DE69133088D1 - Pharmazeutisch wirksame benzochinazolin verbindungen - Google Patents

Pharmazeutisch wirksame benzochinazolin verbindungen

Info

Publication number
DE69133088D1
DE69133088D1 DE69133088T DE69133088T DE69133088D1 DE 69133088 D1 DE69133088 D1 DE 69133088D1 DE 69133088 T DE69133088 T DE 69133088T DE 69133088 T DE69133088 T DE 69133088T DE 69133088 D1 DE69133088 D1 DE 69133088D1
Authority
DE
Germany
Prior art keywords
benzochinazoline
compounds
pharmaceutical effective
pharmaceutical
effective
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69133088T
Other languages
English (en)
Other versions
DE69133088T2 (de
Inventor
William Pendergast
Howard Dickerson
Vass Johnson
Robert Ferone
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of DE69133088D1 publication Critical patent/DE69133088D1/de
Application granted granted Critical
Publication of DE69133088T2 publication Critical patent/DE69133088T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69133088T 1990-06-19 1991-06-18 Pharmazeutisch wirksame benzochinazolin verbindungen Expired - Fee Related DE69133088T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909013615A GB9013615D0 (en) 1990-06-19 1990-06-19 Pharmaceutical compounds
PCT/GB1991/000977 WO1991019700A1 (en) 1990-06-19 1991-06-18 Pharmaceutically active benzoquinazoline compounds

Publications (2)

Publication Number Publication Date
DE69133088D1 true DE69133088D1 (de) 2002-09-19
DE69133088T2 DE69133088T2 (de) 2003-03-20

Family

ID=10677828

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69133088T Expired - Fee Related DE69133088T2 (de) 1990-06-19 1991-06-18 Pharmazeutisch wirksame benzochinazolin verbindungen
DE69133371T Expired - Fee Related DE69133371T2 (de) 1990-06-19 1991-06-18 Pharmazeutische wirksame Benzochinazolin Verbindungen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69133371T Expired - Fee Related DE69133371T2 (de) 1990-06-19 1991-06-18 Pharmazeutische wirksame Benzochinazolin Verbindungen

Country Status (26)

Country Link
US (4) US6090941A (de)
EP (2) EP0535034B1 (de)
JP (1) JP2966929B2 (de)
KR (1) KR0183042B1 (de)
CN (1) CN1049215C (de)
AP (1) AP218A (de)
AT (2) ATE222243T1 (de)
AU (1) AU639815B2 (de)
CA (1) CA2085589C (de)
CS (1) CS186391A3 (de)
DE (2) DE69133088T2 (de)
DK (2) DK0535034T3 (de)
ES (2) ES2178632T3 (de)
FI (1) FI925778A (de)
GB (1) GB9013615D0 (de)
HU (2) HUT62273A (de)
IE (1) IE912073A1 (de)
IL (1) IL98542A (de)
MC (1) MC2290A1 (de)
MY (1) MY107001A (de)
NO (1) NO924929D0 (de)
NZ (1) NZ238582A (de)
PL (1) PL169927B1 (de)
PT (1) PT98021B (de)
WO (1) WO1991019700A1 (de)
ZA (1) ZA914676B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6762188B1 (en) 1990-06-19 2004-07-13 Smithkline Beecham Corporation Pharmaceutically active benzoquinazoline compounds
GB9013615D0 (en) 1990-06-19 1990-08-08 Wellcome Found Pharmaceutical compounds
GB9223352D0 (en) * 1992-11-06 1992-12-23 Ici Plc Tricyclic compounds
GB9226842D0 (en) * 1992-12-23 1993-02-17 Wellcome Found Pharmaceutical compounds
GB9408936D0 (en) * 1994-05-05 1994-06-22 Cancer Res Inst Anti-cancer compounds
AU3883600A (en) 1999-03-16 2000-10-04 Regents Of The University Of California, The Glycosylated polyamines
US6531454B1 (en) 1999-03-16 2003-03-11 The Regents Of The University Of California Glycosylated polyamines and methods of use therefor
PL360470A1 (en) * 2000-06-09 2004-09-06 Osi Pharmaceuticals, Inc. Liposomal benzoquinazoline thymidylate synthase inhibitor formulations
KR20040041177A (ko) * 2001-09-26 2004-05-14 바이엘 파마슈티칼스 코포레이션 당뇨병 치료제로서의 1,6-나프티리딘 유도체
CN100434425C (zh) * 2005-03-09 2008-11-19 首都师范大学 4-喹唑啉酮衍生物及其在抗肿瘤药物中的应用
EP1754484A1 (de) * 2005-08-17 2007-02-21 Dan Stoicescu Kondensierte Pyrimidinderivative als Inhibitoren der Folsäure-abhängiger Enzyme
ATE432955T1 (de) 2005-12-05 2009-06-15 Nitto Denko Corp Polyglutamat-aminosäure-konjugate und verfahren
GB0525069D0 (en) * 2005-12-08 2006-01-18 Novartis Ag Organic compounds
EP2079739A2 (de) 2006-10-04 2009-07-22 Pfizer Products Inc. Pyrido[4,3-d]pyrimidin-4(3h)-onderivate als kalziumrezeptorantagonisten
EP1958632A1 (de) 2007-02-14 2008-08-20 Dan Stoicescu Kondensierte Pyrimidinderivaten zur Behandlung von Entzündungserkrankungen und Autoimmunerkrankungen
ES2430380T3 (es) * 2007-05-09 2013-11-20 Nitto Denko Corporation Composiciones que incluyen un compuesto hidrófobo y un conjugado de poliaminoácido
CN101730549B (zh) * 2007-05-09 2015-12-09 日东电工株式会社 与铂类药物结合的聚合物
JP2010526917A (ja) * 2007-05-09 2010-08-05 日東電工株式会社 複数種の薬物を有するポリグルタミン酸塩複合体及びポリグルタミン酸塩−アミノ酸複合体
US8146622B2 (en) 2007-08-20 2012-04-03 Ford Global Technologies, Llc Switch and hose-valve connection arrangement for vehicle temporary mobility kit
US8517760B2 (en) 2007-08-20 2013-08-27 Ford Global Technologies, Llc Cord wrap and power plug receptacle arrangement for inflator
US8501242B2 (en) 2009-05-29 2013-08-06 University Of Florida Research Foundation Methods and compositions for treating neoplasia
CN101580501B (zh) * 2009-06-01 2011-03-09 南京卡文迪许生物工程技术有限公司 3-(取代二氢异吲哚酮-2-基)-2,6-哌啶二酮的合成方法及其中间体
WO2011078226A1 (ja) * 2009-12-22 2011-06-30 協和発酵キリン株式会社 三環系化合物

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UST862021I4 (en) * 1969-01-27 1969-05-27 Defensive publication
ZA72442B (en) * 1971-02-05 1972-10-25 Apaw Sa Automatic ice-cream machine
DE3069468D1 (en) * 1979-12-19 1984-11-22 Nat Res Dev Quinazoline derivatives, processes for their preparation, compositions containing them and their use as anti-cancer agents
US4814335A (en) * 1982-12-30 1989-03-21 Biomeasure, Incorporated Antiviral compounds
GB8513754D0 (en) * 1985-05-31 1985-07-03 Jones T R Anti-cancer quinazoline derivatives
US4603186A (en) 1985-10-21 1986-07-29 The Standard Oil Company Tetrapolymers containing indene
GB8607683D0 (en) * 1986-03-27 1986-04-30 Ici Plc Anti-tumor agents
US4818819A (en) * 1986-10-20 1989-04-04 The Trustees Of Princeton University Process for the preparation of fused pyridine compounds
GB8707053D0 (en) * 1987-03-25 1987-04-29 Ici Plc Anti-tumour agents
US4857530A (en) * 1987-11-03 1989-08-15 Warner-Lambert Company Substituted quinazolinones as anticancer agents
US4902624A (en) * 1987-11-23 1990-02-20 Eastman Kodak Company Temperature cycling cuvette
GB8727737D0 (en) * 1987-11-26 1987-12-31 Ici Plc Antitumour agents
GB8829296D0 (en) * 1988-12-15 1989-01-25 Ici Plc Anti-tumour compounds
GB9013615D0 (en) * 1990-06-19 1990-08-08 Wellcome Found Pharmaceutical compounds
US5405851A (en) * 1990-06-19 1995-04-11 Burroughs Wellcome Co. Pharmaceutical compounds

Also Published As

Publication number Publication date
EP0535034A1 (de) 1993-04-07
US5661155A (en) 1997-08-26
AU639815B2 (en) 1993-08-05
US5663337A (en) 1997-09-02
EP0535034B1 (de) 2002-08-14
IL98542A0 (en) 1992-07-15
FI925778A0 (fi) 1992-12-18
ES2178632T3 (es) 2003-01-01
HUT62273A (en) 1993-04-28
CN1049215C (zh) 2000-02-09
HU211265A9 (en) 1995-11-28
NZ238582A (en) 1993-12-23
DK1199307T3 (da) 2004-06-14
EP1199307B1 (de) 2004-02-25
CN1058208A (zh) 1992-01-29
ATE222243T1 (de) 2002-08-15
KR930701415A (ko) 1993-06-11
NO924929L (no) 1992-12-18
ZA914676B (en) 1993-02-24
HU9204011D0 (en) 1993-03-29
DK0535034T3 (da) 2002-12-09
FI925778A (fi) 1992-12-18
IL98542A (en) 1995-05-26
DE69133371D1 (de) 2004-04-01
AU8094391A (en) 1992-01-07
CA2085589A1 (en) 1991-12-20
DE69133088T2 (de) 2003-03-20
CA2085589C (en) 2001-12-18
AP218A (en) 1992-09-27
JP2966929B2 (ja) 1999-10-25
WO1991019700A1 (en) 1991-12-26
MC2290A1 (fr) 1993-07-14
EP1199307A1 (de) 2002-04-24
PL169927B1 (pl) 1996-09-30
IE912073A1 (en) 1992-01-01
MY107001A (en) 1995-08-30
DE69133371T2 (de) 2005-01-27
GB9013615D0 (en) 1990-08-08
PT98021A (pt) 1992-04-30
US6090941A (en) 2000-07-18
CS186391A3 (en) 1992-04-15
US6306865B1 (en) 2001-10-23
AP9100283A0 (en) 1991-07-31
ATE260262T1 (de) 2004-03-15
JPH05507704A (ja) 1993-11-04
ES2211851T3 (es) 2004-07-16
PT98021B (pt) 1998-11-30
KR0183042B1 (ko) 1999-05-01
NO924929D0 (no) 1992-12-18

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee