ATE67406T1 - Nicorandil enthaltende zubereitung zum einspritzen. - Google Patents
Nicorandil enthaltende zubereitung zum einspritzen.Info
- Publication number
- ATE67406T1 ATE67406T1 AT87100334T AT87100334T ATE67406T1 AT E67406 T1 ATE67406 T1 AT E67406T1 AT 87100334 T AT87100334 T AT 87100334T AT 87100334 T AT87100334 T AT 87100334T AT E67406 T1 ATE67406 T1 AT E67406T1
- Authority
- AT
- Austria
- Prior art keywords
- preparation
- nicorandil
- freeze
- dissolved
- dried
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP574286 | 1986-01-14 | ||
EP87100334A EP0236679B1 (de) | 1986-01-14 | 1987-01-13 | Nicorandil enthaltende Zubereitung zum Einspritzen |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE67406T1 true ATE67406T1 (de) | 1991-10-15 |
Family
ID=11619552
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT87100334T ATE67406T1 (de) | 1986-01-14 | 1987-01-13 | Nicorandil enthaltende zubereitung zum einspritzen. |
Country Status (12)
Country | Link |
---|---|
US (1) | US4769381A (de) |
EP (1) | EP0236679B1 (de) |
JP (1) | JPH0713018B2 (de) |
KR (1) | KR950010150B1 (de) |
AT (1) | ATE67406T1 (de) |
AU (1) | AU594266B2 (de) |
CA (1) | CA1285485C (de) |
DE (1) | DE3773017D1 (de) |
ES (1) | ES2038605T3 (de) |
GR (1) | GR3003355T3 (de) |
HK (1) | HK65193A (de) |
SG (1) | SG64693G (de) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6351326A (ja) * | 1986-08-22 | 1988-03-04 | Nisshin Flour Milling Co Ltd | ニコランジル外用剤 |
CA1336963C (en) * | 1988-07-18 | 1995-09-12 | Gary James Grover | Method for inhibiting myocardial cell necrosis and preserving heart function during myocardial ischemia and/or reperfusion |
DE69720602T2 (de) * | 1996-06-24 | 2004-02-12 | Tosoh Corp., Shinnanyo | Enzymsubstrat |
SE9803517D0 (sv) | 1998-10-15 | 1998-10-15 | Astra Ab | Pharmaceutical preparation |
AU4841700A (en) | 1999-05-12 | 2000-11-21 | Nitromed, Inc. | Nitrosated and nitrosylated potassium channel activators, compositions and methods of use |
JPWO2003018058A1 (ja) * | 2001-08-22 | 2004-12-09 | 横田 充弘 | 心筋細胞のアポトーシス抑制剤 |
CN100417381C (zh) * | 2006-02-09 | 2008-09-10 | 西安力邦医药科技有限责任公司 | 尼可地尔冻干粉的制备方法 |
CN101474161B (zh) * | 2009-01-14 | 2011-11-16 | 北京四环科宝制药有限公司 | 尼可地尔冻干粉针剂及其制备方法 |
CN103764146A (zh) * | 2011-06-30 | 2014-04-30 | 持田制药株式会社 | 含尼可地尔的药物组合物 |
CN110123749B (zh) * | 2019-06-03 | 2022-01-25 | 太阳升(亳州)生物医药科技有限公司 | 尼可地尔脂微球制剂及其制备方法 |
CN111574441B (zh) * | 2020-05-26 | 2021-12-31 | 中国科学院上海药物研究所 | 一种尼可地尔与水杨酸的共晶及其制备方法和应用 |
CN111606847B (zh) * | 2020-05-26 | 2021-12-31 | 中国科学院上海药物研究所 | 尼可地尔与1-羟基-2-萘甲酸的共晶及其制备方法和应用 |
CN115624527A (zh) * | 2022-09-20 | 2023-01-20 | 朗天药业(湖北)有限公司 | 一种尼可地尔冻干粉针剂及其制备方法和用途 |
CN115487156A (zh) * | 2022-10-17 | 2022-12-20 | 南京正科医药股份有限公司 | 一种注射用尼可地尔粉针剂及其制备方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3168438A (en) * | 1962-08-09 | 1965-02-02 | Synergistics Inc | Vasodilation by nitric acid ester derivatives of nicotinic acid |
US3332848A (en) * | 1963-07-10 | 1967-07-25 | Hoffmann La Roche | Microcrystalline cellulose with starch in niacinamide ascorbic acid tablet granulations |
US4200640A (en) * | 1976-04-02 | 1980-04-29 | Chugai Seiyaku Kabushiki Kaisha | Nitric ester of N-(2-hydroxyethyl)nicotinamide and pharmaceutical use |
JPS599539B2 (ja) * | 1979-11-13 | 1984-03-03 | 日本化薬株式会社 | ニトログリセリン水溶液及びその製造法 |
JPS56139414A (en) * | 1980-04-01 | 1981-10-30 | Dai Ichi Seiyaku Co Ltd | Stabilizing method of aqueous solution |
JPS5727087A (en) * | 1980-07-25 | 1982-02-13 | Toshiba Corp | Wavelength sweeping laser |
US4490377A (en) * | 1980-07-29 | 1984-12-25 | Syntex (U.S.A.) Inc. | Acid stabilized compositions of thieno-pyridine derived compounds |
ATE22530T1 (de) * | 1980-07-29 | 1986-10-15 | Sanofi Sa | Durch saeure stabilisierte mischungen von thienopyridinderivaten und verfahren zum verhindern der zersetzung solcher verbindungen. |
JPS5762284A (en) * | 1980-10-01 | 1982-04-15 | Sumitomo Chem Co Ltd | Stabilizing method |
US4382091A (en) * | 1981-04-30 | 1983-05-03 | Syntex (U.S.A.) Inc. | Stabilization of 1-substituted imidazole derivatives in talc |
JPS5839618A (ja) * | 1981-09-04 | 1983-03-08 | Chugai Pharmaceut Co Ltd | 持続性積層錠剤 |
DE3244178A1 (de) * | 1982-11-30 | 1984-05-30 | Bayer Ag, 5090 Leverkusen | 1,4-dihydropyridinderivate, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
JPS60185727A (ja) * | 1984-03-05 | 1985-09-21 | Sumitomo Chem Co Ltd | 4−カルバモイルイミダゾリウム−5−オレ−ト製剤の安定化法 |
JPH0653658B2 (ja) * | 1984-12-17 | 1994-07-20 | 中外製薬株式会社 | 安定な錠剤の製造法 |
-
1986
- 1986-12-31 KR KR1019860011644A patent/KR950010150B1/ko not_active IP Right Cessation
-
1987
- 1987-01-13 JP JP557387A patent/JPH0713018B2/ja not_active Expired - Lifetime
- 1987-01-13 US US07/003,036 patent/US4769381A/en not_active Expired - Lifetime
- 1987-01-13 EP EP87100334A patent/EP0236679B1/de not_active Expired - Lifetime
- 1987-01-13 AT AT87100334T patent/ATE67406T1/de not_active IP Right Cessation
- 1987-01-13 ES ES198787100334T patent/ES2038605T3/es not_active Expired - Lifetime
- 1987-01-13 DE DE8787100334T patent/DE3773017D1/de not_active Expired - Lifetime
- 1987-01-14 AU AU67562/87A patent/AU594266B2/en not_active Expired
- 1987-01-14 CA CA000527318A patent/CA1285485C/en not_active Expired - Lifetime
-
1991
- 1991-12-16 GR GR91401997T patent/GR3003355T3/el unknown
-
1993
- 1993-05-18 SG SG646/93A patent/SG64693G/en unknown
- 1993-07-08 HK HK651/93A patent/HK65193A/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
SG64693G (en) | 1993-08-06 |
EP0236679A1 (de) | 1987-09-16 |
AU594266B2 (en) | 1990-03-01 |
KR950010150B1 (ko) | 1995-09-11 |
GR3003355T3 (en) | 1993-02-17 |
JPS62252722A (ja) | 1987-11-04 |
EP0236679B1 (de) | 1991-09-18 |
AU6756287A (en) | 1987-07-16 |
CA1285485C (en) | 1991-07-02 |
ES2038605T3 (es) | 1993-08-01 |
US4769381A (en) | 1988-09-06 |
KR870006892A (ko) | 1987-08-13 |
DE3773017D1 (de) | 1991-10-24 |
HK65193A (en) | 1993-07-16 |
JPH0713018B2 (ja) | 1995-02-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
EELA | Cancelled due to lapse of time |