AR031098A1 - Compuestos de hidroxifenil urea sustituidos con sulfonamidas, composiciones farmaceuticas que los comprenden, y uso de los mismos en la fabricacion de medicamentos para tratar una enfermedad mediada por una quimioquina - Google Patents
Compuestos de hidroxifenil urea sustituidos con sulfonamidas, composiciones farmaceuticas que los comprenden, y uso de los mismos en la fabricacion de medicamentos para tratar una enfermedad mediada por una quimioquinaInfo
- Publication number
- AR031098A1 AR031098A1 ARP010101183A ARP010101183A AR031098A1 AR 031098 A1 AR031098 A1 AR 031098A1 AR P010101183 A ARP010101183 A AR P010101183A AR P010101183 A ARP010101183 A AR P010101183A AR 031098 A1 AR031098 A1 AR 031098A1
- Authority
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- Prior art keywords
- alkyl
- heteroaryl
- heterocycle
- optionally substituted
- aryl
- Prior art date
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- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
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- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
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- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract
Compuestos de hidroxifenil urea sustituidos con sulfonamidas, de formula (1) o sales farmacéuticamente aceptables de los mismos, en donde: Rb es independientemente seleccionado del grupo que consiste en hidrogeno, NR6R7, OH, ORa, alquilo C1-5, arilo, aril-alquilo C1-4, aril-alquenilo C2-4, cicloalquilo, cicloalquil-alquilo C1-5, heteroarilo, heteroaril-alquilo C1-4, heteroaril-alquenilo C2-4, heterociclo, heterociclo-alquilo C1-4 y heterociclo-alquenilo C2-4, restos todos que pueden estar opcional e independientemente sustituidos de 1 a 3 veces con un sustituyente seleccionado del grupo que consiste en halogeno, nitro, alquilo C1-4 halosustituido, alquilo C1-4, amino, amina mono- o di-sustituida con alquilo C1-4, ORa, C(O)Ra, NRaC(O)ORa, OC(O)NR6R7, hidroxilo, NR9C(O)Ra, S(O)m'Ra, C(O)NR6R7, C(O)OH, C(O)ORa, S(O)2NR6R7, y NHS(O)2Ra; o los dos sustituyentes Rb están unidos para formar un anillo de 3-10 miembros opcionalmente sustituido y que contiene independientemente, además de carbono, de 1 a 3 restos seleccionados del grupo que consiste en NRa, O, S, SO y SO2, y en el que el sustituyente puede estar opcionalmente insaturado; Ra es seleccionado del grupo que consiste en los restos alquilo, arilo, aril-alquilo C1-4, heteroarilo, heteroaril-alquilo C1-4, heterociclo, COOR13, y heterociclo-alquilo C1-4, todos los cuales pueden estar opcionalmente sustituidos; m es un numero entero que tiene un valor de 1 a 3; m' es 0 o un numero entero que tiene un valor de 1 o 2; n es un numero entero que tiene un valor de 1 a 3; q es 0 o un numero entero que tiene un valor de 1 a 10; t es 0 o un numero entero que tiene un valor de 1 o 2; s es un numero entero que tiene un valor de 1 a 3; R1 es independientemente seleccionado del grupo que consiste en hidrogeno, halogeno, nitro, ciano, alquilo C1-10, alquilo C1-10 halosustituido, alquenilo C2-10, alcoxilo C1-10, alcoxilo C1-10 halosustituido, azida, S(O)tR4, (CR8R8)qS(O)tR4, hidroxilo, alquilo C1-4 sustituido con hidroxilo, arilo, aril-alquilo C1-4, aril-alquenilo C2-10, ariloxilo, aril-alquiloxilo C1-4, heteroarilo, heteroarilalquilo, heteroaril-alquenilo C2-10, heteroaril-alquiloxilo C1-4, heterociclo, heterociclo-alquilo C1-4, heterociclo-alquiloxilo C1-4, heterociclo-alquenilo C2-10, (CR8R8)qNR4R5, (CR8R8)qC(O)NR4R5, alquenil C2-10-C(O)NR4R5, (CR8R8)qC(O)NR4R5, S(O)3R8, (CR8R8)qC(O)R11, alquenil C2-10-C(O)R11, alquenil C2-10-C(O)OR11, (CR8R8)qC(O)OR11, (CR8R8)qOC(O)R11, (CR8R8)qNR4C(O)R11, (CR8R8)qC(NR4)NR4R5, (CR8R8)qNR4C(NR5)R11, (CR8R8)qNHS(O)2R13, y (CR8R8)qS(O)2NR4R5; o dos restos R1 pueden formar conjuntamente O-(CH2)sO o un anillo saturado o insaturado de 5 a 6 miembros, pudiendo estar opcionalmente sustituidos los restos alquilo, arilo, arilalquilo, heteroarilo y heterociclo; R4 y R5 son independientemente seleccionados del grupo que consiste en hidrogeno, alquilo C1-4 opcionalmente sustituido, arilo opcionalmente sustituido, aril-alquilo C1-4 opcionalmente sustituido, heteroarilo opcionalmente sustituido, heteroaril-alquilo C1-4 opcionalmente sustituido, heterociclo, y heterociclo-alquilo C1-4; o R4 y R5 junto con el nitrogeno al que están unidos forman un anillo de 5 a 7 miembros que puede comprender opcionalmente un heteroátomo adicional seleccionado entre O, N y S; R6 y R7 son independientemente seleccionados del grupo que consiste en hidrogeno, alquilo C1-4, heteroarilo, arilo, alquilarilo, y alquil-heteroalquilo C1-4; o R6 y R7 junto con el nitrogeno al que están unidos forman un anillo de 5 a 7 miembros, anillo que puede contener opcionalmente un heteroátomo adicional seleccionado entre oxígeno, nitrogeno y azufre que puede estar opcionalmente sustituido; Y es seleccionado del grupo que consiste en CR14R15, NR14, O, CO, y S(O)t; R8 es hidrogeno o alquilo C1-4; R9 es alquilo C1-4; R10 es alquil C1-10-C(O)2R8; R11es seleccionado del grupo que consiste en hidrogeno, alquilo C1-4 opcionalmente sustituido, arilo opcionalmente sustituido, aril-alquilo C1-4 opcionalmente sustituido, heteroarilo opcionalmente sustituido, heteroaril-alquilo C1-4 opcionalmente sustituido, heterociclo opcionalmente sustituido, y heterociclo-alquilo C1-4 opcionalmente sustituido; R12 es seleccionado del grupo que consiste en hidrogeno, alquilo C1-4, arilo, aril-alquilo C1-4, heteroarilo, heteroaril-alquilo C1-4, heterociclo, y heterociclo-alquilo C1-4; R13 es seleccionado del grupo que consiste en alquilo C1-4, arilo, aril-alquilo C1-4, heteroarilo, heteroaril-alquilo C1-4, heterociclo, y heterociclo-alquilo C1-4; y R14 y R15 son independientemente seleccionados del grupo que consiste en hidrogeno, alquilo C1-4 opcionalmente sustituido, ORa, y NR4R5; o R14 y R15 junto con el(los) átomo(s) al(a los) que están unidos pueden formar un anillo de 4 a 7 miembros que puede contener opcionalmente un heteroátomo adicional que es seleccionado del grupo que consiste en oxígeno, nitrogeno y azufre, anillo que puede estar opcionalmente sustituido. Composiciones farmacéuticas que comprenden estos compuestos y el uso de estos en la fabricacion de medicamentos. Los mencionados compuestos son utiles en el tratamiento de estados morbosos mediados por la interleuquina 8 (IL 8).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US18984800P | 2000-03-16 | 2000-03-16 |
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AR031098A1 true AR031098A1 (es) | 2003-09-10 |
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ARP010101183A AR031098A1 (es) | 2000-03-16 | 2001-03-14 | Compuestos de hidroxifenil urea sustituidos con sulfonamidas, composiciones farmaceuticas que los comprenden, y uso de los mismos en la fabricacion de medicamentos para tratar una enfermedad mediada por una quimioquina |
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EP (1) | EP1263427A4 (es) |
JP (1) | JP2003526664A (es) |
KR (1) | KR20020091130A (es) |
CN (1) | CN1424910A (es) |
AP (1) | AP2002002606A0 (es) |
AR (1) | AR031098A1 (es) |
AU (1) | AU2001250873A1 (es) |
BG (1) | BG107013A (es) |
BR (1) | BR0108749A (es) |
CA (1) | CA2403062A1 (es) |
CO (1) | CO5280089A1 (es) |
CZ (1) | CZ20023075A3 (es) |
DZ (1) | DZ3317A1 (es) |
EA (1) | EA200200981A1 (es) |
HU (1) | HUP0300470A3 (es) |
MA (1) | MA25659A1 (es) |
MX (1) | MXPA02009094A (es) |
NO (1) | NO20024367L (es) |
OA (1) | OA12231A (es) |
PL (1) | PL366034A1 (es) |
SK (1) | SK13282002A3 (es) |
WO (1) | WO2001068084A1 (es) |
ZA (1) | ZA200207325B (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR030689A1 (es) * | 2000-03-14 | 2003-09-03 | Smithkline Beecham Corp | Compuestos de 3-aminosulfonil-2-hidroxifenil urea, composiciones farmaceuticas que los comprenden, y uso de dichos compuestos en la manufactura de medicamentos para tratar enfermedades mediadas por quimioquinas |
EP1745032B1 (en) | 2004-05-12 | 2013-07-31 | Merck Sharp & Dohme Corp. | CXCR1 and CXCR2 chemokine antagonists |
MX2008013599A (es) * | 2006-04-21 | 2008-10-31 | Smithkline Beechman Corp | Antagonistas del receptor il-8. |
PL2009992T3 (pl) * | 2006-04-21 | 2012-11-30 | Glaxosmithkline Llc | Antagoniści receptora IL-8 |
CR20160557A (es) | 2014-05-29 | 2017-01-20 | Glaxosmithkline Ip Dev Ltd | Compuestos derivados de 1-(ciclopent-2-en-1-il)-3-(2-hidroxi-3-(arilsulfonil)fenil)urea como inhibidores cxcr2 |
US20170224679A1 (en) * | 2014-07-31 | 2017-08-10 | Glaxosmithkline Intellectual Property Development Limited | Use of CXCR2 Antagonists For The Prevention and/or Treatment of Chemotherapy Induced Peripheral Neuropathy (CIPN) |
CN111727184B (zh) * | 2018-01-11 | 2022-06-28 | 深圳嘉科生物科技有限公司 | Cxcr2拮抗剂 |
CN114286819B (zh) * | 2019-07-11 | 2024-03-05 | 深圳嘉科生物科技有限公司 | 一种cxcr2拮抗剂的晶型及其应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0809492A4 (en) * | 1995-02-17 | 2007-01-24 | Smithkline Beecham Corp | IL-8 RECEPTOR ANTAGONISTS |
US6133319A (en) * | 1996-06-27 | 2000-10-17 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
WO1998007418A1 (en) * | 1996-08-21 | 1998-02-26 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
DE69908156T2 (de) * | 1998-09-23 | 2003-12-24 | Tularik Inc | Arylsulfonanilid-harnstoffe |
UY25842A1 (es) * | 1998-12-16 | 2001-04-30 | Smithkline Beecham Corp | Antagonistas de receptores de il-8 |
-
2001
- 2001-03-14 CO CO01020681A patent/CO5280089A1/es not_active Application Discontinuation
- 2001-03-14 AR ARP010101183A patent/AR031098A1/es unknown
- 2001-03-16 DZ DZ013317A patent/DZ3317A1/fr active
- 2001-03-16 CZ CZ20023075A patent/CZ20023075A3/cs unknown
- 2001-03-16 PL PL01366034A patent/PL366034A1/xx not_active Application Discontinuation
- 2001-03-16 MX MXPA02009094A patent/MXPA02009094A/es active IP Right Grant
- 2001-03-16 EA EA200200981A patent/EA200200981A1/ru unknown
- 2001-03-16 HU HU0300470A patent/HUP0300470A3/hu unknown
- 2001-03-16 CA CA002403062A patent/CA2403062A1/en not_active Abandoned
- 2001-03-16 EP EP01924195A patent/EP1263427A4/en not_active Withdrawn
- 2001-03-16 OA OA1200200289A patent/OA12231A/en unknown
- 2001-03-16 KR KR1020027012102A patent/KR20020091130A/ko not_active Application Discontinuation
- 2001-03-16 AU AU2001250873A patent/AU2001250873A1/en not_active Abandoned
- 2001-03-16 JP JP2001566648A patent/JP2003526664A/ja not_active Withdrawn
- 2001-03-16 CN CN01806605A patent/CN1424910A/zh active Pending
- 2001-03-16 SK SK1328-2002A patent/SK13282002A3/sk unknown
- 2001-03-16 BR BR0108749-5A patent/BR0108749A/pt not_active Application Discontinuation
- 2001-03-16 WO PCT/US2001/008672 patent/WO2001068084A1/en not_active Application Discontinuation
- 2001-03-16 AP APAP/P/2002/002606A patent/AP2002002606A0/en unknown
-
2002
- 2002-08-20 BG BG107013A patent/BG107013A/bg unknown
- 2002-09-12 ZA ZA200207325A patent/ZA200207325B/en unknown
- 2002-09-12 NO NO20024367A patent/NO20024367L/no unknown
- 2002-09-12 MA MA26815A patent/MA25659A1/fr unknown
Also Published As
Publication number | Publication date |
---|---|
ZA200207325B (en) | 2003-10-17 |
EA200200981A1 (ru) | 2003-02-27 |
DZ3317A1 (es) | 2001-09-20 |
EP1263427A1 (en) | 2002-12-11 |
BR0108749A (pt) | 2004-06-29 |
MA25659A1 (fr) | 2002-12-31 |
MXPA02009094A (es) | 2003-03-12 |
AP2002002606A0 (en) | 2002-09-30 |
AU2001250873A1 (en) | 2001-09-24 |
NO20024367D0 (no) | 2002-09-12 |
JP2003526664A (ja) | 2003-09-09 |
OA12231A (en) | 2003-11-07 |
KR20020091130A (ko) | 2002-12-05 |
CA2403062A1 (en) | 2001-09-20 |
CN1424910A (zh) | 2003-06-18 |
BG107013A (bg) | 2003-05-30 |
NO20024367L (no) | 2002-10-22 |
CZ20023075A3 (cs) | 2003-05-14 |
PL366034A1 (en) | 2005-01-24 |
EP1263427A4 (en) | 2005-08-24 |
HUP0300470A3 (en) | 2005-05-30 |
WO2001068084A1 (en) | 2001-09-20 |
SK13282002A3 (sk) | 2003-02-04 |
HUP0300470A2 (hu) | 2003-06-28 |
CO5280089A1 (es) | 2003-05-30 |
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