ES2061581T3 - Un procedimiento para preparar un compuesto cefem. - Google Patents
Un procedimiento para preparar un compuesto cefem.Info
- Publication number
- ES2061581T3 ES2061581T3 ES88114722T ES88114722T ES2061581T3 ES 2061581 T3 ES2061581 T3 ES 2061581T3 ES 88114722 T ES88114722 T ES 88114722T ES 88114722 T ES88114722 T ES 88114722T ES 2061581 T3 ES2061581 T3 ES 2061581T3
- Authority
- ES
- Spain
- Prior art keywords
- protected
- alkil
- amino
- carboxi
- theta
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
UN COMPONENTE DEFEM DE LA FORMULA: EN DONDE R1 ES AMINO O UN AMINO PROTEGIDO, R2 ES ALKIL BAJO QUE DEBE TENER UNO O MAS SUSTITUYENTES CONVENIENTES, R3 ES COO(THETA), CARBOXI O UN CARBOXI PROTEGIDO, R4 ES HIDROXI (BAJO ALKIL O HIDROXI (BAJO) ALKIL PROTEGIDO , R5 ES AMINO O UN AMINO PROTEGIDO, R6 ES HIDROGENO O ALKIL BAJO, X(THETA) ES UN ANION Y N ES 0 O 1, CON PREVISTO QUE: (I) CUANDO R3 ES COO(THETA), ENTONCES N ES 0 Y (II) CUANDO R3 ES CORBOXI O UN CARBOXI PROTEGIDO, ENTONCES N ES 1. Y SALES ACEPTABLES FARMACEUTICAMENTE DE ELLO, PROCESO PARA SU PREPARACION Y COMPOSICIONES FARMACEUTICAS QUE LES COMPRENDAN COMO INFGREDIENTES ACTIVOS EN MEZCLA CON PORTADORES ACEPTABLES FARMACEUTICAMENTE.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB878721568A GB8721568D0 (en) | 1987-09-14 | 1987-09-14 | Cephem compounds |
GB888815361A GB8815361D0 (en) | 1988-06-28 | 1988-06-28 | New cephem compound & process for preparation thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2061581T3 true ES2061581T3 (es) | 1994-12-16 |
Family
ID=26292732
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES88114722T Expired - Lifetime ES2061581T3 (es) | 1987-09-14 | 1988-09-09 | Un procedimiento para preparar un compuesto cefem. |
Country Status (22)
Country | Link |
---|---|
US (1) | US4952578A (es) |
EP (1) | EP0307804B1 (es) |
JP (1) | JPH01151589A (es) |
KR (1) | KR0133560B1 (es) |
CN (1) | CN1024669C (es) |
AU (1) | AU617358B2 (es) |
CA (1) | CA1338842C (es) |
DE (1) | DE3885688T2 (es) |
DK (1) | DK509988A (es) |
ES (1) | ES2061581T3 (es) |
FI (1) | FI92322C (es) |
HK (1) | HK18396A (es) |
HU (1) | HU211830A9 (es) |
IE (1) | IE63094B1 (es) |
IL (1) | IL87731A (es) |
NO (1) | NO171853C (es) |
NZ (1) | NZ226143A (es) |
OA (1) | OA09014A (es) |
PH (1) | PH24719A (es) |
PT (1) | PT88481B (es) |
RU (1) | RU1787158C (es) |
UA (1) | UA41865C2 (es) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5194432A (en) * | 1985-11-22 | 1993-03-16 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
CA1293719C (en) * | 1986-09-22 | 1991-12-31 | Takao Takaya | Cephem compounds and processes for preparation thereof |
US5162520A (en) * | 1986-09-22 | 1992-11-10 | Fujisawa Pharmaceutical Co., Ltd. | Intermediates for cephem compounds |
US5663163A (en) * | 1987-09-07 | 1997-09-02 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds and processes for preparation thereof |
GB8905301D0 (en) * | 1989-03-08 | 1989-04-19 | Fujisawa Pharmaceutical Co | New cephem compound and a process for preparation thereof |
EP0517041A1 (en) * | 1991-06-07 | 1992-12-09 | Fujisawa Pharmaceutical Co., Ltd. | New Cephem Compounds |
WO2002090364A1 (en) * | 2001-05-01 | 2002-11-14 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
KR100463920B1 (ko) * | 2002-10-18 | 2004-12-30 | 제일약품주식회사 | 신규 세프디토렌 피복실 메지틸렌 설폰산염 및 그 제조방법 |
JP4448821B2 (ja) * | 2002-10-30 | 2010-04-14 | アステラス製薬株式会社 | セフェム化合物 |
AU2003902380A0 (en) * | 2003-05-16 | 2003-06-05 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
ES2340928T3 (es) * | 2003-09-18 | 2010-06-11 | Astellas Pharma Inc. | Compuestos de cefem. |
CN1321109C (zh) * | 2003-11-07 | 2007-06-13 | 天津药物研究院 | 一种头孢烯类鎓盐化合物及其制备方法和以该化合物合成硫酸头孢吡唑的方法 |
CN101747348B (zh) * | 2008-12-11 | 2013-02-06 | 石药集团中奇制药技术(石家庄)有限公司 | 一种硫酸头孢噻利晶型及其制备方法 |
CN101781318B (zh) * | 2010-02-26 | 2013-07-31 | 烟台宝华生物技术有限公司 | 头孢母核衍生化合物、由其制备的头孢烯类鎓盐化合物及采用其制备硫酸头孢吡唑的方法 |
CN101830913B (zh) * | 2010-04-09 | 2012-10-31 | 烟台宝华生物技术有限公司 | 头孢母核衍生化合物、由其制备的头孢烯类鎓盐化合物及采用其制备硫酸头孢吡唑的方法 |
CN101993450B (zh) * | 2010-11-03 | 2011-11-30 | 湖南欧亚生物有限公司 | 一种硫酸头孢噻利的制备方法 |
CN102336771A (zh) * | 2011-07-11 | 2012-02-01 | 珠海联邦制药股份有限公司 | 一种硫酸头孢噻利中间体的制备方法 |
JP6151257B2 (ja) | 2011-09-09 | 2017-06-21 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | 肺内感染症の治療方法 |
US8809314B1 (en) | 2012-09-07 | 2014-08-19 | Cubist Pharmacueticals, Inc. | Cephalosporin compound |
US8476425B1 (en) | 2012-09-27 | 2013-07-02 | Cubist Pharmaceuticals, Inc. | Tazobactam arginine compositions |
CN102875572B (zh) * | 2012-10-26 | 2014-07-30 | 四川科伦药物研究有限公司 | 一种硫酸头孢噻利中间体的精制方法 |
US9872906B2 (en) | 2013-03-15 | 2018-01-23 | Merck Sharp & Dohme Corp. | Ceftolozane antibiotic compositions |
UA121298C2 (uk) | 2013-03-15 | 2020-05-12 | Мерк Шарп І Доум Корп. | Антибіотична композиція на основі цефтолозану і тазобактаму |
US20140274993A1 (en) | 2013-03-15 | 2014-09-18 | Cubist Pharmaceuticals, Inc. | Ceftolozane-tazobactam pharmaceutical compositions |
WO2015035376A2 (en) | 2013-09-09 | 2015-03-12 | Calixa Therapeutics, Inc. | Treating infections with ceftolozane/tazobactam in subjects having impaired renal function |
US8906898B1 (en) | 2013-09-27 | 2014-12-09 | Calixa Therapeutics, Inc. | Solid forms of ceftolozane |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GR63088B (en) * | 1976-04-14 | 1979-08-09 | Takeda Chemical Industries Ltd | Preparation process of novel cephalosporins |
GB2037281B (en) * | 1978-11-15 | 1983-01-19 | Glaxo Group Ltd | 7( -(2-amino-4-thiozolyl)-2-hydroximino-acetanuds)-cephalosporins |
EP0062321B1 (en) * | 1981-04-03 | 1989-03-01 | Fujisawa Pharmaceutical Co., Ltd. | New cephem compounds, processes for their preparation, pharmaceutical compositions containing them and their starting compounds |
JPS584789A (ja) * | 1981-04-03 | 1983-01-11 | Fujisawa Pharmaceut Co Ltd | 新規セフエム化合物およびその製造法 |
US4401668A (en) * | 1981-10-02 | 1983-08-30 | Eli Lilly And Company | Pyrazinium substituted cephalosporins |
CA1299564C (en) * | 1985-09-03 | 1992-04-28 | Akihiro Shimabayashi | Cephalosporin derivative |
DE3539901A1 (de) * | 1985-11-11 | 1987-05-14 | Hoechst Ag | Cephalosporinderivate und verfahren zu ihrer herstellung |
CN86107947A (zh) * | 1985-11-22 | 1987-05-27 | 藤沢药品工业株式会社 | 新的头孢烯化合物及其制备方法 |
-
1988
- 1988-09-06 IE IE269288A patent/IE63094B1/en not_active IP Right Cessation
- 1988-09-07 US US07/241,419 patent/US4952578A/en not_active Expired - Lifetime
- 1988-09-09 EP EP88114722A patent/EP0307804B1/en not_active Expired - Lifetime
- 1988-09-09 DE DE88114722T patent/DE3885688T2/de not_active Expired - Fee Related
- 1988-09-09 ES ES88114722T patent/ES2061581T3/es not_active Expired - Lifetime
- 1988-09-09 IL IL87731A patent/IL87731A/xx not_active IP Right Cessation
- 1988-09-09 PH PH37528A patent/PH24719A/en unknown
- 1988-09-12 NZ NZ226143A patent/NZ226143A/en unknown
- 1988-09-12 KR KR1019880011743A patent/KR0133560B1/ko not_active IP Right Cessation
- 1988-09-13 CA CA000577194A patent/CA1338842C/en not_active Expired - Fee Related
- 1988-09-13 CN CN88106644A patent/CN1024669C/zh not_active Expired - Fee Related
- 1988-09-13 RU SU4356636A patent/RU1787158C/ru active
- 1988-09-13 DK DK509988A patent/DK509988A/da not_active Application Discontinuation
- 1988-09-13 FI FI884193A patent/FI92322C/fi not_active IP Right Cessation
- 1988-09-13 NO NO884058A patent/NO171853C/no not_active IP Right Cessation
- 1988-09-13 PT PT88481A patent/PT88481B/pt not_active IP Right Cessation
- 1988-09-14 OA OA59431A patent/OA09014A/xx unknown
- 1988-09-14 JP JP63233183A patent/JPH01151589A/ja active Granted
- 1988-09-14 AU AU22271/88A patent/AU617358B2/en not_active Ceased
-
1992
- 1992-02-24 UA UA5010902A patent/UA41865C2/uk unknown
-
1995
- 1995-06-22 HU HU95P/P00350P patent/HU211830A9/hu unknown
-
1996
- 1996-02-01 HK HK18396A patent/HK18396A/xx not_active IP Right Cessation
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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