DE602005017033D1 - Amino-5,5-diphenylimidazolon-derivate zur beta-sekretase-hemmung - Google Patents

Amino-5,5-diphenylimidazolon-derivate zur beta-sekretase-hemmung

Info

Publication number
DE602005017033D1
DE602005017033D1 DE602005017033T DE602005017033T DE602005017033D1 DE 602005017033 D1 DE602005017033 D1 DE 602005017033D1 DE 602005017033 T DE602005017033 T DE 602005017033T DE 602005017033 T DE602005017033 T DE 602005017033T DE 602005017033 D1 DE602005017033 D1 DE 602005017033D1
Authority
DE
Germany
Prior art keywords
sekretase
inhibition
beta
amino
diphenylimidazolone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005017033T
Other languages
English (en)
Inventor
Michael Sotirios Malamas
James Joseph Erdei
Iwan Suwandi Gunawan
Ping Zhou
Yinfa Yan
Dominick A Quagliato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
Wyeth LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth LLC filed Critical Wyeth LLC
Publication of DE602005017033D1 publication Critical patent/DE602005017033D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE602005017033T 2004-06-16 2005-06-14 Amino-5,5-diphenylimidazolon-derivate zur beta-sekretase-hemmung Active DE602005017033D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58028604P 2004-06-16 2004-06-16
PCT/US2005/020720 WO2006009653A1 (en) 2004-06-16 2005-06-14 Amino-5,5-diphenylimidazolone derivatives for the inhibition of beta-secretase

Publications (1)

Publication Number Publication Date
DE602005017033D1 true DE602005017033D1 (de) 2009-11-19

Family

ID=34978791

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005017033T Active DE602005017033D1 (de) 2004-06-16 2005-06-14 Amino-5,5-diphenylimidazolon-derivate zur beta-sekretase-hemmung

Country Status (23)

Country Link
US (2) US7482349B2 (de)
EP (1) EP1756087B1 (de)
JP (1) JP2008503459A (de)
CN (1) CN1968945A (de)
AR (1) AR049551A1 (de)
AT (1) ATE444962T1 (de)
AU (1) AU2005264915A1 (de)
BR (1) BRPI0512213A (de)
CA (1) CA2579724A1 (de)
DE (1) DE602005017033D1 (de)
EC (1) ECSP067068A (de)
ES (1) ES2332659T3 (de)
GT (1) GT200500158A (de)
IL (1) IL180017A0 (de)
MX (1) MXPA06014793A (de)
NO (1) NO20070247L (de)
NZ (1) NZ552031A (de)
PA (1) PA8637301A1 (de)
PE (1) PE20060459A1 (de)
RU (1) RU2006142552A (de)
TW (1) TW200602045A (de)
WO (1) WO2006009653A1 (de)
ZA (1) ZA200610592B (de)

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ZA200610592B (en) 2009-09-30
MXPA06014793A (es) 2007-02-16
TW200602045A (en) 2006-01-16
CA2579724A1 (en) 2006-01-26
BRPI0512213A (pt) 2008-02-19
NZ552031A (en) 2009-06-26
PE20060459A1 (es) 2006-05-30
IL180017A0 (en) 2007-05-15
AR049551A1 (es) 2006-08-16
ATE444962T1 (de) 2009-10-15
NO20070247L (no) 2007-02-13
US7482349B2 (en) 2009-01-27
ES2332659T3 (es) 2010-02-10
EP1756087B1 (de) 2009-10-07
RU2006142552A (ru) 2008-07-27
US20090093498A1 (en) 2009-04-09
CN1968945A (zh) 2007-05-23
WO2006009653A1 (en) 2006-01-26
US7700602B2 (en) 2010-04-20
AU2005264915A1 (en) 2006-01-26
GT200500158A (es) 2006-03-02
EP1756087A1 (de) 2007-02-28

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