BRPI0921632A2 - Processo para preparar nebivolol - Google Patents

Processo para preparar nebivolol

Info

Publication number
BRPI0921632A2
BRPI0921632A2 BRPI0921632-4A BRPI0921632A BRPI0921632A2 BR PI0921632 A2 BRPI0921632 A2 BR PI0921632A2 BR PI0921632 A BRPI0921632 A BR PI0921632A BR PI0921632 A2 BRPI0921632 A2 BR PI0921632A2
Authority
BR
Brazil
Prior art keywords
nebivolol
prepare
prepare nebivolol
Prior art date
Application number
BRPI0921632-4A
Other languages
English (en)
Inventor
Paolo Maragni
Ivan Michieletto
Raffaella Volpicelli
Giorgio Soriato
Johnny Foletto
Livius Cotarca
Massimo Verzini
Original Assignee
Zach System Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zach System Spa filed Critical Zach System Spa
Publication of BRPI0921632A2 publication Critical patent/BRPI0921632A2/pt
Publication of BRPI0921632A8 publication Critical patent/BRPI0921632A8/pt
Publication of BRPI0921632B1 publication Critical patent/BRPI0921632B1/pt
Publication of BRPI0921632B8 publication Critical patent/BRPI0921632B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Steroid Compounds (AREA)
BRPI0921632A 2008-10-31 2009-10-28 processo para preparar nebivolol BRPI0921632B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI2008A001924A IT1392067B1 (it) 2008-10-31 2008-10-31 Processo di preparazione di nebivololo
ITMI2008A001924 2008-10-31
PCT/EP2009/064230 WO2010049455A1 (en) 2008-10-31 2009-10-28 Process for preparing nebivolol

Publications (4)

Publication Number Publication Date
BRPI0921632A2 true BRPI0921632A2 (pt) 2015-08-18
BRPI0921632A8 BRPI0921632A8 (pt) 2017-07-11
BRPI0921632B1 BRPI0921632B1 (pt) 2021-03-23
BRPI0921632B8 BRPI0921632B8 (pt) 2021-05-25

Family

ID=40849284

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0921632A BRPI0921632B8 (pt) 2008-10-31 2009-10-28 processo para preparar nebivolol

Country Status (17)

Country Link
US (1) US8927742B2 (pt)
EP (1) EP2346845B1 (pt)
JP (1) JP5560279B2 (pt)
CN (1) CN102186835B (pt)
AU (1) AU2009309680B2 (pt)
BR (1) BRPI0921632B8 (pt)
CA (1) CA2737340C (pt)
DK (1) DK2346845T3 (pt)
ES (1) ES2540092T3 (pt)
HR (1) HRP20150554T1 (pt)
HU (1) HUE025673T2 (pt)
IL (1) IL211497A (pt)
IT (1) IT1392067B1 (pt)
PL (1) PL2346845T3 (pt)
PT (1) PT2346845E (pt)
SI (1) SI2346845T1 (pt)
WO (1) WO2010049455A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2907810A1 (en) * 2014-02-14 2015-08-19 Corden Pharma International GmbH A new method for producing nebivolol hydrochloride of high purity
EP2907809B1 (en) 2014-02-14 2018-08-22 Corden Pharma International GmbH Base-free process for the preparation of ketone intermediates usable for manufacture of nebivolol
DE102014107132A1 (de) 2014-05-20 2015-11-26 Corden Pharma International Gmbh Verfahren zur Herstellung von Epoxiden die in der Herstellung von Nebivolol und dessen Derivaten einsetzbar sind

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1337429C (en) * 1983-12-05 1995-10-24 Guy Rosalia Eugene Van Lommen Derivatives of 2,2'-iminobisethanol
HU227236B1 (en) * 2002-11-06 2010-12-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag New process for the production of racemic and the pure [2s[2r*[r[r*]]]]-and [2r[2s*[s[s*]]]]-enantiomers of nebivolol
EP1737847B1 (en) * 2004-07-30 2008-06-04 Torrent Pharmaceuticals Ltd Nebivolol and its pharmaceutically acceptable salts, process for preparation and pharmaceutical compositions of nebivolol
DE602004026789D1 (de) * 2004-08-11 2010-06-02 Hetero Drugs Ltd Neues verfahren zur herstellung von nebivololzwischenprodukten
EP1803716B1 (en) * 2005-12-28 2012-07-25 Acino Pharma AG A process for preparation of racemic nebivolol
BRPI0719281B8 (pt) * 2006-11-27 2021-05-25 Fis Fabbrica Italiana Sintetici Spa processo para preparação de nebivolol

Also Published As

Publication number Publication date
BRPI0921632B1 (pt) 2021-03-23
CN102186835B (zh) 2016-01-13
JP2012506894A (ja) 2012-03-22
US8927742B2 (en) 2015-01-06
DK2346845T3 (en) 2015-06-08
IL211497A (en) 2014-12-31
PL2346845T3 (pl) 2015-08-31
BRPI0921632A8 (pt) 2017-07-11
AU2009309680B2 (en) 2015-08-06
PT2346845E (pt) 2015-07-30
CN102186835A (zh) 2011-09-14
AU2009309680A1 (en) 2010-05-06
US20110207948A1 (en) 2011-08-25
SI2346845T1 (sl) 2015-10-30
EP2346845B1 (en) 2015-03-25
ES2540092T3 (es) 2015-07-08
EP2346845A1 (en) 2011-07-27
CA2737340C (en) 2016-09-06
HRP20150554T1 (hr) 2015-07-03
ITMI20081924A1 (it) 2010-05-01
HUE025673T2 (en) 2016-04-28
IT1392067B1 (it) 2012-02-09
IL211497A0 (en) 2011-05-31
CA2737340A1 (en) 2010-05-06
WO2010049455A1 (en) 2010-05-06
JP5560279B2 (ja) 2014-07-23
BRPI0921632B8 (pt) 2021-05-25

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT)

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 23/03/2021, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 28/10/2009 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF