AR061867A1 - Derivados de (4,5') bipirimidil 6,4' - diamina como inhibidores de proteinquinasa - Google Patents
Derivados de (4,5') bipirimidil 6,4' - diamina como inhibidores de proteinquinasaInfo
- Publication number
- AR061867A1 AR061867A1 ARP070103061A ARP070103061A AR061867A1 AR 061867 A1 AR061867 A1 AR 061867A1 AR P070103061 A ARP070103061 A AR P070103061A AR P070103061 A ARP070103061 A AR P070103061A AR 061867 A1 AR061867 A1 AR 061867A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- unsaturated
- monocyclic
- independently selected
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Composiciones farmacéuticas que comprenden estos compuestos, y métodos para utilizar tales compuestos con el fin de tratar o prevenir enfermedades o trastornos asociados con una actividad anormal o mal regulada de la cinasa, en particular enfermedades o trastornos que involucren una activacion anormal de la cinasa FGFR3. utiles para proliferacion celular, enfermedades autoinmunes e inflamatorias. Reivindicacion 1: Un compuesto de la formula 1: en donde: Y es N y Z es CH, o bien Z es N e Y es CH; R1 es alcoxilo C1-4; R2 se selecciona a partir de ciano, alcoxilo C1-4, -C(O)NR7R8, -NR7C(O)R8, -NR7S(O)2R8, -S(O)2NR7R8, -NR7R8, -C(O)OR8, -OC(O)R8, -C(O)NR7OR8, y un anillo monocíclico saturado, insaturado, o parcialmente saturado, que contiene de 5 a 7 miembros del anillo seleccionados a partir de C, O, N y S; en donde R7 se selecciona a partir de hidrogeno y alquilo C1-4; y R8 se selecciona a partir de hidrogeno, alquilo C1-4, y cicloalquilo C3-12, o es fenilo que está insustituido o sustituido por uno o más sustituyentes seleccionados a partir de alquilo C1-4, halo-alquilo C1-4, y (pirrolidino, piperidino, piperazino o 4-alquilo C1-4-piperazino)-alquilo C1-4; o R1 y R2 son independientemente H cuando Y es N y Z es CH; R3 se selecciona a partir de H, halogeno, alquilo C1-4, y alcoxilo C1-4; R4a se selecciona a partir de halogeno y alquilo C1-4; R4b se selecciona a partir de H y alquilo C1-4; R5 es H y alquilo C1-4; R6 se selecciona a partir de H, -X1R9 y - X1NR10R11; en donde cada X1 se selecciona independientemente a partir de un enlace y alquileno C1-4; R9 se selecciona a partir de arilo C6-10, un anillo monocíclico que contiene de 5 a 7 miembros del anillo seleccionados a partir de C, O, N y S, y un sistema de anillo bicíclico puenteado o fusionado que contiene de 8 a 14 miembros seleccionados a partir de C, O, N y S; en donde estos anillos monocíclicos y bicíclicos puenteados o fusionados de R9 pueden estar saturados, insaturados, o parcialmente insaturados; R10 y R11 se seleccionan independientemente a partir de H y alquilo C1-4, en donde el arilo de los anillos monocíclicos o bicíclicos de R9 puede estar opcionalmente sustituido con un grupo seleccionado a partir de alquilo C1-4, -X2R12, y -OX2NR13R14; en donde cada X2 se selecciona independientemente a partir de un enlace y alquileno C1-4; R13 y R14 se seleccionan independientemente a partir de hidrogeno y alquilo C1-4; R12 se selecciona a partir de un anillo monocíclico que contiene de 5 a 7 miembros del anillo seleccionados a partir de C, O, N y S opcionalmente sustituido con hasta 3 grupos seleccionados a partir de alquilo C1-4, -X3C(O)NR15R16, -X3OR16, -X3C(O)X3OR15, -X3C(O)R15 y -X3NR15R16; en donde el anillo monocíclico de R12 puede estar saturado, insaturado, o parcialmente insaturado; en donde cada X3 se selecciona independientemente a partir de un enlace y alquileno C1-4; cada R15 y R16 se selecciona independientemente a partir de hidrogeno y alquilo C1-4; en donde cualesquiera sustituyentes de alquilo de R9 pueden estar opcionalmente sustituidos con hasta 3 grupos hidroxilo; un derivado de N-oxido, un isomero individual, una mezcla de isomeros, y/o una sal farmacéuticamente aceptable del mismo, incluyendo un solvato, respectivamente.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83049206P | 2006-07-12 | 2006-07-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR061867A1 true AR061867A1 (es) | 2008-09-24 |
Family
ID=38617203
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070103061A AR061867A1 (es) | 2006-07-12 | 2007-07-10 | Derivados de (4,5') bipirimidil 6,4' - diamina como inhibidores de proteinquinasa |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US8026243B2 (es) |
| EP (1) | EP2044036B1 (es) |
| JP (1) | JP2009543798A (es) |
| KR (1) | KR20090029832A (es) |
| CN (1) | CN101511798B (es) |
| AR (1) | AR061867A1 (es) |
| AT (1) | ATE508119T1 (es) |
| AU (1) | AU2007272646A1 (es) |
| BR (1) | BRPI0714291A2 (es) |
| CA (1) | CA2657381A1 (es) |
| CL (1) | CL2007002017A1 (es) |
| DE (1) | DE602007014374D1 (es) |
| ES (1) | ES2367666T3 (es) |
| MX (1) | MX2009000429A (es) |
| PE (1) | PE20080548A1 (es) |
| PL (1) | PL2044036T3 (es) |
| PT (1) | PT2044036E (es) |
| RU (1) | RU2009104340A (es) |
| TW (1) | TW200811134A (es) |
| UY (1) | UY30477A1 (es) |
| WO (1) | WO2008008747A1 (es) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR064491A1 (es) | 2006-12-22 | 2009-04-08 | Astex Therapeutics Ltd | Derivados de imidazo[1, 2-a]pirimidina, un proceso para su preparacion, una composicion farmaceutica que los comprende y su uso en el tratamiento de enfermedades mediadas por las quinasas fgfr. |
| CA2672213C (en) | 2006-12-22 | 2016-02-16 | Astex Therapeutics Limited | Bicyclic amine derivatives as protein tyrosine kinase inhibitors |
| US8131527B1 (en) | 2006-12-22 | 2012-03-06 | Astex Therapeutics Ltd. | FGFR pharmacophore compounds |
| GB0720038D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New compounds |
| GB0720041D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New Compounds |
| GB0810902D0 (en) | 2008-06-13 | 2008-07-23 | Astex Therapeutics Ltd | New compounds |
| GB0906472D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| GB0906470D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| EP2308866A1 (de) | 2009-10-09 | 2011-04-13 | Bayer CropScience AG | Phenylpyri(mi)dinylpyrazole und ihre Verwendung als Fungizide |
| EP2516423A1 (en) | 2009-12-21 | 2012-10-31 | Bayer CropScience AG | Thienylpyri (mi) dinylazole and their use for controlling phytopathogenic fungi |
| WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
| WO2012175513A1 (en) | 2011-06-20 | 2012-12-27 | Bayer Intellectual Property Gmbh | Thienylpyri(mi)dinylpyrazole |
| KR20140072177A (ko) | 2011-10-06 | 2014-06-12 | 바이엘 인텔렉쳐 프로퍼티 게엠베하 | 헤테로사이클릴피리(미)디닐피라졸 |
| KR20140080522A (ko) | 2011-10-06 | 2014-06-30 | 바이엘 인텔렉쳐 프로퍼티 게엠베하 | 살진균제로서의 헤테로시클릴피리(미)디닐피라졸 |
| DK3459942T3 (da) | 2012-04-24 | 2021-03-08 | Vertex Pharma | DNA-PK-hæmmere |
| KR102406771B1 (ko) | 2012-06-13 | 2022-06-13 | 인사이트 홀딩스 코포레이션 | Fgfr 억제제로서 치환된 트리사이클릭 화합물 |
| US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
| RU2673943C2 (ru) * | 2012-09-27 | 2018-12-03 | Чугаи Сейяку Кабусики Кайся | Fgfr3 гибридный ген и лекарственный препарат, нацеленный на него |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| AR094812A1 (es) | 2013-02-20 | 2015-08-26 | Eisai R&D Man Co Ltd | Derivado de piridina monocíclico como inhibidor del fgfr |
| EP3985003B1 (en) | 2013-03-12 | 2023-08-09 | Vertex Pharmaceuticals Incorporated | Dna-pk inhibitors |
| EP3318564B1 (en) | 2013-04-19 | 2021-07-28 | Incyte Holdings Corporation | Bicyclic heterocycles as fgfr inhibitors |
| SI3424920T1 (sl) | 2013-10-17 | 2020-08-31 | Vertex Pharmaceuticals Incorporated | Kokristali (s)-n-metil-8-(1-((2'-metil-(4,5'-bipirimidin)-6-il)amino)propan-2-il) kinolin-4-karboksamida in devterirani derivati le-teh kot inhibitorji dna-pk |
| AU2015304465B2 (en) | 2014-08-18 | 2019-05-09 | Eisai R&D Management Co., Ltd. | Salt of monocyclic pyridine derivative and crystal thereof |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| ES2751669T3 (es) | 2015-02-20 | 2020-04-01 | Incyte Corp | Heterociclos bicíclicos como inhibidores FGFR |
| WO2016134294A1 (en) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Bicyclic heterocycles as fgfr4 inhibitors |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| MX2019003317A (es) | 2016-09-27 | 2019-08-05 | Vertex Pharma | Metodo para tratar cancer usando una combinacion de agentes que dañan adn e inhibidores de proteina cinasa dependiente de adn (adn-pk). |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| KR102613433B1 (ko) * | 2017-10-11 | 2023-12-13 | 주식회사 대웅제약 | 신규한 페닐피리딘 유도체 및 이를 포함하는 약학 조성물 |
| KR20200135945A (ko) | 2018-03-28 | 2020-12-04 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 간세포 암종 치료제 |
| MA52493A (fr) | 2018-05-04 | 2021-03-10 | Incyte Corp | Sels d'un inhibiteur de fgfr |
| DK3788047T3 (da) | 2018-05-04 | 2024-09-16 | Incyte Corp | Faste former af en FGFR-inhibitor og fremgangsmåder til fremstilling deraf |
| WO2020185532A1 (en) | 2019-03-08 | 2020-09-17 | Incyte Corporation | Methods of treating cancer with an fgfr inhibitor |
| KR102133595B1 (ko) | 2019-05-31 | 2020-07-13 | 에이치케이이노엔 주식회사 | 단백질 키나제 억제제로서의 헤테로고리 화합물 |
| WO2021007269A1 (en) | 2019-07-09 | 2021-01-14 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| KR102112336B1 (ko) | 2019-08-12 | 2020-05-18 | 에이치케이이노엔 주식회사 | 단백질 키나제 억제제로서의 헤테로고리 화합물 |
| WO2021076602A1 (en) | 2019-10-14 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| WO2021076728A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| CA3163875A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| CN115151539A (zh) | 2019-12-04 | 2022-10-04 | 因赛特公司 | Fgfr抑制剂的衍生物 |
| US12012409B2 (en) | 2020-01-15 | 2024-06-18 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| JP2024513575A (ja) | 2021-04-12 | 2024-03-26 | インサイト・コーポレイション | Ｆｇｆｒ阻害剤及びネクチン－４標的化剤を含む併用療法 |
| CA3220274A1 (en) | 2021-06-09 | 2022-12-15 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9924862D0 (en) | 1999-10-20 | 1999-12-22 | Celltech Therapeutics Ltd | Chemical compounds |
| US7244739B2 (en) | 2003-05-14 | 2007-07-17 | Torreypines Therapeutics, Inc. | Compounds and uses thereof in modulating amyloid beta |
| MXPA06003557A (es) * | 2003-09-30 | 2006-06-20 | Irm Llc | Compuestos y composiciones como inhibidores de cinasa de proteina. |
| JP5097539B2 (ja) * | 2004-05-07 | 2012-12-12 | アムジエン・インコーポレーテツド | タンパク質キナーゼ調節剤および使用方法 |
| AU2007212345A1 (en) | 2006-02-06 | 2007-08-16 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
-
2007
- 2007-07-04 TW TW096124311A patent/TW200811134A/zh unknown
- 2007-07-10 DE DE602007014374T patent/DE602007014374D1/de active Active
- 2007-07-10 WO PCT/US2007/073111 patent/WO2008008747A1/en active Application Filing
- 2007-07-10 US US12/373,441 patent/US8026243B2/en not_active Expired - Fee Related
- 2007-07-10 BR BRPI0714291-9A2A patent/BRPI0714291A2/pt not_active Application Discontinuation
- 2007-07-10 MX MX2009000429A patent/MX2009000429A/es not_active Application Discontinuation
- 2007-07-10 PT PT07812739T patent/PT2044036E/pt unknown
- 2007-07-10 AT AT07812739T patent/ATE508119T1/de active
- 2007-07-10 ES ES07812739T patent/ES2367666T3/es active Active
- 2007-07-10 PL PL07812739T patent/PL2044036T3/pl unknown
- 2007-07-10 AR ARP070103061A patent/AR061867A1/es unknown
- 2007-07-10 JP JP2009519623A patent/JP2009543798A/ja active Pending
- 2007-07-10 CA CA002657381A patent/CA2657381A1/en not_active Abandoned
- 2007-07-10 AU AU2007272646A patent/AU2007272646A1/en not_active Abandoned
- 2007-07-10 EP EP07812739A patent/EP2044036B1/en not_active Not-in-force
- 2007-07-10 PE PE2007000885A patent/PE20080548A1/es not_active Application Discontinuation
- 2007-07-10 KR KR1020097002815A patent/KR20090029832A/ko not_active Application Discontinuation
- 2007-07-10 CN CN2007800337140A patent/CN101511798B/zh not_active Expired - Fee Related
- 2007-07-10 RU RU2009104340/04A patent/RU2009104340A/ru not_active Application Discontinuation
- 2007-07-11 CL CL200702017A patent/CL2007002017A1/es unknown
- 2007-07-11 UY UY30477A patent/UY30477A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20090029832A (ko) | 2009-03-23 |
| ES2367666T3 (es) | 2011-11-07 |
| BRPI0714291A2 (pt) | 2014-10-21 |
| RU2009104340A (ru) | 2010-08-20 |
| TW200811134A (en) | 2008-03-01 |
| PL2044036T3 (pl) | 2011-09-30 |
| JP2009543798A (ja) | 2009-12-10 |
| US20100234376A1 (en) | 2010-09-16 |
| MX2009000429A (es) | 2009-01-29 |
| CA2657381A1 (en) | 2008-01-17 |
| WO2008008747A1 (en) | 2008-01-17 |
| EP2044036B1 (en) | 2011-05-04 |
| PE20080548A1 (es) | 2008-06-24 |
| PT2044036E (pt) | 2011-08-23 |
| AU2007272646A1 (en) | 2008-01-17 |
| US8026243B2 (en) | 2011-09-27 |
| UY30477A1 (es) | 2009-04-30 |
| CN101511798B (zh) | 2011-11-02 |
| DE602007014374D1 (de) | 2011-06-16 |
| CL2007002017A1 (es) | 2008-06-13 |
| CN101511798A (zh) | 2009-08-19 |
| ATE508119T1 (de) | 2011-05-15 |
| EP2044036A1 (en) | 2009-04-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR061867A1 (es) | Derivados de (4,5') bipirimidil 6,4' - diamina como inhibidores de proteinquinasa | |
| AR052902A1 (es) | Derivados de piridazina, composicion farmaceutica que los contiene y su uso como agentes terapeuticos para enfermedades mediadas por la estearoil-coa desaturasa | |
| AR052943A1 (es) | Derivados de 2-(4-oxo-4h-quinazolin-3-il)acetamida | |
| AR067662A1 (es) | Derivados de benzo[d]isoxazol-3-il-piperidina, medicamentos que los contienen y usos terapeuticos para enfermedades asociadas al sistema nervioso. | |
| AR053120A1 (es) | Aminopiridinas como inhibidores de beta secretasa | |
| NI200700270A (es) | Derivados benzodioxano y benzodioxolano y usos de los mismos | |
| AR056979A1 (es) | Derivados de dihidrobenzofuranos y usos de los mismos | |
| AR077975A1 (es) | Derivados de pirazol pirimidina y composiciones como inhibidores de cinasa de proteina | |
| AR051753A1 (es) | Metodos para preparar compuestos de indazol | |
| PE20061362A1 (es) | Derivados de tetrahidronaftalina, procedimientos para su preparacion y su uso como inhibidor de la inflamacion | |
| AR064561A1 (es) | Derivados de 2-aza-biciclo[3.1.0]hexano y su uso en la preparacion de un medicamento para el tratamiento de enfermedades relacionadas con disfunciones generales del sistema de la orexina. | |
| AR077977A1 (es) | Compuestos y composiciones como inhibidores de cinasa de proteina | |
| AR066659A1 (es) | Derivados de espiroindolinona | |
| AR073574A1 (es) | Inhibidores heterociclicos de los receptores de histamina para el tratamiento de una enfermedad | |
| AR043700A1 (es) | Derivados de 3-substituida-4-pirimidona | |
| AR052549A1 (es) | Derivados de 2,3,4,9-tetrahidro-1h-carbazol como antagonistas del receptor crth2 | |
| AR064831A1 (es) | Derivados de espiropiperidina-glicinamida | |
| AR071300A1 (es) | Compuestos; composiciones farmaceuticas en base al compuesto y uso del mismo para la manufactura de un medicamento | |
| AR065863A1 (es) | Derivados de imidazolidinona | |
| AR074352A1 (es) | Acidos naftalen-2-il-aceticos sustituidos, composiciones farmaceuticas que los contienen, y uso de los mismos en el tratamiento de enfermedades alergicas,tales como rinitis, asma y dermatitis atopica. | |
| AR084430A1 (es) | Di/tri-aza-espiro-alcanos c | |
| AR075531A1 (es) | Derivados de piperazin-ciclopropil benzamidas, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de trastornos del sistema nervioso central, tales como alzheimer y esquizofrenia, entre otros | |
| AR066103A1 (es) | Derivados de triazolopiridin - carboxamidas, su preparacion y su aplicacion en terapeutica | |
| CO5590916A2 (es) | Dicetopiperacinas sustituidas como antagonistas de oxitocina | |
| AR074353A1 (es) | Acidos naftalen-2-il-aceticos sustituidos, composiciones farmaceuticas que los contienen, y uso de los mismos en el tratamiento de enfermedades alergicas,tales como rinitis, asma y dermatititis atopica. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |