AR063081A1 - Derivados de 3- aza- biciclo [3.1.0] hexano y su uso para la preparacion de medicamentos - Google Patents

Derivados de 3- aza- biciclo [3.1.0] hexano y su uso para la preparacion de medicamentos

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Publication number
AR063081A1
AR063081A1 ARP070104342A ARP070104342A AR063081A1 AR 063081 A1 AR063081 A1 AR 063081A1 AR P070104342 A ARP070104342 A AR P070104342A AR P070104342 A ARP070104342 A AR P070104342A AR 063081 A1 AR063081 A1 AR 063081A1
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AR
Argentina
Prior art keywords
group
substituted
heterocyclyl
alkyl
nr2r3
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ARP070104342A
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English (en)
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Actelion Pharmaceuticals Ltd
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Publication of AR063081A1 publication Critical patent/AR063081A1/es

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    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
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  • Veterinary Medicine (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
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  • Addiction (AREA)
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  • Immunology (AREA)
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Abstract

Compuestos de 3-aza-biciclo [3.1.0] hexano y su uso en la preparacion de medicamentos. Estos compuestos son utiles en trastornos del sueno, como insomnio, apicea del sueno, dolor neuropático y trastornos neurologicos y psiquiátricos. Reivindicacion 1: Un compuesto de formula (1) donde X representa C(O) o SO2; A representa arilo o heterociclilo, donde el arilo o heterociclilo no está sustituido o está independientemente mono- o di-sustituido, donde los sustituyentes se seleccionan independientemente del grupo que consiste en alquilo C1-4, cicloalquilo C3-6, alquinilo C2-6, hidroxi-alquilo C1-4, hidroxi-alquinilo C2-6, trimetilsilil-etinilo, cicloalquil C3-6-etinilo, alcoxi C1-4, trifluorometilo, trifluorometoxi, NR2R3, N(R2)C(O)R3, C(O)NR2R3 y halogeno; B representa un átomo de hidrogeno o un grupo arilo o heterociclilo, donde el arilo o heterociclilo no está sustituido o está independientemente mono-, di- o trisustituido, donde los sustituyentes se seleccionan independientemente del grupo que consiste en alquilo C1-4, cicloalquilo C3-6, alcoxi C1-4, rnetoxi-alcoxi C1-4, ciano, trifluorometilo, trifluorometoxi, NR2R3, N(R2)C(O)R3, C(O)NR2R3 y halogeno; o B representa un grupo 2,3-dihidro-benzo[1 ,4]dioxinilo; o A y B juntos representan un grupo tricíclico; n representa 0 o 1; R1 representa arilo o heterociclilo, donde el arilo o heterociclilo no está sustituido está independientemente mono-, di- o tri-sustituido, donde los sustituyentes se seleccionan independientemente del grupo que consiste en alquilo C1-4, alquinilo C2-6, cicloalquilo C3-6, alcoxi C1-4, alquil C1-4-tio, halogeno, hidroxi, ciano, trifluorometilo, trifluorometoxi, NR2R3, N(R2)C(O)R3, COOR2 y C(O)NR2R3, o R1 representa un grupo heterociclil-etenilo, heterociclil-alquilo C1-4 o ariloxialquilo C1-4, donde dichos grupos no están sustituidos o están independientemente mono- o di-sustituidos en la porcion arilo o heterociclilo, donde los sustituyentes se seleccionan independientemente del grupo que consiste en alquilo C1-4, alcoxi C1-4, halogeno, trifluorometilo, trifluorometoxi y NR2R3, o R1 representa un grupo 2,3-dihidro-benzofuranilo, benzo[1,3jdioxolilo, 2,3-dihidro-benzo[1,4]dioxinilo, 4-oxo- 4H-cromenilo, 2H-cromenilo, cromanilo, 4H-benzo[1,3]dioxinilo, 2,3-dihidro-tieno[3,4-b][1,4]dioxinilo, morfolin-4-il-fenilo, piperazin-1-il-fenilo, 3,4-dihidro-2H-benzo[1,4]oxazinilo, 3-oxo-3,4-dihidro-2H-benzo[1,4]oxazinilo o 2,3,6,7-tetrahidro- benzo[1,2-b;4,5-b']difuranilo, donde dichos grupos no están sustituidos o están independientemente mono- o di-sustituidos, donde los sustituyentes se seleccionan independientemente del grupo que consiste en alquilo C1-4, alcoxi C1-4 y halogeno; R2 representa hidrogeno o alquilo C1-4; y R3 representa hidrogeno o alquilo C1-4; o una sal farmacéuticamente aceptable de dicho compuesto.
ARP070104342A 2006-09-29 2007-10-01 Derivados de 3- aza- biciclo [3.1.0] hexano y su uso para la preparacion de medicamentos AR063081A1 (es)

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IB2006053570 2006-09-29

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AR063081A1 true AR063081A1 (es) 2008-12-23

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US (1) US20100016401A1 (es)
EP (1) EP2079690B1 (es)
JP (1) JP2010504957A (es)
KR (1) KR20090077051A (es)
CN (1) CN101522618A (es)
AR (1) AR063081A1 (es)
AT (1) ATE481383T1 (es)
CA (1) CA2662612A1 (es)
CL (1) CL2007002809A1 (es)
DE (1) DE602007009284D1 (es)
ES (1) ES2350460T3 (es)
TW (1) TW200823227A (es)
WO (1) WO2008038251A2 (es)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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