ATE444962T1 - Amino-5,5-diphenylimidazolon-derivate zur beta- sekretase-hemmung - Google Patents

Amino-5,5-diphenylimidazolon-derivate zur beta- sekretase-hemmung

Info

Publication number
ATE444962T1
ATE444962T1 AT05760367T AT05760367T ATE444962T1 AT E444962 T1 ATE444962 T1 AT E444962T1 AT 05760367 T AT05760367 T AT 05760367T AT 05760367 T AT05760367 T AT 05760367T AT E444962 T1 ATE444962 T1 AT E444962T1
Authority
AT
Austria
Prior art keywords
amino
beta secretase
secretase inhibition
diphenylimidazolone
derivatives
Prior art date
Application number
AT05760367T
Other languages
English (en)
Inventor
Michael Sotirios Malamas
James Joseph Erdei
Iwan Suwandi Gunawan
Ping Zhou
Yinfa Yan
Dominick Quagliato
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Application granted granted Critical
Publication of ATE444962T1 publication Critical patent/ATE444962T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT05760367T 2004-06-16 2005-06-14 Amino-5,5-diphenylimidazolon-derivate zur beta- sekretase-hemmung ATE444962T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58028604P 2004-06-16 2004-06-16
PCT/US2005/020720 WO2006009653A1 (en) 2004-06-16 2005-06-14 Amino-5,5-diphenylimidazolone derivatives for the inhibition of beta-secretase

Publications (1)

Publication Number Publication Date
ATE444962T1 true ATE444962T1 (de) 2009-10-15

Family

ID=34978791

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05760367T ATE444962T1 (de) 2004-06-16 2005-06-14 Amino-5,5-diphenylimidazolon-derivate zur beta- sekretase-hemmung

Country Status (23)

Country Link
US (2) US7482349B2 (de)
EP (1) EP1756087B1 (de)
JP (1) JP2008503459A (de)
CN (1) CN1968945A (de)
AR (1) AR049551A1 (de)
AT (1) ATE444962T1 (de)
AU (1) AU2005264915A1 (de)
BR (1) BRPI0512213A (de)
CA (1) CA2579724A1 (de)
DE (1) DE602005017033D1 (de)
EC (1) ECSP067068A (de)
ES (1) ES2332659T3 (de)
GT (1) GT200500158A (de)
IL (1) IL180017A0 (de)
MX (1) MXPA06014793A (de)
NO (1) NO20070247L (de)
NZ (1) NZ552031A (de)
PA (1) PA8637301A1 (de)
PE (1) PE20060459A1 (de)
RU (1) RU2006142552A (de)
TW (1) TW200602045A (de)
WO (1) WO2006009653A1 (de)
ZA (1) ZA200610592B (de)

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CN1968945A (zh) 2007-05-23
JP2008503459A (ja) 2008-02-07
NZ552031A (en) 2009-06-26
IL180017A0 (en) 2007-05-15
EP1756087B1 (de) 2009-10-07
US7482349B2 (en) 2009-01-27
AU2005264915A1 (en) 2006-01-26
AR049551A1 (es) 2006-08-16
ECSP067068A (es) 2007-01-26
ZA200610592B (en) 2009-09-30
BRPI0512213A (pt) 2008-02-19
DE602005017033D1 (de) 2009-11-19
WO2006009653A1 (en) 2006-01-26
US20090093498A1 (en) 2009-04-09
RU2006142552A (ru) 2008-07-27
US20050282825A1 (en) 2005-12-22
TW200602045A (en) 2006-01-16
ES2332659T3 (es) 2010-02-10
PA8637301A1 (es) 2006-06-02
GT200500158A (es) 2006-03-02
CA2579724A1 (en) 2006-01-26
EP1756087A1 (de) 2007-02-28
PE20060459A1 (es) 2006-05-30
MXPA06014793A (es) 2007-02-16
US7700602B2 (en) 2010-04-20

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