ES8402262A1 - Procedimiento para la obtencion de nuevos derivados de omega-ciano-1,omega-difenil-aza-alcano. - Google Patents

Procedimiento para la obtencion de nuevos derivados de omega-ciano-1,omega-difenil-aza-alcano.

Info

Publication number
ES8402262A1
ES8402262A1 ES521545A ES521545A ES8402262A1 ES 8402262 A1 ES8402262 A1 ES 8402262A1 ES 521545 A ES521545 A ES 521545A ES 521545 A ES521545 A ES 521545A ES 8402262 A1 ES8402262 A1 ES 8402262A1
Authority
ES
Spain
Prior art keywords
omega
diphenyl
cyano
derivatives
azalcane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES521545A
Other languages
English (en)
Other versions
ES521545A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Publication of ES8402262A1 publication Critical patent/ES8402262A1/es
Publication of ES521545A0 publication Critical patent/ES521545A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE OMEGA-CIANO-1, OMEGA-DIFENIL-AZA-ALCANO, DE FORMULA (I), EN LA QUE R ELEVADO1, R ELEVADO 2, R ELEVADO 3, R ELEVADO 6, R ELEVADO 7 Y R ELEVADO 8 SON IGUALES O DIFERENTES Y SIGNIFICAN ATOMOS DE HIDROGENO, ATOMOS DE HALOGENO O GRUPOS HIDROXILO; R ELEVADO 4 ES UN GRUPO ALQUILO LINEAL O RAMIFICADO; R ELEVADO 5 ES UN ATOMO DE HIDROGENO O UN RADICAL ALQUILO CON 1 A 4 ATOMOS DE CARBONO; Y M Y N SON GIAULES O DIFERENTES Y REPRESENTAN 2, 3 O 4, Y SUS SALES CON ACIDOS FISIOLOGICAMENTE ACEPTABLES. CONSISTE EN HACER REACCIONAR UN OMEGA-AMINO-ALQUIL-FENILACETONITRILO, DE FORMULA (II), EN LA QUE R ELEVADO 1 HASTA R ELEVADO 5 Y M TIENEN LOS SIGNIFICADOS YA MENCIONADOS, CON UN ALDEHIDO DE FORMULA (III), EN LA QUE R ELEVADO 6 HASTA R ELEVADO 8 Y N TIENEN LOS SIGNIFICADOS YA INDICADOS, BAJO CONDICIONES REDUCTORAS. DE APLICACION EN EL TRATAMIENTO DE AFECCIONES FUNCIONALES DEL SISTEMA CARDIOVASCULAR. *FORMULA*.
ES521545A 1981-04-10 1983-04-15 Procedimiento para la obtencion de nuevos derivados de omega-ciano-1,omega-difenil-aza-alcano. Granted ES521545A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3114497 1981-04-10
DE19813144150 DE3144150A1 (de) 1981-04-10 1981-11-06 (omega)-cyan-1,(omega)-diphenyl-azaalkan-derivate, ihre herstellung und diese enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
ES8402262A1 true ES8402262A1 (es) 1984-01-16
ES521545A0 ES521545A0 (es) 1984-01-16

Family

ID=25792602

Family Applications (4)

Application Number Title Priority Date Filing Date
ES511260A Granted ES511260A0 (es) 1981-04-10 1982-04-07 Procedimiento para la obtencion de nuevos derivados de omega-ciano-1, omega-difenil-aza-alcano.
ES521543A Granted ES521543A0 (es) 1981-04-10 1983-04-15 Procedimiento para la obtencion de nuevos derivados de omega-ciano-1,omega-difenil-aza-alcano.
ES521545A Granted ES521545A0 (es) 1981-04-10 1983-04-15 Procedimiento para la obtencion de nuevos derivados de omega-ciano-1,omega-difenil-aza-alcano.
ES521544A Granted ES521544A0 (es) 1981-04-10 1983-04-15 Procedimiento para la obtencion de nuevos derivados de omega-ciano-1,omega difenil-aza-alcano.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES511260A Granted ES511260A0 (es) 1981-04-10 1982-04-07 Procedimiento para la obtencion de nuevos derivados de omega-ciano-1, omega-difenil-aza-alcano.
ES521543A Granted ES521543A0 (es) 1981-04-10 1983-04-15 Procedimiento para la obtencion de nuevos derivados de omega-ciano-1,omega-difenil-aza-alcano.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES521544A Granted ES521544A0 (es) 1981-04-10 1983-04-15 Procedimiento para la obtencion de nuevos derivados de omega-ciano-1,omega difenil-aza-alcano.

Country Status (19)

Country Link
US (1) US4438131A (es)
EP (1) EP0064158B1 (es)
AU (1) AU546383B2 (es)
CA (1) CA1184186A (es)
CS (4) CS238635B2 (es)
DD (1) DD201778A5 (es)
DE (2) DE3144150A1 (es)
DK (1) DK156513C (es)
ES (4) ES511260A0 (es)
FI (1) FI76550C (es)
GB (1) GB2100252B (es)
GR (1) GR75531B (es)
HU (1) HU186058B (es)
IE (1) IE54044B1 (es)
MX (1) MX9203501A (es)
NO (1) NO152129C (es)
PH (1) PH19739A (es)
SG (1) SG78584G (es)
SU (1) SU1308195A3 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3344755A1 (de) * 1983-12-10 1985-06-20 Basf Ag, 6700 Ludwigshafen 1,7-diphenyl-3-methylaza-7-cyan-8-methyl-nonan zur verwendung bei der bekaempfung von krankheiten
DE3433383A1 (de) * 1984-09-12 1986-03-20 Boehringer Mannheim Gmbh, 6800 Mannheim Neue phenyl-acetonitril-derivate
US4612329A (en) * 1984-10-17 1986-09-16 Hokuriku Pharmaceutical Co., Ltd. Pharmaceutical alpha-aminoalkyl-alpha-alkylphenylacetonitriles
US4760089A (en) * 1985-09-09 1988-07-26 Smithkline Beckman Corporation Irreversible dopamine-β-hydroxylase inhibitors
FR2588258B1 (fr) * 1985-10-04 1989-12-15 Adir Nouveaux derives d'amino-5 valeronitrile, leurs procedes de preparation et les compositions pharmaceutiques les renfermant
DE3535950A1 (de) * 1985-10-09 1987-04-09 Basf Ag Kombinationspraeparat
DE3535949A1 (de) * 1985-10-09 1987-04-09 Basf Ag Kombinationspraeparat
US4593042A (en) * 1985-10-18 1986-06-03 G. D. Searle & Co. Bicyclo-substituted phenylacetonitrile derivatives
GR862558B (en) * 1985-10-18 1987-02-12 Searle & Co Bicyclo-substituted phenylacetonitrile derivatives
DE3542994A1 (de) * 1985-12-05 1987-06-11 Basf Ag Basisch substituierte phenylacetaldehyde, ihre herstellung und diese enthaltende arzneimittel
DE3603032A1 (de) * 1986-01-31 1987-08-06 Basf Ag Basisch substituierte phenylacetonitrile, ihre herstellung und diese enthaltende arzneimittel
CS258534B1 (en) * 1986-07-18 1988-08-16 Ludvik Blaha Derivatives of valeronitrile and method of their preparation
DE3634389A1 (de) * 1986-10-09 1988-04-21 Knoll Ag Verwendung von anipamil
DE3642331A1 (de) * 1986-12-11 1988-06-23 Basf Ag Basisch substituierte phenylacetonitrile, ihre herstellung und diese enthaltende arzneimittel
ATE46439T1 (de) * 1986-12-13 1989-10-15 Basf Ag Kombinationspraeparat.
US5486539A (en) * 1989-12-21 1996-01-23 G. D. Searle & Co. Method of using phenylacetonitrilealkylaminoalkyl-ortho-substituted aryl compounds as immunosuppressives
US5247119A (en) * 1990-12-12 1993-09-21 G. D. Searle & Co. Phenylacetonitrilehydroxyalkylaminoalkyl-ortho-substituted aryl compounds as immunosuppressives
CS164891A3 (en) * 1991-05-31 1992-12-16 Vyzk Ustav Farm Biochem Sp N-arylalkyl derivatives of 2-aminomethyl-1,4-benzodioxan, and process forpreparing thereof
DE4124252A1 (de) * 1991-07-22 1993-01-28 Knoll Ag Verfahren zur herstellung einer sterilfiltrierbaren wirkstoffloesung
DE4234000A1 (de) * 1992-10-09 1994-04-14 Knoll Ag Verfahren zur Racemattrennung von Anipamil
CA2693627C (en) * 2007-06-20 2016-01-12 Milestone Pharmaceuticals Inc. Short acting phenylalkylamine calcium channel blockers and uses thereof
US9504747B2 (en) 2013-03-08 2016-11-29 Novartis Ag Lipids and lipid compositions for the delivery of active agents
JP6352950B2 (ja) * 2013-03-08 2018-07-04 ノバルティス アーゲー 活性薬物の送達のための脂質と脂質組成物
EP3169309B1 (en) 2014-07-16 2023-05-10 Novartis AG Method of encapsulating a nucleic acid in a lipid nanoparticle host

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA916719A (en) 1972-12-12 Dengel Ferdinand Basically substituted phenylacetonitriles and method for their preparation
DE1154810B (de) 1961-04-01 1963-09-26 Knoll Ag Verfahren zur Herstellung basisch substituierter Phenylacetonitrile
DE1643429A1 (de) * 1967-09-20 1971-01-28 Knoll Ag Basisch substituierte Phenylacetonitrile und Verfahren zu deren Herstellung
GB1202500A (en) 1967-12-08 1970-08-19 Knoll Ag Substituted phenylacetonitriles
GB1202750A (en) 1967-12-11 1970-08-19 Knoll Ag Substituted phenylacetonitriles
DE2059985C3 (de) 1970-12-05 1979-10-04 Knoll Ag, 6700 Ludwigshafen Rechtsdrehende, basisch substituierte Phenylacetonitrile, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
DE2059923C3 (de) 1970-12-05 1979-01-25 Knoll Ag, 6700 Ludwigshafen l-a-Isopropyl-o-[(N-methyl-N-homoveratryl)v-aminopropyl] -3,4-dimethoxyphenylacetonitril, Verfahren zu dessen Herstellung und dieses enthaltende Arzneimittel
DE2946545A1 (de) * 1979-11-17 1981-05-27 Basf Ag, 6700 Ludwigshafen Verfahren zur gewinnung der enantiomeren formen von 4-cyan-1-(n-methyl-n-(2'-((3'',4'',-dimethoxyphenyl))-aethyl)-amino)-5-methyl-4-(3',4',5'-trimethoxyphenyl)-hexan und dessen salzen

Also Published As

Publication number Publication date
ES8402261A1 (es) 1984-01-16
CS238635B2 (en) 1985-12-16
ES8307210A1 (es) 1983-07-01
ES8402560A1 (es) 1984-02-01
FI821252L (fi) 1982-10-11
FI821252A0 (fi) 1982-04-07
MX9203501A (es) 1992-09-01
ES521543A0 (es) 1984-02-01
FI76550B (fi) 1988-07-29
DK156513C (da) 1990-02-05
GB2100252B (en) 1984-06-27
DD201778A5 (de) 1983-08-10
GR75531B (es) 1984-07-26
EP0064158A1 (de) 1982-11-10
FI76550C (fi) 1988-11-10
CS238634B2 (en) 1985-12-16
AU546383B2 (en) 1985-08-29
HU186058B (en) 1985-05-28
DE3144150A1 (de) 1982-12-09
DK156513B (da) 1989-09-04
ES521545A0 (es) 1984-01-16
NO152129B (no) 1985-04-29
GB2100252A (en) 1982-12-22
US4438131A (en) 1984-03-20
SU1308195A3 (ru) 1987-04-30
SG78584G (en) 1985-04-26
DK159882A (da) 1982-10-11
IE54044B1 (en) 1989-05-24
CA1184186A (en) 1985-03-19
EP0064158B1 (de) 1985-03-13
PH19739A (en) 1986-06-23
CS238636B2 (en) 1985-12-16
DE3262516D1 (en) 1985-04-18
ES521544A0 (es) 1984-01-16
IE820856L (en) 1982-10-10
ES511260A0 (es) 1983-07-01
CS238621B2 (en) 1985-12-16
NO821085L (no) 1982-10-11
AU8249082A (en) 1983-04-21
NO152129C (no) 1985-08-07

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20010402