MX2010001575A - Derivados de 1,2-diamido-etileno como antagonistas de orexina. - Google Patents
Derivados de 1,2-diamido-etileno como antagonistas de orexina.Info
- Publication number
- MX2010001575A MX2010001575A MX2010001575A MX2010001575A MX2010001575A MX 2010001575 A MX2010001575 A MX 2010001575A MX 2010001575 A MX2010001575 A MX 2010001575A MX 2010001575 A MX2010001575 A MX 2010001575A MX 2010001575 A MX2010001575 A MX 2010001575A
- Authority
- MX
- Mexico
- Prior art keywords
- diamido
- ethylene derivatives
- orexin antagonists
- orexin
- derivatives
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Abstract
La presente invención se relaciona con derivados de 1,2-diamido-etileno de la fórmula (I) en donde R1, R2, R3 y A son como se describió en la descripción y su uso como productos medicamentos, especialmente como antagonistas receptores de orexina.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IB2007053249 | 2007-08-15 | ||
PCT/IB2008/053264 WO2009022311A2 (en) | 2007-08-15 | 2008-08-14 | 1,2-diamido-ethylene derivatives as orexin antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2010001575A true MX2010001575A (es) | 2010-03-15 |
Family
ID=40206260
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2010001575A MX2010001575A (es) | 2007-08-15 | 2008-08-14 | Derivados de 1,2-diamido-etileno como antagonistas de orexina. |
Country Status (12)
Country | Link |
---|---|
US (1) | US20110263662A1 (es) |
EP (1) | EP2188282B1 (es) |
JP (1) | JP2010536740A (es) |
KR (1) | KR20100055464A (es) |
CN (1) | CN101778846B (es) |
AU (1) | AU2008288151A1 (es) |
BR (1) | BRPI0815079A2 (es) |
CA (1) | CA2694993A1 (es) |
ES (1) | ES2400830T3 (es) |
MX (1) | MX2010001575A (es) |
RU (1) | RU2010109455A (es) |
WO (1) | WO2009022311A2 (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8084601B2 (en) | 2008-09-11 | 2011-12-27 | Royal Holloway And Bedford New College Royal Holloway, University Of London | Oligomers |
US20110212968A1 (en) * | 2008-10-14 | 2011-09-01 | Hamed Aissaoui | Phenethylamide derivatives and their heterocyclic analogues |
CN102781942B (zh) | 2009-10-23 | 2015-09-23 | 詹森药业有限公司 | 用作食欲肽受体调节剂的二取代八氢吡咯并[3,4-c]吡咯 |
EP2491034B1 (en) | 2009-10-23 | 2013-12-18 | Janssen Pharmaceutica, N.V. | Fused heterocyclic compounds as orexin receptor modulators |
WO2011050202A1 (en) | 2009-10-23 | 2011-04-28 | Janssen Pharmaceutica Nv | Fused heterocyclic compounds as orexin receptor modulators |
WO2011073316A1 (en) * | 2009-12-18 | 2011-06-23 | Novartis Ag | 4-aryl-butane-1,3-diamides |
WO2012063207A1 (en) * | 2010-11-10 | 2012-05-18 | Actelion Pharmaceuticals Ltd | Lactam derivatives useful as orexin receptor antagonists |
WO2012145581A1 (en) | 2011-04-20 | 2012-10-26 | Janssen Pharmaceutica Nv | Disubstituted octahy-dropyrrolo [3,4-c] pyrroles as orexin receptor modulators |
US9440982B2 (en) | 2012-02-07 | 2016-09-13 | Eolas Therapeutics, Inc. | Substituted prolines/piperidines as orexin receptor antagonists |
WO2013119639A1 (en) | 2012-02-07 | 2013-08-15 | Eolas Therapeutics, Inc. | Substituted prolines / piperidines as orexin receptor antagonists |
AR098436A1 (es) * | 2013-11-19 | 2016-05-26 | Actelion Pharmaceuticals Ltd | Compuestos tricíclicos de piperidina |
UY36272A (es) | 2014-08-13 | 2016-02-29 | Eolas Therapeutics Inc | Difluoropirrolidinas como moduladores de los receptores de orexinas |
GB201415569D0 (en) * | 2014-09-03 | 2014-10-15 | C4X Discovery Ltd | Therapeutic Compounds |
GB201601703D0 (en) | 2016-01-29 | 2016-03-16 | C4X Discovery Ltd | Therapeutic compounds |
EP3414241B1 (en) | 2016-02-12 | 2022-05-04 | Astrazeneca AB | Halo-substituted piperidines as orexin receptor modulators |
CN108883110B (zh) | 2016-03-10 | 2022-05-27 | 詹森药业有限公司 | 使用食欲素-2受体拮抗剂治疗抑郁症的方法 |
US20190151304A1 (en) | 2016-05-10 | 2019-05-23 | Inserm (Institut National De La Santé Et De La Rechercjae Médicale | Methods and pharmaceutical compositions for the treatment of autoimmune inflammatory |
GB201702174D0 (en) | 2017-02-09 | 2017-03-29 | Benevolentai Bio Ltd | Orexin receptor antagonists |
GB201707499D0 (en) | 2017-05-10 | 2017-06-21 | Benevolentai Bio Ltd | Orexin receptor antagonists |
GB201707504D0 (en) | 2017-05-10 | 2017-06-21 | Benevolentai Bio Ltd | Orexin receptor antagonists |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6191124B1 (en) | 1994-04-29 | 2001-02-20 | Pharmacia & Upjohn Company | Methanol derivatives for treatment of retroviral infections especially HIV infections |
JP4611608B2 (ja) * | 2000-06-16 | 2011-01-12 | スミスクライン ビーチャム ピー エル シー | オレキシン受容体アンタゴニストとして使用するためのピペリジン |
JP4028711B2 (ja) * | 2001-10-31 | 2007-12-26 | 株式会社アーレスティ | 金型冷却装置 |
GB0130341D0 (en) * | 2001-12-19 | 2002-02-06 | Smithkline Beecham Plc | Compounds |
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2008
- 2008-08-14 US US12/673,382 patent/US20110263662A1/en not_active Abandoned
- 2008-08-14 AU AU2008288151A patent/AU2008288151A1/en not_active Abandoned
- 2008-08-14 JP JP2010520669A patent/JP2010536740A/ja not_active Ceased
- 2008-08-14 BR BRPI0815079-6A2A patent/BRPI0815079A2/pt not_active IP Right Cessation
- 2008-08-14 KR KR1020107005493A patent/KR20100055464A/ko not_active Application Discontinuation
- 2008-08-14 ES ES08807317T patent/ES2400830T3/es active Active
- 2008-08-14 EP EP08807317A patent/EP2188282B1/en not_active Not-in-force
- 2008-08-14 RU RU2010109455/04A patent/RU2010109455A/ru not_active Application Discontinuation
- 2008-08-14 WO PCT/IB2008/053264 patent/WO2009022311A2/en active Application Filing
- 2008-08-14 CA CA2694993A patent/CA2694993A1/en not_active Abandoned
- 2008-08-14 CN CN2008801035335A patent/CN101778846B/zh not_active Expired - Fee Related
- 2008-08-14 MX MX2010001575A patent/MX2010001575A/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN101778846B (zh) | 2012-11-14 |
ES2400830T3 (es) | 2013-04-12 |
JP2010536740A (ja) | 2010-12-02 |
RU2010109455A (ru) | 2011-09-20 |
CA2694993A1 (en) | 2009-02-19 |
CN101778846A (zh) | 2010-07-14 |
AU2008288151A1 (en) | 2009-02-19 |
KR20100055464A (ko) | 2010-05-26 |
US20110263662A1 (en) | 2011-10-27 |
WO2009022311A3 (en) | 2009-04-09 |
BRPI0815079A2 (pt) | 2015-02-03 |
EP2188282B1 (en) | 2013-01-23 |
WO2009022311A2 (en) | 2009-02-19 |
EP2188282A2 (en) | 2010-05-26 |
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