ATE533752T1 - Verbesserter herstellungsprozess für nebivolol- hydrocholorid - Google Patents
Verbesserter herstellungsprozess für nebivolol- hydrocholoridInfo
- Publication number
- ATE533752T1 ATE533752T1 AT09011438T AT09011438T ATE533752T1 AT E533752 T1 ATE533752 T1 AT E533752T1 AT 09011438 T AT09011438 T AT 09011438T AT 09011438 T AT09011438 T AT 09011438T AT E533752 T1 ATE533752 T1 AT E533752T1
- Authority
- AT
- Austria
- Prior art keywords
- nebivolol
- hydrocholoride
- manufacturing process
- improved manufacturing
- synthesis
- Prior art date
Links
- KOHIRBRYDXPAMZ-YHBROIRLSA-N (S,R,R,R)-nebivolol Chemical compound C1CC2=CC(F)=CC=C2O[C@H]1[C@H](O)CNC[C@@H](O)[C@H]1OC2=CC=C(F)C=C2CC1 KOHIRBRYDXPAMZ-YHBROIRLSA-N 0.000 title abstract 4
- 229960000619 nebivolol Drugs 0.000 title abstract 4
- IPVYMXZYXFFDGW-UHFFFAOYSA-N 1-methylpiperidin-4-ol;hydrochloride Chemical compound Cl.CN1CCC(O)CC1 IPVYMXZYXFFDGW-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000746 purification Methods 0.000 abstract 2
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 abstract 1
- 239000004593 Epoxy Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000178 monomer Substances 0.000 abstract 1
- 238000005580 one pot reaction Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1888MU2008 | 2008-09-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE533752T1 true ATE533752T1 (de) | 2011-12-15 |
Family
ID=41269112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT09011438T ATE533752T1 (de) | 2008-09-08 | 2009-09-07 | Verbesserter herstellungsprozess für nebivolol- hydrocholorid |
Country Status (2)
| Country | Link |
|---|---|
| EP (1) | EP2163551B1 (de) |
| AT (1) | ATE533752T1 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110082451B (zh) * | 2019-05-23 | 2021-12-24 | 南京趣酶生物科技有限公司 | 一种2-氯-1-(6-氟-色满-2-)乙醇手性醇中间体制备过程的sfc检测方法 |
| CN117567422A (zh) * | 2023-11-24 | 2024-02-20 | 江苏威奇达药业有限公司 | 一种连续流反应合成盐酸奈必洛尔的方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4654362A (en) | 1983-12-05 | 1987-03-31 | Janssen Pharmaceutica, N.V. | Derivatives of 2,2'-iminobisethanol |
| US6545040B1 (en) | 1988-03-23 | 2003-04-08 | Janssen Pharmaceutica N.V. | Method of lowering the blood pressure |
| TW355683B (en) | 1994-02-17 | 1999-04-11 | Janssen Pharmaceutica Nv | Composition containing micronized nebivolol |
| FR2778662B1 (fr) | 1998-05-12 | 2000-06-16 | Adir | Nouveaux composes cycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| ES2307219T3 (es) * | 2004-07-30 | 2008-11-16 | Torrent Pharmaceuticals Ltd | Nebivolol y sus sales farmaceuticamente aceptables, procedimiento de preparacion y composiciones farmaceuticas de nebivolol. |
| US20070021623A1 (en) | 2004-08-11 | 2007-01-25 | Hetero Drugs Limited | Novel process for preparation of nebivolol intermediates |
| US7288805B2 (en) | 2005-02-24 | 2007-10-30 | International Business Machines Corporation | Double gate isolation |
| AT502220A1 (de) | 2005-07-19 | 2007-02-15 | Pharmacon Forschung & Beratung | Verfahren zur herstellung von nebivolol |
| ITMI20061889A1 (it) | 2006-10-03 | 2008-04-04 | Zambon Spa | Processo di preparazione di nebivololo |
| CA2835833C (en) | 2006-11-27 | 2014-11-04 | Zach System S.P.A. | Process for preparing nebivolol |
-
2009
- 2009-09-07 EP EP09011438A patent/EP2163551B1/de active Active
- 2009-09-07 AT AT09011438T patent/ATE533752T1/de active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2163551B1 (de) | 2011-11-16 |
| EP2163551A1 (de) | 2010-03-17 |
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