AP218A - Benzoquinazole derivatives and pharmaceutical compounds thereof. - Google Patents

Benzoquinazole derivatives and pharmaceutical compounds thereof. Download PDF

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Publication number
AP218A
AP218A APAP/P/1991/000283A AP9100283A AP218A AP 218 A AP218 A AP 218A AP 9100283 A AP9100283 A AP 9100283A AP 218 A AP218 A AP 218A
Authority
AP
ARIPO
Prior art keywords
group
amino
methyl
compound
hydrogen
Prior art date
Application number
APAP/P/1991/000283A
Other languages
English (en)
Other versions
AP9100283A0 (en
Inventor
William Pendergast
Howard Dickerson
Julius Vass Johnson
Robert Ferone
Original Assignee
The Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Wellcome Foundation Ltd filed Critical The Wellcome Foundation Ltd
Publication of AP9100283A0 publication Critical patent/AP9100283A0/xx
Application granted granted Critical
Publication of AP218A publication Critical patent/AP218A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
APAP/P/1991/000283A 1990-06-19 1991-06-18 Benzoquinazole derivatives and pharmaceutical compounds thereof. AP218A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909013615A GB9013615D0 (en) 1990-06-19 1990-06-19 Pharmaceutical compounds

Publications (2)

Publication Number Publication Date
AP9100283A0 AP9100283A0 (en) 1991-07-31
AP218A true AP218A (en) 1992-09-27

Family

ID=10677828

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1991/000283A AP218A (en) 1990-06-19 1991-06-18 Benzoquinazole derivatives and pharmaceutical compounds thereof.

Country Status (26)

Country Link
US (4) US6090941A (es)
EP (2) EP1199307B1 (es)
JP (1) JP2966929B2 (es)
KR (1) KR0183042B1 (es)
CN (1) CN1049215C (es)
AP (1) AP218A (es)
AT (2) ATE260262T1 (es)
AU (1) AU639815B2 (es)
CA (1) CA2085589C (es)
CS (1) CS186391A3 (es)
DE (2) DE69133371T2 (es)
DK (2) DK0535034T3 (es)
ES (2) ES2178632T3 (es)
FI (1) FI925778A (es)
GB (1) GB9013615D0 (es)
HU (2) HUT62273A (es)
IE (1) IE912073A1 (es)
IL (1) IL98542A (es)
MC (1) MC2290A1 (es)
MY (1) MY107001A (es)
NO (1) NO924929D0 (es)
NZ (1) NZ238582A (es)
PL (1) PL169927B1 (es)
PT (1) PT98021B (es)
WO (1) WO1991019700A1 (es)
ZA (1) ZA914676B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6762188B1 (en) 1990-06-19 2004-07-13 Smithkline Beecham Corporation Pharmaceutically active benzoquinazoline compounds
GB9013615D0 (en) 1990-06-19 1990-08-08 Wellcome Found Pharmaceutical compounds
GB9223352D0 (en) * 1992-11-06 1992-12-23 Ici Plc Tricyclic compounds
GB9226842D0 (en) * 1992-12-23 1993-02-17 Wellcome Found Pharmaceutical compounds
GB9408936D0 (en) * 1994-05-05 1994-06-22 Cancer Res Inst Anti-cancer compounds
US6531454B1 (en) 1999-03-16 2003-03-11 The Regents Of The University Of California Glycosylated polyamines and methods of use therefor
AU3883600A (en) 1999-03-16 2000-10-04 Regents Of The University Of California, The Glycosylated polyamines
JP2004503491A (ja) * 2000-06-09 2004-02-05 オーエスアイ・ファーマスーティカルズ・インコーポレーテッド ベンゾキナゾリンチミジル酸シンターゼ阻害剤のリポソーム製剤
JP2005504807A (ja) * 2001-09-26 2005-02-17 バイエル・フアーマシユーチカルズ・コーポレーシヨン 抗糖尿病薬としての１，８−ナフチリジン誘導体
CN100434425C (zh) * 2005-03-09 2008-11-19 首都师范大学 4-喹唑啉酮衍生物及其在抗肿瘤药物中的应用
EP1754484A1 (en) * 2005-08-17 2007-02-21 Dan Stoicescu Condensed pyrimidine derivatives as inhibitors of foic acid-dependent enzymes
BRPI0619436A2 (pt) 2005-12-05 2011-10-04 Nitto Denko Corp métodos e conjugados de aminoácido-poliglutamato
GB0525069D0 (en) * 2005-12-08 2006-01-18 Novartis Ag Organic compounds
EP2079739A2 (en) 2006-10-04 2009-07-22 Pfizer Products Inc. Pyrido[4,3-d]pyrimidin-4(3h)-one derivatives as calcium receptor antagonists
EP1958632A1 (en) 2007-02-14 2008-08-20 Dan Stoicescu Use of condensed pyrimidine derivatives for the treatment of autoimmune and inflammatory diseases
WO2008141110A2 (en) * 2007-05-09 2008-11-20 Nitto Denko Corporation Polyglutamate conjugates and polyglutamate-amino acid conjugates having a plurality of drugs
JP2010528122A (ja) * 2007-05-09 2010-08-19 日東電工株式会社 白金薬剤と結合されたポリマー
US8197828B2 (en) * 2007-05-09 2012-06-12 Nitto Denko Corporation Compositions that include a hydrophobic compound and a polyamino acid conjugate
US8146622B2 (en) 2007-08-20 2012-04-03 Ford Global Technologies, Llc Switch and hose-valve connection arrangement for vehicle temporary mobility kit
US8517760B2 (en) 2007-08-20 2013-08-27 Ford Global Technologies, Llc Cord wrap and power plug receptacle arrangement for inflator
US8501242B2 (en) 2009-05-29 2013-08-06 University Of Florida Research Foundation Methods and compositions for treating neoplasia
CN101580501B (zh) 2009-06-01 2011-03-09 南京卡文迪许生物工程技术有限公司 3-(取代二氢异吲哚酮-2-基)-2,6-哌啶二酮的合成方法及其中间体
WO2011078226A1 (ja) * 2009-12-22 2011-06-30 協和発酵キリン株式会社 三環系化合物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0296848A1 (en) * 1987-06-23 1988-12-28 Biomeasure, Inc. Biological response modifiers, their production, and their use in therapy or in prophylaxis
EP0373891A2 (en) * 1988-12-15 1990-06-20 Imperial Chemical Industries Plc Anti-tumour agents

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UST862021I4 (en) * 1969-01-27 1969-05-27 Defensive publication
DE2202847A1 (de) * 1971-02-05 1972-08-17 Apaw Sa Speiseeismaschine,insbesondere fuer Familiengebrauch,Kleinbetriebe od.dgl.
GB2065653B (en) * 1979-12-19 1983-03-09 Nat Res Dev Anti-cancer quinazoline derivatives
GB8513754D0 (en) * 1985-05-31 1985-07-03 Jones T R Anti-cancer quinazoline derivatives
US4603186A (en) 1985-10-21 1986-07-29 The Standard Oil Company Tetrapolymers containing indene
GB8607683D0 (en) * 1986-03-27 1986-04-30 Ici Plc Anti-tumor agents
US4818819A (en) * 1986-10-20 1989-04-04 The Trustees Of Princeton University Process for the preparation of fused pyridine compounds
GB8707053D0 (en) * 1987-03-25 1987-04-29 Ici Plc Anti-tumour agents
US4857530A (en) * 1987-11-03 1989-08-15 Warner-Lambert Company Substituted quinazolinones as anticancer agents
US4902624A (en) * 1987-11-23 1990-02-20 Eastman Kodak Company Temperature cycling cuvette
GB8727737D0 (en) * 1987-11-26 1987-12-31 Ici Plc Antitumour agents
US5405851A (en) * 1990-06-19 1995-04-11 Burroughs Wellcome Co. Pharmaceutical compounds
GB9013615D0 (en) * 1990-06-19 1990-08-08 Wellcome Found Pharmaceutical compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0296848A1 (en) * 1987-06-23 1988-12-28 Biomeasure, Inc. Biological response modifiers, their production, and their use in therapy or in prophylaxis
EP0373891A2 (en) * 1988-12-15 1990-06-20 Imperial Chemical Industries Plc Anti-tumour agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Med. Chem. 1990, 33, pp. 2045-2051 *

Also Published As

Publication number Publication date
PL169927B1 (pl) 1996-09-30
KR930701415A (ko) 1993-06-11
JP2966929B2 (ja) 1999-10-25
US6306865B1 (en) 2001-10-23
NO924929L (no) 1992-12-18
DE69133371D1 (de) 2004-04-01
US5663337A (en) 1997-09-02
AU639815B2 (en) 1993-08-05
CS186391A3 (en) 1992-04-15
DK0535034T3 (da) 2002-12-09
CA2085589C (en) 2001-12-18
KR0183042B1 (ko) 1999-05-01
EP1199307B1 (en) 2004-02-25
ZA914676B (en) 1993-02-24
CN1049215C (zh) 2000-02-09
MY107001A (en) 1995-08-30
MC2290A1 (fr) 1993-07-14
CN1058208A (zh) 1992-01-29
DE69133088D1 (de) 2002-09-19
DE69133088T2 (de) 2003-03-20
JPH05507704A (ja) 1993-11-04
EP0535034A1 (en) 1993-04-07
CA2085589A1 (en) 1991-12-20
AP9100283A0 (en) 1991-07-31
ATE260262T1 (de) 2004-03-15
NO924929D0 (no) 1992-12-18
IE912073A1 (en) 1992-01-01
HUT62273A (en) 1993-04-28
HU9204011D0 (en) 1993-03-29
IL98542A0 (en) 1992-07-15
US6090941A (en) 2000-07-18
US5661155A (en) 1997-08-26
EP1199307A1 (en) 2002-04-24
EP0535034B1 (en) 2002-08-14
GB9013615D0 (en) 1990-08-08
HU211265A9 (en) 1995-11-28
PT98021B (pt) 1998-11-30
FI925778A0 (fi) 1992-12-18
DE69133371T2 (de) 2005-01-27
AU8094391A (en) 1992-01-07
ES2178632T3 (es) 2003-01-01
FI925778A (fi) 1992-12-18
IL98542A (en) 1995-05-26
ES2211851T3 (es) 2004-07-16
PT98021A (pt) 1992-04-30
ATE222243T1 (de) 2002-08-15
WO1991019700A1 (en) 1991-12-26
NZ238582A (en) 1993-12-23
DK1199307T3 (da) 2004-06-14

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