ATE299698T1 - Il-8 rezeptor antagonisten - Google Patents

Il-8 rezeptor antagonisten

Info

Publication number
ATE299698T1
ATE299698T1 AT01914603T AT01914603T ATE299698T1 AT E299698 T1 ATE299698 T1 AT E299698T1 AT 01914603 T AT01914603 T AT 01914603T AT 01914603 T AT01914603 T AT 01914603T AT E299698 T1 ATE299698 T1 AT E299698T1
Authority
AT
Austria
Prior art keywords
receptor antagonists
antagonists
receptor
Prior art date
Application number
AT01914603T
Other languages
English (en)
Inventor
Michael R Palovich
Joseph Weinstock
Katherine L Widdowson
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Application granted granted Critical
Publication of ATE299698T1 publication Critical patent/ATE299698T1/de

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/20—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
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    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/59—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Otolaryngology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Cardiology (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
AT01914603T 2000-03-01 2001-03-01 Il-8 rezeptor antagonisten ATE299698T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18618300P 2000-03-01 2000-03-01
PCT/US2001/006564 WO2001064208A1 (en) 2000-03-01 2001-03-01 Il-8 receptor antagonists

Publications (1)

Publication Number Publication Date
ATE299698T1 true ATE299698T1 (de) 2005-08-15

Family

ID=22683958

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01914603T ATE299698T1 (de) 2000-03-01 2001-03-01 Il-8 rezeptor antagonisten

Country Status (28)

Country Link
EP (1) EP1261328B1 (de)
JP (1) JP2003525242A (de)
KR (1) KR20020080460A (de)
CN (1) CN1416339A (de)
AP (1) AP2002002605A0 (de)
AR (1) AR033803A1 (de)
AT (1) ATE299698T1 (de)
AU (1) AU2001239970A1 (de)
BG (1) BG107014A (de)
BR (1) BR0108866A (de)
CA (1) CA2401659A1 (de)
CZ (1) CZ20022932A3 (de)
DE (1) DE60112051T2 (de)
DZ (1) DZ3309A1 (de)
EA (1) EA200200933A1 (de)
ES (1) ES2245976T3 (de)
HU (1) HUP0300599A3 (de)
IL (1) IL151429A0 (de)
MA (1) MA25657A1 (de)
MX (1) MXPA02008589A (de)
NO (1) NO20024133L (de)
OA (1) OA12184A (de)
PE (1) PE20011190A1 (de)
PL (1) PL358540A1 (de)
SK (1) SK12352002A3 (de)
UY (1) UY26601A1 (de)
WO (1) WO2001064208A1 (de)
ZA (1) ZA200206988B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1454204A (zh) * 2000-05-30 2003-11-05 史密丝克莱恩比彻姆公司 Il－8受体拮抗剂
WO2002067919A1 (en) * 2001-01-16 2002-09-06 Smithkline Beecham Corporation Il-8 receptor antagonists
IL156793A0 (en) * 2001-02-02 2004-02-08 Schering Corp 3,4-di-substituted cyclobutene-1,2-diones as cxc chemokine receptor antagonists
US7132445B2 (en) 2001-04-16 2006-11-07 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
US20040106794A1 (en) 2001-04-16 2004-06-03 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
RU2344123C9 (ru) * 2001-04-16 2009-05-20 Шеринг Корпорейшн 3,4-дизамещенные циклобутен-1,2-дионы как лиганды схс-хемокинового рецептора
MXPA04003439A (es) 2001-10-12 2004-07-08 Schering Corp Compuestos de maleimida 3,4 disustituidos como antagonistas de receptor de quimiocina cxc.
US6878709B2 (en) 2002-01-04 2005-04-12 Schering Corporation 3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists
EP1485089B1 (de) * 2002-03-18 2013-04-17 Merck Sharp & Dohme Corp. Kombinationsbehandlungen für chemokine-bedingte erkrankungen
PE20040570A1 (es) 2002-10-09 2004-08-30 Pharmacopeia Drug Discovery Tiadiazoldioxidos y tiadiazoloxidos como ligandos del receptor de cxc- y cc-quimiocina
EP1694659B8 (de) 2003-12-19 2008-10-08 Schering Corporation Thiadiazole als cxc- und cc-chemokinrezeptorliganden
CA2550540A1 (en) * 2003-12-22 2005-07-28 Schering Corporation Isothiazole dioxides as cxc- and cc- chemokine receptor ligands
WO2007005403A1 (en) 2005-06-29 2007-01-11 Schering Corporation 5,6-di-substituted oxadiazolopyrazines and thiadiazolopyrazines as cxc-chemokine receptor ligands
MX2008000366A (es) 2005-06-29 2008-03-07 Schering Corp Oxadiazoles di-sustituidos como ligandos del receptor cxc-quimiocina.
TWI734715B (zh) 2015-11-19 2021-08-01 美商卡默森屈有限公司 趨化因子受體調節劑
TWI724056B (zh) 2015-11-19 2021-04-11 美商卡默森屈有限公司 Ｃｘｃｒ２抑制劑
US11207294B2 (en) 2018-01-08 2021-12-28 Chemocentryx, Inc. Methods of treating generalized pustular psoriasis with an antagonist of CCR6 or CXCR2
CN112851635B (zh) * 2019-11-28 2022-09-16 中国医学科学院药物研究所 环状砜类化合物及其制备方法、用途和药物组合物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5780483A (en) * 1995-02-17 1998-07-14 Smithkline Beecham Corporation IL-8 receptor antagonists

Also Published As

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HUP0300599A2 (hu) 2003-07-28
ZA200206988B (en) 2003-10-16
EA200200933A1 (ru) 2003-02-27
NO20024133D0 (no) 2002-08-30
SK12352002A3 (sk) 2003-02-04
KR20020080460A (ko) 2002-10-23
AR033803A1 (es) 2004-01-07
EP1261328B1 (de) 2005-07-20
NO20024133L (no) 2002-10-31
DZ3309A1 (en) 2001-09-07
UY26601A1 (es) 2001-08-27
MXPA02008589A (es) 2003-02-24
ES2245976T3 (es) 2006-02-01
DE60112051T2 (de) 2006-04-27
EP1261328A1 (de) 2002-12-04
OA12184A (en) 2006-05-09
CN1416339A (zh) 2003-05-07
CA2401659A1 (en) 2001-09-07
CZ20022932A3 (cs) 2003-05-14
HUP0300599A3 (en) 2003-09-29
WO2001064208A1 (en) 2001-09-07
JP2003525242A (ja) 2003-08-26
BG107014A (bg) 2003-05-30
PL358540A1 (en) 2004-08-09
IL151429A0 (en) 2003-04-10
MA25657A1 (fr) 2002-12-31
PE20011190A1 (es) 2002-01-06
DE60112051D1 (de) 2005-08-25
AU2001239970A1 (en) 2001-09-12
EP1261328A4 (de) 2003-05-28
BR0108866A (pt) 2004-02-25
AP2002002605A0 (en) 2002-09-30

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