BR112015004029A2 - Processo para preparação de teneligliptina, de um composto ou de sal ou hidrato do mesmo - Google Patents

Processo para preparação de teneligliptina, de um composto ou de sal ou hidrato do mesmo

Info

Publication number
BR112015004029A2
BR112015004029A2 BR112015004029A BR112015004029A BR112015004029A2 BR 112015004029 A2 BR112015004029 A2 BR 112015004029A2 BR 112015004029 A BR112015004029 A BR 112015004029A BR 112015004029 A BR112015004029 A BR 112015004029A BR 112015004029 A2 BR112015004029 A2 BR 112015004029A2
Authority
BR
Brazil
Prior art keywords
teneligliptin
hydrate
salt
preparing
compound
Prior art date
Application number
BR112015004029A
Other languages
English (en)
Other versions
BR112015004029B1 (pt
BR112015004029A8 (pt
Inventor
Mahadev Kadam Suresh
Parsottam Kansagra Bipin
Vishnu Kale Ramchandran
Prakashrao Patil Jayant
Reddy Yemireddy Venkataramana
Nilkanth Bhadane Shailendra
Popat Chaudhar Uddhav
Digamabar Patil Ulhas
Bhaskar Bhirud Shekhar
Original Assignee
Glenmark Pharmaceuticals Ltd
Glenmark Generics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glenmark Pharmaceuticals Ltd, Glenmark Generics Ltd filed Critical Glenmark Pharmaceuticals Ltd
Publication of BR112015004029A2 publication Critical patent/BR112015004029A2/pt
Publication of BR112015004029A8 publication Critical patent/BR112015004029A8/pt
Publication of BR112015004029B1 publication Critical patent/BR112015004029B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C07D231/40—Acylated on said nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

PROCESSO PARA PREPARAÇÃO DE TENELIGLIPTINA, DE UM COMPOSTO OU DE SAL OU HIDRATO DO MESMO. Um processo para preparação de teneligliptina por intermédio do compostos intermediários das fórmulas 29 e 32.
BR112015004029-2A 2012-08-31 2013-08-28 Processo para preparação de teneligliptina, de um composto ou de sal ou hidrato do mesmo BR112015004029B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IN2544/MUM/2012 2012-08-31
IN2544MU2012 2012-08-31
IN678/MUM/2013 2013-03-06
IN678MU2013 2013-03-06
PCT/IN2013/000527 WO2014041560A2 (en) 2012-08-31 2013-08-28 Process for the preparation of teneligliptin

Publications (3)

Publication Number Publication Date
BR112015004029A2 true BR112015004029A2 (pt) 2017-08-22
BR112015004029A8 BR112015004029A8 (pt) 2018-01-23
BR112015004029B1 BR112015004029B1 (pt) 2022-03-29

Family

ID=50278800

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015004029-2A BR112015004029B1 (pt) 2012-08-31 2013-08-28 Processo para preparação de teneligliptina, de um composto ou de sal ou hidrato do mesmo

Country Status (5)

Country Link
US (1) US9518048B2 (pt)
BR (1) BR112015004029B1 (pt)
MX (1) MX370649B (pt)
RU (1) RU2654069C2 (pt)
WO (1) WO2014041560A2 (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015019238A1 (en) * 2013-08-06 2015-02-12 Ranbaxy Laboratories Limited Process for the preparation of n-protected (5s)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-one
WO2015173779A1 (en) 2014-05-16 2015-11-19 Micro Labs Limited Process for the preparation of teneligliptin and its novel intermediates
CN105294673B (zh) * 2014-06-18 2018-04-13 四川科伦药物研究院有限公司 一种氢溴酸替格列汀的合成方法
CN105085510B (zh) * 2015-09-11 2018-03-02 沧州那瑞化学科技有限公司 一种(s)‑4‑氧代‑2‑(噻唑烷‑3‑羰基)吡咯烷‑1‑羧酸叔丁酯的制备方法
CN106349237A (zh) * 2016-08-15 2017-01-25 南通普悦生物医药有限公司 氢溴酸特力利汀的制备方法
WO2018142334A1 (en) * 2017-02-03 2018-08-09 Glenmark Pharmaceuticals Limited Formulations comprising oxalate salts of teneligliptin and solvates thereof
WO2019205021A1 (zh) * 2018-04-25 2019-10-31 乳源东阳光药业有限公司 一种氢溴酸替格列汀无定型及其制备方法
CN108752277B (zh) * 2018-06-11 2020-11-24 浙江理工大学 一种1-(3-甲基-1-苯基-1h-吡唑-5-基)哌嗪的安全制备方法
JP7117975B2 (ja) * 2018-10-31 2022-08-15 沢井製薬株式会社 テネリグリプチン含有医薬組成物、テネリグリプチン含有医薬組成物の製造方法、テネリグリプチン含有錠剤及びテネリグリプチン含有錠剤の製造方法
CN109942571B (zh) * 2019-03-18 2021-11-16 深圳市第二人民医院 治疗糖尿病的药物特利列汀的制备方法
WO2021001695A1 (en) * 2019-03-21 2021-01-07 Accord Life Spec Private Limited An improved process for the preparation of teneligliptin hydrobromide hydrate
CN110028496A (zh) * 2019-04-26 2019-07-19 梯尔希（南京）药物研发有限公司 一种特力利汀相关杂质的合成方法
CN110294748B (zh) * 2019-07-25 2020-12-25 浙江沙星科技有限公司 一种替格列汀关键中间体的合成方法
JP2022069426A (ja) * 2020-10-23 2022-05-11 マイラン ラボラトリーズ リミテッド テネリグリプチン２．５臭化水素酸塩のアモルファスを調製する方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ524618A (en) * 2000-08-10 2004-08-27 Mitsubishi Pharma Corp Proline derivatives and use thereof as drugs
US8003790B2 (en) * 2005-02-18 2011-08-23 Mitsubishi Tanabe Pharma Corporation Salt of proline derivative, solvate thereof, and production method thereof
CN101237870B (zh) * 2005-06-03 2011-05-25 田边三菱制药株式会社 伴随的药物试剂及其用途

Also Published As

Publication number Publication date
MX370649B (es) 2019-12-19
WO2014041560A2 (en) 2014-03-20
WO2014041560A3 (en) 2014-05-30
MX2015002487A (es) 2015-09-10
RU2015105294A (ru) 2016-10-20
BR112015004029B1 (pt) 2022-03-29
RU2654069C2 (ru) 2018-05-16
US20150203484A1 (en) 2015-07-23
BR112015004029A8 (pt) 2018-01-23
US9518048B2 (en) 2016-12-13

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06I Publication of requirement cancelled [chapter 6.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

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B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 28/08/2013, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

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