PE20001323A1 - Hidroxidifenilurea sulfonamidas como antagonistas de receptores de il-8 - Google Patents

Hidroxidifenilurea sulfonamidas como antagonistas de receptores de il-8

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Publication number
PE20001323A1
PE20001323A1 PE1999001243A PE00124399A PE20001323A1 PE 20001323 A1 PE20001323 A1 PE 20001323A1 PE 1999001243 A PE1999001243 A PE 1999001243A PE 00124399 A PE00124399 A PE 00124399A PE 20001323 A1 PE20001323 A1 PE 20001323A1
Authority
PE
Peru
Prior art keywords
alkyl
aryl
heteroaryl
chlorophenyl
hydroxy
Prior art date
Application number
PE1999001243A
Other languages
English (en)
Inventor
Katherine L Widdowson
Michael R Palovich
Brent W Mccleland
Qi Jin
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of PE20001323A1 publication Critical patent/PE20001323A1/es

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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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Abstract

SE REFIERE A UN COMPUESTO DE DIFENIL UREA SUSTITUIDO CON SULFONAMIDA DE FORMULA I, DONDE Rb ES H, NR6R7, OH, ORa, ALQUILO C1-C5, ARILO, ARIL-ALQUILO C1-C5, CICLOALQUILO, ENTRE OTROS; Ra ES ALQUILO, ARILO, ARIL-ALQUILO C1-C4, HETEROARILO, HETEROALQUILO-ALQUILO C1-C4, ENTRE OTROS; Ra` ES ALQUILO, ARILO, ARIL-ALQUILO C1-C4, HETEROARILO, HETEROARILO-ALQUILO C1-C4, ENTRE OTROS; m ES 1-3; m' ES 0-2; n ES 1-3; q ES 0-10; t ES 0-2; s ES 1-3; R1 ES H, HALOGENO, NITRO, CIANO, ALQUILO C1-C10, ENTRE OTROS; R4 Y R5 SON H, ALQUILO C1-C4, ARILO, ARIL-ALQUILO C1-C4, HETEROARILO, ENTRE OTROS; R6 Y R7 SON H, ALQUILO C1-C4, HETEROARILO, ARILO, ALQUILARILO, ENTRE OTROS; Y ES H, HALOGENO, NITRO, CIANO, ALQUILO C1-C10, ENTRE OTROS; R8 Y R9 SON H, ALQUILO C1-C4; R10 ES ALQUILO C1-C10- CO2R8; R11 ES H, ALQUILO C1-C4, ARILO, ARIL-ALQUILO C1-C4, ENTRE OTROS. SON COMPUESTOS PREFERIDOS N-(2-HIDROXI-3-AMINOSULFONIL-4-CLOROFENIL)-N'-(2-BROMOFENIL)UREA, N-(2-HIDROXI-3-AMINOSULFONIL-4-CLOROFENIL)-N'-2,3-DICLOROFENIL)UREA, N-(2-HIDROXI-3-N"-BENCILAMINOSULFONIL-4-CLOROFENIL)-N'-(BROMOFENILUREA), ENTRE OTROS. TAMBIEN SE REFIERE A COMPUESTOS INTERMEDIOS. EL COMPUESTO I MODULA A LA QUIMIOCINA, INTERLEUCINA 8 (IL-8) POR LO QUE PUEDE SER UTIL PARA EL TRATAMIENTO DE DERMATITIS ATOPICA, OSTEOARTRITIS, ARTRITIS REUMATOIDE, ASMA, ENFERMEDAD PULMONAR OBSTRUCTIVA
PE1999001243A 1998-12-16 1999-12-14 Hidroxidifenilurea sulfonamidas como antagonistas de receptores de il-8 PE20001323A1 (es)

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CN1334726A (zh) 2002-02-06
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EP1161232A1 (en) 2001-12-12
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US20030109527A1 (en) 2003-06-12
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