DK159882A - Fremgangsmaade til fremstilling af omega-cyan-1,omega-diphenyl-azaalkanderivater - Google Patents

Fremgangsmaade til fremstilling af omega-cyan-1,omega-diphenyl-azaalkanderivater Download PDF

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Publication number
DK159882A
DK159882A DK159882A DK159882A DK159882A DK 159882 A DK159882 A DK 159882A DK 159882 A DK159882 A DK 159882A DK 159882 A DK159882 A DK 159882A DK 159882 A DK159882 A DK 159882A
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DK
Denmark
Prior art keywords
thermostable
preparing
specific lipase
lipase preparation
preparation
Prior art date
Application number
DK159882A
Other languages
English (en)
Other versions
DK156513B (da
DK156513C (da
Inventor
O Ehrmann
M Raschack
J Gries
R Kretzschmar
L Friedrich
C D Mueller
W Frank
D Wuppermann
F Zimmermann
W Seitz
H J Treiber
F Dengel
H-G Kurbjuweit
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of DK159882A publication Critical patent/DK159882A/da
Publication of DK156513B publication Critical patent/DK156513B/da
Application granted granted Critical
Publication of DK156513C publication Critical patent/DK156513C/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
DK159882A 1981-04-10 1982-04-07 Analogifremgangsmaade til fremstilling af omega-cyan-1,-omega-diphenyl-azaalkanderivater eller salte deraf med fysiologisk acceptable syrer DK156513C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE3114497 1981-04-10
DE3114497 1981-04-10
DE19813144150 DE3144150A1 (de) 1981-04-10 1981-11-06 (omega)-cyan-1,(omega)-diphenyl-azaalkan-derivate, ihre herstellung und diese enthaltende arzneimittel
DE3144150 1981-11-06

Publications (3)

Publication Number Publication Date
DK159882A true DK159882A (da) 1982-10-11
DK156513B DK156513B (da) 1989-09-04
DK156513C DK156513C (da) 1990-02-05

Family

ID=25792602

Family Applications (1)

Application Number Title Priority Date Filing Date
DK159882A DK156513C (da) 1981-04-10 1982-04-07 Analogifremgangsmaade til fremstilling af omega-cyan-1,-omega-diphenyl-azaalkanderivater eller salte deraf med fysiologisk acceptable syrer

Country Status (19)

Country Link
US (1) US4438131A (da)
EP (1) EP0064158B1 (da)
AU (1) AU546383B2 (da)
CA (1) CA1184186A (da)
CS (4) CS238634B2 (da)
DD (1) DD201778A5 (da)
DE (2) DE3144150A1 (da)
DK (1) DK156513C (da)
ES (4) ES8307210A1 (da)
FI (1) FI76550C (da)
GB (1) GB2100252B (da)
GR (1) GR75531B (da)
HU (1) HU186058B (da)
IE (1) IE54044B1 (da)
MX (1) MX9203501A (da)
NO (1) NO152129C (da)
PH (1) PH19739A (da)
SG (1) SG78584G (da)
SU (1) SU1308195A3 (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3344755A1 (de) * 1983-12-10 1985-06-20 Basf Ag, 6700 Ludwigshafen 1,7-diphenyl-3-methylaza-7-cyan-8-methyl-nonan zur verwendung bei der bekaempfung von krankheiten
DE3433383A1 (de) * 1984-09-12 1986-03-20 Boehringer Mannheim Gmbh, 6800 Mannheim Neue phenyl-acetonitril-derivate
US4612329A (en) * 1984-10-17 1986-09-16 Hokuriku Pharmaceutical Co., Ltd. Pharmaceutical alpha-aminoalkyl-alpha-alkylphenylacetonitriles
US4760089A (en) * 1985-09-09 1988-07-26 Smithkline Beckman Corporation Irreversible dopamine-β-hydroxylase inhibitors
FR2588258B1 (fr) * 1985-10-04 1989-12-15 Adir Nouveaux derives d'amino-5 valeronitrile, leurs procedes de preparation et les compositions pharmaceutiques les renfermant
DE3535950A1 (de) * 1985-10-09 1987-04-09 Basf Ag Kombinationspraeparat
DE3535949A1 (de) * 1985-10-09 1987-04-09 Basf Ag Kombinationspraeparat
GR862558B (en) * 1985-10-18 1987-02-12 Searle & Co Bicyclo-substituted phenylacetonitrile derivatives
US4593042A (en) * 1985-10-18 1986-06-03 G. D. Searle & Co. Bicyclo-substituted phenylacetonitrile derivatives
DE3542994A1 (de) * 1985-12-05 1987-06-11 Basf Ag Basisch substituierte phenylacetaldehyde, ihre herstellung und diese enthaltende arzneimittel
DE3603032A1 (de) * 1986-01-31 1987-08-06 Basf Ag Basisch substituierte phenylacetonitrile, ihre herstellung und diese enthaltende arzneimittel
CS258534B1 (en) * 1986-07-18 1988-08-16 Ludvik Blaha Derivatives of valeronitrile and method of their preparation
DE3634389A1 (de) * 1986-10-09 1988-04-21 Knoll Ag Verwendung von anipamil
DE3642331A1 (de) * 1986-12-11 1988-06-23 Basf Ag Basisch substituierte phenylacetonitrile, ihre herstellung und diese enthaltende arzneimittel
ATE46439T1 (de) * 1986-12-13 1989-10-15 Basf Ag Kombinationspraeparat.
US5486539A (en) * 1989-12-21 1996-01-23 G. D. Searle & Co. Method of using phenylacetonitrilealkylaminoalkyl-ortho-substituted aryl compounds as immunosuppressives
US5247119A (en) * 1990-12-12 1993-09-21 G. D. Searle & Co. Phenylacetonitrilehydroxyalkylaminoalkyl-ortho-substituted aryl compounds as immunosuppressives
CS164891A3 (en) * 1991-05-31 1992-12-16 Vyzk Ustav Farm Biochem Sp N-arylalkyl derivatives of 2-aminomethyl-1,4-benzodioxan, and process forpreparing thereof
DE4124252A1 (de) * 1991-07-22 1993-01-28 Knoll Ag Verfahren zur herstellung einer sterilfiltrierbaren wirkstoffloesung
DE4234000A1 (de) * 1992-10-09 1994-04-14 Knoll Ag Verfahren zur Racemattrennung von Anipamil
DK2170050T3 (da) * 2007-06-20 2014-09-29 Milestone Pharmaceuticals Inc Korttidsvirkende phenylalkylamin-calciumkanalblokkere og anvendelser deraf
BR112015021791B1 (pt) 2013-03-08 2022-08-30 Novartis Ag Compostos de lipídio catiônico e composições de lipídios e farmacêuticas
US9504747B2 (en) 2013-03-08 2016-11-29 Novartis Ag Lipids and lipid compositions for the delivery of active agents
CN106794141B (zh) 2014-07-16 2021-05-28 诺华股份有限公司 将核酸包封在脂质纳米粒主体中的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA916719A (en) 1972-12-12 Dengel Ferdinand Basically substituted phenylacetonitriles and method for their preparation
DE1154810B (de) 1961-04-01 1963-09-26 Knoll Ag Verfahren zur Herstellung basisch substituierter Phenylacetonitrile
DE1643429A1 (de) * 1967-09-20 1971-01-28 Knoll Ag Basisch substituierte Phenylacetonitrile und Verfahren zu deren Herstellung
GB1202500A (en) 1967-12-08 1970-08-19 Knoll Ag Substituted phenylacetonitriles
GB1202750A (en) 1967-12-11 1970-08-19 Knoll Ag Substituted phenylacetonitriles
DE2059923C3 (de) 1970-12-05 1979-01-25 Knoll Ag, 6700 Ludwigshafen l-a-Isopropyl-o-[(N-methyl-N-homoveratryl)v-aminopropyl] -3,4-dimethoxyphenylacetonitril, Verfahren zu dessen Herstellung und dieses enthaltende Arzneimittel
DE2059985C3 (de) 1970-12-05 1979-10-04 Knoll Ag, 6700 Ludwigshafen Rechtsdrehende, basisch substituierte Phenylacetonitrile, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
DE2946545A1 (de) 1979-11-17 1981-05-27 Basf Ag, 6700 Ludwigshafen Verfahren zur gewinnung der enantiomeren formen von 4-cyan-1-(n-methyl-n-(2'-((3'',4'',-dimethoxyphenyl))-aethyl)-amino)-5-methyl-4-(3',4',5'-trimethoxyphenyl)-hexan und dessen salzen

Also Published As

Publication number Publication date
GB2100252A (en) 1982-12-22
NO152129C (no) 1985-08-07
ES8402560A1 (es) 1984-02-01
AU546383B2 (en) 1985-08-29
FI76550C (fi) 1988-11-10
EP0064158B1 (de) 1985-03-13
NO152129B (no) 1985-04-29
ES521544A0 (es) 1984-01-16
FI821252L (fi) 1982-10-11
IE820856L (en) 1982-10-10
FI821252A0 (fi) 1982-04-07
IE54044B1 (en) 1989-05-24
SU1308195A3 (ru) 1987-04-30
GR75531B (da) 1984-07-26
EP0064158A1 (de) 1982-11-10
CS238634B2 (en) 1985-12-16
MX9203501A (es) 1992-09-01
CS238636B2 (en) 1985-12-16
DD201778A5 (de) 1983-08-10
DE3144150A1 (de) 1982-12-09
HU186058B (en) 1985-05-28
NO821085L (no) 1982-10-11
SG78584G (en) 1985-04-26
DK156513B (da) 1989-09-04
ES8402261A1 (es) 1984-01-16
DE3262516D1 (en) 1985-04-18
CS238621B2 (en) 1985-12-16
CA1184186A (en) 1985-03-19
FI76550B (fi) 1988-07-29
ES521543A0 (es) 1984-02-01
ES511260A0 (es) 1983-07-01
DK156513C (da) 1990-02-05
ES8402262A1 (es) 1984-01-16
GB2100252B (en) 1984-06-27
ES8307210A1 (es) 1983-07-01
US4438131A (en) 1984-03-20
ES521545A0 (es) 1984-01-16
CS238635B2 (en) 1985-12-16
AU8249082A (en) 1983-04-21
PH19739A (en) 1986-06-23

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