ES2178632T3 - Compuestos de benzoquinazolina farmaceuticamente activos. - Google Patents

Compuestos de benzoquinazolina farmaceuticamente activos.

Info

Publication number
ES2178632T3
ES2178632T3 ES91910823T ES91910823T ES2178632T3 ES 2178632 T3 ES2178632 T3 ES 2178632T3 ES 91910823 T ES91910823 T ES 91910823T ES 91910823 T ES91910823 T ES 91910823T ES 2178632 T3 ES2178632 T3 ES 2178632T3
Authority
ES
Spain
Prior art keywords
group
rent
hydrogen
compounds
halo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91910823T
Other languages
English (en)
Inventor
William Pendergast
Scott Howard Dickerson
Julius Vass Johnson
Robert Ferone
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Application granted granted Critical
Publication of ES2178632T3 publication Critical patent/ES2178632T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE PRESENTAN COMPUESTOS DE LA FORMULA (I) O SALES DE LOS MISMOS, EN LA QUE LA LINEA PUNTEADA REPRESENTA UN ENLACE SIMPLE O DOBLE, R1 ES ALQUIL O AMINO OPCIONALMENTE SUBSTITUDO POR UN GRUPO ALQUIL, ALCANOIL O BENCIL; R2, R3, R4 Y R5 SON IGUALES O DIFERENTES Y CADA UNA DE ELLAS ESTA SELECCIONADA ENTRE HIDROGENO, FENIL, HALO, NITRO, UN GRUPO S(O)NR8 EN EL QUE N ES UN ENTERO QUE VALE 0, 1 O 2 Y R8 ES HALO O ALQUIL O UN GRUPO NR9R10 EN EL QUE R9 Y R10 SON AMBAS HIDROGENO, UN GRUPO NR11R12 EN DONDE R11 Y R12 SON IGUALES O DIFERENTES Y CADA UNA DE ELLAS ES HIDROGENO O ALQUIL, UN GRUPO OR13 EN DONDE R13 ES HIDROGENO O UN GRUPO ALQUIL C1-4 OPCIONALMENTE SUBSTITUIDO POR HALO; UN GRUPO ALIFATICO C1-C4 OPCIONALMENTE SUBSTITUIDO POR UN GRUPO OR14 O NR14R15 EN DONDE R14 O R15 SON IGUALES O DIFERENTES Y CADA UNA DE ELLAS ES HIDROGENO O ALQUIL; O DOS DE ENTRE R2 Y R5 SE ENCUENTRAN UNIDAS JUNTAS PARA FORMAR UN GRUPO BENZO, O UNA DE ENTRE R2 Y R5 ES UN GRUPO X-Y-R16 EN EL QUE X ES CH2, NR17, CO O S(O)M E Y ES CH2, NR17, O S(O)M, O X-Y ES O, NR17, -CH=CHN=N. LOS COMPUESTOS SON ADECUADOS COMO AGENTES FARMACOLOGICOS UTILES EN EL TRATAMIENTO DE TUMORES. TAMBIEN SE DESCRIBEN COMPOSICIONES FARMACEUTICAS Y METODOS PARA LA PREPARACION DE LOS COMPUESTOS DE LA FORMULA (I).
ES91910823T 1990-06-19 1991-06-18 Compuestos de benzoquinazolina farmaceuticamente activos. Expired - Lifetime ES2178632T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909013615A GB9013615D0 (en) 1990-06-19 1990-06-19 Pharmaceutical compounds

Publications (1)

Publication Number Publication Date
ES2178632T3 true ES2178632T3 (es) 2003-01-01

Family

ID=10677828

Family Applications (2)

Application Number Title Priority Date Filing Date
ES91910823T Expired - Lifetime ES2178632T3 (es) 1990-06-19 1991-06-18 Compuestos de benzoquinazolina farmaceuticamente activos.
ES02075192T Expired - Lifetime ES2211851T3 (es) 1990-06-19 1991-06-18 Compuesto de benzoquinozolina farmaceuticamente activos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES02075192T Expired - Lifetime ES2211851T3 (es) 1990-06-19 1991-06-18 Compuesto de benzoquinozolina farmaceuticamente activos.

Country Status (26)

Country Link
US (4) US6090941A (es)
EP (2) EP1199307B1 (es)
JP (1) JP2966929B2 (es)
KR (1) KR0183042B1 (es)
CN (1) CN1049215C (es)
AP (1) AP218A (es)
AT (2) ATE222243T1 (es)
AU (1) AU639815B2 (es)
CA (1) CA2085589C (es)
CS (1) CS186391A3 (es)
DE (2) DE69133088T2 (es)
DK (2) DK0535034T3 (es)
ES (2) ES2178632T3 (es)
FI (1) FI925778A0 (es)
GB (1) GB9013615D0 (es)
HU (2) HUT62273A (es)
IE (1) IE912073A1 (es)
IL (1) IL98542A (es)
MC (1) MC2290A1 (es)
MY (1) MY107001A (es)
NO (1) NO924929D0 (es)
NZ (1) NZ238582A (es)
PL (1) PL169927B1 (es)
PT (1) PT98021B (es)
WO (1) WO1991019700A1 (es)
ZA (1) ZA914676B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9013615D0 (en) 1990-06-19 1990-08-08 Wellcome Found Pharmaceutical compounds
US6762188B1 (en) 1990-06-19 2004-07-13 Smithkline Beecham Corporation Pharmaceutically active benzoquinazoline compounds
GB9223352D0 (en) * 1992-11-06 1992-12-23 Ici Plc Tricyclic compounds
GB9226842D0 (en) * 1992-12-23 1993-02-17 Wellcome Found Pharmaceutical compounds
GB9408936D0 (en) * 1994-05-05 1994-06-22 Cancer Res Inst Anti-cancer compounds
US6420344B1 (en) 1999-03-16 2002-07-16 The Regents Of The University Of California Glycosylated polyamines
US6531454B1 (en) 1999-03-16 2003-03-11 The Regents Of The University Of California Glycosylated polyamines and methods of use therefor
KR100851957B1 (ko) 2000-06-09 2008-08-12 오에스아이 파마슈티컬스, 인코포레이티드 벤조퀴나졸린 티미딜레이트 신타제 억제제의 리포솜 제형
RU2004112771A (ru) * 2001-09-26 2005-10-10 Байер Фармасьютикалс Корпорейшн (US) Производные 1, 8-нафтиридина как противодиабетические средства
CN100434425C (zh) * 2005-03-09 2008-11-19 首都师范大学 4-喹唑啉酮衍生物及其在抗肿瘤药物中的应用
EP1754484A1 (en) 2005-08-17 2007-02-21 Dan Stoicescu Condensed pyrimidine derivatives as inhibitors of foic acid-dependent enzymes
KR20080074207A (ko) 2005-12-05 2008-08-12 닛토덴코 가부시키가이샤 폴리글루타메이트-아미노산 콘쥬게이트 및 이의 제조 방법
GB0525069D0 (en) * 2005-12-08 2006-01-18 Novartis Ag Organic compounds
WO2008041118A2 (en) 2006-10-04 2008-04-10 Pfizer Products Inc. Pyrido[4,3-d]pyrimidin-4(3h)-one derivatives as calcium receptor antagonists
EP1958632A1 (en) 2007-02-14 2008-08-20 Dan Stoicescu Use of condensed pyrimidine derivatives for the treatment of autoimmune and inflammatory diseases
CN101730549B (zh) * 2007-05-09 2015-12-09 日东电工株式会社 与铂类药物结合的聚合物
EP2155253A2 (en) * 2007-05-09 2010-02-24 Nitto Denko Corporation Polyglutamate conjugates and polyglutamate-amino acid conjugates having a plurality of drugs
US8197828B2 (en) * 2007-05-09 2012-06-12 Nitto Denko Corporation Compositions that include a hydrophobic compound and a polyamino acid conjugate
US8146622B2 (en) 2007-08-20 2012-04-03 Ford Global Technologies, Llc Switch and hose-valve connection arrangement for vehicle temporary mobility kit
US8517760B2 (en) 2007-08-20 2013-08-27 Ford Global Technologies, Llc Cord wrap and power plug receptacle arrangement for inflator
WO2010138955A2 (en) 2009-05-29 2010-12-02 University Of Florida Research Foundation, Inc. Methods and compositions for treating neoplasia
CN101580501B (zh) * 2009-06-01 2011-03-09 南京卡文迪许生物工程技术有限公司 3-(取代二氢异吲哚酮-2-基)-2,6-哌啶二酮的合成方法及其中间体
WO2011078226A1 (ja) * 2009-12-22 2011-06-30 協和発酵キリン株式会社 三環系化合物

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UST862021I4 (en) * 1969-01-27 1969-05-27 Defensive publication
ZA72442B (en) * 1971-02-05 1972-10-25 Apaw Sa Automatic ice-cream machine
DE3069468D1 (en) * 1979-12-19 1984-11-22 Nat Res Dev Quinazoline derivatives, processes for their preparation, compositions containing them and their use as anti-cancer agents
US4814335A (en) * 1982-12-30 1989-03-21 Biomeasure, Incorporated Antiviral compounds
GB8513754D0 (en) * 1985-05-31 1985-07-03 Jones T R Anti-cancer quinazoline derivatives
US4603186A (en) 1985-10-21 1986-07-29 The Standard Oil Company Tetrapolymers containing indene
GB8607683D0 (en) * 1986-03-27 1986-04-30 Ici Plc Anti-tumor agents
US4818819A (en) * 1986-10-20 1989-04-04 The Trustees Of Princeton University Process for the preparation of fused pyridine compounds
GB8707053D0 (en) * 1987-03-25 1987-04-29 Ici Plc Anti-tumour agents
US4857530A (en) * 1987-11-03 1989-08-15 Warner-Lambert Company Substituted quinazolinones as anticancer agents
US4902624A (en) * 1987-11-23 1990-02-20 Eastman Kodak Company Temperature cycling cuvette
GB8727737D0 (en) * 1987-11-26 1987-12-31 Ici Plc Antitumour agents
GB8829296D0 (en) * 1988-12-15 1989-01-25 Ici Plc Anti-tumour compounds
GB9013615D0 (en) * 1990-06-19 1990-08-08 Wellcome Found Pharmaceutical compounds
US5405851A (en) * 1990-06-19 1995-04-11 Burroughs Wellcome Co. Pharmaceutical compounds

Also Published As

Publication number Publication date
KR0183042B1 (ko) 1999-05-01
CS186391A3 (en) 1992-04-15
CA2085589C (en) 2001-12-18
DK0535034T3 (da) 2002-12-09
CN1049215C (zh) 2000-02-09
JPH05507704A (ja) 1993-11-04
CA2085589A1 (en) 1991-12-20
PT98021A (pt) 1992-04-30
GB9013615D0 (en) 1990-08-08
HUT62273A (en) 1993-04-28
EP1199307B1 (en) 2004-02-25
CN1058208A (zh) 1992-01-29
AU639815B2 (en) 1993-08-05
MY107001A (en) 1995-08-30
DE69133088D1 (de) 2002-09-19
AU8094391A (en) 1992-01-07
NO924929L (no) 1992-12-18
HU9204011D0 (en) 1993-03-29
US5663337A (en) 1997-09-02
AP9100283A0 (en) 1991-07-31
ATE260262T1 (de) 2004-03-15
DE69133371T2 (de) 2005-01-27
AP218A (en) 1992-09-27
FI925778A (fi) 1992-12-18
IL98542A (en) 1995-05-26
ES2211851T3 (es) 2004-07-16
DE69133088T2 (de) 2003-03-20
IE912073A1 (en) 1992-01-01
PT98021B (pt) 1998-11-30
NO924929D0 (no) 1992-12-18
MC2290A1 (fr) 1993-07-14
FI925778A0 (fi) 1992-12-18
EP0535034B1 (en) 2002-08-14
WO1991019700A1 (en) 1991-12-26
EP0535034A1 (en) 1993-04-07
ATE222243T1 (de) 2002-08-15
IL98542A0 (en) 1992-07-15
PL169927B1 (pl) 1996-09-30
NZ238582A (en) 1993-12-23
DK1199307T3 (da) 2004-06-14
JP2966929B2 (ja) 1999-10-25
US6306865B1 (en) 2001-10-23
DE69133371D1 (de) 2004-04-01
EP1199307A1 (en) 2002-04-24
US5661155A (en) 1997-08-26
KR930701415A (ko) 1993-06-11
ZA914676B (en) 1993-02-24
HU211265A9 (en) 1995-11-28
US6090941A (en) 2000-07-18

Similar Documents

Publication Publication Date Title
ES2178632T3 (es) Compuestos de benzoquinazolina farmaceuticamente activos.
AR004219A1 (es) Nuevos derivados de quinazolina, procedimientos para su preparacion, composiciones que los contienen y su uso en la preparacion de medicamentos,particularmente en el tratamiento de trastornos inflamatorios
AR032621A1 (es) Compuestos derivados de tiofeno, metodo para su preparacion, composicion farmaceutica y uso en la fabricacion de medicamentos
MX9504287A (es) Derivados de camptotecina y proceso para su preparacion.
ES2140391T3 (es) Derivados de dialcoxi-piridinil-bencimidazol, procedimiento para su preparacion y su uso farmaceutico.
AR007828A1 (es) Compuestos derivados de piridilpirrol, procedimiento de preparacion y composiciones farmaceuticas conteniendo los mismos
ES2128307T3 (es) Derivados de 1,4,7,10-tetraaza-ciclododecano monosustituidos en n, procedimiento para su preparacion y agentes farmaceuticos que los contienen.
AR035235A1 (es) Derivados heterocicliloxi-,-tioxi- y -aminobenzazol como ligandos de 5-hidroxitriptamina-6, un procedimiento para su preparacion, composicion farmaceutica, y el uso de dichos derivados para la manufactura de un medicamento
AR009938A1 (es) Nuevos derivados de arilglicinamida, procedimientos para su preparacion y composiciones farmaceuticas que contienen estos compuestos
AR048567A1 (es) Derivados de benzoxazinona, su preparacion y composiciones farmaceuticas.
AR045040A1 (es) Derivados de compuestos espiroazabiciclicos, composiciones farmaceuticas que los contienen y su uso en la preparacion de medicamentos
ES2118203T3 (es) Nuevos derivados benzopiranicos, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
ES2071666T3 (es) Derivados de pirazoloisoquinolina, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
ES2167021T3 (es) Derivados de acido 4-bifenil-4-hidroxibutirico sustituidos como inhibidores de metaloproteasa de matriz.
ES2063815T3 (es) 2-alquil-3-benzoilbenzofuranos y composiciones farmaceuticas que los contienen.
AR012826A1 (es) Complejo de bis-platino (ii), metodo para preparar dicho complejo y uso del mismo en la preparacion de una composicion farmaceutica para tratar tumores.
ATE204278T1 (de) Serotoninergische ergolin derivate
ES2056811T3 (es) Derivados de cinolina, procedimiento para su preparacion y composiciones herbicidas que los contienen.
BG93114A (bg) Производни на бензонафтиридин-1,8 ,методи за получаването им и състави които ги съдържат
IT1164387B (it) Derivati n-sostituiti dell'1-(4'-alchilsulfonilfenil)-2-ammino-1,3-propandiolo
AR009732A1 (es) Bisindolilmaleimidas, proceso para su preparacion, su uso en la preparacion de medicamentos, una composicion farmaceutica que los contiene y compuestosintermediarios para su uso exclusivo en el mencionado proceso
ES2037758T3 (es) Un metodo de uso de un derivado quinolincarboxilico y su procedimiento de preparacion.
IT1164389B (it) Derivati n-sostituiti dell'1-(4'-alchiltiofenil)-2-ammino-1,3-propandiolo
ES2059471T3 (es) Un procedimiento para preparar un derivado de rodamina.
PA8474401A1 (es) 3-ceto derivados triciclicos de 6-0-metileritromicina