UA83870C2 - Замещенные бицикло[3.1.1]гептаном производные бензимидазолона и хиназолинона как агонисты человеческих рецепторов orl1 - Google Patents

Замещенные бицикло[3.1.1]гептаном производные бензимидазолона и хиназолинона как агонисты человеческих рецепторов orl1

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Publication number
UA83870C2
UA83870C2 UAA200604720A UAA200604720A UA83870C2 UA 83870 C2 UA83870 C2 UA 83870C2 UA A200604720 A UAA200604720 A UA A200604720A UA A200604720 A UAA200604720 A UA A200604720A UA 83870 C2 UA83870 C2 UA 83870C2
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UA
Ukraine
Prior art keywords
agonists
quinazolinone derivatives
bicycl
receptors
benzimidazolone
Prior art date
Application number
UAA200604720A
Other languages
English (en)
Ukrainian (uk)
Inventor
Хартог Якобус А.Й. Ден
Самуэль Давид
Даниэль Жассеран
Шаренбург Густав Й.М. ван
Стёйвенберг Герман Г. ван
Тынка Тёйнстра
Original Assignee
Сольве Фармасьютикалз Б.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сольве Фармасьютикалз Б.В. filed Critical Сольве Фармасьютикалз Б.В.
Publication of UA83870C2 publication Critical patent/UA83870C2/ru

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    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

Изобретение касается группы гидроноползамещенных производных бензимидазолона и хиназолинона, которые являются агонистами человеческих рецепторов ORL1 (ноцицептина). Изобретение также касается получения этих соединений, фармацевтических композиций, которые содержат фармакологически действующее количество, по крайней мере, одного из этих новых производных бензимидазолона и хиназолинона как действующее вещество, а также применения этих фармацевтических композиций для лечения расстройств, связанных с рецептором ORL1.Изобретение касается соединений общей формулы (1),, (1)где пометки имеют значение, приведенные в описании.
UAA200604720A 2003-10-03 2004-10-01 Замещенные бицикло[3.1.1]гептаном производные бензимидазолона и хиназолинона как агонисты человеческих рецепторов orl1 UA83870C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50794703P 2003-10-03 2003-10-03
EP03103671 2003-10-03
PCT/EP2004/052392 WO2005032547A1 (en) 2003-10-03 2004-10-01 Bicyclo`3.1.1!heptane substituted benzimidazolone and quinazolinone derivatives as agonists on human orl1 receptors

Publications (1)

Publication Number Publication Date
UA83870C2 true UA83870C2 (ru) 2008-08-26

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UAA200604720A UA83870C2 (ru) 2003-10-03 2004-10-01 Замещенные бицикло[3.1.1]гептаном производные бензимидазолона и хиназолинона как агонисты человеческих рецепторов orl1

Country Status (15)

Country Link
US (1) US7851630B2 (ru)
EP (1) EP1670457A1 (ru)
JP (1) JP2007507470A (ru)
CN (1) CN1838951A (ru)
AR (1) AR045843A1 (ru)
AU (1) AU2004277346B2 (ru)
BR (1) BRPI0414494A (ru)
CA (1) CA2534833A1 (ru)
MX (1) MXPA06002065A (ru)
RU (1) RU2357964C2 (ru)
SA (1) SA04250319B1 (ru)
TW (1) TW200519102A (ru)
UA (1) UA83870C2 (ru)
WO (1) WO2005032547A1 (ru)
ZA (1) ZA200603472B (ru)

Families Citing this family (8)

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Publication number Priority date Publication date Assignee Title
ATE429428T1 (de) * 2005-09-30 2009-05-15 Hoffmann La Roche Indanderivate als antagonisten des mch-rezeptors
DE102007009235A1 (de) * 2007-02-22 2008-09-18 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
KR20140139125A (ko) 2007-08-31 2014-12-04 퍼듀 퍼머 엘피 치환-퀴녹살린-형 피페리딘 화합물 및 그의 용도
CN102675226B (zh) * 2012-05-24 2014-04-23 西南大学 3-取代-1-甲基-2，4-喹唑啉二酮类化合物及其制备方法和应用
WO2014030743A1 (ja) * 2012-08-24 2014-02-27 武田薬品工業株式会社 複素環化合物
WO2014102589A1 (en) * 2012-12-27 2014-07-03 Purdue Pharma L.P. Quinazolin-4(3h)-one-type piperidine compounds and uses thereof
CN103420944A (zh) * 2013-07-26 2013-12-04 江西农业大学 一种合成顺式氢化诺卜基甲酰胺类化合物的方法
CN115124441B (zh) * 2022-06-30 2024-04-02 南京林业大学 一类诺卜酸酰肼类化合物的制备方法和产品及其应用

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FR2097031A1 (en) 1970-07-29 1972-03-03 Berri Balzac 2-aminoethoxyethyl-6,6-dimethyl nor pinane derivs - local anaesthetics spasmolytics and anticholinergics
ES2226129T3 (es) 1997-05-30 2005-03-16 Banyu Pharmaceutical Co., Ltd. Derivados de 2-0x0imidazol.
IL137149A0 (en) 1998-01-19 2001-07-24 Pfizer 4-(2-keto-1-benzimidazolinyl) piperidine compounds as orl1-receptor agonists
US6340681B1 (en) * 1999-07-16 2002-01-22 Pfizer Inc 2-benzimidazolylamine compounds as ORL-1-receptor agonists
JP2003524634A (ja) 1999-12-06 2003-08-19 ユーロ−セルティーク，エス．エイ． ノシセプチン受容体親和性を有するベンズイミダゾール化合物
TW200519101A (en) * 2003-09-25 2005-06-16 Solvay Pharm Bv Benzimidazolone and quinazolinone derivatives as agonists on human ORL1 receptors
AR046756A1 (es) * 2003-12-12 2005-12-21 Solvay Pharm Gmbh Derivados de hidronopol como agonistas de receptores orl-1 humanos.

Also Published As

Publication number Publication date
RU2006110519A (ru) 2006-07-27
CN1838951A (zh) 2006-09-27
EP1670457A1 (en) 2006-06-21
AU2004277346B2 (en) 2009-02-19
JP2007507470A (ja) 2007-03-29
TW200519102A (en) 2005-06-16
SA04250319B1 (ar) 2008-07-19
BRPI0414494A (pt) 2006-11-14
CA2534833A1 (en) 2005-04-14
AU2004277346A1 (en) 2005-04-14
RU2357964C2 (ru) 2009-06-10
ZA200603472B (en) 2007-09-26
AR045843A1 (es) 2005-11-16
MXPA06002065A (es) 2006-05-19
US7851630B2 (en) 2010-12-14
WO2005032547A1 (en) 2005-04-14
US20050075355A1 (en) 2005-04-07

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