BRPI0719281B8 - processo para preparação de nebivolol - Google Patents

processo para preparação de nebivolol

Info

Publication number
BRPI0719281B8
BRPI0719281B8 BRPI0719281A BRPI0719281A BRPI0719281B8 BR PI0719281 B8 BRPI0719281 B8 BR PI0719281B8 BR PI0719281 A BRPI0719281 A BR PI0719281A BR PI0719281 A BRPI0719281 A BR PI0719281A BR PI0719281 B8 BRPI0719281 B8 BR PI0719281B8
Authority
BR
Brazil
Prior art keywords
nebivolol
preparation
preparing nebivolol
preparing
carbaldehyde
Prior art date
Application number
BRPI0719281A
Other languages
English (en)
Inventor
Massaccesi Franco
Foletto Johnny
Cotarca Livius
Maragni Paolo
Volpicelli Raffaella
Original Assignee
Fis Fabbrica Italiana Sintetici Spa
Zach System Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fis Fabbrica Italiana Sintetici Spa, Zach System Spa filed Critical Fis Fabbrica Italiana Sintetici Spa
Publication of BRPI0719281A2 publication Critical patent/BRPI0719281A2/pt
Publication of BRPI0719281B1 publication Critical patent/BRPI0719281B1/pt
Publication of BRPI0719281B8 publication Critical patent/BRPI0719281B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

processo para a preparação de nebivolol. a presente invenção relaciona-se a um processo para a preparação de nebivolol e, mais particularmente, a um processo para a preparação de d-nebivolol e seu enantiômero l-nebivolol ou sais de adição ácida desses iniciando a partir de 2,2-dimetil-1,3 dioxolano-4-carbaldeído comercialmente dsponível ou de fácil obtenção e um reagente de grignard de vinil.
BRPI0719281A 2006-11-27 2007-11-23 processo para preparação de nebivolol BRPI0719281B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06124837 2006-11-27
EP06124837.3 2006-11-27
PCT/EP2007/010185 WO2008064827A2 (en) 2006-11-27 2007-11-23 Process for preparing nebivolol

Publications (3)

Publication Number Publication Date
BRPI0719281A2 BRPI0719281A2 (pt) 2014-03-11
BRPI0719281B1 BRPI0719281B1 (pt) 2021-03-30
BRPI0719281B8 true BRPI0719281B8 (pt) 2021-05-25

Family

ID=39149443

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0719281A BRPI0719281B8 (pt) 2006-11-27 2007-11-23 processo para preparação de nebivolol

Country Status (16)

Country Link
US (2) US7999124B2 (pt)
EP (2) EP2228374B1 (pt)
JP (2) JP5259612B2 (pt)
CN (2) CN101553485B (pt)
AT (1) ATE473224T1 (pt)
AU (1) AU2007324896B2 (pt)
BR (1) BRPI0719281B8 (pt)
CA (2) CA2835833C (pt)
DE (1) DE602007007666D1 (pt)
ES (2) ES2426399T3 (pt)
HR (2) HRP20100420T1 (pt)
IL (2) IL198555A (pt)
PL (2) PL2228374T3 (pt)
PT (1) PT2228374E (pt)
SI (2) SI2228374T1 (pt)
WO (1) WO2008064827A2 (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE533752T1 (de) 2008-09-08 2011-12-15 Cadila Pharmaceuticals Ltd Verbesserter herstellungsprozess für nebivolol- hydrocholorid
IT1392067B1 (it) * 2008-10-31 2012-02-09 Zach System Spa Processo di preparazione di nebivololo
IT1395354B1 (it) * 2009-07-23 2012-09-14 Zach System Spa Processo di preparazione di nebivololo
DE102010005953A1 (de) * 2010-01-27 2011-07-28 Corden PharmaChem GmbH, 68305 Verfahren zur Herstellung von Nebivolol
IT1397962B1 (it) 2010-02-11 2013-02-04 Menarini Int Operations Lu Sa Processo per la preparazione del nebivololo.
WO2011132140A2 (en) * 2010-04-20 2011-10-27 Cadila Pharmaceuticals Limited Process for the conversion of (2r)-6-fluoro-2-[(2s)-oxiran-2-yl]-3,4-dihydro-2h-chromene to (2r)-6-fluoro-2-[(2r)-oxiran-2-yl]-3,4-dihydro-2h-chromene
CN102311418B (zh) * 2010-06-29 2013-12-25 成都康弘药业集团股份有限公司 一种苯并二氢吡喃类化合物的制备方法
CN102311417B (zh) * 2010-06-29 2013-09-18 成都弘达药业有限公司 一种苯并二氢吡喃类化合物的制备方法
CN102344431B (zh) * 2010-08-05 2014-03-26 成都康弘药业集团股份有限公司 一种制备奈必洛尔盐酸盐的方法
IT1402974B1 (it) 2010-11-30 2013-09-27 Menarini Int Operations Lu Sa Processo per la preparazione del nebivololo.
CN102180855B (zh) * 2011-03-01 2015-11-25 浙江华海药业股份有限公司 一种奈必洛尔中间体的提纯方法
ITRM20110418A1 (it) * 2011-08-02 2013-02-03 Menarini Int Operations Lu Sa Processo per la preparazione di epossidi quali intermedi per la sintesi del nebivololo.
PT2907809T (pt) 2014-02-14 2019-01-16 Corden Pharma Int Gmbh Processo sem base para a preparação de intermediários de cetona utilizáveis para fabrico de nebivolol
EP2907810A1 (en) 2014-02-14 2015-08-19 Corden Pharma International GmbH A new method for producing nebivolol hydrochloride of high purity
DE102014107132A1 (de) 2014-05-20 2015-11-26 Corden Pharma International Gmbh Verfahren zur Herstellung von Epoxiden die in der Herstellung von Nebivolol und dessen Derivaten einsetzbar sind
GB201506691D0 (en) 2015-04-20 2015-06-03 Greif Int Holding Bv Closure caps
JP6921913B2 (ja) * 2015-05-19 2021-08-18 チョーチアン オウスン ファーマシューティカル カンパニー リミテッド ネビボロールの合成方法及びその中間化合物
PL3299364T3 (pl) * 2015-05-19 2022-02-07 Zhejiang Ausun Pharmaceutical Co., Ltd. Sposób syntezy nebiwololu i jego związek pośredni
KR20220101702A (ko) * 2019-11-19 2022-07-19 루핀 리미티드 크로만 화합물의 제조 공정
JP7302870B2 (ja) 2019-12-24 2023-07-04 株式会社サンセイアールアンドディ 遊技機

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1337429C (en) 1983-12-05 1995-10-24 Guy Rosalia Eugene Van Lommen Derivatives of 2,2'-iminobisethanol
CA1337432C (en) * 1988-03-23 1995-10-24 Raymond M. Xhonneux Method of lowering the blood pressure
US8225408B2 (en) * 1997-11-06 2012-07-17 Finjan, Inc. Method and system for adaptive rule-based content scanners
HU227236B1 (en) * 2002-11-06 2010-12-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag New process for the production of racemic and the pure [2s[2r*[r[r*]]]]-and [2r[2s*[s[s*]]]]-enantiomers of nebivolol
CN101006081B (zh) 2004-07-30 2011-02-09 托伦特药物有限公司 奈必洛尔及其药学可接受盐、制备方法以及奈必洛尔的药物组合物
DE602004026789D1 (de) * 2004-08-11 2010-06-02 Hetero Drugs Ltd Neues verfahren zur herstellung von nebivololzwischenprodukten
CN1279035C (zh) 2004-08-30 2006-10-11 中国科学院理化技术研究所 光学对映体6－氟－3，4－二氢－2h－1－苯骈吡喃－2－羧酸及6－氟－3，4－二氢－2h－1－苯骈吡喃－2－羧酸酯的合成方法
AP2764A (en) * 2005-01-31 2013-09-30 Mylan Lab Inc Hydroxylated nebivolol metabolites
US7560575B2 (en) * 2005-12-28 2009-07-14 Acino Pharma Ag Process for preparation of racemic Nebivolol

Also Published As

Publication number Publication date
PL2099790T3 (pl) 2010-12-31
US20110201831A1 (en) 2011-08-18
JP2010510969A (ja) 2010-04-08
EP2099790B1 (en) 2010-07-07
JP5259612B2 (ja) 2013-08-07
BRPI0719281B1 (pt) 2021-03-30
ES2346371T3 (es) 2010-10-14
AU2007324896A1 (en) 2008-06-05
US8258323B2 (en) 2012-09-04
CN103087028A (zh) 2013-05-08
EP2228374A1 (en) 2010-09-15
WO2008064827A2 (en) 2008-06-05
ATE473224T1 (de) 2010-07-15
PL2228374T3 (pl) 2013-11-29
ES2426399T3 (es) 2013-10-23
HRP20130774T1 (hr) 2013-11-08
PT2228374E (pt) 2013-09-04
CA2835833C (en) 2014-11-04
EP2228374B1 (en) 2013-06-05
CN101553485B (zh) 2013-02-06
JP5735025B2 (ja) 2015-06-17
AU2007324896B2 (en) 2012-08-23
CA2667919C (en) 2014-10-28
US20100056813A1 (en) 2010-03-04
SI2099790T1 (sl) 2010-09-30
IL198555A (en) 2014-03-31
IL222787A0 (en) 2012-12-31
SI2228374T1 (sl) 2013-12-31
CA2667919A1 (en) 2008-06-05
CN103087028B (zh) 2014-12-24
BRPI0719281A2 (pt) 2014-03-11
JP2013100372A (ja) 2013-05-23
CA2835833A1 (en) 2008-06-05
DE602007007666D1 (de) 2010-08-19
HRP20100420T1 (hr) 2010-09-30
IL198555A0 (en) 2010-02-17
WO2008064827A3 (en) 2008-10-23
IL222787A (en) 2015-07-30
US7999124B2 (en) 2011-08-16
CN101553485A (zh) 2009-10-07
EP2099790A2 (en) 2009-09-16

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT)

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 30/03/2021, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 23/11/2007 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF