ATE481383T1 - 3-aza-bicycloä3.1.0ühexanderivate - Google Patents
3-aza-bicycloä3.1.0ühexanderivateInfo
- Publication number
- ATE481383T1 ATE481383T1 AT07826577T AT07826577T ATE481383T1 AT E481383 T1 ATE481383 T1 AT E481383T1 AT 07826577 T AT07826577 T AT 07826577T AT 07826577 T AT07826577 T AT 07826577T AT E481383 T1 ATE481383 T1 AT E481383T1
- Authority
- AT
- Austria
- Prior art keywords
- aza
- derivatives
- Prior art date
Links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
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- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IB2006053570 | 2006-09-29 | ||
PCT/IB2007/053947 WO2008038251A2 (en) | 2006-09-29 | 2007-09-28 | 3-aza-bicyclo[3.1.0]hexane derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE481383T1 true ATE481383T1 (de) | 2010-10-15 |
Family
ID=39106344
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT07826577T ATE481383T1 (de) | 2006-09-29 | 2007-09-28 | 3-aza-bicycloä3.1.0ühexanderivate |
Country Status (13)
Country | Link |
---|---|
US (1) | US20100016401A1 (de) |
EP (1) | EP2079690B1 (de) |
JP (1) | JP2010504957A (de) |
KR (1) | KR20090077051A (de) |
CN (1) | CN101522618A (de) |
AR (1) | AR063081A1 (de) |
AT (1) | ATE481383T1 (de) |
CA (1) | CA2662612A1 (de) |
CL (1) | CL2007002809A1 (de) |
DE (1) | DE602007009284D1 (de) |
ES (1) | ES2350460T3 (de) |
TW (1) | TW200823227A (de) |
WO (1) | WO2008038251A2 (de) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2094685B1 (de) | 2006-12-01 | 2011-01-19 | Actelion Pharmaceuticals Ltd. | 3-heteroaryl (amino bzw. amido)-1- (biphenyl bzw. phenylthiazolyl) carbonylpiperdinderivate als orexinrezeptor-inhibitoren |
TW200833328A (en) * | 2006-12-28 | 2008-08-16 | Actelion Pharmaceuticals Ltd | 2-aza-bicyclo[3.1.0]hexane derivatives |
CL2008000836A1 (es) * | 2007-03-26 | 2008-11-07 | Actelion Pharmaceuticals Ltd | Compuestos derivados de tiazolidina, antagonistas del receptor de orexina; composicion farmaceutica que los comprende; y su uso en el tratamiento de neurosis emocional, depresion grave, trastornos psicoticos, alzheimer, parkinson, dolor, entre otras. |
PT2152690E (pt) | 2007-05-23 | 2012-03-30 | Merck Sharp & Dohme | Antagonistas piridil piperidina de receptor de orexina |
WO2008150364A1 (en) | 2007-05-23 | 2008-12-11 | Merck & Co., Inc. | Cyclopropyl pyrrolidine orexin receptor antagonists |
ES2371514T3 (es) * | 2007-07-03 | 2012-01-04 | Actelion Pharmaceuticals Ltd. | Compuestos de 3-aza-biciclo[3.3.0]octano. |
AR067665A1 (es) | 2007-07-27 | 2009-10-21 | Actelion Pharmaceuticals Ltd | Derivados de trans-3- aza-biciclo ( 3.1.0) hexano |
KR20100046047A (ko) * | 2007-07-27 | 2010-05-04 | 액테리온 파마슈티칼 리미티드 | 2-아자-비시클로[3.3.0]옥탄 유도체 |
CN101790515A (zh) * | 2007-07-27 | 2010-07-28 | 埃科特莱茵药品有限公司 | 反式-3-氮杂-双环[3.1.0]己烷衍生物 |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
WO2009040730A2 (en) * | 2007-09-24 | 2009-04-02 | Actelion Pharmaceuticals Ltd | Pyrrolidines and piperidines as orexin receptor antagonists |
AU2009215243A1 (en) * | 2008-02-21 | 2009-08-27 | Actelion Pharmaceuticals Ltd. | 2-aza-bicyclo[2.2.1]heptane derivatives |
KR20100135962A (ko) * | 2008-04-30 | 2010-12-27 | 액테리온 파마슈티칼 리미티드 | 피페리딘 및 피롤리딘 화합물 |
US20110212968A1 (en) * | 2008-10-14 | 2011-09-01 | Hamed Aissaoui | Phenethylamide derivatives and their heterocyclic analogues |
CA2745433A1 (en) * | 2008-12-02 | 2010-06-10 | Glaxo Group Ltd. | N-{[(ir,4s,6r-3-(2-pyridinylcarbonyl)-3-azabicyclo [4.1.0]hept-4-yl] methyl}-2-heteroarylamine derivatives and uses thereof |
US8133908B2 (en) | 2008-12-02 | 2012-03-13 | Glaxo Group Limited | Heteroaryl derivatives of N-{[(1S,4S,6S)-3-(2-pyridinylcarbonyl)-3-azabicyclo[4.1.0]hept-4-yl]methyl}-2-amine |
GB0823467D0 (en) | 2008-12-23 | 2009-01-28 | Glaxo Group Ltd | Novel Compounds |
CA2747602A1 (en) * | 2008-12-29 | 2010-07-08 | Vanderbilt University | 3.1.0 bicyclic glyt1 inhibitors and methods of making and using same |
KR20120007061A (ko) | 2009-04-24 | 2012-01-19 | 글락소 그룹 리미티드 | 오렉신 길항제로서 사용되는 3-아자비시클로[4.1.0]헵탄 |
EP2275421A1 (de) * | 2009-07-15 | 2011-01-19 | Rottapharm S.p.A. | Spiro-Amino-Verbindungen geeignet zur Behandlung von unter anderem Schlafstörungen und Drogenabhängigkeit |
WO2011023585A1 (en) | 2009-08-24 | 2011-03-03 | Glaxo Group Limited | Piperidine derivatives used as orexin antagonists |
EP2470523A1 (de) | 2009-08-24 | 2012-07-04 | Glaxo Group Limited | 5-methyl-piperidinderivate als orexinrezeptor-antagonisten zur behandlung von schlafstörungen |
CN102781942B (zh) | 2009-10-23 | 2015-09-23 | 詹森药业有限公司 | 用作食欲肽受体调节剂的二取代八氢吡咯并[3,4-c]吡咯 |
BR112012010752B1 (pt) * | 2009-11-05 | 2021-07-20 | University Of Notre Dame Du Lac | Compostos imidazo[1,2-a]piridina |
CA2785957C (en) * | 2009-12-29 | 2015-06-16 | Suven Life Sciences Limited | .alpha.4.beta.2 neuronal nicotinic acetylcholine receptor ligands |
RS54101B1 (en) * | 2010-09-22 | 2015-10-30 | Eisai R&D Management Co. Ltd. | A CYCLOPROPAN UNIT |
WO2012063207A1 (en) * | 2010-11-10 | 2012-05-18 | Actelion Pharmaceuticals Ltd | Lactam derivatives useful as orexin receptor antagonists |
WO2012089606A1 (en) | 2010-12-28 | 2012-07-05 | Glaxo Group Limited | Azabicyclo [4.1.0] hept - 4 - yl derivatives as human orexin receptor antagonists |
WO2012089607A1 (en) | 2010-12-28 | 2012-07-05 | Glaxo Group Limited | Novel compounds with a 3a-azabicyclo [4.1.0] heptane core acting on orexin receptors |
AR088352A1 (es) | 2011-10-19 | 2014-05-28 | Merck Sharp & Dohme | Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina |
US9440982B2 (en) | 2012-02-07 | 2016-09-13 | Eolas Therapeutics, Inc. | Substituted prolines/piperidines as orexin receptor antagonists |
WO2013119639A1 (en) | 2012-02-07 | 2013-08-15 | Eolas Therapeutics, Inc. | Substituted prolines / piperidines as orexin receptor antagonists |
ITMI20120424A1 (it) * | 2012-03-19 | 2013-09-20 | Rottapharm Spa | Composti chimici |
TWI570120B (zh) * | 2012-06-04 | 2017-02-11 | 艾克泰聯製藥有限公司 | 苯并咪唑脯胺酸衍生物 |
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-
2007
- 2007-09-28 KR KR1020097008574A patent/KR20090077051A/ko not_active Application Discontinuation
- 2007-09-28 CA CA002662612A patent/CA2662612A1/en not_active Abandoned
- 2007-09-28 TW TW096136490A patent/TW200823227A/zh unknown
- 2007-09-28 DE DE602007009284T patent/DE602007009284D1/de active Active
- 2007-09-28 CL CL200702809A patent/CL2007002809A1/es unknown
- 2007-09-28 EP EP07826577A patent/EP2079690B1/de not_active Not-in-force
- 2007-09-28 US US12/311,451 patent/US20100016401A1/en not_active Abandoned
- 2007-09-28 JP JP2009529841A patent/JP2010504957A/ja not_active Ceased
- 2007-09-28 CN CNA2007800357375A patent/CN101522618A/zh active Pending
- 2007-09-28 AT AT07826577T patent/ATE481383T1/de not_active IP Right Cessation
- 2007-09-28 WO PCT/IB2007/053947 patent/WO2008038251A2/en active Application Filing
- 2007-09-28 ES ES07826577T patent/ES2350460T3/es active Active
- 2007-10-01 AR ARP070104342A patent/AR063081A1/es unknown
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WO2008038251A3 (en) | 2008-06-26 |
KR20090077051A (ko) | 2009-07-14 |
DE602007009284D1 (de) | 2010-10-28 |
ES2350460T3 (es) | 2011-01-24 |
CL2007002809A1 (es) | 2008-04-18 |
WO2008038251A2 (en) | 2008-04-03 |
TW200823227A (en) | 2008-06-01 |
AR063081A1 (es) | 2008-12-23 |
JP2010504957A (ja) | 2010-02-18 |
EP2079690B1 (de) | 2010-09-15 |
US20100016401A1 (en) | 2010-01-21 |
EP2079690A2 (de) | 2009-07-22 |
CN101522618A (zh) | 2009-09-02 |
CA2662612A1 (en) | 2008-04-03 |
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