ES2161231T3 - Compuestos heterociclicos como antagonistas de bradiquinina. - Google Patents
Compuestos heterociclicos como antagonistas de bradiquinina.Info
- Publication number
- ES2161231T3 ES2161231T3 ES94106486T ES94106486T ES2161231T3 ES 2161231 T3 ES2161231 T3 ES 2161231T3 ES 94106486 T ES94106486 T ES 94106486T ES 94106486 T ES94106486 T ES 94106486T ES 2161231 T3 ES2161231 T3 ES 2161231T3
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- alkilo
- halogen
- optionally
- bradiquinina
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical group 0.000 abstract 3
- -1 AMINO Chemical class 0.000 abstract 2
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical group O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/28—Cinnolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/42—Benzopyrazines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
UN COMPUESTO DE LA FORMULA: EN LA QUE X1 ES N O C R2 ES HALOGENO; R3 ES HIDROGENO, NITRO, AMINO OPCIONALMENTE TENIENDO SUSTITUYENTE(S) O UN GRUPO HETEROCICLICO OPCIONALMENTE TENIENDO ADECUADOS SUSTITUYENTE(S); R4 Y R5 SON CADA UNO HIDROGENO O HALOGENO; R6 Y R8 SON CADA UNO HIDROGENO, HALOGENO, ALKILO INFERIOR, HIDROXI, ALKILTIO INFERIOR, AMINO OPCIONALMENTE SUSTITUIDO CON ALKILO INFERIOR, O ALKOXI INFERIOR OPCIONALMENTE SUSTITUIDO CON UN SUSTITUYENTE SELECCIONADO ENTRE EL GRUPO FORMADO POR HIDROXI, ALKOXI INFERIOR, AMINO, ALKILAMINO INFERIOR Y OPCIONALMENTE SUSTITUIDO CON ALKOXI INFERIOR; R7 ES HIDROGENO O ALKILO INFERIOR; A ES ALKILENO INFERIOR; Y Q ES O O N DONDE R9 ES HIDROGENO O ACILO, SIEMPRE QUE R3 NO SEA HIDROGENO, CUANDO X1 ES C SMOS FARMACEUTICAMENTE ACEPTABLES, PROCESOS PARA SU PREPARACION Y COMPOSICIONES FARMACEUTICAS QUE LOS COMPRENDEN.3
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB939308804A GB9308804D0 (en) | 1993-04-28 | 1993-04-28 | New hetrocyclic compounds |
GB939318929A GB9318929D0 (en) | 1993-09-13 | 1993-09-13 | New heterocyclic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2161231T3 true ES2161231T3 (es) | 2001-12-01 |
Family
ID=26302825
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94106486T Expired - Lifetime ES2161231T3 (es) | 1993-04-28 | 1994-04-26 | Compuestos heterociclicos como antagonistas de bradiquinina. |
Country Status (16)
Country | Link |
---|---|
US (4) | US5563162A (es) |
EP (1) | EP0622361B1 (es) |
JP (1) | JP3346437B2 (es) |
KR (1) | KR100329469B1 (es) |
CN (1) | CN1043344C (es) |
AT (1) | ATE206412T1 (es) |
AU (1) | AU680870B2 (es) |
CA (1) | CA2122236C (es) |
DE (1) | DE69428476T2 (es) |
DK (1) | DK0622361T3 (es) |
ES (1) | ES2161231T3 (es) |
HU (1) | HU223140B1 (es) |
IL (1) | IL109395A (es) |
PH (1) | PH30752A (es) |
PT (1) | PT622361E (es) |
RU (1) | RU2135478C1 (es) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU680870B2 (en) | 1993-04-28 | 1997-08-14 | Astellas Pharma Inc. | New heterocyclic compounds |
DE4345062A1 (de) * | 1993-12-31 | 1995-07-13 | Hoechst Ag | Verwendung von Bradykinin-Antagonisten zur Herstellung von Arzneimitteln zur Behandlung von Viruserkrankungen |
WO1996004251A1 (fr) | 1994-08-03 | 1996-02-15 | Fujisawa Pharmaceutical Co., Ltd. | Compose heterocyclique |
ES2218554T3 (es) * | 1994-10-27 | 2004-11-16 | Fujisawa Pharmaceutical Co., Ltd. | Piridopirimidonas, quinolinas y n-heterociclos condensados que son antagonistas de bradiquinina. |
DE19517051A1 (de) * | 1995-05-10 | 1996-11-14 | Hoechst Ag | 1-Fluor-6,7-dihydro-5H-isochinolin-8-on-Derivate und ihre Verwendung in flüssigkristallinen Mischungen |
FR2735128B1 (fr) * | 1995-06-07 | 1997-07-25 | Fournier Ind & Sante | Nouveaux composes de benzenesulfonamide, leur procede de preparation et utilisation en therapeutique. |
FR2737892B1 (fr) * | 1995-08-17 | 1997-10-24 | Fournier Ind & Sante | Nouveaux composes de benzenesulfonamide, procede de preparation et utilisation en therapeutique |
GB9519077D0 (en) * | 1995-09-18 | 1995-11-15 | Fujisawa Pharmaceutical Co | New heterocyclic compounds |
JPH11514361A (ja) * | 1995-10-16 | 1999-12-07 | 藤沢薬品工業株式会社 | H+−ATPaseとしての複素環式化合物 |
FR2743073B1 (fr) * | 1995-12-29 | 1998-02-20 | Fournier Ind & Sante | Nouveaux composes de 1-benzenesulfonylpyrrolidine, procede de preparation et utilisation en therapeutique |
GB9602029D0 (en) * | 1996-02-01 | 1996-04-03 | Fujisawa Pharmaceutical Co | New heterocyclic compounds |
DE19609827A1 (de) * | 1996-03-13 | 1997-09-18 | Hoechst Ag | Aminoalkyl- und Acylaminoalkylether, Verfahren zu deren Herstellung und ihre Verwendung als Bradykinin-Rezeptorantagonisten |
DE19610784A1 (de) * | 1996-03-19 | 1997-09-25 | Hoechst Ag | Fluoralkyl- und Fluoralkoxysubstituierte heterocyclische Bradykinin-Antagonisten, Verfahren zu ihrer Herstellung und ihre Verwendung |
DE19612067A1 (de) * | 1996-03-27 | 1997-10-02 | Hoechst Ag | Verwendung von Bradykinin-Antagonisten zur Herstellung von Arzneimitteln zur Behandlung von chronisch fibrogenetischen Lebererkrankungen und akuten Lebererkrankungen |
AUPN952696A0 (en) * | 1996-04-29 | 1996-05-23 | Fujisawa Pharmaceutical Co., Ltd. | New heterocyclic compounds |
EP0808627A2 (de) * | 1996-05-22 | 1997-11-26 | Hoechst Aktiengesellschaft | Verwendung nicht-peptidischer Bradykinin-Antagonisten zur Behandlung und Prävention von chronisch-fibrogenetischen Lebererkrankungen, akuten Lebererkrankungen und den damit verbundenen Komplikationen |
DE19620508A1 (de) * | 1996-05-22 | 1997-11-27 | Hoechst Ag | Schwefelenthaltende heterocyclische Bradykinin-Antagonisten, Verfahren zu ihrer Herstellung und ihre Verwendung |
FR2751650B1 (fr) * | 1996-07-24 | 1998-10-09 | Fournier Ind & Sante | Nouveaux composes de n-benzenesulfonyl-l-proline, procede de preparation et utilisation en therapeutique |
DK0835659T3 (da) * | 1996-10-14 | 2005-04-18 | Aventis Pharma Gmbh | Anvendelse af ikke-peptidiske antagonister for bradykinin til fremstilling af lægemidler til behandling og forebyggelse af Alzheimer's sygdom |
FR2756562B1 (fr) * | 1996-12-04 | 1999-01-08 | Fournier Ind & Sante | Nouveaux composes de n-benzenesulfonyl-l-proline, procede de preparation et utilisation en therapeutique |
AU6422098A (en) * | 1997-03-24 | 1998-10-20 | Kyowa Hakko Kogyo Co. Ltd. | Benzene derivatives |
DE19712960A1 (de) * | 1997-03-27 | 1998-10-01 | Hoechst Ag | Benzyloxy-substituierte, anellierte N-Heterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Bradykininrezeptorantagonisten |
FR2765222B1 (fr) * | 1997-06-27 | 1999-12-31 | Fournier Ind & Sante | Nouveaux composes de n-benzenesulfonyl-l-proline, procede de preparation et utilisation en therapeutique |
HUP0104110A3 (en) * | 1998-10-21 | 2003-01-28 | Astellas Pharma Inc Chuo Ku | Vitreous form of known bradykinin antagonist and medicament containing it |
FR2790260B1 (fr) | 1999-02-26 | 2001-05-04 | Fournier Ind & Sante | Nouveaux composes de n-(benzenesulfonamide), procede de preparation et utilisation en therapeutique |
US6455734B1 (en) * | 2000-08-09 | 2002-09-24 | Magnesium Diagnostics, Inc. | Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states |
US7105172B1 (en) | 1999-11-18 | 2006-09-12 | Bolla John D | Treatment of rosacea |
US6699486B1 (en) | 1999-11-18 | 2004-03-02 | Bolla Corporation | Treatment or prevention of photoaging and skin cancer |
WO2002012228A1 (en) | 2000-08-09 | 2002-02-14 | Astrazeneca Ab | Cinnoline compounds |
CA2481855A1 (en) | 2002-04-10 | 2003-10-23 | Ortho-Mcneil Pharmaceutical, Inc. | Novel heteroaryl alkylamide derivatives useful as bradykinin receptor modulators |
EP1914236A1 (en) | 2002-04-10 | 2008-04-23 | Ortho-McNeil Pharmaceutical, Inc. | Novel heteroaryl alkylamide derivatives useful as bradykinin receptor modulators |
CA2483573A1 (en) | 2002-05-03 | 2003-11-13 | Elan Pharmaceuticals, Inc. | Sulfonylquinoxalone acetamide derivatives and related compounds as bradykinin antagonists |
KR101128065B1 (ko) * | 2004-05-26 | 2012-04-12 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 신나미드 화합물 |
EP1808432B1 (en) | 2004-10-26 | 2010-02-24 | Eisai R&D Management Co., Ltd. | Amorphous form of cinnamide compound |
WO2007058304A1 (ja) * | 2005-11-18 | 2007-05-24 | Eisai R & D Management Co., Ltd. | シンナミド化合物の塩またはそれらの溶媒和物 |
WO2007058305A1 (ja) * | 2005-11-18 | 2007-05-24 | Eisai R & D Management Co., Ltd. | シンナミド誘導体の製造方法 |
TWI370130B (en) * | 2005-11-24 | 2012-08-11 | Eisai R&D Man Co Ltd | Two cyclic cinnamide compound |
BRPI0618814A2 (pt) * | 2005-11-24 | 2014-04-29 | Eisai R&D Man Co Ltd | Composto ou um sal farmacologicamente aceitável do mesmo, e, agente farmacêutico |
TWI378091B (en) | 2006-03-09 | 2012-12-01 | Eisai R&D Man Co Ltd | Multi-cyclic cinnamide derivatives |
CA2652484A1 (en) * | 2006-05-19 | 2007-11-29 | Eisai R & D Management Co., Ltd. | Heterocyclic type cinnamide derivative |
AR062095A1 (es) | 2006-07-28 | 2008-10-15 | Eisai R&D Man Co Ltd | Profarmaco de compuesto cinamida |
CL2008000582A1 (es) | 2007-02-28 | 2008-06-27 | Eisai R&D Man Co Ltd | Compuestos ciclicos derivados de oximorfolina condensados; farmacos que comprenden a dichos compuestos; y su uso para tratar enfermedad de alzheimer, demencia senil, sindrome de down o amiloidosis. |
TWI407960B (zh) | 2007-03-23 | 2013-09-11 | Jerini Ag | 小分子緩激肽b2受體調節劑 |
CA2687262A1 (en) * | 2007-05-16 | 2008-11-20 | Naoyuki Shimomura | One-pot production process for cinnamide derivative |
MX2009012847A (es) * | 2007-06-13 | 2009-12-08 | Bristol Myers Squibb Co | Analogos dipeptidicos como inhibidores de factores de coagulacion. |
US8513422B2 (en) | 2007-08-31 | 2013-08-20 | Astellas Pharma Inc. | Piperidine derivative |
US7935815B2 (en) | 2007-08-31 | 2011-05-03 | Eisai R&D Management Co., Ltd. | Imidazoyl pyridine compounds and salts thereof |
AR068121A1 (es) | 2007-08-31 | 2009-11-04 | Eisai R&D Man Co Ltd | Compuestos multiciclicos para tratar enfermedades neurodegenerativas |
US20100317860A1 (en) * | 2008-01-28 | 2010-12-16 | Ikuo Kushida | Crystalline cinnamide compounds or salts thereof |
US8883857B2 (en) | 2012-12-07 | 2014-11-11 | Baylor College Of Medicine | Small molecule xanthine oxidase inhibitors and methods of use |
MX2015012650A (es) * | 2013-03-14 | 2016-06-21 | Shire Human Genetic Therapies | Metodos para el tratamiento de angioedema mediado receptores debradicinina b2. |
DK3341367T3 (da) * | 2015-08-27 | 2021-04-12 | Pfizer | Bicyklisk-fusionerede heteroaryl- eller arylforbindelser som irak4-modulatorer |
IL274883B2 (en) | 2017-11-24 | 2023-11-01 | Pharvaris Netherlands B V | BRADYKININ B2 receptor antagonists |
AR118983A1 (es) | 2019-05-23 | 2021-11-17 | Pharvaris Gmbh | Antagonistas cíclicos del receptor b2 de bradiquinina |
AR118982A1 (es) | 2019-05-23 | 2021-11-17 | Pharvaris Gmbh | Antagonistas cíclicos del receptor b2 de bradiquinina |
CN113717079B (zh) * | 2021-09-30 | 2023-03-31 | 内蒙古康普药业有限公司 | 一种甲氧氯普胺双胺新杂质的制备方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3682927A (en) * | 1968-06-15 | 1972-08-08 | Massimo Carissimi | 5,7-bichloro-8-hydroxy-2-acetylamino quinoline |
EP0138773B1 (de) * | 1983-10-18 | 1990-08-29 | Ciba-Geigy Ag | Verwendung von Chinolinderivaten zum Schützen von Kulturpflanzen |
DE3617183A1 (de) * | 1985-11-16 | 1987-05-27 | Bayer Ag | Substituierte benzylether |
US5202336A (en) * | 1986-09-24 | 1993-04-13 | Bayer Aktiengesellschaft | Antiflammatory quinolin methoxy phenylsulphonamides |
DE3632329A1 (de) * | 1986-09-24 | 1988-03-31 | Bayer Ag | Substituierte phenylsulfonamide |
US5294622A (en) * | 1988-01-29 | 1994-03-15 | Dowelanco | Substituted quinolines and cinnolines |
US5212182A (en) * | 1990-10-03 | 1993-05-18 | American Home Products Corpooration | Substituted quinolinyl- and naphthalenylbenzamides or benzylamines and related compounds useful as analgesics |
MX9200299A (es) * | 1991-02-07 | 1992-12-01 | Roussel Uclaf | Nuevos derivados biciclicos nitrogenados, su procedimiento de preparacion los nuevos compuestos intermedios obtenidos su aplicacion como medicamentos y las composiciones farmaceuticas que los contienen. |
US5480883A (en) | 1991-05-10 | 1996-01-02 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
US5574042A (en) * | 1992-11-02 | 1996-11-12 | Fujisawa Pharmaceutical Co., Ltd | Imidazo [1,2-a] pyridines and their pharmaceutical use |
AU680870B2 (en) | 1993-04-28 | 1997-08-14 | Astellas Pharma Inc. | New heterocyclic compounds |
AU2985499A (en) | 1998-04-03 | 1999-10-25 | Alcon Laboratories, Inc. | Non-peptide bradykinin receptor antagonists for use in treating ophthalmic diseases and disorders |
-
1994
- 1994-04-19 AU AU60525/94A patent/AU680870B2/en not_active Ceased
- 1994-04-21 PH PH48129A patent/PH30752A/en unknown
- 1994-04-22 IL IL10939594A patent/IL109395A/en not_active IP Right Cessation
- 1994-04-22 RU RU94013439/04A patent/RU2135478C1/ru not_active IP Right Cessation
- 1994-04-26 DK DK94106486T patent/DK0622361T3/da active
- 1994-04-26 CA CA002122236A patent/CA2122236C/en not_active Expired - Fee Related
- 1994-04-26 DE DE69428476T patent/DE69428476T2/de not_active Expired - Lifetime
- 1994-04-26 ES ES94106486T patent/ES2161231T3/es not_active Expired - Lifetime
- 1994-04-26 JP JP08889794A patent/JP3346437B2/ja not_active Expired - Fee Related
- 1994-04-26 KR KR1019940008888A patent/KR100329469B1/ko not_active IP Right Cessation
- 1994-04-26 AT AT94106486T patent/ATE206412T1/de not_active IP Right Cessation
- 1994-04-26 EP EP94106486A patent/EP0622361B1/en not_active Expired - Lifetime
- 1994-04-26 PT PT94106486T patent/PT622361E/pt unknown
- 1994-04-26 US US08/233,771 patent/US5563162A/en not_active Expired - Lifetime
- 1994-04-27 CN CN94105013A patent/CN1043344C/zh not_active Expired - Fee Related
- 1994-04-27 HU HU9401221A patent/HU223140B1/hu not_active IP Right Cessation
-
1996
- 1996-06-07 US US08/660,393 patent/US5708173A/en not_active Expired - Lifetime
-
1997
- 1997-09-19 US US08/933,354 patent/US5922711A/en not_active Expired - Fee Related
-
1999
- 1999-01-12 US US09/228,973 patent/US6169095B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
IL109395A (en) | 1998-09-24 |
CA2122236C (en) | 2007-02-13 |
US5708173A (en) | 1998-01-13 |
PT622361E (pt) | 2002-03-28 |
HU9401221D0 (en) | 1994-08-29 |
JPH072780A (ja) | 1995-01-06 |
IL109395A0 (en) | 1994-07-31 |
DK0622361T3 (da) | 2001-12-03 |
RU2135478C1 (ru) | 1999-08-27 |
DE69428476D1 (de) | 2001-11-08 |
ATE206412T1 (de) | 2001-10-15 |
KR100329469B1 (ko) | 2003-01-09 |
EP0622361A1 (en) | 1994-11-02 |
JP3346437B2 (ja) | 2002-11-18 |
EP0622361B1 (en) | 2001-10-04 |
CN1097417A (zh) | 1995-01-18 |
PH30752A (en) | 1997-10-17 |
US6169095B1 (en) | 2001-01-02 |
HU223140B1 (hu) | 2004-03-29 |
DE69428476T2 (de) | 2002-05-08 |
AU680870B2 (en) | 1997-08-14 |
CA2122236A1 (en) | 1994-10-29 |
US5922711A (en) | 1999-07-13 |
CN1043344C (zh) | 1999-05-12 |
HUT70493A (en) | 1995-10-30 |
AU6052594A (en) | 1994-11-03 |
US5563162A (en) | 1996-10-08 |
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