ES2140391T3 - Derivados de dialcoxi-piridinil-bencimidazol, procedimiento para su preparacion y su uso farmaceutico. - Google Patents

Derivados de dialcoxi-piridinil-bencimidazol, procedimiento para su preparacion y su uso farmaceutico.

Info

Publication number
ES2140391T3
ES2140391T3 ES91911618T ES91911618T ES2140391T3 ES 2140391 T3 ES2140391 T3 ES 2140391T3 ES 91911618 T ES91911618 T ES 91911618T ES 91911618 T ES91911618 T ES 91911618T ES 2140391 T3 ES2140391 T3 ES 2140391T3
Authority
ES
Spain
Prior art keywords
dialcoxi
bencimidazole
piridinil
derivatives
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91911618T
Other languages
English (en)
Inventor
Arne Elof Brandstrom
Per Lennart Lindberg
Gunnel Elisabeth Sunden
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Astra AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9002206A external-priority patent/SE9002206D0/xx
Priority claimed from SE9002207A external-priority patent/SE9002207D0/xx
Application filed by Astra AB filed Critical Astra AB
Application granted granted Critical
Publication of ES2140391T3 publication Critical patent/ES2140391T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE DESCRIBEN LOS NUEVOS COMPUESTOS DE FORMULA (I) Y LAS SALES FISIOLOGICAMENTE ACEPTABLES DE LOS MISMOS, ASI COMO INTERMEDIARIOS, COMPOSICIONES FARMACEUTICAS QUE CONTIENEN DICHOS COMPUESTOS COMO INGREDIENTE ACTIVO Y EL EMPLEO DE LOS MISMOS EN MEDICINA, EN DONDE R1 Y R2, QUE SON DIFERENTES, SON CADA UNO H, ALQUILO QUE CONTIENE 1 EN DONDE R5 ES ALQUILO QUE CONTIENE 1 ALCOXI QUE CONTIENE 1 ESTA SIEMPRE SELECCIONADO DE UN GRUPO IGUALES O DIFERENTES Y ESTAN SELECCIONADOS ENTRE 5, (A), (B), Y CH2CH2OCH3 O R3 Y R4 JUNTO CON LOS ATOMOS DE OXIGENO ADYACENTES UNIDOS AL ANILLO DE PIRIMIDINA Y LOS ATOMOS DE CARBONO DEL ANILLO DE PIRIMIDINA FORMAN UN ANILLO, EN DONDE LA PARTE CONSTITUIDA POR R3 Y R4 ES O
ES91911618T 1990-06-20 1991-06-11 Derivados de dialcoxi-piridinil-bencimidazol, procedimiento para su preparacion y su uso farmaceutico. Expired - Lifetime ES2140391T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9002206A SE9002206D0 (sv) 1990-06-20 1990-06-20 New compounds
SE9002207A SE9002207D0 (sv) 1990-06-20 1990-06-20 New compounds i

Publications (1)

Publication Number Publication Date
ES2140391T3 true ES2140391T3 (es) 2000-03-01

Family

ID=26660803

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91911618T Expired - Lifetime ES2140391T3 (es) 1990-06-20 1991-06-11 Derivados de dialcoxi-piridinil-bencimidazol, procedimiento para su preparacion y su uso farmaceutico.

Country Status (28)

Country Link
US (1) US5430042A (es)
EP (1) EP0593463B1 (es)
JP (1) JP3049367B2 (es)
CN (1) CN1058213A (es)
AP (1) AP253A (es)
AT (1) ATE184602T1 (es)
AU (1) AU649456B2 (es)
CA (1) CA2083606C (es)
CZ (1) CZ279434B6 (es)
DE (1) DE69131627T2 (es)
EG (1) EG19752A (es)
ES (1) ES2140391T3 (es)
FI (1) FI925767A (es)
HU (1) HUT62882A (es)
IE (1) IE912026A1 (es)
IL (1) IL98472A (es)
IS (1) IS3720A7 (es)
LV (1) LV10269B (es)
MA (1) MA22198A1 (es)
NO (1) NO924650D0 (es)
NZ (1) NZ238545A (es)
OA (1) OA09683A (es)
PL (2) PL165898B1 (es)
PT (1) PT98036A (es)
RO (1) RO110497B1 (es)
TN (1) TNSN91050A1 (es)
WO (1) WO1991019712A1 (es)
YU (1) YU104091A (es)

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US6645988B2 (en) 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
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WO2004073654A2 (en) * 2003-02-20 2004-09-02 Santarus, Inc. A novel formulation, omeprazole antacid complex-immediate release for rapid and sustained supression of gastric acid
CA2529984C (en) 2003-06-26 2012-09-25 Isa Odidi Oral multi-functional pharmaceutical capsule preparations of proton pump inhibitors
US8993599B2 (en) * 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
TWI337877B (en) * 2003-07-18 2011-03-01 Santarus Inc Pharmaceutical formulation and method for treating acid-caused gastrointestinal disorders
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US20050075371A1 (en) * 2003-10-03 2005-04-07 Allergan, Inc. Methods and compositions for the oral administration of prodrugs of proton pump inhibitors
US20060241037A1 (en) * 2003-10-03 2006-10-26 Allergan Inc. Compositions comprising trefoil factor family peptides and/or mucoadhesives and proton pump ihhibitor prodrugs
US20070060621A1 (en) * 2004-02-18 2007-03-15 Hughes Patrick M Methods and compositions for the administration of prodrugs of proton pump inhibitors
BRPI0507837A (pt) * 2004-02-18 2007-07-10 Allergan Inc métodos e composições para a administração intravenosa de compostos relacionados a inibidores de bomba de prótons
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US9561188B2 (en) 2006-04-03 2017-02-07 Intellipharmaceutics Corporation Controlled release delivery device comprising an organosol coat
WO2007122686A1 (ja) * 2006-04-14 2007-11-01 Eisai R & D Management Co., Ltd. ベンズイミダゾール化合物
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JP2009196894A (ja) * 2006-10-13 2009-09-03 Eisai R & D Management Co Ltd スルフィニルベンズイミダゾール化合物またはその塩の製造方法
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Also Published As

Publication number Publication date
CS189391A3 (en) 1992-06-17
PL297295A1 (es) 1992-07-13
FI925767A0 (fi) 1992-12-18
LV10269B (en) 1995-10-20
RO110497B1 (ro) 1996-01-30
CZ279434B6 (cs) 1995-04-12
OA09683A (en) 1993-05-15
ATE184602T1 (de) 1999-10-15
PL166209B1 (pl) 1995-04-28
LV10269A (lv) 1994-10-20
DE69131627T2 (de) 2000-04-27
HU9204034D0 (en) 1993-03-29
FI925767A (fi) 1992-12-18
AP253A (en) 1993-05-03
NZ238545A (en) 1993-08-26
IL98472A (en) 1995-08-31
IL98472A0 (en) 1992-07-15
NO924650L (no) 1992-12-02
AU8061791A (en) 1992-01-07
PL297294A1 (es) 1992-07-13
HUT62882A (en) 1993-06-28
JPH05507714A (ja) 1993-11-04
CA2083606C (en) 2001-08-21
CA2083606A1 (en) 1991-12-21
NO924650D0 (no) 1992-12-02
US5430042A (en) 1995-07-04
MA22198A1 (fr) 1992-04-01
PT98036A (pt) 1992-03-31
IS3720A7 (is) 1991-12-21
JP3049367B2 (ja) 2000-06-05
CN1058213A (zh) 1992-01-29
AU649456B2 (en) 1994-05-26
AP9100286A0 (en) 1991-07-31
EP0593463B1 (en) 1999-09-15
IE912026A1 (en) 1992-01-01
DE69131627D1 (de) 1999-10-21
WO1991019712A1 (en) 1991-12-26
TNSN91050A1 (fr) 1992-10-25
PL165898B1 (pl) 1995-02-28
YU104091A (sh) 1994-01-20
EG19752A (en) 1996-01-31
EP0593463A1 (en) 1994-04-27

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