IT1392067B1 - Processo di preparazione di nebivololo - Google Patents

Processo di preparazione di nebivololo

Info

Publication number
IT1392067B1
IT1392067B1 ITMI2008A001924A ITMI20081924A IT1392067B1 IT 1392067 B1 IT1392067 B1 IT 1392067B1 IT MI2008A001924 A ITMI2008A001924 A IT MI2008A001924A IT MI20081924 A ITMI20081924 A IT MI20081924A IT 1392067 B1 IT1392067 B1 IT 1392067B1
Authority
IT
Italy
Prior art keywords
preparation process
nebivolol
nebivolol preparation
preparation
Prior art date
Application number
ITMI2008A001924A
Other languages
English (en)
Inventor
Ivan Michieletto
Raffaella Volpicelli
Giorgio Soriato
Paolo Maragni
Livius Cotarca
Massimo Verzini
Johnny Foletto
Original Assignee
Zach System Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ITMI2008A001924A priority Critical patent/IT1392067B1/it
Application filed by Zach System Spa filed Critical Zach System Spa
Priority to PT97518542T priority patent/PT2346845E/pt
Priority to HUE09751854A priority patent/HUE025673T2/en
Priority to ES09751854.2T priority patent/ES2540092T3/es
Priority to DK09751854.2T priority patent/DK2346845T3/en
Priority to BRPI0921632A priority patent/BRPI0921632B8/pt
Priority to JP2011533712A priority patent/JP5560279B2/ja
Priority to AU2009309680A priority patent/AU2009309680B2/en
Priority to CN200980140649.0A priority patent/CN102186835B/zh
Priority to CA2737340A priority patent/CA2737340C/en
Priority to PCT/EP2009/064230 priority patent/WO2010049455A1/en
Priority to PL09751854T priority patent/PL2346845T3/pl
Priority to EP09751854.2A priority patent/EP2346845B1/en
Priority to SI200931205T priority patent/SI2346845T1/sl
Priority to US13/126,800 priority patent/US8927742B2/en
Publication of ITMI20081924A1 publication Critical patent/ITMI20081924A1/it
Priority to IL211497A priority patent/IL211497A/en
Application granted granted Critical
Publication of IT1392067B1 publication Critical patent/IT1392067B1/it
Priority to HRP20150554TT priority patent/HRP20150554T1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrane Compounds (AREA)
  • Steroid Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
ITMI2008A001924A 2008-10-31 2008-10-31 Processo di preparazione di nebivololo IT1392067B1 (it)

Priority Applications (17)

Application Number Priority Date Filing Date Title
ITMI2008A001924A IT1392067B1 (it) 2008-10-31 2008-10-31 Processo di preparazione di nebivololo
PCT/EP2009/064230 WO2010049455A1 (en) 2008-10-31 2009-10-28 Process for preparing nebivolol
ES09751854.2T ES2540092T3 (es) 2008-10-31 2009-10-28 Proceso para preparar nebivolol
DK09751854.2T DK2346845T3 (en) 2008-10-31 2009-10-28 Process for the preparation of nebivolol
BRPI0921632A BRPI0921632B8 (pt) 2008-10-31 2009-10-28 processo para preparar nebivolol
JP2011533712A JP5560279B2 (ja) 2008-10-31 2009-10-28 ネビボロールの調製プロセス
AU2009309680A AU2009309680B2 (en) 2008-10-31 2009-10-28 Process for preparing nebivolol
CN200980140649.0A CN102186835B (zh) 2008-10-31 2009-10-28 制备奈比洛尔的方法
PT97518542T PT2346845E (pt) 2008-10-31 2009-10-28 Processo para preparar nebivolol
HUE09751854A HUE025673T2 (en) 2008-10-31 2009-10-28 Process for making nebivolol
PL09751854T PL2346845T3 (pl) 2008-10-31 2009-10-28 Sposób wytwarzania nebiwololu
EP09751854.2A EP2346845B1 (en) 2008-10-31 2009-10-28 Process for preparing nebivolol
SI200931205T SI2346845T1 (sl) 2008-10-31 2009-10-28 Postopek za pripravo nebivolol-a
US13/126,800 US8927742B2 (en) 2008-10-31 2009-10-28 Process for preparing Nebivolol
CA2737340A CA2737340C (en) 2008-10-31 2009-10-28 Process for preparing nebivolol
IL211497A IL211497A (en) 2008-10-31 2011-03-01 Process for making nevivol
HRP20150554TT HRP20150554T1 (hr) 2008-10-31 2015-05-25 Postupak za pripravu nebivolola

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI2008A001924A IT1392067B1 (it) 2008-10-31 2008-10-31 Processo di preparazione di nebivololo

Publications (2)

Publication Number Publication Date
ITMI20081924A1 ITMI20081924A1 (it) 2010-05-01
IT1392067B1 true IT1392067B1 (it) 2012-02-09

Family

ID=40849284

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI2008A001924A IT1392067B1 (it) 2008-10-31 2008-10-31 Processo di preparazione di nebivololo

Country Status (17)

Country Link
US (1) US8927742B2 (it)
EP (1) EP2346845B1 (it)
JP (1) JP5560279B2 (it)
CN (1) CN102186835B (it)
AU (1) AU2009309680B2 (it)
BR (1) BRPI0921632B8 (it)
CA (1) CA2737340C (it)
DK (1) DK2346845T3 (it)
ES (1) ES2540092T3 (it)
HR (1) HRP20150554T1 (it)
HU (1) HUE025673T2 (it)
IL (1) IL211497A (it)
IT (1) IT1392067B1 (it)
PL (1) PL2346845T3 (it)
PT (1) PT2346845E (it)
SI (1) SI2346845T1 (it)
WO (1) WO2010049455A1 (it)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2907809T (pt) 2014-02-14 2019-01-16 Corden Pharma Int Gmbh Processo sem base para a preparação de intermediários de cetona utilizáveis para fabrico de nebivolol
EP2907810A1 (en) 2014-02-14 2015-08-19 Corden Pharma International GmbH A new method for producing nebivolol hydrochloride of high purity
DE102014107132A1 (de) 2014-05-20 2015-11-26 Corden Pharma International Gmbh Verfahren zur Herstellung von Epoxiden die in der Herstellung von Nebivolol und dessen Derivaten einsetzbar sind

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1337429C (en) * 1983-12-05 1995-10-24 Guy Rosalia Eugene Van Lommen Derivatives of 2,2'-iminobisethanol
HU227236B1 (en) * 2002-11-06 2010-12-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag New process for the production of racemic and the pure [2s[2r*[r[r*]]]]-and [2r[2s*[s[s*]]]]-enantiomers of nebivolol
RU2378272C2 (ru) * 2004-07-30 2010-01-10 Торрент Фармасьютикалз Лимитед Небиволол и его фармацевтически приемлемые соли, способ их получения и фармацевтические композиции небиволола
ES2341250T3 (es) * 2004-08-11 2010-06-17 Hetero Drugs Limited Procedimiento novedoso de preparacion de intermediarios de nebivolol.
EP1803716B1 (en) * 2005-12-28 2012-07-25 Acino Pharma AG A process for preparation of racemic nebivolol
CN101553485B (zh) * 2006-11-27 2013-02-06 Zach系统股份公司 制备奈必洛尔的方法

Also Published As

Publication number Publication date
BRPI0921632B8 (pt) 2021-05-25
CN102186835B (zh) 2016-01-13
HUE025673T2 (en) 2016-04-28
DK2346845T3 (en) 2015-06-08
HRP20150554T1 (hr) 2015-07-03
JP5560279B2 (ja) 2014-07-23
BRPI0921632A8 (pt) 2017-07-11
BRPI0921632B1 (pt) 2021-03-23
WO2010049455A1 (en) 2010-05-06
ES2540092T3 (es) 2015-07-08
IL211497A0 (en) 2011-05-31
EP2346845A1 (en) 2011-07-27
IL211497A (en) 2014-12-31
BRPI0921632A2 (pt) 2015-08-18
CA2737340C (en) 2016-09-06
CN102186835A (zh) 2011-09-14
AU2009309680A1 (en) 2010-05-06
CA2737340A1 (en) 2010-05-06
ITMI20081924A1 (it) 2010-05-01
US20110207948A1 (en) 2011-08-25
SI2346845T1 (sl) 2015-10-30
US8927742B2 (en) 2015-01-06
EP2346845B1 (en) 2015-03-25
AU2009309680B2 (en) 2015-08-06
PL2346845T3 (pl) 2015-08-31
PT2346845E (pt) 2015-07-30
JP2012506894A (ja) 2012-03-22

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