh not_active Expired - Fee Related
- 2005-08-01 AU AU2005278782A patent/AU2005278782B2/en not_active Expired - Fee Related
-
2007
- 2007-01-26 ZA ZA200700765A patent/ZA200700765B/xx unknown
-
2013
- 2013-04-09 US US13/859,226 patent/US8633241B2/en not_active Expired - Lifetime
- 2013-04-09 JP JP2013081448A patent/JP2013151550A/ja active Pending
-
2014
- 2014-10-27 JP JP2014218548A patent/JP5837975B2/ja not_active Expired - Fee Related
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