ES2159738T3 - Derivados de benzamida y su uso como antagonistas de vasopresina. - Google Patents
Derivados de benzamida y su uso como antagonistas de vasopresina.Info
- Publication number
- ES2159738T3 ES2159738T3 ES96916324T ES96916324T ES2159738T3 ES 2159738 T3 ES2159738 T3 ES 2159738T3 ES 96916324 T ES96916324 T ES 96916324T ES 96916324 T ES96916324 T ES 96916324T ES 2159738 T3 ES2159738 T3 ES 2159738T3
- Authority
- ES
- Spain
- Prior art keywords
- sup
- derivatives
- vasopresine
- benzamide
- antagonist
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical class NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000008569 process Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
- C07C243/26—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C243/28—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of a saturated carbon skeleton
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- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
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- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
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- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
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- C07C271/48—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
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- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/08—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by singly-bound oxygen atoms
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- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/24—Y being a hetero atom
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- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/28—Nitrogen atoms
- C07D295/32—Nitrogen atoms acylated with carboxylic or carbonic acids, or their nitrogen or sulfur analogues
Abstract
ESTA INVENCION SE REFIERE A NUEVOS DERIVADOS DE BENZAMIDA QUE POSEEN ACTIVIDAD ANTAGONISTA DE VASOPRESINA, ETC. Y QUE ESTAN REPRESENTADOS POR LA FORMULA GENERAL (I) EN LA QUE R SUP,1} ES ARILO OPCIONALMENTE SUSTITUIDO CON ALCOXI INFERIOR, ETC., R SUP,2} ES ALQUILO INFERIOR, ETC., R SUP,3} ES HIDROGENO, ETC., R SUP,4} ES ALCOXI INFERIOR, ETC., R SUP,5} ES HIDROGENO, ETC., A ES NH, ETC., E ES (A), ETC., X ES S Y Y ES CH O N, Y SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS, PROCESOS PARA SU PREPARACION Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9511694.3A GB9511694D0 (en) | 1995-06-09 | 1995-06-09 | Benzamide derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2159738T3 true ES2159738T3 (es) | 2001-10-16 |
Family
ID=10775780
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96916324T Expired - Lifetime ES2159738T3 (es) | 1995-06-09 | 1996-06-06 | Derivados de benzamida y su uso como antagonistas de vasopresina. |
Country Status (22)
Country | Link |
---|---|
US (1) | US6054457A (es) |
EP (1) | EP0832061B1 (es) |
JP (2) | JP4042160B2 (es) |
KR (1) | KR19990022448A (es) |
CN (1) | CN1192729A (es) |
AR (1) | AR003005A1 (es) |
AT (1) | ATE205185T1 (es) |
AU (1) | AU5911096A (es) |
CA (1) | CA2223869A1 (es) |
DE (1) | DE69615025T2 (es) |
DK (1) | DK0832061T3 (es) |
EA (1) | EA199800051A1 (es) |
ES (1) | ES2159738T3 (es) |
GB (1) | GB9511694D0 (es) |
GR (1) | GR3036881T3 (es) |
HU (1) | HUP9802694A3 (es) |
IL (1) | IL122345A0 (es) |
MX (1) | MX9709951A (es) |
PT (1) | PT832061E (es) |
TR (1) | TR199600488A2 (es) |
WO (1) | WO1996041795A1 (es) |
ZA (1) | ZA964895B (es) |
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GB9408185D0 (en) * | 1994-04-25 | 1994-06-15 | Fujisawa Pharmaceutical Co | New benzamide derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same |
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GB9824579D0 (en) * | 1998-11-10 | 1999-01-06 | Novartis Ag | Organic compounds |
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US4764619A (en) * | 1985-03-26 | 1988-08-16 | Asahi Glass Company Ltd. | Optically active compounds, smectic liquid crystal compositions containing them and smectic liquid crystal display devices |
DE3523705A1 (de) * | 1985-07-03 | 1987-01-08 | Hoechst Ag | Arzneimittel und deren verwendung |
SU1754712A1 (ru) * | 1989-12-21 | 1992-08-15 | Институт медицинской паразитологии и тропической медицины им.Е.И.Марциновского | N-(3-нитро-4-хлорфенилсульфонил)-антранилова кислота в качестве промежуточного продукта дл получени N-(4-хлорфенил)-2-[(3-нитро-4-хлорфенилсульфонил)-амино]-5-бромбензамида, обладающего противотрихоцефалезной активностью |
GB9307527D0 (en) * | 1993-04-13 | 1993-06-02 | Fujisawa Pharmaceutical Co | New venzamide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same |
GB9408185D0 (en) * | 1994-04-25 | 1994-06-15 | Fujisawa Pharmaceutical Co | New benzamide derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same |
JP3582199B2 (ja) * | 1995-01-31 | 2004-10-27 | 三菱化学株式会社 | 静電荷像現像用帯電制御剤及びそれを用いたトナー |
WO1996025398A1 (de) * | 1995-02-13 | 1996-08-22 | Bayer Aktiengesellschaft | Substituierte heterocyclische verbindungen und ihre verwendung als fungizide |
JP3162953B2 (ja) * | 1995-06-07 | 2001-05-08 | 株式会社資生堂 | ピラゾリジン誘導体及びラジカルスカベンジャー、虚血再潅流障害抑制剤 |
-
1995
- 1995-06-09 GB GBGB9511694.3A patent/GB9511694D0/en active Pending
-
1996
- 1996-06-06 EP EP96916324A patent/EP0832061B1/en not_active Expired - Lifetime
- 1996-06-06 JP JP50289697A patent/JP4042160B2/ja not_active Expired - Fee Related
- 1996-06-06 IL IL12234596A patent/IL122345A0/xx unknown
- 1996-06-06 US US08/973,103 patent/US6054457A/en not_active Expired - Fee Related
- 1996-06-06 CN CN96196175A patent/CN1192729A/zh active Pending
- 1996-06-06 KR KR1019970708929A patent/KR19990022448A/ko not_active Application Discontinuation
- 1996-06-06 AU AU59110/96A patent/AU5911096A/en not_active Abandoned
- 1996-06-06 DK DK96916324T patent/DK0832061T3/da active
- 1996-06-06 CA CA002223869A patent/CA2223869A1/en not_active Abandoned
- 1996-06-06 PT PT96916324T patent/PT832061E/pt unknown
- 1996-06-06 MX MX9709951A patent/MX9709951A/es unknown
- 1996-06-06 ES ES96916324T patent/ES2159738T3/es not_active Expired - Lifetime
- 1996-06-06 DE DE69615025T patent/DE69615025T2/de not_active Expired - Lifetime
- 1996-06-06 EA EA199800051A patent/EA199800051A1/ru unknown
- 1996-06-06 AT AT96916324T patent/ATE205185T1/de not_active IP Right Cessation
- 1996-06-06 HU HU9802694A patent/HUP9802694A3/hu unknown
- 1996-06-06 WO PCT/JP1996/001533 patent/WO1996041795A1/en not_active Application Discontinuation
- 1996-06-07 ZA ZA964895A patent/ZA964895B/xx unknown
- 1996-06-07 TR TR96/00488A patent/TR199600488A2/xx unknown
- 1996-11-06 AR ARP960103098A patent/AR003005A1/es unknown
-
2001
- 2001-10-11 GR GR20010401746T patent/GR3036881T3/el unknown
-
2007
- 2007-09-04 JP JP2007259213A patent/JP2008074855A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
ATE205185T1 (de) | 2001-09-15 |
KR19990022448A (ko) | 1999-03-25 |
JP4042160B2 (ja) | 2008-02-06 |
AU5911096A (en) | 1997-01-09 |
TR199600488A2 (tr) | 1997-05-21 |
GB9511694D0 (en) | 1995-08-02 |
US6054457A (en) | 2000-04-25 |
EP0832061B1 (en) | 2001-09-05 |
GR3036881T3 (en) | 2002-01-31 |
PT832061E (pt) | 2002-02-28 |
EP0832061A1 (en) | 1998-04-01 |
ZA964895B (en) | 1996-12-12 |
DK0832061T3 (da) | 2001-11-19 |
CA2223869A1 (en) | 1996-12-27 |
AR003005A1 (es) | 1998-05-27 |
DE69615025D1 (de) | 2001-10-11 |
JP2008074855A (ja) | 2008-04-03 |
MX9709951A (es) | 1998-03-29 |
EA199800051A1 (ru) | 1998-08-27 |
DE69615025T2 (de) | 2002-03-21 |
WO1996041795A1 (en) | 1996-12-27 |
IL122345A0 (en) | 1998-04-05 |
CN1192729A (zh) | 1998-09-09 |
JPH11508244A (ja) | 1999-07-21 |
HUP9802694A3 (en) | 1999-03-29 |
HUP9802694A1 (hu) | 1999-02-01 |
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