AR063081A1 - Derivados de 3- aza- biciclo [3.1.0] hexano y su uso para la preparacion de medicamentos - Google Patents
Derivados de 3- aza- biciclo [3.1.0] hexano y su uso para la preparacion de medicamentosInfo
- Publication number
- AR063081A1 AR063081A1 ARP070104342A ARP070104342A AR063081A1 AR 063081 A1 AR063081 A1 AR 063081A1 AR P070104342 A ARP070104342 A AR P070104342A AR P070104342 A ARP070104342 A AR P070104342A AR 063081 A1 AR063081 A1 AR 063081A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- substituted
- heterocyclyl
- alkyl
- nr2r3
- Prior art date
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A61P15/16—Masculine contraceptives
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
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- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Reproductive Health (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Child & Adolescent Psychology (AREA)
- Addiction (AREA)
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Abstract
Compuestos de 3-aza-biciclo [3.1.0] hexano y su uso en la preparacion de medicamentos. Estos compuestos son utiles en trastornos del sueno, como insomnio, apicea del sueno, dolor neuropático y trastornos neurologicos y psiquiátricos. Reivindicacion 1: Un compuesto de formula (1) donde X representa C(O) o SO2; A representa arilo o heterociclilo, donde el arilo o heterociclilo no está sustituido o está independientemente mono- o di-sustituido, donde los sustituyentes se seleccionan independientemente del grupo que consiste en alquilo C1-4, cicloalquilo C3-6, alquinilo C2-6, hidroxi-alquilo C1-4, hidroxi-alquinilo C2-6, trimetilsilil-etinilo, cicloalquil C3-6-etinilo, alcoxi C1-4, trifluorometilo, trifluorometoxi, NR2R3, N(R2)C(O)R3, C(O)NR2R3 y halogeno; B representa un átomo de hidrogeno o un grupo arilo o heterociclilo, donde el arilo o heterociclilo no está sustituido o está independientemente mono-, di- o trisustituido, donde los sustituyentes se seleccionan independientemente del grupo que consiste en alquilo C1-4, cicloalquilo C3-6, alcoxi C1-4, rnetoxi-alcoxi C1-4, ciano, trifluorometilo, trifluorometoxi, NR2R3, N(R2)C(O)R3, C(O)NR2R3 y halogeno; o B representa un grupo 2,3-dihidro-benzo[1 ,4]dioxinilo; o A y B juntos representan un grupo tricíclico; n representa 0 o 1; R1 representa arilo o heterociclilo, donde el arilo o heterociclilo no está sustituido está independientemente mono-, di- o tri-sustituido, donde los sustituyentes se seleccionan independientemente del grupo que consiste en alquilo C1-4, alquinilo C2-6, cicloalquilo C3-6, alcoxi C1-4, alquil C1-4-tio, halogeno, hidroxi, ciano, trifluorometilo, trifluorometoxi, NR2R3, N(R2)C(O)R3, COOR2 y C(O)NR2R3, o R1 representa un grupo heterociclil-etenilo, heterociclil-alquilo C1-4 o ariloxialquilo C1-4, donde dichos grupos no están sustituidos o están independientemente mono- o di-sustituidos en la porcion arilo o heterociclilo, donde los sustituyentes se seleccionan independientemente del grupo que consiste en alquilo C1-4, alcoxi C1-4, halogeno, trifluorometilo, trifluorometoxi y NR2R3, o R1 representa un grupo 2,3-dihidro-benzofuranilo, benzo[1,3jdioxolilo, 2,3-dihidro-benzo[1,4]dioxinilo, 4-oxo- 4H-cromenilo, 2H-cromenilo, cromanilo, 4H-benzo[1,3]dioxinilo, 2,3-dihidro-tieno[3,4-b][1,4]dioxinilo, morfolin-4-il-fenilo, piperazin-1-il-fenilo, 3,4-dihidro-2H-benzo[1,4]oxazinilo, 3-oxo-3,4-dihidro-2H-benzo[1,4]oxazinilo o 2,3,6,7-tetrahidro- benzo[1,2-b;4,5-b']difuranilo, donde dichos grupos no están sustituidos o están independientemente mono- o di-sustituidos, donde los sustituyentes se seleccionan independientemente del grupo que consiste en alquilo C1-4, alcoxi C1-4 y halogeno; R2 representa hidrogeno o alquilo C1-4; y R3 representa hidrogeno o alquilo C1-4; o una sal farmacéuticamente aceptable de dicho compuesto.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IB2006053570 | 2006-09-29 |
Publications (1)
Publication Number | Publication Date |
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AR063081A1 true AR063081A1 (es) | 2008-12-23 |
Family
ID=39106344
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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ARP070104342A AR063081A1 (es) | 2006-09-29 | 2007-10-01 | Derivados de 3- aza- biciclo [3.1.0] hexano y su uso para la preparacion de medicamentos |
Country Status (13)
Country | Link |
---|---|
US (1) | US20100016401A1 (es) |
EP (1) | EP2079690B1 (es) |
JP (1) | JP2010504957A (es) |
KR (1) | KR20090077051A (es) |
CN (1) | CN101522618A (es) |
AR (1) | AR063081A1 (es) |
AT (1) | ATE481383T1 (es) |
CA (1) | CA2662612A1 (es) |
CL (1) | CL2007002809A1 (es) |
DE (1) | DE602007009284D1 (es) |
ES (1) | ES2350460T3 (es) |
TW (1) | TW200823227A (es) |
WO (1) | WO2008038251A2 (es) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008065626A2 (en) | 2006-12-01 | 2008-06-05 | Actelion Pharmaceuticals Ltd | 3-heteroaryl (amino or amido)-1- (biphenyl or phenylthiazolyl) carbonylpiperidine derivativesas orexin receptor inhibitors |
CL2007003827A1 (es) * | 2006-12-28 | 2008-09-26 | Actelion Pharmaceuticals Ltd | Compuestos derivados de n-(2-aza-biciclo(3.1.0)hex-3-ilmetil)amida; y su uso para prevenir o tratar la depresion, neurosis, esquizofrenia, ansiedad, adicciones, epilepsia, dolor, enfermedades cardiacas, entre otras. |
CL2008000836A1 (es) * | 2007-03-26 | 2008-11-07 | Actelion Pharmaceuticals Ltd | Compuestos derivados de tiazolidina, antagonistas del receptor de orexina; composicion farmaceutica que los comprende; y su uso en el tratamiento de neurosis emocional, depresion grave, trastornos psicoticos, alzheimer, parkinson, dolor, entre otras. |
MY148544A (en) | 2007-05-23 | 2013-04-30 | Merck Sharp & Dohme | Pyridyl piperidine orexin receptor antagonists |
US8030495B2 (en) * | 2007-05-23 | 2011-10-04 | Coleman Paul J | Cyclopropyl pyrrolidine orexin receptor antagonists |
ATE524466T1 (de) * | 2007-07-03 | 2011-09-15 | Actelion Pharmaceuticals Ltd | 3-azabicycloä3.3.0üoktanverbindungen |
EP2185512B1 (en) * | 2007-07-27 | 2010-12-29 | Actelion Pharmaceuticals Ltd. | Trans-3-aza-bicyclo[3.1.0]hexane derivatives |
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- 2007-09-28 ES ES07826577T patent/ES2350460T3/es active Active
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- 2007-09-28 CL CL200702809A patent/CL2007002809A1/es unknown
- 2007-09-28 AT AT07826577T patent/ATE481383T1/de not_active IP Right Cessation
- 2007-09-28 KR KR1020097008574A patent/KR20090077051A/ko not_active Application Discontinuation
- 2007-09-28 TW TW096136490A patent/TW200823227A/zh unknown
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ATE481383T1 (de) | 2010-10-15 |
EP2079690B1 (en) | 2010-09-15 |
TW200823227A (en) | 2008-06-01 |
CA2662612A1 (en) | 2008-04-03 |
KR20090077051A (ko) | 2009-07-14 |
WO2008038251A3 (en) | 2008-06-26 |
JP2010504957A (ja) | 2010-02-18 |
DE602007009284D1 (de) | 2010-10-28 |
CL2007002809A1 (es) | 2008-04-18 |
WO2008038251A2 (en) | 2008-04-03 |
CN101522618A (zh) | 2009-09-02 |
US20100016401A1 (en) | 2010-01-21 |
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