SG11201507240RA - Benzo-fused heterocyclic derivatives useful as agonists of gpr120 - Google Patents

Benzo-fused heterocyclic derivatives useful as agonists of gpr120

Info

Publication number
SG11201507240RA
SG11201507240RA SG11201507240RA SG11201507240RA SG11201507240RA SG 11201507240R A SG11201507240R A SG 11201507240RA SG 11201507240R A SG11201507240R A SG 11201507240RA SG 11201507240R A SG11201507240R A SG 11201507240RA SG 11201507240R A SG11201507240R A SG 11201507240RA
Authority
SG
Singapore
Prior art keywords
gpr120
agonists
benzo
fused heterocyclic
derivatives useful
Prior art date
Application number
SG11201507240RA
Inventor
Zhihua Sui
Nalin L Subasinghe
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of SG11201507240RA publication Critical patent/SG11201507240RA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80Radicals substituted by oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56Benzopyrazoles; Hydrogenated benzopyrazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62Benzothiazoles
    • C07D277/64Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56Radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04Ortho-condensed systems
SG11201507240RA 2013-03-14 2014-03-07 Benzo-fused heterocyclic derivatives useful as agonists of gpr120 SG11201507240RA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361783118P 2013-03-14 2013-03-14
PCT/US2014/021790 WO2014159061A2 (en) 2013-03-14 2014-03-07 Benzo-fused heterocyclic derivatives useful as agonists of gpr120

Publications (1)

Publication Number Publication Date
SG11201507240RA true SG11201507240RA (en) 2015-10-29

Family

ID=50439484

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201507240RA SG11201507240RA (en) 2013-03-14 2014-03-07 Benzo-fused heterocyclic derivatives useful as agonists of gpr120
SG10201709565QA SG10201709565QA (en) 2013-03-14 2014-03-07 Benzo-fused heterocyclic derivatives useful as agonists of gpr120

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10201709565QA SG10201709565QA (en) 2013-03-14 2014-03-07 Benzo-fused heterocyclic derivatives useful as agonists of gpr120

Country Status (19)

Country Link
US (4) US9562053B2 (en)
EP (2) EP2970157B1 (en)
JP (2) JP6479751B2 (en)
KR (2) KR102249047B1 (en)
CN (1) CN105209444B (en)
AU (2) AU2014241397B2 (en)
BR (2) BR112015022290B1 (en)
CA (1) CA2905293C (en)
DK (2) DK3421458T3 (en)
EA (1) EA027781B1 (en)
ES (2) ES2836053T3 (en)
IL (2) IL240643B (en)
MX (1) MX2015012094A (en)
NZ (2) NZ751217A (en)
PH (2) PH12015501941B1 (en)
PL (2) PL3421458T3 (en)
SG (2) SG11201507240RA (en)
UA (2) UA117241C2 (en)
WO (1) WO2014159061A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2970157B1 (en) 2013-03-14 2018-04-25 Janssen Pharmaceutica NV Benzo-fused heterocyclic derivatives useful as agonists of gpr120
EP3509587B1 (en) 2016-09-12 2023-12-06 Valo Health, Inc. Monocyclic compounds useful as gpr120 modulators
JP7065081B2 (en) 2016-09-12 2022-05-11 インテグラル ヘルス, インコーポレイテッド Bicyclic compounds useful as GPR120 modulators
CA3090445A1 (en) 2018-03-15 2019-09-19 Axxam S.P.A. Substituted pyrazoles ffa4/gpr120 receptor agonists
CN111233724A (en) * 2020-01-22 2020-06-05 广东工业大学 Sulfydryl functionalized organic aromatic carboxylic acid ligand and preparation method and application thereof
CN111153841A (en) * 2020-01-22 2020-05-15 广东工业大学 Sulfydryl functionalized organic aromatic carboxylic acid ligand and preparation method and application thereof

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004041266A1 (en) 2002-11-08 2004-05-21 Takeda Pharmaceutical Company Limited Receptor function controlling agent
EP1585726A1 (en) 2003-01-06 2005-10-19 Eli Lilly And Company Fused heterocyclic derivatives as ppar modulators
JP4922615B2 (en) * 2003-11-26 2012-04-25 武田薬品工業株式会社 Receptor function regulator
US7544707B2 (en) 2003-12-22 2009-06-09 Eli Lilly And Company Bicyclic derivatives as PPAR modulators
US7456218B2 (en) 2003-12-25 2008-11-25 Takeda Pharmaceutical Company Limited 3-(4-benzyloxyphenyl) propanoic acid derivatives
US7517910B2 (en) 2004-03-30 2009-04-14 Takeda Pharmaceutical Company Limited Alkoxyphenylpropanoic acid derivatives
WO2008030618A1 (en) 2006-09-07 2008-03-13 Amgen Inc. Benzo-fused compounds for use in treating metabolic disorders
WO2008030520A1 (en) 2006-09-07 2008-03-13 Amgen Inc. Heterocyclic gpr40 modulators
WO2008038251A2 (en) 2006-09-29 2008-04-03 Actelion Pharmaceuticals Ltd 3-aza-bicyclo[3.1.0]hexane derivatives
AU2008218951B2 (en) 2007-02-22 2011-11-17 Irm Llc Compounds and methods for modulating g protein-coupled receptors
WO2008139987A1 (en) 2007-04-26 2008-11-20 Japan Science And Technology Agency G-protein-conjugated receptor agonist
WO2009117421A2 (en) 2008-03-17 2009-09-24 Kalypsys, Inc. Heterocyclic modulators of gpr119 for treatment of disease
MX2011004125A (en) 2008-10-21 2011-05-19 Metabolex Inc Aryl gpr120 receptor agonists and uses thereof.
AR074760A1 (en) * 2008-12-18 2011-02-09 Metabolex Inc GPR120 RECEIVER AGONISTS AND USES OF THE SAME IN MEDICINES FOR THE TREATMENT OF DIABETES AND METABOLIC SYNDROME.
CA2754688A1 (en) * 2009-03-11 2010-09-16 Msd K.K. Novel isoindolin-1-one derivative
JP5234029B2 (en) * 2009-08-05 2013-07-10 山栄化学株式会社 No-clean active resin composition and surface mounting technology
WO2011094890A1 (en) 2010-02-02 2011-08-11 Argusina Inc. Phenylalanine derivatives and their use as non-peptide glp-1 receptor modulators
US8299117B2 (en) * 2010-06-16 2012-10-30 Metabolex Inc. GPR120 receptor agonists and uses thereof
WO2011159297A1 (en) * 2010-06-16 2011-12-22 Metabolex, Inc. Gpr120 receptor agonists and uses thereof
EP2747560A4 (en) 2011-07-29 2015-02-25 Tempero Pharmaceuticals Inc Compounds and methods
EP2970157B1 (en) 2013-03-14 2018-04-25 Janssen Pharmaceutica NV Benzo-fused heterocyclic derivatives useful as agonists of gpr120

Also Published As

Publication number Publication date
CA2905293A1 (en) 2014-10-02
US11254647B2 (en) 2022-02-22
JP2016516690A (en) 2016-06-09
EP3421458B1 (en) 2020-11-11
EP2970157A2 (en) 2016-01-20
PH12015501941A1 (en) 2016-02-01
IL240643B (en) 2019-06-30
WO2014159061A2 (en) 2014-10-02
IL240643A0 (en) 2015-10-29
WO2014159061A3 (en) 2015-01-15
PH12019500467A1 (en) 2020-11-04
CA2905293C (en) 2021-10-12
US20140275172A1 (en) 2014-09-18
DK3421458T3 (en) 2020-12-14
SG10201709565QA (en) 2017-12-28
AU2018214053A1 (en) 2018-08-23
UA117241C2 (en) 2018-07-10
BR122021021616B1 (en) 2022-08-30
US20200317629A1 (en) 2020-10-08
IL267196B (en) 2021-06-30
US9562053B2 (en) 2017-02-07
AU2014241397B2 (en) 2018-05-10
KR20150127722A (en) 2015-11-17
BR112015022290B1 (en) 2022-03-03
KR102422559B1 (en) 2022-07-18
US10730847B2 (en) 2020-08-04
EP3421458A1 (en) 2019-01-02
JP2019094341A (en) 2019-06-20
UA123269C2 (en) 2021-03-10
US20170088531A1 (en) 2017-03-30
EA201591734A1 (en) 2016-03-31
DK2970157T3 (en) 2018-07-16
EA027781B1 (en) 2017-08-31
CN105209444A (en) 2015-12-30
JP6479751B2 (en) 2019-03-06
CN105209444B (en) 2017-12-29
PL3421458T3 (en) 2021-04-19
JP6802302B2 (en) 2020-12-16
BR112015022290A2 (en) 2017-07-18
AU2014241397A1 (en) 2015-09-03
ES2836053T3 (en) 2021-06-23
IL267196A (en) 2019-08-29
PH12015501941B1 (en) 2016-02-01
KR20210050601A (en) 2021-05-07
EP2970157B1 (en) 2018-04-25
US20190152937A1 (en) 2019-05-23
PL2970157T3 (en) 2019-02-28
ES2673921T3 (en) 2018-06-26
US10155737B2 (en) 2018-12-18
MX2015012094A (en) 2016-04-15
KR102249047B1 (en) 2021-05-07
AU2018214053B2 (en) 2020-03-12
NZ751217A (en) 2020-07-31
NZ711191A (en) 2019-05-31

Similar Documents

Publication Publication Date Title
IL267196B (en) Benzo-fused heterocyclic derivatives useful as agonists of gpr120
HRP20181710T1 (en) Use of benzimidazole-proline derivatives
EP2982666A4 (en) Heterocyclic compound
EP3013796A4 (en) Biaryl derivatives as gpr120 agonists
AP2016009176A0 (en) Novel heterocyclic compounds
EP3018126A4 (en) Heterocyclic compound
IL245443A0 (en) Substituted pyridine derivatives useful as gsk-3 inhibitors
ZA201602198B (en) Preparation of hydroxy-benzylbenzene derivatives
EP2980089A4 (en) Heterocyclic compound
HRP20190133T1 (en) Heterocyclic compound
EP2961403A4 (en) Heterocyclic inhibitors of the sodium channel
EP2982670A4 (en) Heterocyclic compound
EP2914580A4 (en) Thioaryl derivatives as gpr120 agonists
IL240763A0 (en) Halogenopyrazoles as inhibitors of therombin
GB201314960D0 (en) Heterocyclic derivatives
GB201300306D0 (en) Heterocyclic derivatives
TH1501003198A (en) Heterocyclic compounds