ES2171911T3 - Poliaminas conformacionalmente restringidas y su uso como agentes antineoplasicos. - Google Patents
Poliaminas conformacionalmente restringidas y su uso como agentes antineoplasicos.Info
- Publication number
- ES2171911T3 ES2171911T3 ES97911695T ES97911695T ES2171911T3 ES 2171911 T3 ES2171911 T3 ES 2171911T3 ES 97911695 T ES97911695 T ES 97911695T ES 97911695 T ES97911695 T ES 97911695T ES 2171911 T3 ES2171911 T3 ES 2171911T3
- Authority
- ES
- Spain
- Prior art keywords
- polyamins
- independently
- compounds
- conformationally restricted
- cicloarilo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
- C07C211/36—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing at least two amino groups bound to the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/16—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings other than six-membered aromatic rings
- C07C211/18—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings other than six-membered aromatic rings containing at least two amino groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/20—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
- C07C211/22—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton containing at least two amino groups bound to the carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
LA INVENCION SE REFIERE A COMPUESTOS DE FORMULA (I): E NH - D NH - B - A - B - NH - D - NH - E, DONDE A ES ALQUENO C SUB,2 C 6 , CICLOALQUILO C 3 - C 6 , CICLOALQUEN ILO O CICLOARILO; B ES INDEPENDIENTEMENTE UN ENLACE SIMPLE, ALQUILALQUENILO C 1 - C 6 ; D ES INDEPENDIENTEMENTE ALQ UILO O ALQUENILO C 1 - C 6 , O CICLOALQUILO C 3 - C 6 , CICLOALQUENILO O CICLOARILO; Y E ES INDEPENDIENTEMENTE H, ALQUILO C 1 - C 6 O ALQUENILO. SE INCLUYEN A SIMISMO LAS SALES FARMACEUTICAMENTE ACEPTABLES DE DICHOS COMPUESTOS, UN PROCEDIMIENTO DE SINTESIS DE LOS MISMOS, FORMAS DE ADMINISTRACION FARMACEUTICAS QUE INCLUYEN UNO O MAS DE DICHOS COMPUESTOS, Y LA UTILIZACION DE LOS MISMOS EN EL TRATAMIENTO DE LA PROLIFERACION CELULAR NEOPLASICA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2868096P | 1996-10-18 | 1996-10-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2171911T3 true ES2171911T3 (es) | 2002-09-16 |
Family
ID=21844851
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97911695T Expired - Lifetime ES2171911T3 (es) | 1996-10-18 | 1997-10-15 | Poliaminas conformacionalmente restringidas y su uso como agentes antineoplasicos. |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0934249B1 (es) |
JP (2) | JP3891496B2 (es) |
AU (1) | AU4900797A (es) |
DE (1) | DE69711413T2 (es) |
ES (1) | ES2171911T3 (es) |
WO (1) | WO1998017624A1 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8198334B2 (en) | 1997-10-27 | 2012-06-12 | Pathologica Llc | Methods for modulating macrophage proliferation in ocular disease using polyamine analogs |
US7087648B1 (en) | 1997-10-27 | 2006-08-08 | The Regents Of The University Of California | Methods for modulating macrophage proliferation using polyamine analogs |
JP2002543163A (ja) * | 1999-04-30 | 2002-12-17 | スリル バイオメディカル コーポレイション | 癌および前立腺疾患のための治療としての結合体 |
NZ515140A (en) | 1999-04-30 | 2003-07-25 | Slil Biomedical Corp | Conformationally restricted polyamine analogs as disease therapies for cancer, epilepsy, alzheimers, infections, grafts and others |
US6482943B1 (en) | 1999-04-30 | 2002-11-19 | Slil Biomedical Corporation | Quinones as disease therapies |
AU2002364539A1 (en) * | 2001-12-07 | 2003-06-23 | Cellgate, Inc. | Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor |
KR20040091014A (ko) * | 2002-02-07 | 2004-10-27 | 위스콘신 얼럼나이 리서어치 화운데이션 | 항암 요법과 병행해서 사용하기 위한 폴리아민 화합물 및조성물 |
WO2005014524A2 (en) | 2003-08-07 | 2005-02-17 | Wisconsin Alumni Research Foundation | Amino thiol compounds and compositions for use in conjunction with cancer therapy |
CA2619005A1 (en) * | 2005-08-10 | 2007-02-22 | Johns Hopkins University | Polyamines useful as anti-parasitic and anti-cancer therapeutics and as lysine-specific demethylase inhibitors |
CA2623203C (en) | 2005-09-23 | 2014-08-12 | Pathologica, Llc | Methods for treating viral infections using polyamine analogs |
WO2012009475A1 (en) * | 2010-07-14 | 2012-01-19 | Oregon Health & Science University | Methods of treating cancer with inhibition of lysine-specific demethylase 1 |
CN102212013A (zh) * | 2011-03-30 | 2011-10-12 | 广东中科药物研究有限公司 | 一种多胺化合物及其制备方法和应用 |
EP2822936B1 (en) | 2012-03-07 | 2021-09-08 | The McLean Hospital Corporation | Aminoquinoline derivatives and uses thereof |
CN104072624B (zh) * | 2014-05-15 | 2016-05-18 | 温州医科大学 | 一种多胺改性高分子药物及其制备方法与作为抗肿瘤药物的应用 |
CN109651235B (zh) * | 2018-12-13 | 2020-09-22 | 天津利安隆新材料股份有限公司 | 一种尼龙助剂的制备方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5091576A (en) * | 1986-12-02 | 1992-02-25 | University Of Florida | Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives |
CA1305425C (en) * | 1986-12-02 | 1992-07-21 | Raymond J. Bergeron | Anti-neoplastic spermine derivative |
ATE169614T1 (de) * | 1993-12-27 | 1998-08-15 | Ciba Geigy Ag | Ungesättigte aminoverbindungen zur verwendung als antikrebsmittel und als mittelgegen protozoen |
-
1997
- 1997-10-15 ES ES97911695T patent/ES2171911T3/es not_active Expired - Lifetime
- 1997-10-15 DE DE69711413T patent/DE69711413T2/de not_active Expired - Lifetime
- 1997-10-15 AU AU49007/97A patent/AU4900797A/en not_active Abandoned
- 1997-10-15 EP EP97911695A patent/EP0934249B1/en not_active Expired - Lifetime
- 1997-10-15 WO PCT/US1997/018453 patent/WO1998017624A1/en active IP Right Grant
- 1997-10-15 JP JP51944298A patent/JP3891496B2/ja not_active Expired - Fee Related
-
2005
- 2005-05-25 JP JP2005153153A patent/JP4322842B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE69711413T2 (de) | 2002-07-18 |
AU4900797A (en) | 1998-05-15 |
EP0934249A1 (en) | 1999-08-11 |
WO1998017624A1 (en) | 1998-04-30 |
EP0934249B1 (en) | 2002-03-27 |
JP3891496B2 (ja) | 2007-03-14 |
JP2002508739A (ja) | 2002-03-19 |
DE69711413D1 (de) | 2002-05-02 |
JP4322842B2 (ja) | 2009-09-02 |
JP2005255690A (ja) | 2005-09-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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