NO20080669L - Acetylenpiperaziner som metabotrofiske glutamatreseptorantagonister - Google Patents

Acetylenpiperaziner som metabotrofiske glutamatreseptorantagonister

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Publication number
NO20080669L
NO20080669L NO20080669A NO20080669A NO20080669L NO 20080669 L NO20080669 L NO 20080669L NO 20080669 A NO20080669 A NO 20080669A NO 20080669 A NO20080669 A NO 20080669A NO 20080669 L NO20080669 L NO 20080669L
Authority
NO
Norway
Prior art keywords
piperazines
acetylene
receptor antagonists
glutamate receptor
metabotrophic glutamate
Prior art date
Application number
NO20080669A
Other languages
English (en)
Inventor
Abdelmalik Slassi
Louise Edwards
Methvin Isaac
Guang-Ri Sun
Peter Dove
Erwan Arzel
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of NO20080669L publication Critical patent/NO20080669L/no

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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nutrition Science (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Det beskrives forbindelser med formel I eller farmasøytisk akseptable salter eller solvater derav der Ar1 , A, B, R1, m og n er som angitt i beskrivelsen. Det beskrives videre farmasøytiske preparater og anvendelser av, og fremgangsmåter for fremstilling av slike forbindelser, så vel som metoder for medisinsk behandling av mGluR5-medierte forstyrrelser. (I)
NO20080669A 2005-08-15 2008-02-05 Acetylenpiperaziner som metabotrofiske glutamatreseptorantagonister NO20080669L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70794405P 2005-08-15 2005-08-15
PCT/US2006/030394 WO2007021575A2 (en) 2005-08-15 2006-08-04 Acetylenic piperazines as metabotropic glutamate receptor antagonists

Publications (1)

Publication Number Publication Date
NO20080669L true NO20080669L (no) 2008-05-15

Family

ID=37670907

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20080669A NO20080669L (no) 2005-08-15 2008-02-05 Acetylenpiperaziner som metabotrofiske glutamatreseptorantagonister

Country Status (16)

Country Link
US (2) US20070037817A1 (no)
EP (1) EP1919915A2 (no)
JP (1) JP2009504736A (no)
KR (1) KR20080050569A (no)
CN (1) CN101248076A (no)
AR (1) AR055113A1 (no)
AU (1) AU2006280233A1 (no)
BR (1) BRPI0614481A2 (no)
CA (1) CA2616318A1 (no)
IL (1) IL188807A0 (no)
MX (1) MX2008001608A (no)
NO (1) NO20080669L (no)
TW (1) TW200801005A (no)
UY (1) UY29733A1 (no)
WO (1) WO2007021575A2 (no)
ZA (1) ZA200801033B (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090061041A (ko) 2006-09-11 2009-06-15 노파르티스 아게 대사성 글루타메이트 수용체의 조절제로서의 니코틴산 유도체
WO2009047303A2 (en) * 2007-10-12 2009-04-16 Novartis Ag Metabotropic glutamate receptor modulators for the treatment of pervasive developmental disorder
SG185293A1 (en) * 2007-10-12 2012-11-29 Novartis Ag Organic compounds
RU2496494C2 (ru) 2008-06-30 2013-10-27 Новартис Аг КОМБИНАЦИИ, СОДЕРЖАЩИЕ МОДУЛЯТОРЫ mGluR, ДЛЯ ЛЕЧЕНИЯ БОЛЕЗНИ ПАРКИНСОНА
BR112012027816A2 (pt) 2010-04-30 2017-08-08 Novartis Ag marcadores preditivos úteis no tratamento da síndrome do x frágil (fxs).
WO2013131981A1 (en) 2012-03-08 2013-09-12 Novartis Ag Predictive markers useful in the diagnosis and treatment of fragile x syndrome (fxs)
KR20200120915A (ko) * 2018-01-26 2020-10-22 레코다티인더스트리아치미카이파마슈티카에스.피.에이. mGlu5 수용체의 조절제로서 트리아졸, 이미다졸 및 피롤 축합된 피페라진 유도체 및 이의 용도

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6231833B1 (en) * 1999-08-05 2001-05-15 Pfizer Inc 2,7-substituted octahydro-1H-pyrido[1,2-A]pyrazine derivatives as ligands for serotonin receptors
ES2161377T3 (es) * 1995-12-21 2001-12-01 Pfizer Derivados de octahidro-pirrolo(1,2-a)-pirazina 2,7-sustituidos.
EP0982030A3 (en) * 1998-08-17 2000-05-10 Pfizer Products Inc. 2,7-substituted octahydro-pyrrolo 1,2-a]pyrazine derivatives as 5ht 1a ligands
AU1542201A (en) * 1999-11-05 2001-05-14 Nps Allelix Corp. Compounds having 5-HT6 receptor antagonist activity
WO2003104235A1 (en) * 2002-06-06 2003-12-18 Novo Nordisk A/S Substituted hexahydropyrrolo[1,2-a]pyrazines, octahydropyrido[1,2-a]pyrazines and decahydropyrazino[1,2-a]azepines

Also Published As

Publication number Publication date
UY29733A1 (es) 2007-02-28
WO2007021575A3 (en) 2007-04-05
WO2007021575A2 (en) 2007-02-22
CA2616318A1 (en) 2007-02-22
BRPI0614481A2 (pt) 2017-06-06
US20080194571A1 (en) 2008-08-14
CN101248076A (zh) 2008-08-20
KR20080050569A (ko) 2008-06-09
EP1919915A2 (en) 2008-05-14
JP2009504736A (ja) 2009-02-05
IL188807A0 (en) 2008-08-07
AR055113A1 (es) 2007-08-08
US20070037817A1 (en) 2007-02-15
TW200801005A (en) 2008-01-01
MX2008001608A (es) 2008-04-14
ZA200801033B (en) 2009-01-28
AU2006280233A1 (en) 2007-02-22

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