AR039673A1 - Derivados de heteroarilamida benzocondensada de tienopiridinas utiles como agentes terapeuticos, composiciones farmaceuticas que incluyen a los mismos y metodos para su aplicacion - Google Patents

Derivados de heteroarilamida benzocondensada de tienopiridinas utiles como agentes terapeuticos, composiciones farmaceuticas que incluyen a los mismos y metodos para su aplicacion

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Publication number
AR039673A1
AR039673A1 ARP030102121A ARP030102121A AR039673A1 AR 039673 A1 AR039673 A1 AR 039673A1 AR P030102121 A ARP030102121 A AR P030102121A AR P030102121 A ARP030102121 A AR P030102121A AR 039673 A1 AR039673 A1 AR 039673A1
Authority
AR
Argentina
Prior art keywords
alkyl
aryl
membered heterocycle
cycloalkyl
independently selected
Prior art date
Application number
ARP030102121A
Other languages
English (en)
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of AR039673A1 publication Critical patent/AR039673A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4743—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Composiciones farmacéuticas que contiene los compuestos de fórmula (1) y a métodos para tratar trastornos hiperproliferativos en un mamífero administrando los compuestos de fórmula (1). Estos compuestos son útiles en el tratamiento de enfermedades. Reivindicación 1: Un compuesto representando por la fórmula (1) caracterizado porque: Y es -NH-, -O-, -S-, o -CH2-; Z es -O-, -S-, o -N-; R14 es un alquilo C1-6, alquil(C1-6)-amino, alquil(C1-6)-hidroxi, cicloalquil(C3-10)-amino, o grupo metilureido; R15 y R17 son independientemente H, halo, o un grupo alquilo C1-6 sin sustituir o sustituido con uno o más grupos R5; R16 es H o un grupo alquilo C1-6 Z es N, y R16 está ausente cuando Z es -O- o -S-; R11 es H, alquilo C1-6, cicloalquilo C3-10, -C(O)NR12R13, -C(O)(arilo C1-6); -(CH2)t(arilo C6-10), -(CH2)t(heterociclo de 5 a 10 miembros), -(CH2)tNR12R13, -SO2NR12R13 o -CO2R12, en la que dicho alquilo C1-6, -C(O)(arilo C6-10), -(CH2)t(arilo C6-10), y restos -(CH2)t(heterociclo de 5 a 10 miembros) de dichos grupos R11 están sin sustituir o sustituidos con uno o más grupos R5; cada R5 se selecciona independientemente de halo, ciano, nitro, trifluorometoxi, trifluorometilo, azido, -C(O)R8, -C(O)OR8, -OC(O)R8, -OC(O)OR8, -NR6C(O)R7, -C(O)NR6R7, -NR6R7, -OR9, -SO2NR6R7, alquilo C1-6, cicloalquilo C3-10, alquil(C1-6)-amino, -(CH2)jO(CH2)qNR6R7, (CH2)tO(CH2)qOR9, (CH2)tOR9, -S(O)j(alquilo C1-6), -(CH2)t(arilo C6-10), -(CH2)t(heterociclo de 5 a 10 miembros), -C(O)(CH2)t(arilo C6-10), -(CH2)tO(CH2)j(arilo C6-10), -(CH2)tO(CH2)q(heterociclo de 5 a 10 miembros), -C(O)(CH2)t(heterociclo de 5 a 10 miembros), -(CH2)jNR7(CH2)qNR6R7, -(CH2)jNR7CH2C(O)NR6R7, -(CH2)jNR7(CH2)qNR9C(O)R8, -(CH2)jNR7(CH2)tO(CH2)qOR9, -(CH2)jNR7(CH2)qS(O)j(alquilo C1-6), -(CH2)jNR7(CH2)tR6, -SO2(CH2)t(arilo C6-10), y -SO2(CH2)t(heterociclo de 5 a 10 miembros), los restos -(CH2)q- y -(CH2)t- de dichos grupos R5 opcionalmente incluyen un doble o triple enlace carbono-carbono, y el alquilo, arilo y restos heterocíclicos de dichos grupos R5 están sin sustituir o sustituidos con uno o más sustituyentes independientemente seleccionados de halo, ciano, nitro, trifluorometilo, azido, -OH, -C(O)R8, -C(O)OR8, -OC(O)R8, -OC(O)OR8, -NR6C(O)R7, -C(O)NR6R7, -(CH2)tNR6R7, alquilo C1-6, cicloalquilo C3-10, -(CH2)t(arilo C6-10), -(CH2)t(heterociclo de 5 a 10 miembros), -(CH2)tO(CH2)qOR9, y -(CH2)tOR9; cada R6 y R7 se selecciona independientemente de H, OH, alquilo C1-6, cicloalquilo C3-10, -(CH2)t(arilo C6-10), -(CH2)t((heterociclo de 5 a 10 miembros), -(CH2)tO(CH2)qOR9, -(CH2)tCN(CH2)tOR9, -(CH2)tCN(CH2)tR9 y -(CH2)tOR9, y el alquilo, arilo y restos heterocíclicos de dichos grupos R6 y R7 están sin sustituir o sustituidos con uno o más sustituyentes independientemente seleccionados de hidroxi, halo, ciano, nitro, trifluorometilo, azido, -C(O)R8, -C(O)OR8, -CO(O)R8, -OC(O)OR8, -NR9C(O)R10, -C(O)NR9R10, -NR9R10, alquilo C1-6, -(CH2)t(arilo C6-10), -(CH2)t(heterociclo de 5 a 10 miembros), -(CH2)tO(CH2)qOR9, y -(CH2)tOR9, en los que cuando R6 y R7 están ambos unidos al mismo nitrógeno, entonces R6 y R7 no están ambos unidos al nitrógeno directamente por medio de un oxígeno; cada R8 se selecciona independientemente de H, alquilo C1-10, cicloalquilo c3-10, -(CH2)t(arilo C6-10), y -(CH2)t(heterociclo de 5 a 10 miembros); t es un número entero de 0 a 6; j es un número entero de 0 a 2, q es un número entero de 2 a 6; cada R9 y R10 se selecciona independientemente de H, -OR6, alquilo C1-6 y cicloalquilo C3-10; y cada R12 y R13 se selecciona independientemente de H, alquilo C1-6, cicloalquilo C3-10, -(CH2)t(cicloalquilo C3-10), -(CH2)t(arilo C6-10), -(CH2)t(heterociclo de 5 a 10 miembros), -(CH2)tO(CH2)qOR9, y -(CH2)tOR9, y el alquilo, arilo y restos heterocíclicos de dichos grupos R12 y R13 están sin sustituir o sustituidos con uno o más sustituyentes independientemente seleccionados de R5, o R12 y R13 se toman conjuntamente con el nitrógeno al que están unidos para formar un anillo azabiciclo C5-9, aziridinilo, azetidinilo, pirrolidinilo, piperidinilo, piperazinilo, morfolinilo, tiomorfolinilo, isoquinolinilo o dihidroisoquinolinilo, en los que dichos anillos azabiciclo C5-9, aziridinilo, azetidinilo, pirrolidinilo, piperidinilo, piperazinilo, morfolinilo, tiomorfolinilo, isoquinolinilo o dihidroisoquinolinilo están sustituidos o sin sustituir con uno o más sustituyentes R5, en los que R12 y R13 no están ambos unidos al nitrógeno directamente por medio de un oxígeno; o sus profármacos o metabolitos, o sales o solvatos farmacéuticamente aceptables de dichos compuestos y dichos profármacos y dichos metabolitos.
ARP030102121A 2002-06-14 2003-06-13 Derivados de heteroarilamida benzocondensada de tienopiridinas utiles como agentes terapeuticos, composiciones farmaceuticas que incluyen a los mismos y metodos para su aplicacion AR039673A1 (es)

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US (3) US6869962B2 (es)
EP (1) EP1515975B1 (es)
JP (1) JP2005534669A (es)
KR (2) KR100714545B1 (es)
CN (1) CN1671714A (es)
AP (1) AP2004003184A0 (es)
AR (1) AR039673A1 (es)
AT (1) ATE373665T1 (es)
AU (1) AU2003233134A1 (es)
BR (1) BR0311806A (es)
CA (1) CA2489466A1 (es)
CO (1) CO5631447A2 (es)
DE (1) DE60316440T2 (es)
EA (1) EA008255B1 (es)
EC (1) ECSP045483A (es)
ES (1) ES2290460T3 (es)
GE (1) GEP20074033B (es)
GT (1) GT200300129A (es)
HN (1) HN2003000182A (es)
HR (1) HRP20041173A2 (es)
IL (1) IL165591A0 (es)
IS (1) IS7552A (es)
MA (1) MA27596A1 (es)
MX (1) MXPA04011637A (es)
NO (1) NO20045103L (es)
NZ (1) NZ537140A (es)
OA (1) OA12865A (es)
PA (1) PA8575401A1 (es)
PE (1) PE20050123A1 (es)
PL (1) PL374542A1 (es)
RS (1) RS107504A (es)
TN (1) TNSN04246A1 (es)
TW (1) TW200404070A (es)
UA (1) UA77303C2 (es)
WO (1) WO2003106462A1 (es)
ZA (1) ZA200409862B (es)

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