ATE483711T1 - Spiroindolinonderivate - Google Patents

Spiroindolinonderivate

Info

Publication number
ATE483711T1
ATE483711T1 AT07712430T AT07712430T ATE483711T1 AT E483711 T1 ATE483711 T1 AT E483711T1 AT 07712430 T AT07712430 T AT 07712430T AT 07712430 T AT07712430 T AT 07712430T AT E483711 T1 ATE483711 T1 AT E483711T1
Authority
AT
Austria
Prior art keywords
spiroindolinone derivatives
spiroindolinone
derivatives
Prior art date
Application number
AT07712430T
Other languages
English (en)
Inventor
Li Chen
Qingjie Ding
Jin-Jun Liu
Song Yang
Zhuming Zhang
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE483711T1 publication Critical patent/ATE483711T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
AT07712430T 2006-03-13 2007-03-05 Spiroindolinonderivate ATE483711T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78195806P 2006-03-13 2006-03-13
US88175607P 2007-01-22 2007-01-22
PCT/EP2007/052038 WO2007104664A1 (en) 2006-03-13 2007-03-05 Spiroindolinone derivatives

Publications (1)

Publication Number Publication Date
ATE483711T1 true ATE483711T1 (de) 2010-10-15

Family

ID=38179455

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07712430T ATE483711T1 (de) 2006-03-13 2007-03-05 Spiroindolinonderivate

Country Status (15)

Country Link
US (1) US20070213341A1 (de)
EP (1) EP1996590B1 (de)
JP (1) JP5038337B2 (de)
KR (1) KR101131031B1 (de)
AR (1) AR059957A1 (de)
AT (1) ATE483711T1 (de)
AU (1) AU2007224505B2 (de)
BR (1) BRPI0709605A2 (de)
CA (1) CA2645062A1 (de)
DE (1) DE602007009650D1 (de)
IL (1) IL193641A0 (de)
NO (1) NO20083726L (de)
RU (1) RU2435771C2 (de)
TW (1) TW200801000A (de)
WO (1) WO2007104664A1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2320955B1 (es) * 2007-03-02 2010-03-16 Laboratorios Almirall S.A. Nuevos derivados de 3-((1,2,4)triazolo(4,3-a)piridin-7-il)benzamida.
ES2329639B1 (es) 2007-04-26 2010-09-23 Laboratorios Almirall S.A. Nuevos derivados de 4,8-difenilpoliazanaftaleno.
US7553833B2 (en) * 2007-05-17 2009-06-30 Hoffmann-La Roche Inc. 3,3-spiroindolinone derivatives
US8134001B2 (en) * 2007-12-14 2012-03-13 Hoffmann-La Roche Inc. Spiroindolinone derivatives
US7776875B2 (en) * 2007-12-19 2010-08-17 Hoffman-La Roche Inc. Spiroindolinone derivatives
US7723372B2 (en) * 2008-03-19 2010-05-25 Hoffman-La Roche Inc. Spiroindolinone derivatives
EP2108641A1 (de) 2008-04-11 2009-10-14 Laboratorios Almirall, S.A. Neue substituierte Spiro[Cycloalkyl-1,3'-indo]-2'(1'H)-on-Derivate und ihre Verwendung als p38 mitogen-activated Kinase Inhibitoren
EP2113503A1 (de) * 2008-04-28 2009-11-04 Laboratorios Almirall, S.A. Neue substituierte Indolin-2-on- Derivate und ihre Verwendung als p39 mitogen-activated Kinase Inhibitoren
KR100915320B1 (ko) 2008-09-29 2009-09-03 (주)메디룬 생리통완화를 위한 휴대용 조합자극기
US20100190814A1 (en) 2009-01-26 2010-07-29 Li Chen Spiroindolinone derivative prodrugs
US7928233B2 (en) * 2009-02-10 2011-04-19 Hoffmann-La Roche Inc. Spiroindolinone pyridine derivatives
US8217051B2 (en) * 2009-02-17 2012-07-10 Hoffmann-La Roche Inc. Spiroindolinone derivatives
US8076482B2 (en) 2009-04-23 2011-12-13 Hoffmann-La Roche Inc. 3,3′-spiroindolinone derivatives
CN102741259B (zh) 2009-07-31 2016-04-13 全球结核病药物研发联盟 硝基咪唑并噁嗪和硝基咪唑并噁唑的类似物及其用途
US8088815B2 (en) 2009-12-02 2012-01-03 Hoffman-La Roche Inc. Spiroindolinone pyrrolidines
US8288431B2 (en) 2010-02-17 2012-10-16 Hoffmann-La Roche Inc. Substituted spiroindolinones
US8217044B2 (en) 2010-04-28 2012-07-10 Hoffmann-La Roche Inc. Spiroindolinone pyrrolidines
JO2998B1 (ar) 2010-06-04 2016-09-05 Amgen Inc مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان
US9962459B2 (en) * 2010-07-02 2018-05-08 Basf Se Ultrathin fluid-absorbent cores
JP5792279B2 (ja) 2011-03-10 2015-10-07 第一三共株式会社 ジスピロピロリジン誘導体
WO2013049250A1 (en) 2011-09-27 2013-04-04 Amgen Inc. Heterocyclic compounds as mdm2 inhibitors for the treatment of cancer
TWI586668B (zh) 2012-09-06 2017-06-11 第一三共股份有限公司 二螺吡咯啶衍生物之結晶
WO2014100065A1 (en) 2012-12-20 2014-06-26 Merck Sharp & Dohme Corp. Substituted imidazopyridines as hdm2 inhibitors
US11407721B2 (en) 2013-02-19 2022-08-09 Amgen Inc. CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer
AU2014223547B2 (en) 2013-02-28 2017-11-16 Amgen Inc. A benzoic acid derivative MDM2 inhibitor for the treatment of cancer
WO2014151863A1 (en) 2013-03-14 2014-09-25 Amgen Inc. Heteroaryl acid morpholinone compounds as mdm2 inhibitors for the treatment of cancer
JOP20200296A1 (ar) 2013-06-10 2017-06-16 Amgen Inc عمليات صنع وأشكال بلورية من mdm2 مثبط
EP3164401B1 (de) 2014-07-03 2018-12-26 Boehringer Ingelheim International GmbH Neue spiro[3h-indole-3,2´-pyrrolidin]-2(1h)-one verbindungen und deren derivate als mdm2-p53 inhibitoren
EP3260119B1 (de) 2015-02-20 2023-11-15 Daiichi Sankyo Company, Limited Kombinationsverfahren zur behandlung von krebs
EP3284466A4 (de) 2015-04-13 2018-12-05 Daiichi Sankyo Company, Limited Behandlungsverfahren mit kombination aus mdm2-inhibitor und btk-inhibitor
MX2018004207A (es) 2015-10-09 2018-07-06 Boehringer Ingelheim Int Nuevos compuestos de espiro[3h-indol-3,2â´-pirrolidin]-2(1h)-ona y derivados como inhibidores de mdm2-p53.
ES2858151T3 (es) 2016-05-20 2021-09-29 Hoffmann La Roche Conjugados de PROTAC-anticuerpo y procedimientos de uso
WO2018074387A1 (ja) 2016-10-17 2018-04-26 第一三共株式会社 Ｍｄｍ２阻害剤とｄｎａメチルトランスフェラーゼ阻害剤との併用治療法
EP3511334A1 (de) * 2018-01-16 2019-07-17 Adamed sp. z o.o. 1,2,3',5'-tetrahydro-2'h-spiro[indol-3,1'-pyrrolo[3,4-c]pyrrol] -2,3'-dion-verbindungen als therapeutische mittel, die tp53 aktivieren
WO2023056069A1 (en) 2021-09-30 2023-04-06 Angiex, Inc. Degrader-antibody conjugates and methods of using same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003505388A (ja) * 1999-07-21 2003-02-12 アストラゼネカ・アクチエボラーグ 新規化合物
BRPI0708883A2 (pt) * 2006-03-13 2011-06-14 Hoffmann La Roche derivados de espiroindolinona

Also Published As

Publication number Publication date
TW200801000A (en) 2008-01-01
US20070213341A1 (en) 2007-09-13
BRPI0709605A2 (pt) 2011-07-19
EP1996590B1 (de) 2010-10-06
KR101131031B1 (ko) 2012-04-12
JP5038337B2 (ja) 2012-10-03
AU2007224505A1 (en) 2007-09-20
CA2645062A1 (en) 2007-09-20
DE602007009650D1 (de) 2010-11-18
RU2008140386A (ru) 2010-04-20
AU2007224505B2 (en) 2012-05-03
NO20083726L (no) 2008-11-25
WO2007104664A1 (en) 2007-09-20
EP1996590A1 (de) 2008-12-03
IL193641A0 (en) 2009-05-04
AR059957A1 (es) 2008-05-14
JP2009529566A (ja) 2009-08-20
KR20080095279A (ko) 2008-10-28
RU2435771C2 (ru) 2011-12-10

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