NO924650L - Dialkoksy-pyridinyl-benzimidazolderivater, fremgangsmaate for deres fremstilling og deres farmasoeytiske anvendelse - Google Patents
Dialkoksy-pyridinyl-benzimidazolderivater, fremgangsmaate for deres fremstilling og deres farmasoeytiske anvendelseInfo
- Publication number
- NO924650L NO924650L NO92924650A NO924650A NO924650L NO 924650 L NO924650 L NO 924650L NO 92924650 A NO92924650 A NO 92924650A NO 924650 A NO924650 A NO 924650A NO 924650 L NO924650 L NO 924650L
- Authority
- NO
- Norway
- Prior art keywords
- dialcoxy
- pyridinyl
- procedures
- preparation
- pharmaceutical use
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Nye forbindelser med formel (I) l ^"ACH2 hvor R1 og R2, som er forskjellige, hver er H, alkyl Inneholdende 1-4 karbonatomer eller -C(0)-R5; hvor R5 er alkyl inneholdende 1-4 karbonataner eller alkoksy Inneholdende 1-4 karbonataner; og en av R1, eller R2 alltid er valgt fra gruppen -C(0)-R5; R3 og R4 er like eller forskjellige og er valgt fra -GH3. -C2H5, -CH2- -<C]. -CHz-V ) °8 eller R3 og R* sammen med de tilstøtende oksygenatomer som er festet til ; pyridinringen og karbonatomene i pyridinringen danner en ring, | hvor den del som utgjøres av R3 og R4 er -C&2CS2C&2~ r -CHgCIfø- eller -CH2-; samt mellomprodukter, farmasøytiske preparater inneholdende slike forbindelser som aktiv bestanddel og anvendelse av forbindelsene i medisinen.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9002207A SE9002207D0 (sv) | 1990-06-20 | 1990-06-20 | New compounds i |
SE9002206A SE9002206D0 (sv) | 1990-06-20 | 1990-06-20 | New compounds |
PCT/SE1991/000416 WO1991019712A1 (en) | 1990-06-20 | 1991-06-11 | Dialkoxy-pyridinyl-benzimidazole derivatives, process for their preparation and their pharmaceutical use |
Publications (2)
Publication Number | Publication Date |
---|---|
NO924650D0 NO924650D0 (no) | 1992-12-02 |
NO924650L true NO924650L (no) | 1992-12-02 |
Family
ID=26660803
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO92924650A NO924650L (no) | 1990-06-20 | 1992-12-02 | Dialkoksy-pyridinyl-benzimidazolderivater, fremgangsmaate for deres fremstilling og deres farmasoeytiske anvendelse |
Country Status (29)
Country | Link |
---|---|
US (1) | US5430042A (no) |
EP (1) | EP0593463B1 (no) |
JP (1) | JP3049367B2 (no) |
CN (1) | CN1058213A (no) |
AP (1) | AP253A (no) |
AT (1) | ATE184602T1 (no) |
AU (1) | AU649456B2 (no) |
BG (1) | BG97198A (no) |
CA (1) | CA2083606C (no) |
CZ (1) | CZ279434B6 (no) |
DE (1) | DE69131627T2 (no) |
EG (1) | EG19752A (no) |
ES (1) | ES2140391T3 (no) |
FI (1) | FI925767A0 (no) |
HU (1) | HUT62882A (no) |
IE (1) | IE912026A1 (no) |
IL (1) | IL98472A (no) |
IS (1) | IS3720A7 (no) |
LV (1) | LV10269B (no) |
MA (1) | MA22198A1 (no) |
NO (1) | NO924650L (no) |
NZ (1) | NZ238545A (no) |
OA (1) | OA09683A (no) |
PL (2) | PL166209B1 (no) |
PT (1) | PT98036A (no) |
RO (1) | RO110497B1 (no) |
TN (1) | TNSN91050A1 (no) |
WO (1) | WO1991019712A1 (no) |
YU (1) | YU104091A (no) |
Families Citing this family (63)
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SE9103776D0 (sv) * | 1991-12-19 | 1991-12-19 | Astra Ab | New compounds |
TNSN95062A1 (fr) * | 1994-05-27 | 1996-02-06 | Astra Ab | Nouveaux derives dialkoxy-pyridinyle-benzimidazole |
SE9402431D0 (sv) * | 1994-07-08 | 1994-07-08 | Astra Ab | New tablet formulation |
ATE414509T1 (de) * | 1994-07-08 | 2008-12-15 | Astrazeneca Ab | Aus vielen einzeleinheiten zusammengesetzte tablettierte dosisform |
GB9423970D0 (en) * | 1994-11-28 | 1995-01-11 | Astra Ab | Oxidation |
SE9500422D0 (sv) * | 1995-02-06 | 1995-02-06 | Astra Ab | New oral pharmaceutical dosage forms |
SE9500478D0 (sv) * | 1995-02-09 | 1995-02-09 | Astra Ab | New pharmaceutical formulation and process |
US5545661A (en) * | 1995-05-16 | 1996-08-13 | Eli Lilly And Company | Methods for inhibiting bone loss with bis-pyrone oxovanadium compounds |
US6489346B1 (en) * | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
US5840737A (en) | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
US6699885B2 (en) * | 1996-01-04 | 2004-03-02 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and methods of using same |
US6645988B2 (en) * | 1996-01-04 | 2003-11-11 | Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
SE9600070D0 (sv) * | 1996-01-08 | 1996-01-08 | Astra Ab | New oral pharmaceutical dosage forms |
EP0983263A1 (en) * | 1997-05-30 | 2000-03-08 | Dr. Reddy's Research Foundation | Novel benzimidazole derivatives as antiulcer agents, process for their preparation and pharmaceutical compositions containing them |
KR100570104B1 (ko) * | 1997-07-11 | 2006-04-11 | 에자이 가부시키가이샤 | 피리딘 유도체의 제조방법 |
GB9805558D0 (en) * | 1998-03-17 | 1998-05-13 | Knoll Ag | Chemical process` |
US6093734A (en) * | 1998-08-10 | 2000-07-25 | Partnership Of Michael E. Garst, George Sachs, And Jai Moo Shin | Prodrugs of proton pump inhibitors |
TR200100431T2 (tr) | 1998-08-10 | 2001-06-21 | Partnership Of Michael E. Garst, George Sachs & Jai Moo | Proton pompalama önleyici ilaçlar |
SE0101379D0 (sv) | 2001-04-18 | 2001-04-18 | Diabact Ab | Komposition som hämmar utsöndring av magsyra |
US8206741B2 (en) | 2001-06-01 | 2012-06-26 | Pozen Inc. | Pharmaceutical compositions for the coordinated delivery of NSAIDs |
US20040006111A1 (en) * | 2002-01-25 | 2004-01-08 | Kenneth Widder | Transmucosal delivery of proton pump inhibitors |
EP1492511B3 (fr) | 2002-04-09 | 2012-05-02 | Flamel Technologies | Formulation pharmaceutique orale sous forme de suspension aqueuse de microcapsules permettant la liberation modifiee de principe(s) actif(s) |
RU2292342C2 (ru) * | 2002-07-19 | 2007-01-27 | Уинстон Фармасьютикалс ЛЛС. | Производные бензимидазола и их применение в качестве пролекарств ингибиторов протонного насоса |
SE0203065D0 (sv) | 2002-10-16 | 2002-10-16 | Diabact Ab | Gastric acid secretion inhibiting composition |
CA2517005A1 (en) * | 2003-02-20 | 2004-09-02 | Santarus, Inc. | A novel formulation, omeprazole antacid complex-immediate release for rapid and sustained suppression of gastric acid |
EP2112920B1 (en) * | 2003-06-26 | 2018-07-25 | Intellipharmaceutics Corp. | Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient |
AU2004257864A1 (en) * | 2003-07-18 | 2005-01-27 | Santarus, Inc. | Pharmaceutical formulation and method for treating acid-caused gastrointestinal disorders |
US8993599B2 (en) * | 2003-07-18 | 2015-03-31 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
CA2540308C (en) | 2003-09-26 | 2013-08-06 | Alza Corporation | Drug coating providing high drug loading and methods for providing the same |
WO2005039640A1 (en) * | 2003-10-03 | 2005-05-06 | Allergan Inc. | Compositions comprising trefoil factor family peptides and/or mucoadhesives and proton pump inhibitor prodrugs |
US20050075371A1 (en) * | 2003-10-03 | 2005-04-07 | Allergan, Inc. | Methods and compositions for the oral administration of prodrugs of proton pump inhibitors |
EP1715854A2 (en) * | 2004-02-18 | 2006-11-02 | Allergan, Inc. | Prodrugs for the intravenous administration of proton pump inhibitors |
EP1715861A2 (en) * | 2004-02-18 | 2006-11-02 | Allergan, Inc. | Compositions comprising prodrugs of proton pump inhibitors |
TW200606163A (en) * | 2004-04-22 | 2006-02-16 | Eisai Co Ltd | Imidazopyridine compound |
US8815916B2 (en) * | 2004-05-25 | 2014-08-26 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
US8906940B2 (en) * | 2004-05-25 | 2014-12-09 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
US8394409B2 (en) | 2004-07-01 | 2013-03-12 | Intellipharmaceutics Corp. | Controlled extended drug release technology |
US7829718B2 (en) * | 2004-08-06 | 2010-11-09 | Eisai R&D Management Co., Ltd. | Salts of benzimidazole derivative with amines and process for manufacturing the same |
US10624858B2 (en) | 2004-08-23 | 2020-04-21 | Intellipharmaceutics Corp | Controlled release composition using transition coating, and method of preparing same |
US8541026B2 (en) | 2004-09-24 | 2013-09-24 | Abbvie Inc. | Sustained release formulations of opioid and nonopioid analgesics |
US20070015782A1 (en) | 2005-04-15 | 2007-01-18 | Eisai Co., Ltd. | Benzimidazole compound |
US9040564B2 (en) | 2005-04-28 | 2015-05-26 | Eisai R&D Management Co., Ltd. | Stabilized composition |
US7803817B2 (en) | 2005-05-11 | 2010-09-28 | Vecta, Ltd. | Composition and methods for inhibiting gastric acid secretion |
US7981908B2 (en) | 2005-05-11 | 2011-07-19 | Vecta, Ltd. | Compositions and methods for inhibiting gastric acid secretion |
US10064828B1 (en) | 2005-12-23 | 2018-09-04 | Intellipharmaceutics Corp. | Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems |
US9561188B2 (en) | 2006-04-03 | 2017-02-07 | Intellipharmaceutics Corporation | Controlled release delivery device comprising an organosol coat |
WO2007122686A1 (ja) * | 2006-04-14 | 2007-11-01 | Eisai R & D Management Co., Ltd. | ベンズイミダゾール化合物 |
US10960077B2 (en) | 2006-05-12 | 2021-03-30 | Intellipharmaceutics Corp. | Abuse and alcohol resistant drug composition |
RU2467747C2 (ru) | 2006-07-25 | 2012-11-27 | Векта Лтд. | Композиции и способы для ингибирования секреции желудочной кислоты с использованием производных малых дикарбоновых кислот в сочетании с ppi |
US20100317689A1 (en) * | 2006-09-19 | 2010-12-16 | Garst Michael E | Prodrugs of proton pump inhibitors including the 1h-imidazo[4,5-b] pyridine moiety |
US20090092658A1 (en) * | 2007-10-05 | 2009-04-09 | Santarus, Inc. | Novel formulations of proton pump inhibitors and methods of using these formulations |
WO2008047681A1 (fr) | 2006-10-13 | 2008-04-24 | Eisai R & D Management Co., Ltd. | Benzimidazole présentant une activité inhibitrice de la sécrétion d'acide gastrique |
JP2009196894A (ja) * | 2006-10-13 | 2009-09-03 | Eisai R & D Management Co Ltd | スルフィニルベンズイミダゾール化合物またはその塩の製造方法 |
US20080103169A1 (en) | 2006-10-27 | 2008-05-01 | The Curators Of The University Of Missouri | Compositions comprising acid labile proton pump inhibiting agents, at least one other pharmaceutically active agent and methods of using same |
US20080194307A1 (en) * | 2007-02-13 | 2008-08-14 | Jeff Sanger | Sports-based game of chance |
CN101980700A (zh) | 2008-02-20 | 2011-02-23 | 密苏里大学董事会 | 包含奥美拉唑和兰索拉唑以及缓冲剂的组合的组合物及其使用方法 |
KR20110079641A (ko) | 2008-09-09 | 2011-07-07 | 아스트라제네카 아베 | 제약 조성물을 이를 필요로 하는 환자에게 전달하는 방법 |
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EP2519229A2 (en) | 2009-12-29 | 2012-11-07 | Novartis AG | New pharmaceutical dosage form for the treatment of gastric acid-related disorders |
EP2601947A1 (en) | 2011-12-05 | 2013-06-12 | Abo Bakr Mohammed Ali Al-Mehdar | Fixed-dose combination for treatment of helicobacter pylori associated diseases |
CN104519888A (zh) | 2011-12-28 | 2015-04-15 | 波曾公司 | 用于递送奥美拉唑和乙酰水杨酸的改良组合物和方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE7804231L (sv) * | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
US4359465A (en) * | 1980-07-28 | 1982-11-16 | The Upjohn Company | Methods for treating gastrointestinal inflammation |
AU568441B2 (en) * | 1984-09-24 | 1987-12-24 | Upjohn Company, The | 2-(pyridylalkenesulfinyl) benzimidazole derivatives |
IL76839A (en) * | 1984-10-31 | 1988-08-31 | Byk Gulden Lomberg Chem Fab | Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same |
SE8500996D0 (sv) * | 1985-03-01 | 1985-03-01 | Haessle Ab | Method of treatment |
US4738975A (en) * | 1985-07-02 | 1988-04-19 | Takeda Chemical Industries, Ltd. | Pyridine derivatives, and use as anti-ulcer agents |
SE8505112D0 (sv) * | 1985-10-29 | 1985-10-29 | Haessle Ab | Novel pharmacological compounds |
NZ234564A (en) * | 1986-11-21 | 1991-04-26 | Haessle Ab | 1-substituted benzimidazoles and pharmaceutical compositions |
DE3722810A1 (de) * | 1987-07-10 | 1989-01-19 | Hoechst Ag | Substituierte benzimidazole, verfahren zu deren herstellung, diese enthaltende pharmazeutische zubereitungen und deren verwendung |
JPH02501930A (ja) * | 1987-10-30 | 1990-06-28 | アクチエボラゲツト・ヘツスレ | 薬学的化合物のための新規な用途 |
ZA889194B (en) * | 1987-12-11 | 1989-08-30 | Byk Gulden Lomberg Chemisch Fa | Novel benzimidazole derivatives |
JPH03504497A (ja) * | 1988-05-25 | 1991-10-03 | ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | 新規フルオルアルコキシ化合物 |
SE8804628D0 (sv) * | 1988-12-22 | 1988-12-22 | Ab Haessle | New compounds |
US4965269A (en) * | 1989-12-20 | 1990-10-23 | Ab Hassle | Therapeutically active chloro substituted benzimidazoles |
-
1991
- 1991-06-11 WO PCT/SE1991/000416 patent/WO1991019712A1/en active IP Right Grant
- 1991-06-11 AU AU80617/91A patent/AU649456B2/en not_active Ceased
- 1991-06-11 JP JP3511436A patent/JP3049367B2/ja not_active Expired - Fee Related
- 1991-06-11 PL PL91297294A patent/PL166209B1/pl unknown
- 1991-06-11 PL PL91297295A patent/PL165898B1/pl unknown
- 1991-06-11 HU HU924034A patent/HUT62882A/hu unknown
- 1991-06-11 EP EP91911618A patent/EP0593463B1/en not_active Expired - Lifetime
- 1991-06-11 CA CA002083606A patent/CA2083606C/en not_active Expired - Fee Related
- 1991-06-11 RO RO92-01543A patent/RO110497B1/ro unknown
- 1991-06-11 ES ES91911618T patent/ES2140391T3/es not_active Expired - Lifetime
- 1991-06-11 DE DE69131627T patent/DE69131627T2/de not_active Expired - Fee Related
- 1991-06-11 AT AT91911618T patent/ATE184602T1/de not_active IP Right Cessation
- 1991-06-12 YU YU104091A patent/YU104091A/sh unknown
- 1991-06-12 IL IL9847291A patent/IL98472A/en not_active IP Right Cessation
- 1991-06-14 IE IE202691A patent/IE912026A1/en unknown
- 1991-06-14 NZ NZ238545A patent/NZ238545A/xx unknown
- 1991-06-18 EG EG38491A patent/EG19752A/xx active
- 1991-06-18 MA MA22461A patent/MA22198A1/fr unknown
- 1991-06-19 TN TNTNSN91050A patent/TNSN91050A1/fr unknown
- 1991-06-19 AP APAP/P/1991/000286A patent/AP253A/en active
- 1991-06-19 PT PT98036A patent/PT98036A/pt not_active Application Discontinuation
- 1991-06-20 IS IS3720A patent/IS3720A7/is unknown
- 1991-06-20 US US07/718,188 patent/US5430042A/en not_active Expired - Lifetime
- 1991-06-20 CZ CS911893A patent/CZ279434B6/cs unknown
- 1991-06-20 CN CN91105025A patent/CN1058213A/zh active Pending
-
1992
- 1992-11-27 OA OA60307A patent/OA09683A/en unknown
- 1992-12-02 NO NO92924650A patent/NO924650L/no unknown
- 1992-12-18 BG BG097198A patent/BG97198A/bg unknown
- 1992-12-18 FI FI925767A patent/FI925767A0/fi not_active Application Discontinuation
-
1993
- 1993-06-30 LV LVP-93-820A patent/LV10269B/en unknown
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