SI2228374T1 - Nebivolol formiat - Google Patents

Nebivolol formiat

Info

Publication number
SI2228374T1
SI2228374T1 SI200731290T SI200731290T SI2228374T1 SI 2228374 T1 SI2228374 T1 SI 2228374T1 SI 200731290 T SI200731290 T SI 200731290T SI 200731290 T SI200731290 T SI 200731290T SI 2228374 T1 SI2228374 T1 SI 2228374T1
Authority
SI
Slovenia
Prior art keywords
nebivolol
formate
nebivolol formate
useful
modified
Prior art date
Application number
SI200731290T
Other languages
English (en)
Inventor
Raffaella Volpicelli
Paolo Maragni
Livius Cotarca
Johnny Foletto
Franco Massaccesi
Original Assignee
Zach System S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zach System S.P.A. filed Critical Zach System S.P.A.
Publication of SI2228374T1 publication Critical patent/SI2228374T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
SI200731290T 2006-11-27 2007-11-23 Nebivolol formiat SI2228374T1 (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06124837 2006-11-27
EP10162649.7A EP2228374B1 (en) 2006-11-27 2007-11-23 Nebivolol formate

Publications (1)

Publication Number Publication Date
SI2228374T1 true SI2228374T1 (sl) 2013-12-31

Family

ID=39149443

Family Applications (2)

Application Number Title Priority Date Filing Date
SI200731290T SI2228374T1 (sl) 2006-11-27 2007-11-23 Nebivolol formiat
SI200730293T SI2099790T1 (sl) 2006-11-27 2007-11-23 Postopek za pripravo nebivolola

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI200730293T SI2099790T1 (sl) 2006-11-27 2007-11-23 Postopek za pripravo nebivolola

Country Status (16)

Country Link
US (2) US7999124B2 (sl)
EP (2) EP2099790B1 (sl)
JP (2) JP5259612B2 (sl)
CN (2) CN101553485B (sl)
AT (1) ATE473224T1 (sl)
AU (1) AU2007324896B2 (sl)
BR (1) BRPI0719281B8 (sl)
CA (2) CA2667919C (sl)
DE (1) DE602007007666D1 (sl)
ES (2) ES2346371T3 (sl)
HR (2) HRP20100420T1 (sl)
IL (2) IL198555A (sl)
PL (2) PL2228374T3 (sl)
PT (1) PT2228374E (sl)
SI (2) SI2228374T1 (sl)
WO (1) WO2008064827A2 (sl)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE533752T1 (de) 2008-09-08 2011-12-15 Cadila Pharmaceuticals Ltd Verbesserter herstellungsprozess für nebivolol- hydrocholorid
IT1392067B1 (it) * 2008-10-31 2012-02-09 Zach System Spa Processo di preparazione di nebivololo
IT1395354B1 (it) * 2009-07-23 2012-09-14 Zach System Spa Processo di preparazione di nebivololo
DE102010005953A1 (de) * 2010-01-27 2011-07-28 Corden PharmaChem GmbH, 68305 Verfahren zur Herstellung von Nebivolol
IT1397962B1 (it) 2010-02-11 2013-02-04 Menarini Int Operations Lu Sa Processo per la preparazione del nebivololo.
WO2011132140A2 (en) * 2010-04-20 2011-10-27 Cadila Pharmaceuticals Limited Process for the conversion of (2r)-6-fluoro-2-[(2s)-oxiran-2-yl]-3,4-dihydro-2h-chromene to (2r)-6-fluoro-2-[(2r)-oxiran-2-yl]-3,4-dihydro-2h-chromene
CN102311417B (zh) * 2010-06-29 2013-09-18 成都弘达药业有限公司 一种苯并二氢吡喃类化合物的制备方法
CN102311418B (zh) * 2010-06-29 2013-12-25 成都康弘药业集团股份有限公司 一种苯并二氢吡喃类化合物的制备方法
CN102344431B (zh) * 2010-08-05 2014-03-26 成都康弘药业集团股份有限公司 一种制备奈必洛尔盐酸盐的方法
IT1402974B1 (it) 2010-11-30 2013-09-27 Menarini Int Operations Lu Sa Processo per la preparazione del nebivololo.
CN102180855B (zh) * 2011-03-01 2015-11-25 浙江华海药业股份有限公司 一种奈必洛尔中间体的提纯方法
ITRM20110418A1 (it) * 2011-08-02 2013-02-03 Menarini Int Operations Lu Sa Processo per la preparazione di epossidi quali intermedi per la sintesi del nebivololo.
EP2907810A1 (en) 2014-02-14 2015-08-19 Corden Pharma International GmbH A new method for producing nebivolol hydrochloride of high purity
EP2907809B1 (en) 2014-02-14 2018-08-22 Corden Pharma International GmbH Base-free process for the preparation of ketone intermediates usable for manufacture of nebivolol
DE102014107132A1 (de) 2014-05-20 2015-11-26 Corden Pharma International Gmbh Verfahren zur Herstellung von Epoxiden die in der Herstellung von Nebivolol und dessen Derivaten einsetzbar sind
GB201506691D0 (en) 2015-04-20 2015-06-03 Greif Int Holding Bv Closure caps
KR20230068441A (ko) * 2015-05-19 2023-05-17 저장 아우선 파마슈티칼 씨오., 엘티디. 네비볼롤 합성방법 및 그의 중간 화합물
JP6921913B2 (ja) * 2015-05-19 2021-08-18 チョーチアン オウスン ファーマシューティカル カンパニー リミテッド ネビボロールの合成方法及びその中間化合物
MX2022006087A (es) * 2019-11-19 2022-08-11 Lupin Ltd Proceso de preparación de compuestos de cromano.
JP7302870B2 (ja) 2019-12-24 2023-07-04 株式会社サンセイアールアンドディ 遊技機

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1337429C (en) 1983-12-05 1995-10-24 Guy Rosalia Eugene Van Lommen Derivatives of 2,2'-iminobisethanol
CA1337432C (en) * 1988-03-23 1995-10-24 Raymond M. Xhonneux Method of lowering the blood pressure
US8225408B2 (en) * 1997-11-06 2012-07-17 Finjan, Inc. Method and system for adaptive rule-based content scanners
HU227236B1 (en) * 2002-11-06 2010-12-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag New process for the production of racemic and the pure [2s[2r*[r[r*]]]]-and [2r[2s*[s[s*]]]]-enantiomers of nebivolol
EP1741712B1 (en) * 2004-07-30 2011-06-15 Torrent Pharmaceuticals Ltd amorphous form of nebivolol hydrochloride and its preparation
DE602004026789D1 (de) 2004-08-11 2010-06-02 Hetero Drugs Ltd Neues verfahren zur herstellung von nebivololzwischenprodukten
CN1279035C (zh) 2004-08-30 2006-10-11 中国科学院理化技术研究所 光学对映体6－氟－3，4－二氢－2h－1－苯骈吡喃－2－羧酸及6－氟－3，4－二氢－2h－1－苯骈吡喃－2－羧酸酯的合成方法
AP2764A (en) * 2005-01-31 2013-09-30 Mylan Lab Inc Hydroxylated nebivolol metabolites
US7560575B2 (en) * 2005-12-28 2009-07-14 Acino Pharma Ag Process for preparation of racemic Nebivolol

Also Published As

Publication number Publication date
PL2228374T3 (pl) 2013-11-29
AU2007324896B2 (en) 2012-08-23
IL222787A0 (en) 2012-12-31
JP5259612B2 (ja) 2013-08-07
CA2835833C (en) 2014-11-04
CN103087028A (zh) 2013-05-08
WO2008064827A3 (en) 2008-10-23
ATE473224T1 (de) 2010-07-15
EP2228374B1 (en) 2013-06-05
CN101553485A (zh) 2009-10-07
EP2228374A1 (en) 2010-09-15
JP5735025B2 (ja) 2015-06-17
BRPI0719281A2 (pt) 2014-03-11
HRP20130774T1 (hr) 2013-11-08
HRP20100420T1 (hr) 2010-09-30
ES2346371T3 (es) 2010-10-14
DE602007007666D1 (de) 2010-08-19
SI2099790T1 (sl) 2010-09-30
AU2007324896A1 (en) 2008-06-05
JP2013100372A (ja) 2013-05-23
WO2008064827A2 (en) 2008-06-05
IL198555A (en) 2014-03-31
EP2099790A2 (en) 2009-09-16
CN101553485B (zh) 2013-02-06
PL2099790T3 (pl) 2010-12-31
CA2835833A1 (en) 2008-06-05
EP2099790B1 (en) 2010-07-07
ES2426399T3 (es) 2013-10-23
US7999124B2 (en) 2011-08-16
US20110201831A1 (en) 2011-08-18
IL222787A (en) 2015-07-30
BRPI0719281B1 (pt) 2021-03-30
JP2010510969A (ja) 2010-04-08
US20100056813A1 (en) 2010-03-04
CA2667919C (en) 2014-10-28
US8258323B2 (en) 2012-09-04
CA2667919A1 (en) 2008-06-05
PT2228374E (pt) 2013-09-04
IL198555A0 (en) 2010-02-17
BRPI0719281B8 (pt) 2021-05-25
CN103087028B (zh) 2014-12-24

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