ES8800666A1 - Procedimiento para la obtencion de derivados de 1,4-dihidropiridina - Google Patents

Procedimiento para la obtencion de derivados de 1,4-dihidropiridina

Info

Publication number
ES8800666A1
ES8800666A1 ES554339A ES554339A ES8800666A1 ES 8800666 A1 ES8800666 A1 ES 8800666A1 ES 554339 A ES554339 A ES 554339A ES 554339 A ES554339 A ES 554339A ES 8800666 A1 ES8800666 A1 ES 8800666A1
Authority
ES
Spain
Prior art keywords
medicaments
preparation
dihydropyridine derivatives
dihydropyridine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES554339A
Other languages
English (en)
Other versions
ES554339A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES554339A0 publication Critical patent/ES554339A0/es
Publication of ES8800666A1 publication Critical patent/ES8800666A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE 1,4-DIHIDROPIRIDINA, DE FORMULA (I). COMPRENDE LA REACCION DE 2-BENCILIDEN-ACETOACETATOS, DE FORMULA (II), CON 2-AMINOCROTONATO DE (2-ACETOXI-2-METIL)-PROPILO, EN UN DISOLVENTE INERTE, A UNA TEMPERATURA COMPRENDIDA ENTRE 20JC Y 150JC; SEGUIDA DE LA SOLVOLISIS DEL COMPUESTO FORMADO, EN UN DISOLVENTE INERTE, A UNA TEMPERATURA COMPRENDIDA ENTRE 0JC Y 180JC, PARA OBTENER EL COMPUESTO DE FORMULA (I), EN LA QUE R1, R2 Y R3 PUEDEN SER VARIOS TIPOS DE RADICALES. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU EFECTO SOBRE EL SISTEMA CIRCULATORIO.
ES554339A 1985-04-25 1986-04-24 Procedimiento para la obtencion de derivados de 1,4-dihidropiridina Expired ES8800666A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853514865 DE3514865A1 (de) 1985-04-25 1985-04-25 1,4-dihydropyridin-derivate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln

Publications (2)

Publication Number Publication Date
ES554339A0 ES554339A0 (es) 1987-11-16
ES8800666A1 true ES8800666A1 (es) 1987-11-16

Family

ID=6269035

Family Applications (1)

Application Number Title Priority Date Filing Date
ES554339A Expired ES8800666A1 (es) 1985-04-25 1986-04-24 Procedimiento para la obtencion de derivados de 1,4-dihidropiridina

Country Status (4)

Country Link
EP (1) EP0199238A1 (es)
JP (1) JPS61251661A (es)
DE (1) DE3514865A1 (es)
ES (1) ES8800666A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0688973B2 (ja) * 1987-03-12 1994-11-09 京都薬品工業株式会社 １，４−ジヒドロピリジン誘導体
ES2193148T3 (es) * 1993-12-10 2003-11-01 Bayer Ag 1,4-dihidropiridinas sustituidas con fenilo con actividad cerebral.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2847236A1 (de) * 1978-10-31 1980-05-14 Bayer Ag Neue dihydropyridine mit substituierten estergruppierungen, mehrer verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
GB2111978B (en) * 1981-10-19 1985-05-01 Maruko Pharmaceutical Co 1 4-dihydropyridine compounds

Also Published As

Publication number Publication date
ES554339A0 (es) 1987-11-16
EP0199238A1 (de) 1986-10-29
JPS61251661A (ja) 1986-11-08
DE3514865A1 (de) 1986-11-06

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