PL2698372T3 - Nowy związek imidazooksazynowy lub jego sól - Google Patents
Nowy związek imidazooksazynowy lub jego sólInfo
- Publication number
- PL2698372T3 PL2698372T3 PL12768337T PL12768337T PL2698372T3 PL 2698372 T3 PL2698372 T3 PL 2698372T3 PL 12768337 T PL12768337 T PL 12768337T PL 12768337 T PL12768337 T PL 12768337T PL 2698372 T3 PL2698372 T3 PL 2698372T3
- Authority
- PL
- Poland
- Prior art keywords
- salt
- oxazine compound
- novel imidazo
- imidazo
- novel
- Prior art date
Links
- -1 imidazo-oxazine compound Chemical class 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011084880 | 2011-04-06 | ||
| PCT/JP2012/059376 WO2012137870A1 (ja) | 2011-04-06 | 2012-04-05 | 新規イミダゾオキサジン化合物又はその塩 |
| EP12768337.3A EP2698372B1 (en) | 2011-04-06 | 2012-04-05 | Novel imidazo-oxazine compound or salt thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2698372T3 true PL2698372T3 (pl) | 2016-07-29 |
Family
ID=46969260
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL12768337T PL2698372T3 (pl) | 2011-04-06 | 2012-04-05 | Nowy związek imidazooksazynowy lub jego sól |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8772283B2 (pl) |
| EP (1) | EP2698372B1 (pl) |
| JP (1) | JP5599941B2 (pl) |
| KR (1) | KR101658274B1 (pl) |
| CN (1) | CN103459400B (pl) |
| AU (1) | AU2012239157B2 (pl) |
| BR (1) | BR112013025732B1 (pl) |
| CA (1) | CA2830367C (pl) |
| DK (1) | DK2698372T3 (pl) |
| ES (1) | ES2567605T3 (pl) |
| HU (1) | HUE027509T2 (pl) |
| MX (1) | MX342064B (pl) |
| MY (1) | MY163187A (pl) |
| PH (1) | PH12013501873A1 (pl) |
| PL (1) | PL2698372T3 (pl) |
| RU (1) | RU2578608C2 (pl) |
| SG (1) | SG193327A1 (pl) |
| TW (1) | TWI525097B (pl) |
| WO (1) | WO2012137870A1 (pl) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2868660B1 (en) | 2012-07-02 | 2017-12-27 | Taiho Pharmaceutical Co., Ltd. | Antitumor effect potentiator comprising an imidazooxazine compound |
| US20140275504A1 (en) * | 2013-03-13 | 2014-09-18 | Dow Agrosciences Llc | Process for the preparation of certain triaryl rhamnose carbamates |
| DK3543355T3 (da) * | 2013-06-20 | 2021-03-01 | Taiho Pharmaceutical Co Ltd | Fremgangsmåde til forudsigelse af terapeutisk effektivitet for pi3k/akt/mtor-hæmmer på basis af phlda1- eller pik3c2b-ekspression |
| US10124003B2 (en) | 2013-07-18 | 2018-11-13 | Taiho Pharmaceutical Co., Ltd. | Therapeutic agent for FGFR inhibitor-resistant cancer |
| PT3023100T (pt) | 2013-07-18 | 2019-05-29 | Taiho Pharmaceutical Co Ltd | Fármaco antitumoral para administração intermitente de inibidor de fgfr |
| JPWO2016136928A1 (ja) * | 2015-02-27 | 2017-08-31 | 大鵬薬品工業株式会社 | イミダゾオキサジンの結晶、当該結晶を含む医薬組成物、及び当該結晶の製造方法 |
| DK3279202T3 (da) | 2015-03-31 | 2020-08-17 | Taiho Pharmaceutical Co Ltd | Krystal af 3,5-disubstitueret benzenalkynylforbindelse |
| US11883404B2 (en) | 2016-03-04 | 2024-01-30 | Taiho Pharmaceuticals Co., Ltd. | Preparation and composition for treatment of malignant tumors |
| KR20220110859A (ko) * | 2016-03-04 | 2022-08-09 | 다이호야쿠힌고교 가부시키가이샤 | 악성 종양 치료용 제제 및 조성물 |
| MX2020009762A (es) | 2018-03-19 | 2021-01-08 | Taiho Pharmaceutical Co Ltd | Composicion farmaceutica que incluye alquil sulfato de sodio. |
| CN112888440A (zh) | 2018-10-16 | 2021-06-01 | 豪夫迈·罗氏有限公司 | Akt抑制剂在眼科中的用途 |
| MA56549A (fr) | 2019-06-21 | 2022-04-27 | Taiho Pharmaceutical Co Ltd | Méthode de traitement d'une tumeur maligne |
| WO2021055728A1 (en) | 2019-09-18 | 2021-03-25 | Merck Sharp & Dohme Corp. | Small molecule inhibitors of kras g12c mutant |
| CR20220230A (es) | 2019-10-28 | 2022-06-15 | Merck Sharp & Dohme | Inhibidores de pequeñas moléculas de mutante g12c de kras |
| WO2021085653A1 (en) | 2019-10-31 | 2021-05-06 | Taiho Pharmaceutical Co., Ltd. | 4-aminobut-2-enamide derivatives and salts thereof |
| WO2021106231A1 (en) | 2019-11-29 | 2021-06-03 | Taiho Pharmaceutical Co., Ltd. | A compound having inhibitory activity against kras g12d mutation |
| US20230174518A1 (en) | 2020-04-24 | 2023-06-08 | Taiho Pharmaceutical Co., Ltd. | Kras g12d protein inhibitors |
| WO2021215545A1 (en) | 2020-04-24 | 2021-10-28 | Taiho Pharmaceutical Co., Ltd. | Anticancer combination therapy with n-(1-acryloyl-azetidin-3-yl)-2-((1h-indazol-3-yl)amino)methyl)-1h-imidazole-5-carboxamide inhibitor of kras-g12c |
| EP4183395A4 (en) | 2020-07-15 | 2024-07-24 | Taiho Pharmaceutical Co., Ltd. | PYRIMIDINE COMPOUND-CONTAINING COMBINATION FOR USE IN TUMOR TREATMENT |
| US20240122937A1 (en) * | 2021-02-01 | 2024-04-18 | Taiho Pharmaceutical Co., Ltd. | Treating cancer in patient with pten inactivating mutation |
| CN117769554A (zh) | 2021-05-28 | 2024-03-26 | 大鹏药品工业株式会社 | Kras突变蛋白的小分子抑制剂 |
| TW202515582A (zh) | 2023-08-24 | 2025-04-16 | 日商大塚製藥股份有限公司 | 西區嘧啶(cedazuridine)之固定劑量組合 |
| US11970475B1 (en) | 2023-09-05 | 2024-04-30 | King Faisal University | 4-(1-(2-Hydroxypropyl)-4,5-diphenyl-1H-imidazol-2-yl)pyridin-3-ol as an antimicrobial compound |
| TW202535891A (zh) | 2023-10-20 | 2025-09-16 | 美商默沙東有限責任公司 | Ｋｒａｓ蛋白之小分子抑制劑 |
| WO2025128834A1 (en) * | 2023-12-15 | 2025-06-19 | Alterome Therapeutics, Inc. | Akt1 modulators |
| CN119912475B (zh) * | 2025-03-06 | 2026-01-06 | 复旦大学 | 用作tlr2拮抗剂的化合物或其衍生物及其制备方法和应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57212188A (en) | 1981-06-25 | 1982-12-27 | Sankyo Co Ltd | Imidazobenzoxazine derivative and its preparation |
| US5985871A (en) * | 1997-12-24 | 1999-11-16 | Cortex Pharmaceuticals, Inc. | Benzoxazine compounds for enhancing synaptic response |
| DE602005026509D1 (de) * | 2004-04-09 | 2011-04-07 | Merck Sharp & Dohme | Hemmer der akt aktivität |
| AR064010A1 (es) | 2006-12-06 | 2009-03-04 | Merck & Co Inc | Inhibidores de la actividad de la akt |
| MX2010001745A (es) * | 2007-08-14 | 2010-03-10 | Bayer Schering Pharma Ag | Imidazoles fusionados para el tratamiento del cancer. |
| US9451809B2 (en) | 2008-05-29 | 2016-09-27 | Nike, Inc. | Article of footwear with a marking system |
| CA2726317A1 (en) * | 2008-06-03 | 2009-12-10 | Merck Sharp & Dohme Corp. | Inhibitors of akt activity |
| WO2010088177A1 (en) | 2009-02-02 | 2010-08-05 | Merck Sharp & Dohme Corp. | Inhibitors of akt activity |
| US8614221B2 (en) | 2009-03-11 | 2013-12-24 | Merck Sharp & Dohme Corp. | Inhibitors of Akt activity |
| US8691825B2 (en) | 2009-04-01 | 2014-04-08 | Merck Sharp & Dohme Corp. | Inhibitors of AKT activity |
| US8975265B2 (en) * | 2010-07-12 | 2015-03-10 | Bayer Intellectual Property Gmbh | Substituted imidazo[1,2-a]pyrimidines and —pyridines |
-
2012
- 2012-04-05 US US14/004,446 patent/US8772283B2/en active Active
- 2012-04-05 TW TW101112057A patent/TWI525097B/zh active
- 2012-04-05 DK DK12768337.3T patent/DK2698372T3/en active
- 2012-04-05 CA CA2830367A patent/CA2830367C/en active Active
- 2012-04-05 BR BR112013025732-6A patent/BR112013025732B1/pt active IP Right Grant
- 2012-04-05 MY MYPI2013701632A patent/MY163187A/en unknown
- 2012-04-05 RU RU2013149174/04A patent/RU2578608C2/ru active
- 2012-04-05 MX MX2013011429A patent/MX342064B/es active IP Right Grant
- 2012-04-05 PH PH1/2013/501873A patent/PH12013501873A1/en unknown
- 2012-04-05 WO PCT/JP2012/059376 patent/WO2012137870A1/ja not_active Ceased
- 2012-04-05 HU HUE12768337A patent/HUE027509T2/en unknown
- 2012-04-05 SG SG2013066949A patent/SG193327A1/en unknown
- 2012-04-05 EP EP12768337.3A patent/EP2698372B1/en active Active
- 2012-04-05 KR KR1020137029041A patent/KR101658274B1/ko active Active
- 2012-04-05 PL PL12768337T patent/PL2698372T3/pl unknown
- 2012-04-05 JP JP2013508918A patent/JP5599941B2/ja active Active
- 2012-04-05 CN CN201280017414.4A patent/CN103459400B/zh active Active
- 2012-04-05 AU AU2012239157A patent/AU2012239157B2/en active Active
- 2012-04-05 ES ES12768337.3T patent/ES2567605T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| HK1188451A1 (zh) | 2014-05-02 |
| ES2567605T3 (es) | 2016-04-25 |
| MX342064B (es) | 2016-09-12 |
| KR101658274B1 (ko) | 2016-09-22 |
| DK2698372T3 (en) | 2016-03-21 |
| MX2013011429A (es) | 2013-12-09 |
| AU2012239157B2 (en) | 2015-11-05 |
| WO2012137870A1 (ja) | 2012-10-11 |
| KR20140039186A (ko) | 2014-04-01 |
| MY163187A (en) | 2017-08-15 |
| EP2698372B1 (en) | 2016-02-03 |
| EP2698372A4 (en) | 2014-09-10 |
| JP5599941B2 (ja) | 2014-10-01 |
| HUE027509T2 (en) | 2016-10-28 |
| AU2012239157A1 (en) | 2013-09-26 |
| CA2830367C (en) | 2016-08-30 |
| EP2698372A1 (en) | 2014-02-19 |
| US20140005185A1 (en) | 2014-01-02 |
| US8772283B2 (en) | 2014-07-08 |
| BR112013025732B1 (pt) | 2022-02-22 |
| CA2830367A1 (en) | 2012-10-11 |
| BR112013025732A2 (pt) | 2016-12-13 |
| SG193327A1 (en) | 2013-10-30 |
| CN103459400A (zh) | 2013-12-18 |
| TWI525097B (zh) | 2016-03-11 |
| PH12013501873A1 (en) | 2013-10-14 |
| TW201247679A (en) | 2012-12-01 |
| RU2578608C2 (ru) | 2016-03-27 |
| JPWO2012137870A1 (ja) | 2014-07-28 |
| RU2013149174A (ru) | 2015-05-20 |
| CN103459400B (zh) | 2016-05-18 |
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