PL2069332T3 - Związki azetydynowe jako antagoniści receptorów oreksynowych - Google Patents

Związki azetydynowe jako antagoniści receptorów oreksynowych

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Publication number
PL2069332T3
PL2069332T3 PL07826034T PL07826034T PL2069332T3 PL 2069332 T3 PL2069332 T3 PL 2069332T3 PL 07826034 T PL07826034 T PL 07826034T PL 07826034 T PL07826034 T PL 07826034T PL 2069332 T3 PL2069332 T3 PL 2069332T3
Authority
PL
Poland
Prior art keywords
receptor antagonists
orexin receptor
azetidine compounds
compounds
azetidine
Prior art date
Application number
PL07826034T
Other languages
English (en)
Inventor
Hamed Aissaoui
Christoph Boss
Markus Gude
Ralf Koberstein
Thierry Sifferlen
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of PL2069332T3 publication Critical patent/PL2069332T3/pl

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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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PL07826034T 2006-08-15 2007-08-15 Związki azetydynowe jako antagoniści receptorów oreksynowych PL2069332T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IB2006052814 2006-08-15
PCT/IB2007/053244 WO2008020405A2 (en) 2006-08-15 2007-08-15 Azetidine compounds as orexin receptor antagonists
EP07826034A EP2069332B1 (en) 2006-08-15 2007-08-15 Azetidine compounds as orexin receptor antagonists

Publications (1)

Publication Number Publication Date
PL2069332T3 true PL2069332T3 (pl) 2011-07-29

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PL07826034T PL2069332T3 (pl) 2006-08-15 2007-08-15 Związki azetydynowe jako antagoniści receptorów oreksynowych

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US (1) US7994336B2 (pl)
EP (1) EP2069332B1 (pl)
JP (1) JP2010500401A (pl)
KR (1) KR101113626B1 (pl)
CN (1) CN101506199A (pl)
AT (1) ATE500250T1 (pl)
AU (1) AU2007285371A1 (pl)
BR (1) BRPI0715893A2 (pl)
CA (1) CA2659299A1 (pl)
DE (1) DE602007012910D1 (pl)
ES (1) ES2360376T3 (pl)
MX (1) MX2009001432A (pl)
PL (1) PL2069332T3 (pl)
RU (1) RU2447070C2 (pl)
WO (1) WO2008020405A2 (pl)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CL2007002809A1 (es) * 2006-09-29 2008-04-18 Actelion Pharmaceuticals Ltd Compuestos derivados de 3-aza biciclo [3.1.0]hexano; y su uso en el tratamiento de enfermedades tales como desordenes psicoticos y de ansiedad, desordenes del sueno, uso y abuso de sustancias psicoactivas, demencia y deterioro de funciones cognitivas
US8133901B2 (en) 2006-12-01 2012-03-13 Actelion Pharmaceuticals Ltd. 3-heteroaryl (amino or amido)-1-(biphenyl or phenylthiazolyl) carbonylpiperidine derivatives as orexin receptor inhibitors
CL2007003827A1 (es) * 2006-12-28 2008-09-26 Actelion Pharmaceuticals Ltd Compuestos derivados de n-(2-aza-biciclo(3.1.0)hex-3-ilmetil)amida; y su uso para prevenir o tratar la depresion, neurosis, esquizofrenia, ansiedad, adicciones, epilepsia, dolor, enfermedades cardiacas, entre otras.
CL2008000836A1 (es) * 2007-03-26 2008-11-07 Actelion Pharmaceuticals Ltd Compuestos derivados de tiazolidina, antagonistas del receptor de orexina; composicion farmaceutica que los comprende; y su uso en el tratamiento de neurosis emocional, depresion grave, trastornos psicoticos, alzheimer, parkinson, dolor, entre otras.
AU2008257411B2 (en) 2007-05-23 2012-04-26 Merck Sharp & Dohme Corp. Pyridyl piperidine orexin receptor antagonists
US8106215B2 (en) 2007-07-03 2012-01-31 Actelion Pharmaceuticals Ltd. 3-aza-bicyclo[3.3.0]octane compounds
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US8288411B2 (en) * 2007-09-24 2012-10-16 Actelion Pharmaceuticals Ltd. Pyrrolidines and piperidines as orexin receptor antagonists
WO2009104155A1 (en) * 2008-02-21 2009-08-27 Actelion Pharmaceuticals Ltd 2-aza-bicyclo[2.2.1]heptane derivatives
JP2011519849A (ja) * 2008-04-30 2011-07-14 アクテリオン ファーマシューティカルズ リミテッド ピペリジン及びピロリジン化合物
EP2161266A1 (en) 2008-08-22 2010-03-10 EVOTEC Neurosciences GmbH Benzofuran derivatives as orexin receptor antagonists
CN102164896A (zh) * 2008-10-14 2011-08-24 埃科特莱茵药品有限公司 苯乙基酰胺衍生物及其杂环类似物
US8796297B2 (en) 2009-06-30 2014-08-05 Abbvie Inc. 4-substituted-2-amino-pyrimidine derivatives
US8653263B2 (en) 2009-10-23 2014-02-18 Janssen Pharmaceutica Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators
WO2011138265A2 (en) 2010-05-03 2011-11-10 Evotec Ag Indole and indazole derivatives as orexin receptor antagonists
WO2011138266A1 (en) 2010-05-03 2011-11-10 Evotec Ag Indolizine and imidazopyridine derivatives as orexin receptor antagonists
US9242970B2 (en) * 2010-11-10 2016-01-26 Actelion Pharmaceuticals Ltd. Lactam derivatives useful as orexin receptor antagonists
AR088352A1 (es) 2011-10-19 2014-05-28 Merck Sharp & Dohme Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina
ES2672732T3 (es) 2012-02-07 2018-06-15 Eolas Therapeutics Inc. Prolinas/piperidinas sustituidas como antagonistas del receptor de orexina
US9440982B2 (en) 2012-02-07 2016-09-13 Eolas Therapeutics, Inc. Substituted prolines/piperidines as orexin receptor antagonists
MY169986A (en) 2012-06-04 2019-06-19 Idorsia Pharmaceuticals Ltd Benzimidazole-proline derivatives
EP2875029B8 (en) * 2012-07-18 2021-12-15 University of Notre Dame du Lac 5,5-heteroaromatic anti-infective compounds
AR092955A1 (es) 2012-10-10 2015-05-06 Actelion Pharmaceuticals Ltd Antagonistas de receptores de orexina los cuales son derivados de [orto bi-(hetero-)aril]-[2-(meta bi-(hetero-)aril)-pirrolidin-1-il]-metanona
WO2014141065A1 (en) 2013-03-12 2014-09-18 Actelion Pharmaceuticals Ltd Azetidine amide derivatives as orexin receptor antagonists
NZ721438A (en) 2013-12-03 2021-12-24 Idorsia Pharmaceuticals Ltd Crystalline form of (s)-(2-(6-chloro-7-methyl-1h-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1 -yl)(5-methoxy-2-(2h-1,2,3-triazol-2-yl)phenyl)methanone and its use as orexin receptor antagonists
UA119151C2 (uk) 2013-12-03 2019-05-10 Ідорсія Фармасьютікалз Лтд КРИСТАЛІЧНА СОЛЬОВА ФОРМА (S)-(2-(6-ХЛОР-7-МЕТИЛ-1H-БЕНЗО[d]ІМІДАЗОЛ-2-ІЛ)-2-МЕТИЛПІРОЛІДИН-1-ІЛ)(5-МЕТОКСИ-2-(2H-1,2,3-ТРИАЗОЛ-2-ІЛ)ФЕНІЛ)МЕТАНОНУ ЯК АНТАГОНІСТ ОРЕКСИНОВОГО РЕЦЕПТОРА
JP6421185B2 (ja) 2013-12-04 2018-11-07 イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ ベンゾイミダゾール−プロリン誘導体の使用
UY36272A (es) 2014-08-13 2016-02-29 Eolas Therapeutics Inc Difluoropirrolidinas como moduladores de los receptores de orexinas
TWI710557B (zh) 2016-02-12 2020-11-21 美商伊歐拉斯治療學公司 作為食慾素受體調節劑之經鹵素取代之六氫吡啶
BR112018067906A2 (pt) 2016-03-10 2019-01-29 Janssen Pharmaceutica Nv métodos de tratamento de depressão usando antagonistas do receptor de orexina-2
WO2017194548A1 (en) 2016-05-10 2017-11-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of autoimmune inflammatory diseases
PT3619199T (pt) 2017-05-03 2021-10-01 Idorsia Pharmaceuticals Ltd Preparação de derivados de ácido 2-([1,2,3]triazol-2-il)- benzoico
EP3663281B1 (en) * 2017-08-03 2022-12-28 Takeda Pharmaceutical Company Limited Heterocyclic compound and application thereof
WO2020007964A1 (en) 2018-07-05 2020-01-09 Idorsia Pharmaceuticals Ltd 2-(2-azabicyclo[3.1.0]hexan-1-yl)-1h-benzimidazole derivatives
WO2020007977A1 (en) 2018-07-06 2020-01-09 Idorsia Pharmaceuticals Ltd 7-trifluoromethyl-[1,4]diazepan derivatives
WO2020099511A1 (en) 2018-11-14 2020-05-22 Idorsia Pharmaceuticals Ltd Benzimidazole-2-methyl-morpholine derivatives
TW202400149A (zh) 2022-05-13 2024-01-01 瑞士商愛杜西亞製藥有限公司 經噻唑并芳基-甲基取代之環狀肼-n-甲醯胺衍生物
WO2025224168A1 (en) 2024-04-24 2025-10-30 Idorsia Pharmaceuticals Ltd Aryl sulfone and sulfanone derivatives as orexin receptor modulators

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH621126A5 (pl) * 1974-02-07 1981-01-15 Plantex Ltd
US4956372A (en) 1987-10-02 1990-09-11 Kyorin Pharmaceutical Co., Ltd. Cyclic anthranilic acid derivatives and process for their preparation
GB9303340D0 (en) 1993-02-19 1993-04-07 Smithkline Beecham Plc Pharmaceuticals
AU2381995A (en) 1994-04-29 1995-11-29 Pharmacia & Upjohn Company Methanol derivatives for treatment of retroviral infections especially hiv infections
US6303593B1 (en) 1999-03-02 2001-10-16 Merck & Co., Inc. 3-thienyl and 3-furanyl pyrrolidine modulators of chemokine receptor activity
EP1289955B1 (en) 2000-06-16 2005-04-13 Smithkline Beecham Plc Piperidines for use as orexin receptor antagonists
CA2429258A1 (en) 2000-11-20 2002-06-13 Scios Inc. Piperidine/piperazine-type inhibitors of p38 kinase
TW591020B (en) 2001-06-20 2004-06-11 Wyeth Corp 6-(aryl-amido or aryl-amidomethyl)-naphthalen-2-yloxy-acidic derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1)
WO2004026866A1 (en) 2002-09-18 2004-04-01 Glaxo Group Limited N-aroyl cyclic amines as orexin receptor antagonists
GB0305553D0 (en) 2003-03-11 2003-04-16 Glaxo Group Ltd Compounds
TW200508221A (en) * 2003-06-13 2005-03-01 Astrazeneca Ab New azetidine compounds
US7939534B2 (en) * 2006-08-01 2011-05-10 Cytokinetics, Inc. Certain chemical entities, compositions, and methods

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