BR112013025732A2 - composto de imidazo-oxazina ou sal do mesmo - Google Patents

composto de imidazo-oxazina ou sal do mesmo

Info

Publication number
BR112013025732A2
BR112013025732A2 BR112013025732A BR112013025732A BR112013025732A2 BR 112013025732 A2 BR112013025732 A2 BR 112013025732A2 BR 112013025732 A BR112013025732 A BR 112013025732A BR 112013025732 A BR112013025732 A BR 112013025732A BR 112013025732 A2 BR112013025732 A2 BR 112013025732A2
Authority
BR
Brazil
Prior art keywords
imidazo
salt
oxazine compound
oxazine
compound
Prior art date
Application number
BR112013025732A
Other languages
English (en)
Other versions
BR112013025732B1 (pt
Inventor
Kaori Kamijo
Kenji Niiyama
Masayuki Nakamura
Mitsuru Ohkubo
Toshiyasu Shimomura
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Publication of BR112013025732A2 publication Critical patent/BR112013025732A2/pt
Publication of BR112013025732B1 publication Critical patent/BR112013025732B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems

Abstract

resumo patente de invenção: "composto de imidazo-oxazina ou sal do mesmo". a presente invenção refere-se a um composto de imidazo-oxazina representado pela fórmula (i) ou um sal do mesmo, em que a, b, c, e d são como definidos na especificação.
BR112013025732-6A 2011-04-06 2012-04-05 Compostos de imizazo-oxazina, seus usos e composição farmacêutica e fármaco compreendendo os mesmos BR112013025732B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2011-084880 2011-04-06
JP2011084880 2011-04-06
PCT/JP2012/059376 WO2012137870A1 (ja) 2011-04-06 2012-04-05 新規イミダゾオキサジン化合物又はその塩

Publications (2)

Publication Number Publication Date
BR112013025732A2 true BR112013025732A2 (pt) 2016-12-13
BR112013025732B1 BR112013025732B1 (pt) 2022-02-22

Family

ID=46969260

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013025732-6A BR112013025732B1 (pt) 2011-04-06 2012-04-05 Compostos de imizazo-oxazina, seus usos e composição farmacêutica e fármaco compreendendo os mesmos

Country Status (19)

Country Link
US (1) US8772283B2 (pt)
EP (1) EP2698372B1 (pt)
JP (1) JP5599941B2 (pt)
KR (1) KR101658274B1 (pt)
CN (1) CN103459400B (pt)
AU (1) AU2012239157B2 (pt)
BR (1) BR112013025732B1 (pt)
CA (1) CA2830367C (pt)
DK (1) DK2698372T3 (pt)
ES (1) ES2567605T3 (pt)
HK (1) HK1188451A1 (pt)
HU (1) HUE027509T2 (pt)
MX (1) MX342064B (pt)
MY (1) MY163187A (pt)
PL (1) PL2698372T3 (pt)
RU (1) RU2578608C2 (pt)
SG (1) SG193327A1 (pt)
TW (1) TWI525097B (pt)
WO (1) WO2012137870A1 (pt)

Families Citing this family (19)

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Publication number Priority date Publication date Assignee Title
RU2618423C2 (ru) * 2012-07-02 2017-05-03 Тайхо Фармасьютикал Ко., Лтд. Усилитель противоопухолевого эффекта, содержащий имидазооксазиновое соединение
US20140275504A1 (en) * 2013-03-13 2014-09-18 Dow Agrosciences Llc Process for the preparation of certain triaryl rhamnose carbamates
PT3543355T (pt) * 2013-06-20 2021-02-19 Taiho Pharmaceutical Co Ltd Método para prever a eficácia terapêutica do inibidor de pi3k/akt/mtor com base na expressão de phlda1 ou pik3c2b
JP6084292B2 (ja) 2013-07-18 2017-02-22 大鵬薬品工業株式会社 Ｆｇｆｒ阻害剤耐性癌の治療薬
KR101974254B1 (ko) 2013-07-18 2019-04-30 다이호야쿠힌고교 가부시키가이샤 Fgfr 저해제의 간헐 투여용 항종양제
CN107428779A (zh) * 2015-02-27 2017-12-01 大鹏药品工业株式会社 咪唑并噁嗪晶体、含有所述晶体的药物组合物和制备所述晶体的方法
ES2812785T3 (es) 2015-03-31 2021-03-18 Taiho Pharmaceutical Co Ltd Cristal de compuesto de alquinilo de benceno 3,5-disustituido
JP7085985B2 (ja) * 2016-03-04 2022-06-17 大鵬薬品工業株式会社 悪性腫瘍治療用製剤及び組成物
US11883404B2 (en) 2016-03-04 2024-01-30 Taiho Pharmaceuticals Co., Ltd. Preparation and composition for treatment of malignant tumors
MX2020009762A (es) 2018-03-19 2021-01-08 Taiho Pharmaceutical Co Ltd Composicion farmaceutica que incluye alquil sulfato de sodio.
WO2020078865A1 (en) 2018-10-16 2020-04-23 F. Hoffmann-La Roche Ag Use of akt inhibitors in ophthalmology
US20220354858A1 (en) 2019-06-21 2022-11-10 Taiho Pharmaceutical Co., Ltd. Method for treating malignant tumor
WO2021086833A1 (en) 2019-10-28 2021-05-06 Merck Sharp & Dohme Corp. Small molecule inhibitors of kras g12c mutant
CN115551500A (zh) 2019-10-31 2022-12-30 大鹏药品工业株式会社 4-氨基丁-2-烯酰胺衍生物及其盐
WO2021106231A1 (en) 2019-11-29 2021-06-03 Taiho Pharmaceutical Co., Ltd. A compound having inhibitory activity against kras g12d mutation
US20230181536A1 (en) 2020-04-24 2023-06-15 Taiho Pharmaceutical Co., Ltd. Anticancer combination therapy with n-(1-acryloyl-azetidin-3-yl)-2-((1h-indazol-3-yl)amino)methyl)-1h-imidazole-5-carboxamide inhibitor of kras-g12c
WO2021215544A1 (en) 2020-04-24 2021-10-28 Taiho Pharmaceutical Co., Ltd. Kras g12d protein inhibitors
JP7373664B2 (ja) 2020-07-15 2023-11-02 大鵬薬品工業株式会社 腫瘍の治療に使用されるピリミジン化合物を含む組み合わせ
EP4347041A1 (en) 2021-05-28 2024-04-10 Taiho Pharmaceutical Co., Ltd. Small molecule inhibitors of kras mutated proteins

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JPS57212188A (en) * 1981-06-25 1982-12-27 Sankyo Co Ltd Imidazobenzoxazine derivative and its preparation
US5985871A (en) * 1997-12-24 1999-11-16 Cortex Pharmaceuticals, Inc. Benzoxazine compounds for enhancing synaptic response
EP1737843B1 (en) * 2004-04-09 2011-02-23 Merck Sharp & Dohme Corp. Inhibitors of akt activity
AR064010A1 (es) 2006-12-06 2009-03-04 Merck & Co Inc Inhibidores de la actividad de la akt
CL2008002397A1 (es) 2007-08-14 2009-09-25 Bayer Schering Pharma Ag Compuestos derivados de imidazoles biciclicos fusionados; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar neoplasia benigna o maligna.
US9451809B2 (en) 2008-05-29 2016-09-27 Nike, Inc. Article of footwear with a marking system
EP2303269B1 (en) 2008-06-03 2014-07-30 Merck Sharp & Dohme Corp. Inhibitors of akt activity
US20110288090A1 (en) 2009-02-02 2011-11-24 Armstrong Donna J Inhibitors of AKT Activity
WO2010104933A1 (en) 2009-03-11 2010-09-16 Merck Sharp & Dohme Corp. Inhibitors of akt activity
WO2010114780A1 (en) 2009-04-01 2010-10-07 Merck Sharp & Dohme Corp. Inhibitors of akt activity
CN103097384B (zh) * 2010-07-12 2017-02-15 拜耳知识产权有限责任公司 取代的咪唑并[1,2‑a]嘧啶和吡啶

Also Published As

Publication number Publication date
RU2578608C2 (ru) 2016-03-27
HUE027509T2 (en) 2016-10-28
CA2830367C (en) 2016-08-30
CA2830367A1 (en) 2012-10-11
TWI525097B (zh) 2016-03-11
ES2567605T3 (es) 2016-04-25
EP2698372B1 (en) 2016-02-03
EP2698372A1 (en) 2014-02-19
KR20140039186A (ko) 2014-04-01
BR112013025732B1 (pt) 2022-02-22
HK1188451A1 (zh) 2014-05-02
MX342064B (es) 2016-09-12
US20140005185A1 (en) 2014-01-02
CN103459400B (zh) 2016-05-18
WO2012137870A1 (ja) 2012-10-11
MX2013011429A (es) 2013-12-09
SG193327A1 (en) 2013-10-30
MY163187A (en) 2017-08-15
PL2698372T3 (pl) 2016-07-29
DK2698372T3 (en) 2016-03-21
AU2012239157A1 (en) 2013-09-26
CN103459400A (zh) 2013-12-18
RU2013149174A (ru) 2015-05-20
TW201247679A (en) 2012-12-01
US8772283B2 (en) 2014-07-08
EP2698372A4 (en) 2014-09-10
JPWO2012137870A1 (ja) 2014-07-28
JP5599941B2 (ja) 2014-10-01
KR101658274B1 (ko) 2016-09-22
AU2012239157B2 (en) 2015-11-05

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 05/04/2012, OBSERVADAS AS CONDICOES LEGAIS.