ES8705448A1 - Procedimiento para la obtencion de derivados de piridina - Google Patents

Procedimiento para la obtencion de derivados de piridina

Info

Publication number
ES8705448A1
ES8705448A1 ES555545A ES555545A ES8705448A1 ES 8705448 A1 ES8705448 A1 ES 8705448A1 ES 555545 A ES555545 A ES 555545A ES 555545 A ES555545 A ES 555545A ES 8705448 A1 ES8705448 A1 ES 8705448A1
Authority
ES
Spain
Prior art keywords
preparation
pyridine derivatives
ch2ch2nhr4
substances
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES555545A
Other languages
English (en)
Other versions
ES555545A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Publication of ES555545A0 publication Critical patent/ES555545A0/es
Publication of ES8705448A1 publication Critical patent/ES8705448A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE PIRIDINA, DE FORMULA (I), Y DE SUS SALES CON ACIDOS FISIOLOGICAMENTE COMPATIBLES. COMPRENDE LA REACCION DE UN PIRIDINOL DE FORMULA (II), CON UN COMPUESTO, DE FORMULA X-(CH2)4NHR4, PARA OBTENER UN COMPUESTO DE FORMULA (I), EN LAS QUE X ES UN GRUPO REACTIVO Y R1-R4 PUEDEN SER VARIOS TIPOS DE RADICALES. TAMBIEN SE PUEDE HACER REACCIONAR EL COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA Y-(CH2)4-Z, DONDE Y Y Z REPRESENTAN HALOGENO SEGUIDO DE REACCION CON LA AMINA DE FORMULA NH2-R4. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE ARRITMIAS.
ES555545A 1985-06-01 1986-05-30 Procedimiento para la obtencion de derivados de piridina Expired ES8705448A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853519693 DE3519693A1 (de) 1985-06-01 1985-06-01 Pyridin-derivate, ihre herstellung und verwendung

Publications (2)

Publication Number Publication Date
ES555545A0 ES555545A0 (es) 1987-05-01
ES8705448A1 true ES8705448A1 (es) 1987-05-01

Family

ID=6272202

Family Applications (1)

Application Number Title Priority Date Filing Date
ES555545A Expired ES8705448A1 (es) 1985-06-01 1986-05-30 Procedimiento para la obtencion de derivados de piridina

Country Status (13)

Country Link
US (1) US4730042A (es)
EP (1) EP0204269B1 (es)
JP (1) JPS61282360A (es)
AT (1) ATE53837T1 (es)
AU (1) AU587034B2 (es)
CA (1) CA1288102C (es)
DE (2) DE3519693A1 (es)
DK (1) DK159114C (es)
ES (1) ES8705448A1 (es)
FI (1) FI84827C (es)
HU (1) HU196199B (es)
IL (1) IL78666A (es)
ZA (1) ZA864041B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8808001D0 (en) * 1988-04-06 1988-05-05 Scras Stereospecific preparative process for furol(3,4-c)pyridine derivatives
PT1169322E (pt) 1999-03-08 2007-04-30 Medicure Inc Análogos de piridoxal para o tratamento de desordens causadas por uma deficiência em vitamina b-6.
AU5840200A (en) * 1999-07-13 2001-01-30 Medicure Inc. Treatment of diabetes and related pathologies
WO2001013900A2 (en) * 1999-08-24 2001-03-01 Medicure International Inc. Compositions for the treatment of cardiovascular diseases containing pyridoxal compounds and cardiovascular compounds
DK1268498T3 (da) 2000-02-29 2005-08-08 Medicure Int Inc Kardioprotektive phosphater
US7442689B2 (en) * 2000-02-29 2008-10-28 Medicure International Inc. Cardioprotective phosphonates and malonates
WO2001072309A2 (en) 2000-03-28 2001-10-04 Medicure International Inc. Treatment of cerebrovascular disease
US6548519B1 (en) 2001-07-06 2003-04-15 Medicure International Inc. Pyridoxine and pyridoxal analogues: novel uses
EP1299358B1 (en) 2000-07-07 2007-06-13 Medicure International Inc. Pyridoxine and pyridoxal analogues as cardiovascular therapeutics
US6897228B2 (en) * 2000-07-07 2005-05-24 Medicure International Inc. Pyridoxine and pyridoxal analogues: new uses
US20040121988A1 (en) * 2001-03-28 2004-06-24 Medicure International Inc. Treatment of cerebrovascular disease
US20040186077A1 (en) * 2003-03-17 2004-09-23 Medicure International Inc. Novel heteroaryl phosphonates as cardioprotective agents
EP1773370A1 (en) * 2004-07-07 2007-04-18 Medicure International Inc. Combination therapies employing platelet aggregation drugs
US20070060549A1 (en) * 2004-08-10 2007-03-15 Friesen Albert D Combination therapies employing ace inhibitors and uses thereof for the treatment of diabetic disorders
US7459468B2 (en) * 2004-10-28 2008-12-02 Medicure International, Inc. Aryl sulfonic pyridoxines as antiplatelet agents
US20060094749A1 (en) * 2004-10-28 2006-05-04 Medicure International Inc. Substituted pyridoxines as anti-platelet agents
WO2006050598A1 (en) * 2004-10-28 2006-05-18 Medicure International Inc. Dual antiplatelet/anticoagulant pyridoxine analogs
WO2007059631A1 (en) * 2005-11-28 2007-05-31 Medicure International Inc. Selected dosage for the treatment of cardiovascular and related pathologies
KR102240821B1 (ko) * 2017-03-13 2021-04-15 광주과학기술원 Ｐ2ｘ1 및 ｐ2ｘ3 수용체 길항제로 사용되는 신규한 5-히드록시 피리딘계 화합물 및 이를 포함하는 약학적 조성물

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2711655A1 (de) * 1977-03-17 1978-09-21 Basf Ag Pyridinyl-aminoalkylaether
IL62602A (en) * 1980-05-19 1984-06-29 Labaz Sanofi Nv Pyridoxine derivatives,their preparation and pharmaceutical compositions containing them
IN156817B (es) * 1981-02-10 1985-11-09 Scras

Also Published As

Publication number Publication date
FI862314A0 (fi) 1986-05-30
DK254386A (da) 1986-12-02
JPS61282360A (ja) 1986-12-12
HU196199B (en) 1988-10-28
US4730042A (en) 1988-03-08
ES555545A0 (es) 1987-05-01
DK159114C (da) 1991-02-11
FI84827B (fi) 1991-10-15
AU587034B2 (en) 1989-08-03
DE3519693A1 (de) 1987-01-02
FI84827C (fi) 1992-01-27
DK159114B (da) 1990-09-03
CA1288102C (en) 1991-08-27
ZA864041B (en) 1987-01-28
DE3670841D1 (de) 1990-06-07
DK254386D0 (da) 1986-05-30
EP0204269A1 (de) 1986-12-10
ATE53837T1 (de) 1990-06-15
AU5809586A (en) 1986-12-04
HUT41795A (en) 1987-05-28
IL78666A (en) 1989-09-28
IL78666A0 (en) 1986-08-31
FI862314A (fi) 1986-12-02
EP0204269B1 (de) 1990-05-02

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970203